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Nicholas Petrelli, M.D., Receives Lifetime Achievement Award
Nicholas Petrelli, M.D., Bank of America Endowed Medical Director of ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, has received the Lifetime Achievement Award from Tulane University School of Medicine in New Orleans, Louisiana. Petrelli is a 1973 graduate of the school. Dr. Petrelli, center, receives the Lifetime Achievement Award from Julius L. Levy, Jr., M.D., past president, Tulane Medical Alumni Association, left, and Lee Hamm, M.D., senior vice president & dean of the School of Medicine, and the James R. Doty Distinguished Professor and Chair, Tulane University School of Medicine, New Orleans, Louisiana. The award recognizes an alumnus of the school who has made significant contributions to the field of medicine and has offered outstanding leadership in the community. Under Petrelli’s leadership at ChristianaCare since 2001, the Helen F. Graham Cancer Center & Research Institute has become a national model for multidisciplinary cancer care and a top enroller in U.S. clinical research trials. The Graham Cancer Center is a National Cancer Institute Community Oncology Research Program and one of only five hybrid academic community cancer centers in the nation. Through the work of the Graham Cancer Center and partnerships with health care providers, community organizations and the state to improve the prevention, diagnosis and treatment of cancer, Delaware’s cancer mortality rate has dropped twice as fast as the national rate. In addition, the state is outpacing the nation in reducing deaths from a number of cancers. Delaware has gone from number one in cancer mortality 22 years ago to number 17 today. Petrelli has numerous achievements in cancer care and research. He has established several firsts for Delaware, including a multidisciplinary disease center site, the Cawley Center for Translational Cancer Research, a tissue procurement center, an adult genetic counseling program, a statewide high-risk family cancer registry consisting of more than 500,000 individuals and an innovative oncology express unit to provide patients with cancer a way to address urgent care needs without having to go to the emergency department. Among his accomplishments on the national level are the first primary care practice established at a cancer center and the first gene editing research program integrated into a community cancer center. Through a unique research partnership with the Ellen and Ronald Caplan Cancer Center of The Wistar Institute, he has brought cutting-edge cancer treatments and diagnostics to Delawareans. And in a ground-breaking collaboration among the government, community organizations and the Graham Cancer Center nearly 10 years ago, Delaware ended the disparity between Black and white people for colorectal cancer screenings and mortality, which continues to this day. Petrelli has received numerous awards and has authored 360 peer-reviewed manuscripts and 31 book chapters. He has served on advisory panels of the National Cancer Institute, the American Society of Clinical Oncology, the American Cancer Society and the Society of Surgical Oncology. He was president of the Society of Surgical Oncology from 2007 to 2008. In 2013 he received the Order of the First State Award, the highest honor in the state, from Delaware Gov. Jack Markell. In 2019 he received the James Tilton award (named for the first U.S. Army Surgeon General) from the Medical Society of Delaware.
Program addresses disparities in breast cancer between Black and white women ChristianaCare’s Helen F. Graham Cancer Center & Research Institute is partnering with Susan G. Komen®, the world’s leading breast cancer organization, in an expansion of Komen’s screening and diagnostics program to income-eligible residents of Delaware. Under the program, Delaware women who meet income qualifications will be able to access no-cost breast cancer screening mammograms and necessary diagnostic follow-up tests. Once approved by Susan G. Komen for care, they can select ChristianaCare for services. ChristianaCare is one of 20 health systems nationwide partnering with Susan G. Komen in the program, which seeks to reduce disparities in areas where the breast cancer mortality gap between Black and white women is the greatest. “The Graham Cancer Center is proud of its longstanding partnership with Susan G. Komen to bring breast cancer screenings to our community and to reduce disparities and save lives,” said Nicholas Petrelli, M.D., Bank of America endowed medical director of the Helen F. Graham Cancer Center & Research Institute. “This new partnership with Komen is an innovative way that we are stronger together as we continue to reduce barriers to care and help more Delaware women access timely breast imaging and treatment,” he said. “The screening and diagnostics program is critical for individuals who may have been putting off their breast cancer screening due to concerns about cost,” said Nora Katurakes, RN, OCN, manager of the Graham Cancer Center’s Community Outreach & Education program. “Early detection saves lives, and cost should not be a barrier to accessing high-quality health care services for anyone in need. This program seeks to achieve health equity for all.” “Early detection saves lives, and cost should not be a barrier to accessing high-quality health care services for anyone in need,” said Nora Katurakes, RN, OCN, manager of Community Outreach and Education According to the Delaware Division of Public Health, breast cancer is the most common cancer diagnosed among women in Delaware, and Black women are disproportionately more affected by breast cancer than white and Hispanic women and have a higher mortality rate. In addition, Black women in Delaware have among the highest incidence rates in the U.S. of triple negative breast cancer, an aggressive form of the disease that is harder to treat and more likely to return. The Komen screening and diagnostics program is a service provided through the Komen Patient Care Center. Last year, Susan G. Komen provided nearly 3,000 screening and diagnostics services. Komen hopes to serve another 3,000 individuals in 2023. To be eligible for the program, individuals must have a current annual household income at or below 300% of the Federal Poverty Level. For one person that is $43,740. A two-person family must have a $59,160 household income to be eligible. The Tatiana Copeland Breast Center at the Helen F. Graham Cancer Center & Research Institute is one of the few facilities in the region devoted exclusively to breast care, diagnosis and treatment, and was the first center in the state to offer high-definition 3D mammography imaging. About Breast Cancer Screening Screening mammography tests are used to find breast cancer before it causes any warning signs or symptoms. Regular screening tests along with follow-up tests and treatment, if diagnosed, reduce an individual’s chance of dying from breast cancer. Mammography is a test that uses X-rays to create images of the breast. These images are called mammograms. A radiologist trained to read mammograms studies the images and looks for signs of breast cancer. A mammogram may show: No signs of breast cancer. A benign (not cancer) condition or other change that does not suggest cancer. An abnormal finding that needs follow-up tests to rule out cancer. Income eligible people seeking access to a breast cancer screening mammogram or diagnostic service should contact the Komen Breast Care Helpline at 1-877-465-6636 or helpline@komen.org to learn more. Individuals who would like more information about breast cancer screening in Delaware can also call ChristianaCare Community Health Outreach & Education at 302-623-4661.
Birmingham MP officially opens £1.5 million healthcare simulation facilities at Aston University
Paulette Hamilton MP officially opens healthcare simulation facilities at Aston Medical School and School of Optometry State-of-the-art facilities including medical simulation room with high fidelity manikins for students to practise real life scenarios opens The first in Europe ocular simulation suite allows students to refine skills in examining the health of the eyes and experience a wide range of eye disease. New £1.5 million healthcare simulation facilities have officially opened at Aston Medical School and in the School of Optometry at Aston University. The state-of-the-art facilities were formally opened by Paulette Hamilton, member of parliament for Birmingham Erdington, on Friday 2 December at a ribbon cutting ceremony that was attended by Aston University Vice-Chancellor Professor Aleks Subic as well as other members of the University executive and staff from the College of Health and Life Sciences. Commenting on the new facilities Paulette Hamilton MP said: “It’s been brilliant to visit and officially open the new healthcare simulation facilities at Aston University. “I know from my time as a nurse how important it is to have access to good training and the latest equipment. These fantastic facilities will give students the best possible learning experience as they prepare to enter their profession, providing healthcare in Birmingham and beyond.” Hosted by Professor Anthony Hilton, Pro-Vice-Chancellor and Executive Dean of the College of Health and Life Sciences, guests were invited to take a tour of the new facilities including a clinical skills simulation room which allows students to practise in emergency settings and an ocular simulation unit facility, the only one in Europe. Professor Hilton said: "We are delighted these new facilities have opened in time for the start of the new term and that students can benefit from practising their clinical skills in a variety of scenarios. “The acute care simulation room will allow for simulated emergency resuscitation scenarios that are very difficult to teach in real life situations, such as heart attacks, acute breathlessness and severe allergic reaction and will be of great value in training students of medicine, pharmacy and optometry.” The healthcare simulation facilities will be used by students studying medicine, pharmacy and optometry, where they will be able to practise in emergency settings using high quality manikins where they will simulate treating patients for acute conditions such as a heart attack or learning how to intubate a patient onto a ventilator. Professor Aleks Subic, Vice-Chancellor, Aston University said: “The launch of the Aston University healthcare simulation facilities marks an important milestone in the development of our digital health precinct within the Birmingham Knowledge Quarter. By establishing world-class medical imaging, advanced visualisation, and digital diagnostics capabilities we are in fact bringing Industry 4.0 to healthcare. “Our students from the Aston Medical School and School of Optometry in particular, will benefit immensely from this development as they will be able to detect a wide range of clinical conditions and diseases and explore different interventions and scenarios, safely within a simulated environment.” The high-fidelity acute care simulation room will also be equipped with recording facilities, a debrief room and control room. The funding has allowed for the purchase of other training equipment such as a hospital grade bed and single task trainer simulation equipment. For example, male and female catheterisation models, pelvic and rectal trainers, venepuncture arms, breast trainers and abdominal trainers. The facilities were part funded by the Office for Students which awarded the University £806,226 to set up the ‘high fidelity’ simulation A&E room with further expenditure by Aston University on the ocular simulation unit. The ocular simulation facility is unique in Europe. It allows students to refine their skills in examining the health of the front and back of the eyes and to experience a wide range of eye disease. One of the simulators allows students to utilise their smartphones to practise at home. They can gain direct feedback and be assessed by the simulators, allowing more flexible, diverse and intensive learning than can be achieve with clinical practice placements. Professor Liz Moores, deputy dean of the College of Health and Life Sciences, said: “The College of Health and Life Sciences is thrilled with this investment. The enhanced facilities will help to support many of our healthcare students, including those now applying for our new nursing degree. It will also support us with the introduction of the new pharmacy and optometry education standards, providing a step change in our ability to simulate a wide range of clinical scenarios.” For more information about studying in the College of Health and Life Sciences please visit our website.
Aston University has teamed up with biotechnology company Biocleave Ltd in a new knowledge transfer partnership (KTP) to develop the company’s capacity to produce membrane-associated proteins on a competitive commercial scale. The partnership will see Aston University’s world-leading expertise provide next-level solutions to a complex problem and provide exciting breakthroughs from both commercial and scientific standpoints. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. Biocleave Ltd produces ‘Research Use Only’ (RUO) proteins. These are used widely in industry and academia to study and develop diagnostics and disease treatments. The process of manufacturing these proteins is known as ‘expression’, requiring host cells to produce them. The company is the first to engineer the non-pathogenic microbe Clostridia as a recombinant protein expression host, enabling them to overcome the typical expression challenges of production host toxicity and costly development cycles. Initial trials have demonstrated advantages to making membrane-associated proteins in Clostridia compared with established production systems. However, these proteins are associated with the fatty membrane that surrounds a cell and are not soluble in water. While Biocleave has well-established proprietary technology for manipulating the microbes, they want to extend their expertise for purifying these challenging membrane proteins, essential to commercialising their production. The Aston University team will be led by Dr Alan Goddard, senior lecturer in biochemistry in the School of Biosciences and founding member of Aston Membrane Proteins and Lipids (AMPL). Dr Goddard’s research focuses on the application of membrane biology to industrially relevant problems. He has nearly 20 years' experience working with membranes and their integral proteins. Dr Goddard will be joined by Professor Roslyn Bill, associate dean (research) for the College of Health and Life Sciences and director of AMPL. Professor Bill’s research focuses on the purification and characterisation of membrane proteins and she has published extensively on yeast as a recombinant expression host. Commenting on the project, Dr Goddard said: “This is a really exciting opportunity to leverage the decades of research experience Professor Bill and I have with expressing and purifying membrane proteins. It will allow Biocleave to enter new markets, many of which are important for drug development and healthcare. Hopefully, the products we make will have positive benefits not only for Biocleave’s customers but also wider society.” Dr Liz Jenkinson, chief executive of Biocleave Ltd, said: “We’ve made great progress in establishing the technology to work with Clostridia, a promising host, and although we’re constantly learning, so much is still unknown about the clostridial membrane. Through this KTP partnership with Aston University, we’re excited to develop the skills of our staff and expand our commercial offering to extend our range of RUO protein targets.” Because the Clostridial membrane adds a new level of complexity, successfully developing the required tools internally to resolve these issues, without input from experts, would take considerable time.
Toolkit is easily incorporated into any laboratory science course Wilmington, Del., April 1, 2021 – St. Georges Technical High School in southern New Castle County, Delaware is the first high school in the United States to use ChristianaCare Gene Editing Institute’s innovative CRISPR in a Box Educational Toolkit™ in a science class. CRISPR in a Box brings to life the much-heralded CRISPR gene editing technology – the “genetic scissors” that allow scientists to edit DNA. The toolkit is designed for educational sessions in secondary and post-secondary schools and is suitable for remote learning. “Gene editing is the future of medicine,” said Eric Kmiec, Ph.D., director of ChristianaCare’s Gene Editing Institute. “Our partnership with the Delaware Department of Education will help cultivate the next generation of genetic scientists and enhance Delaware’s position as a leader in the biosciences.” “We are thrilled that students at St. Georges Technical High School will be the first In the United States to experience a live demonstration of CRISPR gene editing using our Innovative CRISPR in a Box educational toolkit,” said Siobhan Hawthorne, Education and Community Outreach leader at ChristianaCare’s Gene Editing Institute. “This toolkit will provide STEM students with a visual understanding of how the exciting CRISPR technology can unlock medical treatments to improve lives.” Delaware Secretary of Education Susan Bunting praised her department's partnership with ChristianaCare's Gene Editing Institute to develop the “Seeds of STEM” course that teaches high school students about gene editing. “Gene editing approaches diseases in new ways and will have significant impact in the health care and agriscience fields,” Bunting said. “This is a great example of an industry and education partnership investing in youth by providing hands-on knowledge and skills around emerging technology.” “We are so fortunate that ChristianaCare’s Gene Editing Institute reached out to our program to plan a high school ‘first’ opportunity with this new CRISPR experiment,” said Danya Espadas, one of the St. Georges biotech teachers. “Giving students the chance to use a cutting-edge, 21st century tool for medicine in their own high school lab – to have that technology at their fingertips – transcends what they see in a textbook or a video. By being able to do it themselves, it makes it real for them.” Espada said the experiment focuses on editing a gene of a non-infectious E.coli bacteria to become resistant to an antibiotic, thereby allowing researchers to create a new class of antibiotics that cannot be overcome by bacteria that are gene resistant. “We’re talking about eventually saving lives, here,” she said. “What can be more important than that?” The tools in CRISPR in a Box have been designed based on the pioneering discoveries of the Gene Editing Institute that are currently being used to explore next-generation medical therapies and diagnostics for diseases, including lung cancer and sickle-cell anemia. Component items in the toolkit include the CRISPR/Cas complex, a target DNA molecule, a mammalian cell free extract and a synthetic DNA molecule. All materials in the kit are safe, synthetic materials. There are no live cultures or viruses involved. The kit is meant to provide a hands-on demonstration of CRISPR’s capabilities, and not allow for manipulations of living organisms. “The kit is easy and fun to use,” said Kristen Pisarcik, research assistant at the Gene Editing Institute who has taught students at Delaware Technical Community College which first used the toolkit. “In a short period of time students will reliably and successfully complete the laboratory activity and be able to see the results of gene editing,” she said. Since the foundations of the kit touch upon key themes in biology, it can be readily incorporated into practically any science or biology course with a laboratory component, “One of the beauties of CRISPR in a Box is that there is no need to purchase specialized equipment. If a teaching lab can support bacterial cultivation, it can perform the in vitro gene editing lab activity,” Pisarcik said. CRISPR in a Box is the evolution of a partnership between the Gene Editing Institute, Delaware Technical Community College and Rockland Immunochemicals that began in 2017 with a National Science Foundation grant to develop the first-ever gene editing curriculum for community college students. Video and photo collection of first class in U.S. to use CRISPR in a Box™ educational gene editing toolkit. About ChristianaCare’s Gene Editing Institute The Gene Editing Institute, a worldwide leader in CRISPR gene editing technology and the only institute of its kind based within a community health care system, takes a patient-first approach in all its research to improve the lives of people with life-threatening disease. Since 2015, researchers at the Gene Editing Institute have been involved in several ground-breaking firsts in the field, including the development of the first CRISPR gene editing tool to allow DNA repairs outside the human cell which will rapidly speed therapies to patients and a unique version of CRISPR called EXACT that reduces the number of off-target edits to other areas of the genome, which is vital for further research and patient applications. Its researchers are currently developing a patient trial for lung cancer using CRISPR and employing the technology to combat the COVID-19 pandemic. About the biotech program St. Georges Technical High School The Biotech career program of study at St. Georges Technical High School is the first such program offered in a Delaware high school. With two teachers and approximately 100 students in grades 10-12, the program presents advanced content in biology and chemistry with opportunities for students to learn basic laboratory techniques and procedures and to maintain and operate common instruments and equipment used in a biotechnology laboratory. St. Georges is a comprehensive career and technical high school with 1,100 students who study in one of 16 different career pathways.
Locking down your data. Are lawmakers finally waking up to the importance of privacy?
Data collection and data control are becoming international issues. As the lucrative and important pieces of customer data collection become a priority for major tech and software companies – privacy and protection is now emerging as the key issue for international legislators. Just recently, Microsoft had to update several of its agreements with cloud customers and re-classify its role in Europe. Last month, as part of an enquiry that opened earlier this year, the European Data Protection Supervisor (EDPS) expressed 'serious concerns' over whether the relevant contractual terms were compliant with GDPR, and over Microsoft's role as a data processor or data controller for EU institutions. The report followed the publication of a series of papers by the Dutch Ministry of Justice and Security, suggesting that Office 365 was breaching GDPR by collecting 'functional and diagnostics data', including email subject lines and text run through a spell-checker. Microsoft has now acknowledged its position as a data controller - which has a higher bar for ensuring user data - when it comes to the provision of enterprise services. "In the [Online Services Terms] OST update, we will clarify that Microsoft assumes the role of data controller when we process data for specified administrative and operational purposes incident to providing the cloud services covered by this contractual framework, such as Azure, Office 365, Dynamics and Intune," says Julie Brill, Microsoft's corporate vice president for global privacy and regulatory affairs and chief privacy officer. "This subset of data processing serves administrative or operational purposes such as account management; financial reporting; combating cyber attacks on any Microsoft product or service; and complying with our legal obligations." Forbes Magazine – November 18 Data collection and control are becoming big issues on a global scale as more and more governments are looking for consumer protection while companies are seeking the profit that comes from the information customers provide voluntarily and sometimes unwillingly . Are you a reporter covering technology, privacy and data collection and control? Did you know that there is value in the results of spell-checkers and document review tools? If you have questions or need an expert source for insight and perspective – let us help. Dr. Rachel Cummings is an expert in data privacy, algorithmic economics, optimization, statistics, and information theory. Dr. Cummings is available to speak with media regarding data privacy and other topics, simply click on her icon to arrange an interview.
