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A Virginia Commonwealth University researcher has developed an alternative method of producing semiconductor materials that is environmentally friendly. Semiconductors are crucial to modern electronics and displays, but they are constructed from toxic solvents. They also are created at high temperatures and pressures, resulting in both environmental damage and high production costs. The new technique has been introduced by Leah Spangler, Ph.D., assistant professor in the VCU College of Engineering’s Department of Chemical and Life Science Engineering, and Michael Hecht, a professor of chemistry at Princeton University. It demonstrates an alternative method to produce semiconductor materials called quantum dots using proteins at room temperature in water, resulting in a more environmentally friendly synthesis method. “This research uses de novo proteins, which are not taken from natural organisms but instead made by design for specific purposes,” Spangler said. “Therefore, this work shows that protein design can be leveraged to control material properties, creating an exciting new direction to explore for future research.” This work builds on natural examples of proteins creating materials, known as biomineralization. But this is the first example that uses de novo proteins made by design to control the synthesis of quantum dots. The study, “De Novo Proteins Template the Formation of Semiconductor Quantum Dots,” was published in the journal ACS Central Science. The work is related to a recent Department of Defense grant to Spangler to test an eco-friendly approach for separating rare earth elements into a refined final product using de novo proteins.
The Impact of Counterfeit Goods in Global Commerce
Introduction Counterfeiting has been described as “the world’s second oldest profession.” In 2018, worldwide counterfeiting was estimated to cost the global economy between USD 1.7 trillion and USD 4.5 trillion annually, as well as resulting in more than 70 deaths and 350,000 serious injuries annually. It is estimated that more than a quarter of US consumers have purchased a counterfeit product. The counterfeiting problem is expected to be exacerbated by the unprecedented shift in tariff policy. Tariffs, designed as an import tax or duty on an imported product, are often a percentage of the price and can have different values for different products. Tariffs drive up the cost of imported brand name products but may not, or only to a lesser extent, impact the cost of counterfeit goods. In this article, we examine the extent of the global counterfeit dilemma, the role experts play in tracking and mitigating the problem, the use of anti-counterfeiting measures, and the potential impact that tariffs may have on the flow of counterfeit goods. Brand goods have always been a target of counterfeits due to their high price and associated prestige. These are often luxury goods and clothing, but can also be pharmaceuticals, cosmetics, and electronics. The brand name is an indication of quality materials, workmanship, and technology. People will pay more for the “real thing,” or decide to buy something cheaper that looks “just as good.” In many cases, “just as good” is a counterfeit of the brand name product. A tariff is an import tax or duty that is typically paid by the importer and can drive up the cost of imported brand name products. For example, a Yale study has shown that shoe prices may increase by 87% and apparel prices by 65%, due to tariffs. On the other hand, counterfeit products don’t play by the rules and can often avoid paying tariffs, such as the case of many smaller, online transactions, shipped individually. Therefore, we expect to see an increase in counterfeit products as well as a need to increase efforts to reduce the economic losses of counterfeiting. The Scale of the Counterfeit Problem In their 2025 report, the Organisation for Economic Co-operation and Development (OECD) and the European Union Intellectual Property Office (EUIPO), estimated that in 2021, “global trade in counterfeit goods was valued at approximately USD 467 billion, or 2.3% of total global imports. This absolute value represents an increase from 2019, when counterfeit trade was estimated at USD 464 billion, although its relative share decreased compared to 2019 when it accounted for 2.5% of world trade. For imports into the European Union, the value of counterfeit goods was estimated at USD 117 billion, or 4.7% of total EU imports.” In a 2020 report, the US Patent and Trademark Office (USPTO) estimated the size of the international counterfeit market as having a “range from a low of USD 200 billion in 2008 to a high of USD 509 billion in 2019.” According to the OEDC / EUIPO General Trade-Related Index of Counterfeiting for economies (GTRIC-e), China continues to be the primary source of counterfeit goods, as well as Bangladesh, Lebanon, Syrian Arab Republic, and Türkiye. Based on customs seizures in 2020-21, the most common items are clothing (21.6%), footwear (21.4%), and handbags, followed by electronics and watches. Based on the value of goods seized, watches (23%) and footwear (15%) had the highest value. However, it should be noted that items that are easier to detect and seize are likely to be overrepresented in the data. Although the share of watches declined, and electronics, toys, and games increased, it remains unclear whether this represents a long term trend or just a short term fluctuation. In general, high value products in high demand continue to be counterfeited. Data from the US Library of Congress indicates that 60% – 80% of counterfeit products are purchased by Americans. The US accounts for approximately 5% of the world’s consumers; however, it represents greater than 20% of the world’s purchasing power. Though it is still possible to find counterfeit products at local markets, a large number of counterfeit goods are obtained through online retailers and shipped directly to consumers as small parcels classified as de minimis trade. This allows for the duty-free import of products up to USD 800 in value. Counterfeit items may be knowingly or unknowingly purchased from online retailers and shipped directly to consumers, duty-free. Purchased products can be shipped via postal services, classified as de minimis trade. Approximately 79% of packages seized contained less than 10 items. Given the size and volume of the packages arriving daily, many or most will evade scrutiny by customs officials. This means of import is increasing over time. In 2017-19 it was 61% of seizures. By 2020-21, it was 79%. Economic Impact of Counterfeiting The scale of the counterfeiting problem has significant impacts on the US economy, US business interests, and US innovations in lost sales and lost jobs. Moreover, counterfeit products are often made quickly and cheaply, using materials that may be toxic. The companies producing these goods may not dispose of waste properly and may dump it into waterways, causing significant environmental consequences. Counterfeit products from electrical equipment and life jackets to batteries and smoke alarms may be made without adhering to safety standards or be properly tested. These products may fail to function when you need it and may lead to fire, electric shock, poisoning, and other accidents that can seriously injure and even kill consumers. Counterfeit cosmetics and pharmaceuticals can also lead to injuries by either including unsafe ingredients or by failing to provide the benefits of the real product. The Tariff Counterfeit Connection Tariffs may be seen as a tax on consumers and raise the price of imported products that are already the target of counterfeiters such as luxury leather products and apparel. It’s commonly understood that raising prices on genuine products can only drive up the demand for counterfeit goods. In general, consumers will have less disposable income and the brand goods they desire will cost more which is bound to increase the demand for counterfeit goods. Although recent changes removing the USD 800 tax exemption on de minimis shipments from China and Hong Kong will make it more expensive for counterfeiters to ship their goods internationally, tariffs are typically applied as a percentage of the cost of an object. This will cause the price of more expensive legitimate goods to increase even more than the cheaper counterfeit goods and likely make the counterfeit products even more attractive economically. Therefore, we expect to see an increase in counterfeit products as well as an increase in efforts to reduce the economic losses of counterfeiting. The Role of Technical Experts in Counterfeit Detection Technical experts play an important role in both the prevention and detection of counterfeits and helping to identify counterfeiting entities. Whether counterfeit money, clothing, shoes, electronics, cosmetics or pharmaceuticals, the first step in fighting counterfeits is detecting them. In some cases, the counterfeit product is obvious. A leather product may not be leather, a logo may be wrong, packaging may have a spelling mistake, or a holographic label may be missing. These products may be seized by customs. However, some counterfeit products are very difficult to detect. In the case of a counterfeit memory card with less than the stated capacity or a pharmaceutical that contains the wrong active ingredient, technical analysis may be needed to identify the parts. Technical analysis may also be used to try and identify the source of the counterfeit goods. For prevention measures, manufacturers may use radio frequency identification (RFID) or Near Field Communication (NFC) tags within their products. RFID tags are microscopic semiconductor chips attached to a metallic printed antenna. The tag itself may be flexible and easy to incorporate into packaging or into the product itself. A passive RFID requires no power and has sufficient storage to store information such as product name, stock keeping unit (SKU), place of manufacture, date of manufacture, as well as some sort of cryptographic information to attest to the authenticity of the tag. A simple scanner powers the tag using an electromagnetic field and reads the tag. If manufacturers include RFID tags in products, an X-ray to identify a product in a de minimis shipment (perhaps using artificial intelligence technology) and an RFID scanner to verify the authenticity of the product can be used to efficiently screen a large number of packages. Many products also may be marked with photo-luminescent dyes with unique properties that may be read by special scanners and allow authorities to detect legitimate products. Similarly, doped hybrid oxide particles with distinctive photo-responsive features may be printed on products. These particles, when exposed to laser light, experience a fast increase in temperature which may be quickly detected. For either of these examples, the ability to identify legitimate products, or – due to the absence of marking – track counterfeit products, allows authorities to map the flow of the counterfeit goods through the supply chain as they are manufactured, shipped, and are exported and imported to countries. For many years, electronic memory cards such as SD cards and USB sticks have been counterfeited. In many cases, the fake card will have a capacity much smaller than listed. For example, a 32GB memory card for a camera may only hold 1GB. Sometimes, these products may be identified by analyzing the packaging for discrepancies from the brand name products. In other cases, software must be used to verify the capacity and performance of each one, which is time-consuming when analyzing a large number of products. Forensic investigators, comprised of forensic accountants and forensic technologists, are heavily involved in efforts to combat this illicit trade. By analyzing financial records, supply-chain data, and transaction histories, they trace the origins and pathways of counterfeit products. Their work often involves identifying suspicious procurement patterns, shell companies, and irregular inventory flows that signal counterfeit activity. Forensic investigators often begin by mapping the counterfeit supply chain, an intricate web that often spans continents. Using data analytics, transaction tracing, and inventory audits, they identify anomalies in procurement, distribution, and sales records. These methodologies help pinpoint the origin of counterfeit goods, the intermediaries involved, and the final points of sale. By reconstructing the flow of goods and money, forensic investigators can begin to unmask activities. Cross-border partnerships are essential for tracking assets, sharing insights, and coordinating with financial regulators. Public-private partnerships further enhance the effectiveness of anti-counterfeiting efforts. Forensic investigators often serve as bridges between government agencies, brand owners, and financial institutions, facilitating the exchange of key information. These partnerships increase information-sharing, streamline investigations, and amplify the impact of enforcement actions. A promising development in this space is the World Customs Organization’s Smart Customs Project, which integrates artificial intelligence to detect and intercept counterfeit goods. Forensic investigators can leverage this initiative by analyzing AI-generated alerts and incorporating them into broader financial investigations, which allows for faster and more accurate identification of illicit networks. Jurisdictional complexity is a major hurdle in anti-counterfeiting efforts. Forensic investigators work closely with legal teams to navigate these challenges to ensure that investigations comply with local laws, and evidence is admissible and can withstand scrutiny in court, especially when dealing with offshore accounts and international money laundering schemes. Forensic investigators follow the money, tracing illicit profits through bank accounts, shell companies, and cryptocurrency transactions. Their findings not only help recover stolen assets but also support disputes by providing expert testimony that quantifies financial losses and identifies the bad actors. Conclusion Imitations of brand name products have become more convincing, harder to detect, and the sources of the counterfeit goods more difficult to identify. While counterfeiting clearly has evolved because of technological advancements, e-commerce, and the growing sophistication of bad actors, the process has now been complicated even further by the unpredictable tariff and trade policies that are affecting businesses worldwide. Consequently, companies need to take a multi-faceted approach to these new challenges introduced into the counterfeiting of products by tariffs. By engaging high-tech product authentication measures, utilizing technology-based alerts about counterfeits, and retaining the specialized skills of forensic investigators and other experts, companies will be able to navigate the risks posed by the complex and changing relationship between tariffs and counterfeit goods. To learn more about this topic and how it can impact your business or connect with James E. Malackowski simply click on his icon now to arrange an interview today. To connect with David Fraser or Matthew Brown - contact : Kristi L. Stathis, J.S. Held +1 786 833 4864 Kristi.Stathis@JSHeld.com
Masoud Davari, Ph.D., associate professor of Electrical and Computer Engineering in the Allen E. Paulson College of Engineering & Computing, was recognized for his achievements in the field of power electronics control and testing with the IEEE Region 3 Outstanding Engineer Award. He was also granted membership into Eta Kappa Nu (HKN), IEEE’s international honor society. IEEE, the Institute of Electrical and Electronics Engineers, is the world’s largest professional organization for electrical engineers, with its membership numbering over 486,000 in more than 190 countries. Davari has been a member of IEEE since 2008 and a senior member of IEEE’s Region 3 since 2019. The organization’s Region 3 encompasses the southeastern United States and has over 24,000 members. The Outstanding Engineer Award, given annually to one member per region, recognizes those who have advanced knowledge and improved humanity through any of the technical subjects covered by the IEEE societies, councils, and affinity groups. Davari was praised for “outstanding, technical, and professional contributions to synthesizing reinforcement learning optimal controls for power electronic converters, creating robust integration of power electronics considering the impact of cyberattacks on modern grids, and advancing IEEE standards for hardware-in-the-loop testing and education through impactful research and service.” This impactful research and service includes eight years of teaching at Georgia Southern. He currently teaches introductory courses on circuit analysis and power systems fundamentals. He has also served as a chapter lead of the IEEE Working Group (WG) P2004 for testing based on hardware-in-the-loop simulations in the IEEE Standards Association (IEEE SA) and that of the IEEE Power and Energy Society Task Force on innovative teaching methods for modern power and energy systems (TR 120). In addition to being an engaged educator, Davari is also a prolific researcher. He was selected as the finalist for the 2024 Curtis W. McGraw Research Award by the Awards Committee of the American Society for Engineering Education (ASEE); has also been awarded a research fellowship by Gulfstream Aerospace Corporation in 2024; was included in Stanford/Elsevier’s Top 2% Scientist Rankings list; and has received $1.17 million in grants from the National Science Foundation Davari’s work ethic and commitment to bridging the gap between industry and research led Rami Haddad, Ph.D., interim dean of the College of Engineering & Computing, to nominate him. “Dr. Davari’s recognition as the IEEE Region 3 Outstanding Engineer and his induction into IEEE-Eta Kappa Nu (HKN) are truly remarkable honors that reflect his outstanding contributions to electrical and computer engineering,” Haddad said. “Being recognized among more than 24,000 IEEE members across the Southeast is a testament to the impact and excellence of his work. We are proud to have Dr. Davari as a valued member of our college, and we celebrate his achievements as a shining example of the innovation and leadership that define our faculty.” This award marks the first time a Georgia Southern faculty member has received it in its 55-year history. It is a career milestone for Davari, who has published research on advanced technology integration into modern power and energy systems in high-impact-factor IEEE Transactions/Journal venues and has extensively researched the era of grid-edge technologies. “I’m deeply honored by this prestigious award,” Davari said. “Not only does it reaffirm my dedication to my research field, but it also fuels my passion for creating a technologically advanced future. Receiving this IEEE award on behalf of my outstanding team is a privilege. Their relentless commitment and hard work since 2015 have truly made this achievement possible.” Davari’s induction into HKN places him among the best in his field. The membership, which is received through invitation only from HKN’s Board of Governors and is based on the candidate’s record of contributions to the field, demonstrated leadership, and community service. “With a legacy that stretches over a century, IEEE-HKN represents the pinnacle of prestige and tradition in our profession, indicating academic achievements and dedication to research, potential leadership, exemplary character, and a positive attitude. Notably, many of our industry’s most influential leaders initiated their journeys through induction into IEEE-HKN as professional members, so receiving this honor is a privilege.” Davari received his award and was inducted into Eta Kappa Nu (HKN) in March at IEEE Region 3’s SoutheastCon 2025 in Charlotte, North Carolina. If you're interested in learning more and want to book time to talk or interview with Masoud Davari then let us help - simply contact Georgia Southern's Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to arrange an interview today.
When Luis Quiroga-Nuñez, Ph.D was appointed director of Florida Tech’s Ortega Observatory and its primary tenant – a non-functioning, 32-inch telescope – in 2023, he decided it was time to provide astronomy students and others a window to space. The observatory is already a base for research across a spectrum of cosmic exploration through disciplines such as astronomy and astrophysics, heliophysics, planetary science and astrobiology. However, current students have yet to see the stars up close, as the aging telescope, commissioned in 2008, has sat dormant for the last several years. With restoration, the telescope could be a powerful tool to train students to use professional telescopes and make observations – critical skills that will help prepare them for their future careers. It soon became apparent, however, that this was no simple task. The restoration would necessitate reverse engineering on a large scale to even understand how to fix and upgrade the telescope, much less actually repair it. It would also, as Quiroga-Nuñez wisely recognized, be its own powerful educational opportunity, providing unique hands-on learning opportunities for students in the College of Engineering and Science. “We are an institute of technology. We have perfectly capable people, like these young students, ready to join hands-on projects, get crazy and start to be creative.” Luis Quiroga-Nuñez With various issues to tackle and eager to support home-grown expertise, Quiroga-Nuñez and Lee Caraway, Ph.D, an instructor in the department of electrical engineering and computer science, recruited students with varied backgrounds, from astronomy to electrical engineering and computer science. Students could apply what they learned in class and grow their portfolios with a real-world project, the sort of experiential learning that is a hallmark of a Florida Tech education. Some improvements have been made, but the project remains an exciting puzzle for students and faculty alike. Here’s how they are doing it. An Interdisciplinary Project In January 2023, Quiroga-Nuñez partnered with Caraway to rebuild the telescope from the inside out. They say the conversation started over lunch, sketching ideas on a napkin. With various issues to tackle and eager to support home-grown expertise, Caraway and Quiroga-Nuñez recruited students with varied backgrounds, from astronomy to engineering to computer science. “This is about as real-world as you can get without leaving school. We have this giant piece of technology that is not working. Figure out why,” said recent graduate Adrianna Agustin ’24, who helped update the telescope’s communication system. “All of those problem-solving skills will directly translate to wherever we go in the future.” The project’s multidisciplinary nature also boosts collaboration between both sides of the college. “We keep integrating different parts of the university and involving students in a project that we were blinded by,” Quiroga-Nuñez says. “We sit between the scientists and the engineers.” And there’s no shortage of tasks. In addition to the refurbishment, Quiroga-Nuñez and Caraway are also completing routine telescope maintenance, with students taking on adjacent projects around the observatory. With the telescope repair, each student is given their own task, such as redesigning a small clip that supports the dome’s electric current, reviewing the conditions of the finder’s lens or understanding how analog devices control the telescope’s focus. This allocation allows each student to claim their own individual contribution to the greater telescope puzzle. Opening a Time Capsule The telescope’s biggest issues were mechanical and electrical, all exacerbated by age. Its motors were decades old and naturally failing, Caraway said. These motors controlled the telescope’s right ascension and declination – essentially, its ability to move. The chaotic interior also involved multiple individual systems with dozens of wires. And the circuits controlling the motors, which dated back to the 1980s, were also failing due to age. As Caraway noted, his students are sweeping off “dust older than them.” “The technology back then simply did not exist to control the motors, run the diagnostics and make it all happen,” Caraway explained. “They’re not designed to run 30 years.” Additionally, the computer program that controlled the motors was outdated and did not meet to the university’s security requirements. Given all this, the team needed to develop a new communication system for the telescope, starting with the computer software. They decided instead of purchasing an upgraded computer system, they could build and program their own in-house from scratch. Next, once the new computer was up and running, it needed motors to command. Marisa Guerra ’24 worked on a senior design project involving a robotic arm whose motor structure was the same as the telescope’s. She crafted a blueprint for the telescope’s new motors using what she learned for her capstone project. At the same time, Agustin worked on developing a cleaner communication system between the computer to the motors. Her senior design research focused on electric vehicles and their internal circuit systems, and she could replicate something similar within the telescope – but not without digging through the decaying electronics first. “We had to reverse engineer and actually redraw the circuits, which was good practice because a lot of the time, for senior design at least, you don’t really have to design a new circuit. You are just kind of puzzle-piecing it together,” Agustin said. “But with this circuit, all of them were bad.” Using Guerra’s and Agustin’s senior design research, the team reprogrammed the telescope’s circuits. What once took 20 wires to operate now only takes two. They also reduced the weight of the telescope’s motors from 40 pounds to just 2 pounds. Once the communication system was finished, the team was just waiting for mobility. And on a day in Spring 2024, thanks to the refurbished system, they were able to create movement within the telescope for the first time in years. “I didn’t even know if that device could move internally,” Quiroga-Nuñez says. The moment was celebrated, but the team knew this success triggered a new challenge. It was time to tackle high astrometric precision – a crucial element of properly tracking movement in space. “We are pointing to tiny points in the sky. If we do not track that properly, we are going to be lost in the universe,” Quiroga-Nuñez says. The Value of Time Perfecting precise movement is expected to take some time, but that’s not a bad thing, Quiroga-Nuñez says. He believes that a lengthy timeline will offer more value in the long run because it will give even more students a chance to get involved. Besides, its primary purpose will be to teach students how to use a telescope and allow them to make observations and prepare for their future careers. Ultimately, Quiroga-Nuñez predicts that the telescope could pick up its first image from space in about a year if everything stays on track. However, the team still has a lot of ground within the telescope to uncover, with an unpredictable number of potential troubleshooting challenges. For example, while rebuilding the motor, they discovered that the internal mirror that illuminates the telescope’s visuals was in poor condition – it needed cleaning and new aluminum to reflect enough light to see the telescope’s imagery, Agustin explains. So, the team had to remove the mirror and ship it to New York for refurbishment – a process that took several months. Once the mirror is reinstalled, they can return to their quest for better precision. The mirror is just one example of unpredictability in reverse-engineering. Ultimately, dedicating more time to understanding and solving the unforeseen challenges allows more students to participate in the telescope’s journey, Quiroga-Nuñez says. “This is like a big Lego for them,” he says. “They are learning the process, and the students, I think, will have found a very valuable life experience.” If you're interested in connecting with Luis Quiroga-Nuñez, director of Florida Tech’s Ortega Observatory - simply contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology at adam@fit.edu to arrange an interview today.
Research Matters: Ultra-conductive molecule sets stage for post-silicon computing era
A research team has uncovered what it believes is “the world’s most electrically conductive organic molecule,” a discovery that opens new possibilities for building smaller, more powerful, and more energy-efficient computers. It could also allow computer chip manufacturers to eliminate their reliance on silicon and metal as conductors. “Molecules are nature’s tiniest, mightiest, and most configurable building blocks and can be engineered to build ultra-compact, ultra-efficient technology for everything from computers to quantum devices,” said Ignacio Franco, who was part of the research team that was led by scientists at the University of Miami. Their research was detailed in a paper published in the Journal of the American Chemical Society. The molecule, which is composed of chemical elements found in nature, including carbon, sulfur, and nitrogen, can carry electrical current over record-breaking distances without losing efficiency. Using molecular materials in electronic chips offers several advantages. They consume less power. They can be more easily customized than silicon. They are more environmentally friendly. And, perhaps most importantly to manufacturers, they are potentially cheaper to produce. “This molecular design overcomes many of the big issues that for decades have prevented the use of molecules in electronics,” Franco said. To learn more about this ground-breaking research, read about it at the University of Rochester News Center, and contact Franco at ignacio.franco@rochester.edu.
Chemical and Life Science Engineering Professor Michael “Pete” Peters, Ph.D., is investigating more efficient ways to manufacture biologic pharmaceuticals using a radial flow bioreactor he developed. With applications in vaccines and other personalized therapeutic treatments, biologics are versatile. Their genetic base can be manipulated to create a variety of effects from fighting infections by stimulating an immune response to weight loss by producing a specific hormone in the body. Ozempic, Wegovy and Victoza are some of the brand names for Glucagon-Like Peptide-1 (GLP-1) receptor agonists used to treat diabetes. These drugs mimic the GLP-1 peptide, a hormone naturally produced in the body that regulates appetite, hunger and blood sugar. “I have a lot of experience with helical peptides like GLP-1 from my work with COVID therapeutics,” says Peters. “When it was discovered that these biologic pharmaceuticals can help with weight loss, demand spiked. These drug types were designed for people with type-2 diabetes and those diabetic patients couldn’t get their GLP-1 treatments. We wanted to find a way for manufacturers to scale up production to meet demand, especially now that further study of GLP-1 has revealed other applications for the drug, like smoking cessation.” Continuous Manufacturing of Biologic Pharmaceuticals Pharmaceuticals come in two basic forms: small-molecule and biologic. Small-molecule medicines are synthetically produced via chemical reactions while biologics are produced from microorganisms. Both types of medications are traditionally produced in a batch process, where base materials are fed into a staged system that produces “batches” of the small-molecule or biologic medication. This process is similar to a chef baking a single cake. Once these materials are exhausted, the batch is complete and the entire system needs to be reset before the next batch begins. “ The batch process can be cumbersome,” says Peters. “Shutting the whole process down and starting it up costs time and money. And if you want a second batch, you have to go through the entire process again after sterilization. Scaling the manufacturing process up is another problem because doubling the system size doesn’t equate to doubling the product. In engineering, that’s called nonlinear phenomena.” Continuous manufacturing improves efficiency and scalability by creating a system where production is ongoing over time rather than staged. These manufacturing techniques can lead to “end-to-end” continuous manufacturing, which is ideal for producing high-demand biologic pharmaceuticals like Ozempic, Wegovy and Victoza. Virginia Commonwealth University’s Medicines for All Institute is also focused on these production innovations. Peters’ continuous manufacturing system for biologics is called a radial flow bioreactor. A disk containing the microorganisms used for production sits on a fixture with a tube coming up through the center of the disk. As the transport fluid comes up the tube, the laminar flow created by its exiting the tube spreads it evenly and continuously over the disk. The interaction between the transport medium coming up the tube and the microorganisms on the disk creates the biological pharmaceutical, which is then taken away by the flow of the transport medium for continuous collection. Flowing the transport medium liquid over a disc coated with biologic-producing microorganisms allows the radial flow bioreactor to continuously produce biologic pharmaceuticals. “There are many advantages to a radial flow bioreactor,” says Peters. “It takes minutes to switch out the disk with the biologic-producing microorganisms. While continuously producing your biologic pharmaceutical, a manufacturer could have another disk in an incubator. Once the microorganisms in the incubator have grown to completely cover the disk, flow of the transport medium liquid to the radial flow bioreactor is shut off. The disk is replaced and then the transport medium flow resumes. That’s minutes for a production changeover instead of the many hours it takes to reset a system in the batch flow process.” The Building Blocks of Biologic Pharmaceuticals Biologic pharmaceuticals are natural molecules created by genetically manipulating microorganisms, like bacteria or mammalian cells. The technology involves designing and inserting a DNA plasmid that carries genetic instructions to the cells. This genetic code is a nucleotide sequence used by the cell to create proteins capable of performing a diverse range of functions within the body. Like musical notes, each nucleotide represents specific genetic information. The arrangement of these sequences, like notes in a song, changes what the cell is instructed to do. In the same way notes can be arranged to create different musical compositions, nucleotide sequences can completely alter a cell’s behavior. Microorganisms transcribe the inserted DNA into a much smaller, mRNA coded molecule. Then the mRNA molecule has its nucleotide code translated into a chain of amino acids, forming a polypeptide that eventually folds into a protein that can act within the body. “One of the disadvantages of biologic design is the wide range of molecular conformations biological molecules can adopt,” says Peters. “Small-molecule medications, on the other hand, are typically more rigid, but difficult to design via first-principle engineering methods. A lot of my focus has been on helical peptides, like GLP-1, that are a programmable biologic pharmaceutical designed from first principles and have the stability of a small-molecule.” The stability Peters describes comes from the helical peptide’s structure, an alpha helix where the amino acid chain coils into a spiral that twists clockwise. Hydrogen bonds that occur between the peptide’s backbone creates a repeating pattern that pulls the helix tightly together to resist conformational changes. “It’s why we used it in our COVID therapeutic and makes it an excellent candidate for GLP-1 continuous production because of its relative stability,” says Peters. Programming The Cell Chemical and Life Science Engineering Assistant Professor Leah Spangler, Ph.D., is an expert at instructing cells to make specific things. Her material science background employs proteins to build or manipulate products not found in nature, like purifying rare-earth elements for use in electronics. “My lab’s function is to make proteins every day,” says Spangler. “The kind of proteins we make depends entirely on the project they are for. More specifically I use proteins to make things that don’t occur in nature. The reason proteins don’t build things like solar cells or the quantum dots used in LCD TVs is because nature is not going to evolve a solar cell or a display surface. Nature doesn’t know what either of those things are. However, proteins can be instructed to build these items, if we code them to.” Spangler is collaborating with Peters in the development of his radial flow bioreactor, specifically to engineer a microorganismal bacteria cell capable of continuously producing biologic pharmaceuticals. “We build proteins by leveraging bacteria to make them for us,” says Spangler. “It’s a well known technology. For this project, we’re hypothesizing that Escherichia coli (E. coli) can be modified to make GLP-1. Personally, I like working with E. coli because it’s a simple bacteria that has been thoroughly studied, so there’s lots of tools available for working with it compared to other cell types.” Development of the process and technique to use E. coli with the radial flow bioreactor is ongoing. “Working with Dr. Spangler has been a game changer for me,” says Peters. “She came to the College of Engineering with a background in protein engineering and an expertise with bacteria. Most of my work was in mammalian cells, so it’s been a great collaboration. We’ve been able to work together and develop this bioreactor to produce GLP-1.” Other Radial Flow Bioreactor Applications Similar to how the GLP-1 peptide has found applications beyond diabetes treatment, the radial flow bioreactor can also be used in different roles. Peters is currently exploring the reactor’s viability for harnessing solar energy. “One of the things we’ve done with the internal disc is to use it as a solar panel,” says Peters. “The disk can be a black body that absorbs light and gets warm. If you run water through the system, water also absorbs the radiation’s energy. The radial flow pattern automatically optimizes energy driving forces with fluid residence time. That makes for a very effective solar heating system. This heating system is a simple proof of concept. Our next step is to determine a method that harnesses solar radiation to create electricity in a continuous manner.” The radial flow bioreactor can also be implemented for environmental cleanup. With a disk tailored for water filtration, desalination or bioremediation, untreated water can be pushed through the system until it reaches a satisfactory level of purification. “The continuous bioreactor design is based on first principles of engineering that our students are learning through their undergraduate education,” says Peters. “The nonlinear scaling laws and performance predictions are fundamentally based. In this day of continued emphasis on empirical AI algorithms, the diminishing understanding of fundamental physics, chemistry, biology and mathematics that underlie engineering principles is a challenge. It’s important we not let first-principles and fundamental understanding be degraded from our educational mission, and projects like the radial flow bioreactor help students see these important fundamentals in action.”
ExpertSpotlight: Tariffs and Trade Wars
Tariffs and trade wars have long been powerful tools in international relations, influencing everything from consumer prices to global supply chains. As nations impose duties on imports and retaliate with countermeasures, economies can experience ripple effects that impact businesses, jobs, and everyday consumers. Understanding how tariffs work and why trade wars escalate is essential for grasping the complexities of global commerce and national economic policies. With ongoing disputes between major economies, this topic remains highly relevant to the public. Key story angles include: What Are Tariffs and How Do They Work? A breakdown of tariffs, their purpose, and their impact on industries and consumers. Historical Trade Wars and Their Consequences: Examining past trade disputes, their economic fallout, and lessons learned. U.S.-China Trade Relations: Analyzing the impact of tariffs between the world’s two largest economies and their influence on global markets. The Role of Tariffs in Domestic Job Creation: Investigating whether tariffs protect local industries or lead to unintended economic consequences. How Trade Wars Affect Everyday Consumers: Exploring how tariffs on goods like electronics, food, and automobiles translate to higher prices. The Future of Global Trade Agreements: Discussing potential shifts in international trade policies and their implications for businesses and governments. As countries navigate economic policies in an increasingly interconnected world, tariffs and trade wars remain central to discussions on financial stability, political strategy, and economic growth. Connect with an expert about trade and tariffs: To search our full list of experts visit www.expertfile.com
Black Friday Shoppers Seek Deals on Electronics, Early Sales and Convenience in a Competitive Market
This year’s Black Friday shopping will bring a fresh wave of trends for both consumers and retailers. With electronics, online convenience and competitive pricing at the forefront, the landscape of Black Friday is evolving to match the shifting shopping habits of today’s consumers, said Baylor University consumer behavior expert James A. Roberts, Ph.D. Roberts – who serves as The Ben H. Williams Professor of Marketing at Baylor’s Hankamer School of Business – keeps a close watch on Black Friday, including what he sees as the Top 5 trends for holiday shopping in 2024. Top Trends for Black Friday 2024 The Shift in Shopping Habits: The balance between online and in-store sales remains steady, with consumers enjoying a 50/50 split in shopping preference, Robert said. While COVID-19 accelerated a surge in online shopping, this year, both are expected to perform equally as shoppers appreciate the flexibility of both options. Holiday Deals Start Early: As the competitive landscape has grown, Black Friday sales now launch weeks in advance. This early kickoff benefits consumers who are eager to lock in discounts and spreads out the typical holiday rush, providing retailers a longer window to capture consumer interest, Roberts noted. Electronics Dominate Sales: As in previous years, electronics will be the driving force of Black Friday 2024, accounting for nearly half of all sales. Roberts said that shoppers are especially focused on deals for televisions, laptops, smartwatches and gaming consoles – underscoring the lasting demand for high-quality technology at competitive prices. Gen Z and Millennials Drive Online Growth: Digital natives like Gen Z and Millennials continue to shape holiday shopping habits. Roberts said their comfort with online shopping – coupled with their mobile-first approach – makes them a powerful force in the online retail space. Retailers can expect these younger consumers to leverage social media, mobile apps and seamless e-commerce platforms for their holiday purchases. Rising Categories: Beyond electronics, Roberts predicts that other sectors will see strong sales this season, particularly in clothing, cosmetics and home appliances. As consumer preferences expand, brands in these categories should prepare for increased demand. Factors shaping consumer choices For Black Friday in 2024, competitive pricing and convenience remain top priorities, Roberts said. “Retailers who offer the best deals alongside quick and reliable delivery options stand out among consumers,” he said. Additionally, low-cost brands – such as Shein – have set consumer expectations for affordable pricing, even as “Buy Now, Pay Later” options have increased in popularity – though Roberts said retailers and consumers alike should be cautious when using this financing option at the risk of overspending. Future of Black Friday Looking ahead, Roberts said Black Friday’s trajectory appears geared more towards online channels, with each year seeing a slight shift away from brick-and-mortar shopping. Retailers are encouraged to keep an eye on pricing expectations and financing trends, as they’ll play an increasingly influential role in the holiday season. ABOUT JAMES A. ROBERTS, PH.D. James A. Roberts, Ph.D., is The Ben H. Williams Professor of Marketing at Baylor University’s Hankamer School of Business. A noted consumer behavior expert, he is among the "World's Top 2%" most-cited scientists in a database compiled by Stanford University. In addition to journal citations, Roberts has often been called upon by national media outlets for his consumer expertise and latest research. He has appeared on the CBS Early Show, ABC World News Tonight, ABC Good Morning America, NBC’s TODAY Show and NPR’s Morning Edition, as well as in articles in The New York Times, USA TODAY, The Wall Street Journal, TIME and many others. Roberts’ research has focused on how individual consumer attitudes and behavior impact personal and collective well-being. His research has investigated the factors that drive ecologically and socially conscious consumer behavior, the impact of materialism and compulsive buying on well-being and the impact of smartphone and social media use on personal well-being. He is the author of “Shiny Objects: Why We Spend Money We Don’t Have in Search of Happiness We Can’t Buy” and “Too Much of a Good Thing: Are You Addicted to Your Smartphone?”
A future with one plug: how universal EV outlets simplify charging for electric vehicle owners
Have you ever found yourself frustrated with the numerous types of charging plugs for electric vehicles when going to charge your car? Picture this: a future where every charging station supports a universal outlet. No more worrying about whether your plug will fit or if you need an adapter. Sounds like a dream, right? Well that dream is now real. University of Delaware professor Willett Kempton and his coauthors have recently released a new paper outlining a new universal EV outlet standard in World Electric Vehicle Journal. His coauthors include University of Delaware PhD graduates Rodney McGee and Garrett Ejzak. There are three standard EV charging connectors – the part you hold in your hand that plugs into EVs with matching inlets – in North America. Rather than requiring three charging stations at each location, Willett and his team proposed to have a universal EV outlet on the charging station, and cars would come with a cable with a universal plug to plug into the station. The solution for EV charging is similar to what has already evolved for charging cell phones and other portable electronics. Cell phones and laptops have many different types of power inlet connections on the device, incompatible with each other. This solution was deliberately designed so that todays’ EVs and charging stations do not need to be replaced. Because these new standards have resulted from a consensus of more than 150 participants from the automotive, charger, and power industries, new innovations will also be coming with the adoption of the new standards. These include lower-cost and lower-maintenance charging stations, higher energy efficiency. Kempton, McGee and Ejzak can be reached by clicking Kempton's contact button.
Optical research illuminates a possible future for computing technology
Nathaniel Kinsey, Ph.D., Engineering Foundation Professor in the Department of Electrical and Computer Engineering (ECE), is leading a group to bring new relevance to a decades-old computing concept called a perceptron. Emulating biological neuron functions of the messenger cells within the body’s central nervous system, perceptrons are an algorithmic model for classifying binary input. When combined within a neural network, perceptrons become a powerful component for machine learning. However, instead of using traditional digital processing, Kinsey seeks to create this system using light with funding from the Air Force Office of Scientific Research. This “nonlinear optical perceptron” is an ambitious undertaking that blends advanced optics, machine learning and nanotechnology. “If you put a black sheet outside on a sunny day, it heats up, causing properties such as its refractive index to change,” Kinsey said. “That’s because the object is absorbing various wavelengths of light. Now, if you design a material that is orders of magnitude more complex than a sheet of black plastic, we can use this change in refractive index to modify the reflection or transmission of individual colors – controlling the flow of light with light.” Refractive index is an expression of a material’s ability to bend light. Researchers can harness those refractive qualities to create a switch similar to the binary 1-0 base of digital silicon chip computing. Kinsey and collaborators from the U.S. National Institute of Standards and Technology, including his former VCU Ph.D. student Dhruv Fomra, are currently working to design a new kind of optically sensitive material. Their goal is to engineer and produce a device combining a unique nonlinear material, called epsilon-near-zero, and a nanostructured surface to offer improved control over transmission and reflection of light. Kinsey’s prior research has demonstrated that epsilon-near-zero materials combine unique features that allow their refractive index to be modified quite radically – from 0.3 to 1.3 under optical illumination – which is roughly equivalent to the difference between a reflective metal and transparent water. While an effective binary switch, the large change in index requires a lot of energy (~1 milli-Joules per square centimeter). By combining epsilon-near-zero with a specifically designed nanostructure exhibiting surface lattice resonance, Kinsey hopes to achieve a reduction in the required energy to activate the response. The unique response of a nanostructure exhibiting surface lattice resonance allows light to effectively be bent 90 degrees, arriving perpendicular to the surface while being split into two waves that travel along the surface. When a large area of the nanostructure is illuminated, the waves traveling along the surface mix, where they interfere constructively or destructively with each other. This interference can produce strong modification to reflection and transmission that is very sensitive to the geometry of the nanostructure, the wavelength of the incident light and the refractive index of the surrounding materials. The mixing of optical signals along the surface can also selectively switch regions of the epsilon-near-zero material thereby performing processing operations. A key aspect of Kinsey’s work is to build nonlinear components, like diodes and transistors, that use optical signals instead of electrical ones. Transistors and other traditional electronic components are nonlinear by default because electrical charges strongly interact with each other (for example, two electrons will tend to repel each other). Creating optical nonlinear components is challenging because photons do not strongly interact, they just pass through each other. To correct for this, Kinsey employs materials whose properties change in response to incident light, but the interaction is weak and thus requires large energies to utilize. Kinsey’s device aims to reduce that energy requirement while simultaneously shaping light to perform useful operations through the use of the nanostructured surface and lightwave interference. The United States Department of Defense sees optical computing as the next step in military imaging. Kinsey’s work, while challenging, has potential to yield an enormous payoff. “Let’s say you want to find a tank within an image,” Kinsey said, “Using a camera to capture the scene, translate that image into an electrical signal and run it through a traditional, silicon-circuit-based computer processor takes a lot of processing power. Especially when you try to detect, transfer, and process higher pixel resolutions. With the nonlinear optical perceptron, we’re trying to discover if we can perform the same kinds of operations purely in the optical domain without having to translate anything into electrical signals.” Linear optical systems, like metasurfaces and photonic integrated circuits, can already process information using only a fraction of the power of traditional tools. Building nonlinear optical systems would expand the functionality of these existing linear systems, making them ideal for remote sensing platforms on drones and satellites. Initially, the resolution would not be as sharp as traditional cameras, but optical processing built into the device would translate an image into a notification of tanks, troops on the move, for example. Kinsey suggests optical-computing surveillance would make an ideal early warning system to supplement traditional technology. “Elimination or minimization of electronics has been a kind of engineering holy grail for a number of years,” Kinsey said, “For situations where information naturally exists in the form of light, why not have an optical-in and optical-out system without electronics in the middle?” Linear optical computing uses minimal power, but is not capable of complex image processing. Kinsey’s research seeks to answer if the additional power requirement of nonlinear optical computing is worthwhile given its ability to handle more complex processing tasks. Nonlinear optical computing could be applied to a number of non-military applications. In driverless cars, optical computing could make better light detection and ranging equipment (better known as LIDAR). Dark field microscopy already uses related optical processing techniques for ‘edge detection’ that allows researchers to directly view details without the electronic processing of an image. Telecommunications could also benefit from optical processing, using optical neural networks to read address labels and send data packets without having to do an optical to electrical conversion. The concept of optical computing is not new, but interest (and funding) in theory and development waned in the 1980s and 1990s when silicon chip processing proved to be more cost effective. Recent years have seen many advancements in computing, but the more recent slowdown in scaling of silicon-based technologies have opened the door to new data processing technologies. “Optical computing could be the next big thing in computing technology,” Kinsey said. “But there are plenty of other contenders — such as quantum computing — for the next new presence in the computational ecosystem. Whatever comes up, I think that photonics and optics are going to be more and more prevalent in these new ways of computation, even if it doesn’t look like a processor that does optical computing.” Kinsey and other researchers working in the field are in the early stages of scientific exploration into these optical computing devices. Consumer applications are still decades away, but with silicon-based systems reaching the limit of their potential, the future for this light-based technology is bright.