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FAU ‘Shark-Repellent’ Method Can Reform Fisheries by Curbing Bycatch
Study Snapshot: Shark bycatch is a major global problem, with millions of sharks caught unintentionally each year in fisheries targeting tuna, swordfish and other species. Even in U.S. waters, sharks are frequently caught on longlines, and many are discarded dead. Because sharks grow and reproduce slowly, these high bycatch rates threaten already vulnerable populations and disrupt marine ecosystems. Researchers at FAU’s Charles E. Schmidt College of Science have developed a patent-pending zinc-and-graphite device to address the problem. The metals generate a small electric field that repels sharks from baited hooks while leaving target species unaffected. In Florida field trials, the device reduced shark bycatch by more than 60%. Inexpensive, scalable and practical for fishers, this technology has the potential to dramatically reduce bycatch and support more sustainable fisheries. For decades, sharks have been the unintended victims of longline fisheries aimed at tuna and swordfish. Rising accidental catches have contributed to population declines and created serious challenges for both conservation and commercial fishing. And the impacts go beyond the sharks themselves – every time a shark takes the bait, hooks are lost to target species, gear gets damaged, costs climb, and crews face added risks when handling or releasing the animals. Although some gear modifications can reduce bycatch, they often also cut into catches of valuable species, making it hard to protect sharks without putting fisheries at a disadvantage. To tackle this challenge, researchers at Florida Atlantic University’s Charles E. Schmidt College of Science have developed an innovative, patent-pending shark deterrent. The device works by pairing zinc and graphite in seawater. The zinc reacts with the graphite to produce a small electric field in the surrounding seawater through a galvanic chemical reaction. This electric field can be detected by the sharks, repelling them from the bait without affecting target fish. To test the efficacy of the zinc/graphite treatment at deterring elasmobranch species, longline fishing gear was deployed to target demersal sharks (live and hunt near the sea floor) off the Florida panhandle and Massachusetts, and pelagic sharks (live and hunt in open water) in the Gulf of America. The results of the field trials, published in the Canadian Journal of Fisheries and Aquatic Sciences, delivered striking results. In Florida, the zinc/graphite treatment reduced the catch of coastal sharks on demersal longlines by 62% to 70% compared to untreated hooks. The effect was particularly strong for Atlantic sharpnose (Rhizoprionodon terraenovae) and blacktip sharks (Carcharhinus limbatus), two common coastal species. “Sharks have an incredible ability to sense even the smallest electric fields, and our tests show that this new approach can be used to keep them away from baited hooks,” said Stephen Kajiura, Ph.D., senior author, inventor and a professor in the FAU Department of Biological Sciences. “At the same time, important target species like tuna and swordfish are completely unaffected. What makes this approach so exciting is its practicality – zinc and graphite are inexpensive, widely available, and already familiar to fishers because zinc is commonly used to prevent corrosion on boats. This means it could be adopted quickly and cost-effectively, providing a real solution to reduce shark bycatch while supporting sustainable fisheries.” Importantly, the treatment did not reduce catches of commercially important fish species. Preliminary pelagic trials suggest swordfish and yellowfin tuna were caught at similar or slightly higher rates on treated hooks, showing the approach could protect sharks without hurting the catch of target species. The study also outlines practical considerations for real-world use. Because the electric field is strongest close to the hook, each line would need its own zinc-graphite device. The zinc anode slowly wears down, but it’s cheap and easy to swap out. Shark bycatch is a widespread and pressing problem, both in the United States and around the world. Globally, millions of sharks are caught unintentionally every year in fisheries targeting other species, and some estimates suggest tens of millions fall victim to bycatch annually. In U.S. waters, despite strict regulations, sharks are still caught incidentally on longlines and other gear. Because sharks reproduce slowly and have long lifespans, these high bycatch rates can push populations toward dangerously low levels. The scope of shark bycatch, from small coastal fisheries to large international fleets, makes it a global conservation challenge with serious ecological consequences. “Our approach could be scaled up to pelagic longline fisheries, where millions of sharks are caught as bycatch annually,” said Kajiura. “Even a 60% to 70% reduction in shark bycatch, like that observed in Florida demersal trials, could have a dramatic impact on global shark populations. The zinc/graphite treatment offers a practical, affordable and environmentally responsible tool for reducing shark bycatch while maintaining commercial catch rates.” Study co-authors are FAU graduate students Tanner H. Anderson and Kieran T. Smith; co-inventor on the patent application; Cheston T. Peterson, a Ph.D. student at Florida State University; Bryan A. Keller, Ph.D., a foreign affairs specialist at NOAA Fisheries; and Dean Grubbs, Ph.D., a full research faculty and associate director of research at FSU. This research was supported by the Florida SeaGrant awarded to Kajiura and Grubbs. The patent-pending device works by pairing zinc and graphite in seawater, creating an electric field that can be detected by the sharks, repelling them from the bait without affecting target fish.
VR Teaches the Danger of “Short-Fuse” Weather Events
Dr. Jase Bernhardt, associate professor of geology, environment, and sustainability and director of Hofstra University’s meteorology program, was interviewed by Newsday about the use of virtual reality technology to teach the public about the danger of driving in a snow squall.
Domestic abuse affects millions of people every year, often in unseen and deeply personal ways, and online threats toward victims can be particularly harmful. To address this reality locally, the University of Florida’s Center for Privacy and Security for Marginalized and Vulnerable Populations, or PRISM, works with Gainesville-based domestic abuse support center Peaceful Paths to help people stay safe in the digital world. Kevin Butler, Ph.D., the director of PRISM and the Florida Institute for Cybersecurity Research at UF, has been researching issues related to security and privacy of technologies that affect survivors of intimate partner violence for years. He and his graduate students connected with Peaceful Paths in 2022, presenting their findings on cybersecurity and demonstrating how their research may help improve online safety for vulnerable populations. They developed a pilot study, a survey and interview protocols that are now helping those in need at the center. “[We aim to] develop principles of design that will allow for a robust technology design that really mitigates harms and improves benefits for all,” Butler said about PRISM. Educating abuse survivors has been a key component of the collaboration between UF and Peaceful Paths. For example, PRISM’s team has conducted research on the effects of stalkerware, also known as spyware, which is a type of software or app designed to be installed secretly on people’s devices to monitor their activities without their consent. Abusers may use this tool to track and harass victims, and stalkerware is regularly linked to domestic violence – a fact that is not widely known. "Even the first presentation [UF] gave enhanced our advocates' knowledge of security pieces, which helps them safety plan with survivors," said Peaceful Paths CEO Crystal Sorrow. “It actually increases the safety of everyone in the community we work with when we talk about red flags, digital dating abuse and healthy relationships.” While PRISM, which is supported by the National Science Foundation, is making an impact on the local community, its overall reach is much broader. PRISM was the first academic partner in the Coalition Against Stalkerware, which includes groups such as the National Network to End Domestic Violence, the Electronic Frontier Foundation, and law enforcement agencies throughout the United States and the world.
The AI Journal: UF and other research universities will fuel AI. Here’s why
In the global AI race between small and major competitors, established companies versus new players, and ubiquitous versus niche uses, the next giant leap isn’t about faster chips or improved algorithms. Where AI agents have already vacuumed up so much of the information on the internet, the next great uncertainty is where they’ll find the next trove of big data. The answer is not in Silicon Valley. It’s all across the nation at our major research universities, which are key to maintaining global competitiveness against China. To teach an AI system to “think” requires it to draw on massive amounts of data to build models. At a recent conference, Ilya Sutskever, the former chief scientist at OpenAI — the creator of ChatGPT — called data the “fossil fuel of AI.” Just as we will use up fossil fuels because they are not renewable, he said we are running out of new data to mine to keep fueling the gains in AI. However, so much of this thinking assumes AI was created by private Silicon Valley start-ups and the like. AI’s history is actually deeply rooted in U.S. universities dating back to the 1940s, when early research laid the groundwork for the algorithms and tools used today. While the computing power to use those tools was created only recently, the foundation was laid after World War II, not in the private sector but at our universities. Contrary to a “fossil fuel problem,” I believe AI has its own renewable fuel source: the data and expertise generated from our comprehensive public academic institutions. In fact, at the major AI conferences driving the field, most papers come from academic institutions. Our AI systems learn about our world only from the data we offer them. Current AI models like ChatGPT are scraping information from some academic journal articles in open-access repositories, but there are enormous troves of untapped academic data that could be used to make all these models more meaningful. A way past data scarcity is to develop new AI methods that leverage all of our knowledge in all of its forms. Our research institutions have the varied expertise in all aspects of our society to do this. Here’s just one example: We are creating the next generation of “digital twin” technology. Digital twins are virtual recreations of places or systems in our world. Using AI, we can develop digital twins that gather all of our data and knowledge about a system — whether a city, a community or even a person — in one place and allow users to ask “what if” questions. The University of Florida, for example, is building a digital twin for the city of Jacksonville, which contains the profile of each building, elevation data throughout the city and even septic tank locations. The twin also embeds detailed state-of-the-art waterflow models. In that virtual world, we can test all sorts of ideas for improving Jacksonville’s hurricane evacuation planning and water quality before implementing them in the actual city. As we continue to layer more data into the twin — real-time traffic information, scans of road conditions and more — our ability to deploy city resources will be more informed and driven by real-time actionable data and modeling. Using an AI system backed by this digital twin, city leaders could ask, “How would a new road in downtown Jacksonville impact evacuation times? How would the added road modify water runoff?” and so on. The possibilities for this emerging area of AI are endless. We could create digital twins of humans to layer human biology knowledge with personalized medical histories and imaging scans to understand how individuals may respond to particular treatments. Universities are also acquiring increasingly powerful supercomputers that are supercharging their innovations, such as the University of Florida’s HiPerGator, recently acquired from NVIDIA, which is being used for problems across all disciplines. Oregon State University and the University of Missouri, for example, are using their own access to supercomputers to advance marine science discoveries and improve elder care. In short, to see the next big leap in AI, don’t immediately look to Silicon Valley. Start scanning the horizon for those research universities that have the computing horsepower and the unique ability to continually renew the data and knowledge that will supercharge the next big thing in AI. Read more...
From classroom to cosmos: Students aim to build big things in space
In the vast vacuum of space, Earth-bound limitations no longer apply. And that’s exactly where UF engineering associate professor Victoria Miller, Ph.D., and her students are pushing the boundaries of possibilities. In partnership with the Defense Advanced Research Projects Agency, known as DARPA, and NASA’s Marshall Space Flight Center, the University of Florida engineering team is exploring how to manufacture precision metal structures in orbit using laser technology. “We want to build big things in space. To build big things in space, you must start manufacturing things in space. This is an exciting new frontier,” said Miller. An associate professor in the Department of Materials Science & Engineering at UF’s Herbert Wertheim College of Engineering, Miller said the project called NOM4D – which means Novel Orbital and Moon Manufacturing, Materials, and Mass-efficient Design – seeks to transform how people think about space infrastructure development. Picture constructing massive structures in orbit, like a 100-meter solar array built using advanced laser technology. “We’d love to see large-scale structures like satellite antennas, solar panels, space telescopes or even parts of space stations built directly in orbit. This would be a major step toward sustainable space operations and longer missions,” said team member Tianchen Wei, a third-year Ph.D. student in materials science and engineering. UF received a $1.1 million DARPA contract to carry out this pioneering research over three phases. While other universities explore various aspects of space manufacturing, UF is the only one specifically focused on laser forming for space applications, Miller said. A major challenge of the NOM4D project is overcoming the size and weight limitations of rocket cargo. To address these concerns, Miller’s team is developing laser-forming technology to trace precise patterns on metals to bend them into shape. If executed correctly, the heat from the laser bends the metal without human touch; a key step toward making orbital manufacturing a reality. “With this technology, we can build structures in space far more efficiently than launching them fully assembled from Earth,” said team member Nathan Fripp, also a third-year Ph.D. student studying materials science and engineering. “This opens up a wide range of new possibilities for space exploration, satellite systems and even future habitats.” Miller said laser bending is complex but getting the correct shape from the metal is only part of the equation. “The challenge is ensuring that the material properties stay good or improve during the laser-forming process,” she said. “Can we ensure when we bend this sheet metal that bent regions still have really good properties and are strong and tough with the right flexibility?” To analyze the materials, Miller’s students are running controlled tests on aluminum, ceramics and stainless steel, assessing how variables like laser input, heat and gravity affect how materials bend and behave. “We run many controlled tests and collect detailed data on how different metals respond to laser energy: how much they bend, how much they heat up, how the heat affects them and more. We have also developed models to predict the temperature and the amount of bending based on the material properties and laser energy input,” said Wei. “We continuously learn from both modeling and experiments to deepen our understanding of the process.” The research started in 2021 and has made significant progress, but the technology must be developed further before it’s ready for use in space. This is why collaboration with the NASA Marshall Space Center is so critical. It enables UF researchers to dramatically increase the technology readiness level (TRL) by testing laser forming in space-like conditions inside a thermal vacuum chamber provided by NASA. Fripp leads this testing using the chamber to observe how materials respond to the harsh environment of space. “We've observed that many factors, such as laser parameters, material properties and atmospheric conditions, can significantly determine the final results. In space, conditions like extreme temperatures, microgravity and vacuums further change how materials behave. As a result, adapting our forming techniques to work reliably and consistently in space adds another layer of complexity,” said Fripp. Another important step is building a feedback loop into the manufacturing process. A sensor would detect the bending angle in real time, allowing for feedback and recalibration of the laser’s path. As the project enters its final year, finishing in June of 2026, questions remain -- especially around maintaining material integrity during the laser-forming process. Still, Miller’s team remains optimistic. UF moves one step closer to a new era of construction with each simulation and laser test. “It's great to be a part of a team pushing the boundaries of what's possible in manufacturing, not just on Earth, but beyond,” said Wei.
Long proclaimed Italy’s “moral capital,” Milan is renowned worldwide for its significant contributions to fashion, design and the arts. Soon, another point of pride will be added to the city’s storied history, when the regional hub—and partnering town Cortina d’Ampezzo—plays host to the 2026 Winter Olympics in February. Luca Cottini, PhD, is a professor of Italian Studies and an expert on the evolution of Italian culture, particularly through the 19th and 20th centuries. Recently, he shared some thoughts concerning Milan and Cortina’s successful joint bid for the Olympics, the themes and iconography expected to define this year’s opening ceremony and the symbolic significance of Italy’s selection as a host nation. Question: What was the role of past major events in Milan and Cortina—like the 2015 World’s Fair and the 1956 Winter Olympics—in helping to elevate their appeal for these games? Luca Cottini: I’ll start by saying that although people notice world’s fairs less than the Olympics, they are more impactful to a city and country because they generate more revenue, business, political relationships and positive reputation. They are events in which all the world comes together and each country exposes its excellence, while the host nation brings a visibility that it would not carry otherwise. In 2015, Milan hosted the world’s fair, which generated a completely new fairgrounds area and a visibility of politics, industry, technology and modernity in a way that brings the city to a global stage. I would say that is when the ascent of Milan really started, especially as a desirable destination. With Cortina, after the 2015 World’s Fair—and especially after the COVID-19 pandemic—the Dolomites became really a popular region for travelers to visit. Cortina is also symbolic to Olympic history, because it's the site of the first Olympics that took place in Italy, in 1956 during the reconstruction era. That was the Dolce Vita period, in the middle of the 1950s economic boom, and those games were followed by Rome’s Summer Olympics in 1960. They both represented a way in which Italy, coming out of the war destroyed, was reaffirming its rebirth. Over the years, fewer cities have wanted to host the Olympics because they tend to carry a lot of economic burden, financial debt and little return on investment. In this sense, Milan and Cortina, helped by increased popularity after the world’s fair, sold themselves as a sustainable Olympics. Ninety percent of the buildings were refurbished from older buildings, and they will serve purposes after the Olympics. It’s difficult to tell whether it’s economically sound or not, but it is a way to promote two cities that are in big moments of growth. Q: These Olympic Games will be celebrating Milan’s contributions to fashion. What is the city’s significance to the fashion world? LC: Milan is certainly the capital of fashion in Italy, and is one of the capitals of fashion in the world, along with Paris, New York and London. The fashion heritage that the city carries now in iconic brands like Armani, Versace, Moschino and Dolce & Gabbana is the outcome of a process that took shape in the late 1970s. Until then, fashion in Italy was mainly related to Rome, through cinema, and Florence, as that city represented a new Renaissance in the postwar years. But in the 1970s, much of this fashion world moved from those cities to Milan, because there was a conglomeration of labor, skills, capital and creativity that generated a complex productive and cultural system, or the so-called “Sistema Moda.” This is a particular approach to the industry in Italy that coordinates management and creativity around the figures of a big creative director and a big manager who work together in creating not just nice styles, but also sustainable outlets and markets in and outside Italy. In turn, with its reputation, Milan gives the Olympics that seal of grandeur and coolness. The connection with fashion and promotion of uniqueness is part of the national rhetoric that surrounds what we call “Made in Italy,” this idea of luxury, styling, beauty, order and measure that is endowed in the Italian DNA. Q: Andrea Bocelli—who also appeared in Torino’s 2006 closing ceremony—is supposed to sing once again in this year’s opening ceremony. Aside from his popularity, what is the symbolic significance of his selection as a performer? LC: Bocelli is an interesting case. He is a prototypical Italian success story, which is born in the peninsula but is then ratified outside of Italy. As Bocelli became a global sensation in the U.S., he then came back to his roots in Italy, where his voice has become a symbol of national unity, as epitomized in his solo concerto of Milan, during the pandemic, when he sang in front of the empty Piazza del Duomo, facing the city’s cathedral. In his Catholic faith and secular operatic repertoire, he symbolizes Italian culture as a similar piazza or open space where different voices can converge in a temperate balance. When you put together Bocelli, Mariah Carey and whoever else will be part of the ceremony, that same Italian identity will give rise to a new synthesis, as the encounter of tradition and novelty, grounded-ness and openness. Q: The Olympic flames are supposed to be lit in two cauldrons—one in Milan and one in Cortina—each with a design inspired by Leonardo da Vinci. What was da Vinci’s importance to Milan, specifically? LC: Da Vinci is part of the fabric of Milan. He spent 20 years in the city, painting “The Last Supper” and working at Castello Sforzesco, as well as many other places. His footprint is all over Milan, in its design, walls, canal system and more. He is an archetype of the Italian mind in as much as it represents the combination of engineering and beauty. The word Ingenium in Latin, meaning “genius,” overflows in English into the word “engineering” and also “ingenuity,” which reflects the creative mind. Da Vinci represents the synthesis of Italian Ingenium as a combination of aesthetics and problem solving, which you still see in the city today.
Six University of Delaware online graduate degree programs are ranked among the best in the nation by U.S. News & World Report in its 2026 U.S. News Best Online Programs, released Jan. 27, 2026. Both UD’s online master’s in education and online MBA ranked among the top 10% of their respective programs, at No. 25 and 26, respectively. Announced on Jan. 6, the online MBA program recently rose nine spots to No. 32 in the Poets&Quants 2026 Online MBA rankings. UD’s online master’s in nursing program ranked No. 35 out of 209 programs, rising 99 places over the past year. New for UD, the online master’s in educational/instructional media design program was recognized by peers at No. 11 in this education specialty ranking. UD’s online master’s in computer information technology program and online master’s in engineering ranked No. 64 in their respective areas. “These latest rankings recognize the expertise and dedication of our faculty and staff in delivering UD’s outstanding online graduate programs,” Interim Provost Bill Farquhar said. “We are committed to continually enhancing these programs and all the transformative opportunities that enable our students to meet their educational and career goals throughout their lives.” U.S. News selects several factors, known as ranking indicators, to assess each program in the categories outlined above. A program's score for each ranking indicator is calculated using data that the program reported to U.S. News in a statistical survey and from data collected in a separate peer assessment survey. This year’s edition evaluates more than 1,850 online bachelor’s and master’s degree programs using metrics specific to online learning. The rankings include only degree-granting programs offered primarily online by institutions with accreditation from recognized commissions. While the overall rankings methodology remains largely unchanged, U.S. News reported increased participation in this year’s data collection cycle, with more programs submitting statistical data and completing peer assessment surveys. According to U.S. News, this broader participation may reflect continued growth in online education nationwide. The University of Delaware offers over 35 online credit and non-degree professional programs. An online program from UD offers the same quality and rigor as an on-campus program and provides the flexibility to accommodate your busy schedule. UD is accredited by the Middle States Commission on Higher Education, and its online and on-campus degree programs have rigorous curricula delivered by experts, offer affordable program options, and provide students access to student support services, career fairs, recruiting opportunities and graduation ceremonies to celebrate student success. “UD's high-level rankings are in large part due to the positive outcomes that our students experience as a result of taking one of our online degrees or programs,” said Associate Provost for Online Learning and Innovation George Irvine. “Students tell us how much they enjoy learning from our accessible faculty and doing so in engaging and interactive online courses.” For more information about UD’s online degree programs, visit online.udel.edu. A complete listing of UD’s high-profile rankings is available on UD’s Institutional Research and Effectiveness Rankings webpage. Please note that the programs and specialties used in rankings may differ slightly from the names of UD’s degree programs.
How Higher Ed Should Tackle AI
Higher learning in the age of artificial intelligence isn’t about policing AI, but rather reinventing education around the new technology, says Chris Kanan, an associate professor of computer science at the University of Rochester and an expert in artificial intelligence and deep learning. “The cost of misusing AI is not students cheating, it’s knowledge loss,” says Kanan. “My core worry is that students can deprive themselves of knowledge while still producing ‘acceptable work.’” Kanan, who writes about and studies artificial intelligence, is helping to shape one of the most urgent debates in academia today: how universities should respond to the disruptive force of AI. In his latest essay on the topic, Kanan laments that many universities consider AI “a writing problem,” noting that student writing is where faculty first felt the force of artificial intelligence. But, he argues, treating student use of AI as something to be detected or banned misunderstands the technological shift at hand. “Treating AI as ‘writing-tech’ is like treating electricity as ‘better candles,’” he writes. “The deeper issue is not prose quality or plagiarism detection,” he continues. “The deeper issue is that AI has become a general-purpose interface to knowledge work: coding, data analysis, tutoring, research synthesis, design, simulation, persuasion, workflow automation, and (increasingly) agent-like delegation.” That, he says, forces a change in pedagogy. What Higher Ed Needs to Do His essay points to universities that are “doing AI right,” including hiring distinguished artificial intelligence experts in key administrative leadership roles and making AI competency a graduation requirement. Kanan outlines structural changes he believes need to take place in institutions of higher learning. • Rework assessment so it measures understanding in an AI-rich environment. • Teach verification habits. • Build explicit norms for attribution, privacy, and appropriate use. • Create top-down leadership so AI strategy is coherent and not fractured among departments. • Deliver AI literacy across the entire curriculum. • Offer deep AI degrees for students who will build the systems everyone else will use. For journalists covering AI’s impact on education, technology, workforce development, or institutional change, Kanan offers a research-based, forward-looking perspective grounded in both technical expertise and a deep commitment to the mission of learning. Connect with him by clicking on his profile.
Gene Editing Breakthrough Offers New Hope for Head and Neck Cancer Patients
Researchers at the ChristianaCare Gene Editing Institute have made an important advance in treating head and neck cancers. By using CRISPR gene editing, the team found a way to restore how well chemotherapy works in tumors that have stopped responding to treatment. Their results, now published in Molecular Therapy Oncology, could change how doctors treat these aggressive cancers and give new hope to many patients who face limited options. Head and neck cancer is the seventh most common cancer worldwide, and cases are expected to rise by 30 percent every year by 2030. Even with progress in surgery, chemotherapy and immunotherapy, many patients still reach a point where treatment no longer works. The ChristianaCare team aimed to solve this challenge at its source. Targeting the Heart of Drug Resistance The researchers focused on a gene called NRF2. This gene acts like a master switch that helps cancer cells survive stress and resist chemotherapy. Because NRF2 plays such a central role in tumor growth, the team chose to develop a genetic therapy that disables the gene itself rather than targeting a single protein, which is common in traditional drug development. Since NRF2 is a transcription factor, shutting it down in a lasting way is more likely to succeed through CRISPR gene editing. Their major advance was showing that CRISPR can successfully disrupt NRF2 in head and neck cancer cells and in esophageal cancer cells. This work builds on earlier studies in lung cancer, where blocking NRF2 made tumors more sensitive to chemotherapy and improved survival in animal models. “Our goal was to break through the wall of drug resistance that so many patients face,” said Natalia Rivera Torres, Ph.D., the study’s lead author. “By precisely editing the NRF2 gene, we can make cancer cells vulnerable again to standard treatments. This could improve outcomes and quality of life.” Precision Matters: The Power of Target Choice The study also showed that the location of the CRISPR cut within the NRF2 gene makes a big difference. The strongest results came from targeting exon 4, a part of the gene that controls a key section of the NRF2 protein. Editing this region reduced NRF2 levels by 90 percent and made cancer cells much more sensitive to chemotherapy. In comparison, editing exon 2 was less effective even though it still caused high levels of gene disruption. The team also found that a process called exon skipping, where sections of genetic code are rearranged, can affect the outcome of gene editing. This discovery highlights how important careful design and testing are when building gene editing therapies. A Platform for Broader Impact ChristianaCare researchers saw the same results in both head and neck cancer cells and esophageal cancer cells. This suggests the strategy could help treat many solid tumors that have high levels of NRF2 and are known for strong drug resistance. “This is more than just a single experiment,” said Eric Kmiec, Ph.D., director of the Gene Editing Institute and senior author of the study. “We are building a platform that can be adapted to different cancers. Our earlier work in lung cancer showed the promise of this approach, and now we see it working in other hard to treat tumors. It is an exciting step toward making gene editing a meaningful part of cancer treatment.” Looking Ahead: Toward Clinical Application With these strong results, the team is now focused on finding the safest and most effective way to deliver the gene editing tools directly to tumors. Their goal is to reduce how much standard treatment a patient needs in order to get the best result with fewer side effects. “Drug resistance is one of the biggest challenges in cancer care,” Rivera Torres said. “If we can overcome it with gene editing, we could give patients more time, better quality of life and a renewed sense of hope.” Kmiec added, “We are committed to moving this technology forward quickly while always keeping the patient in mind. The future of cancer treatment is personal, precise and, we believe, within reach.”
Natural defenses: UF researchers use living infrastructure to protect Florida’s shores
Armed with a $7 million grant from the Army Corp of Engineers, University of Florida researchers are working to bolster shoreline resilience and restore troubled wetlands in St. Augustine through nature-based solutions. “The idea of nature-based solutions is to build what we sometimes refer to as green infrastructure, to use living, natural components as the building blocks,” said Andrew Altieri, Ph.D., an assistant professor with the Engineering School of Sustainable Infrastructure & Environment and interim director of the Center for Coastal Solutions, also known as CCS. Instead of building man-made structures to protect wetlands, for example, restoration crews can move dredged natural sediment otherwise destined for costly disposal to increase wetlands’ size and elevation, restoring their ability to protect shorelines from storm surge, keep pace with sea-level change, filter toxins, store carbon and provide habitats for wildlife. The project is in concert with the Army Corps of Engineers’ goal to naturally reuse and repurpose at least 70% of dredged sediment into other natural areas to benefit habitats and restoration by 2030. “It is critical to understand, test and model how natural processes can be harnessed and strategically implemented to sustainably meet the challenge of rapidly intensifying coastal hazards while also providing environmental, economic and social benefits,” Altieri wrote in the project’s technical summary. Overall, the multi-disciplinary project closely examines patterns and processes of change in coastal landscapes. That includes wetlands — marshes and mangroves — and beach/dune systems. The project comes as these coastal areas are facing threats both natural and human. These areas are essential to wildlife, air quality, native vegetation, storm protection and the overall health of the ecosystem. A 2008 study by the U.S. Fish and Wildlife Service reported a net loss of about 361,000 acres of wetlands in the coastal watersheds of the eastern United States between 1998 and 2004 — an average net decrease of 59,000 acres each year, with experts citing sea-level rise as one of the primary factors. “We're trying to understand the patterns of that loss and what's leading to it,” Altieri said. “These systems are essentially the first and sometimes last line of defense against coastal hazards, risks that include storm surges and coastal flooding. They are forming a buffer, this kind of protective layer on our coast. But they're changing, generally for the worse and are in danger of being lost.” With this project, the CCS-led research team plans to advance the science, technology and engineering principles of nature-based solutions. With marshes, the primary concern is elevation loss, which can drown the vegetation critical to the ecosystem. They are sinking, eroding and succumbing to sea-level changes, Altieri said. “The plants are really important for trapping sediment and holding sediment,” he said. “You lose some of the plants, then you get more erosional loss and a lack of the accumulation of sediment.” Sediment is natural muck on the bottom of water bodies. “If we can add sufficient sediment to increase the elevation to a level where the plants thrive, then they will retain that sediment that's been added to hopefully trap more sediment and accumulate more biomass through their growth,” Altieri said. “It’s something that may need to be done periodically. You may stop that decline, but you may even reverse the process of loss and change the trajectory.” As a bonus, this process saves the cost of disposing of dredged sediment, which is usually piped offshore or to a materials-management area. This project is the next step for CCS-led coastal resilience efforts in St. Augustine. In 2024, CCS and WSP Environment & Infrastructure Inc. launched a coastal wetlands-restoration project to keep pace with sea level change and erosion. The 2025 work is a standalone project with separate funding, Altieri said. The current project also has more research disciplines and project partners, including UF researchers from Landscape Architecture, Geological Sciences and the School of Forest, Fisheries and Geomatic Sciences. “Storm surges, wave energy, coastal flooding – all of that can be slowed or reduced because of wetlands,” Altieri said. “They are basically like shock absorbers. These wetlands, beaches and dunes can be lost or eroded to some degree, but the upland area behind them is essentially protected.” Researching the resilience of dunes comes with a different set of dynamics. Here, they are looking at the plants that support the dunes – sea oats and panic grass, for example. That vegetation also provides a habitat for animals such as beach mice, turtles and birds. On the beach, the team also is looking at water energy and how grain size affects the stability of dunes. “It’s understanding water movement, water energy. How is that interacting with depositing sediment, moving sediment around, sorting sediment? With water, you tend to carry finer particles further than coarser materials,” he said. What does success look like after the award’s five years end? “We'll have an understanding of what's changing on our coasts and why,” Altieri said. “We'll have an understanding of how we can work within this system to modify the natural components and utilize the natural processes. And we will hopefully be working with partners through additional funding mechanisms to actually apply that towards implementation of solutions to increase coastal resilience.” The team also includes Peter Adams, Department of Geological Sciences; Julie Bruck, Department of Landscape Architecture, School of Landscape Architecture and Planning; Maitane Olabarrieta, ESSIE; Alex Sheremet, ESSIE; Nina Stark, ESSIE; Ben Wilkinson, Geomatics Program, School of Forest, Fisheries, and Geomatics Sciences; and Xiao Yu, ESSIE.
