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EU-UK Trade Deal continues to stifle trade with 27% drop in exports since 2021

New report shows persistent stifling effects of the impact of the Trade and Cooperation Agreement on UK-EU trade relations Monthly data show a 27% drop in UK exports and a 32% reduction in imports to and from the EU between 2021 and 2023 Recommendations for policy interventions include to negotiate sector-specific deals, engage with individual EU countries, and work on reducing non-tariff barriers A comprehensive analysis by researchers at the Centre for Business Prosperity at Aston University reveals that negative impacts of the UK-EU Trade and Cooperation Agreement (TCA) have intensified over time. The new report, Unbound: UK Trade Post Brexit, also shows a 33% reduction in the variety of goods exported, with the agricultural, textiles, clothing and materials sectors most affected. To assess the impact of the UK-EU TCA, the authors analysed monthly import and export between the UK and the EU, from January 2017 to December 2023 and separated into pre- and post-January 2021 when the agreement came into force. The monthly data shows a 27% drop in UK exports and a 32% decline in imports from the EU. Lead author, Professor Jun Du of Aston University says: “The Trade and Cooperation Agreement introduced substantial barriers and there are ongoing and marked declines in the value and variety of UK exports and imports. Without urgent policy interventions, the UK’s economic position and place in the global market will continue to weaken.” The UK-EU TCA redefined trade and investment rules and market access between the UK and the EU. Since it came into force, the UK government has negotiated several trade agreements, but the EU remains the UK’s largest trade partner. Exports for most sectors have decreased since January 2021, although the impact is varied. Agrifood, textile and clothing and material-based manufacturing have been among the hardest hit, with substantial declines in both export value and the variety of products exported. At the same time, some sectors such as tobacco, railway and aircraft manufacturing have seen modest increases in varieties of products exported. On the import side, most sectors have shrunk in both value and variety, particularly agrifood products, optical, textile and material-based manufacturing. A few sectors, for example, ships and furniture, have demonstrated noticeable increases in import product variety. The large variations across different goods categories and EU trade partners underscore the uneven effects of Brexit and the TCA on UK-EU trade dynamics, highlighting the need to understand the nuances and come up with tailored strategies that address the unique challenges of each sector within the new regulatory environment. The researchers make recommendations, outlining how sector-specific negotiations, streamlining customs procedures with digital technologies and reducing regulatory divergence could mitigate some of the impacts. Dr Oleksandr Shepotylo, the report’s co-author says: “Our findings indicate a decoupling of the UK from key EU final goods markets, accompanied by a shift in UK supply chains toward geographically closer EU trading partners for exports and smaller countries for imports. “This shift raises concerns and underscores the urgent need for a strategic reconfiguration of UK supply chains to maintain competitiveness.” Professor Du continues: “The TCA has introduced considerable barriers to UK-EU trade, particularly through increased Non-tariff measures (NTMs). “Addressing these issues through targeted improvements to the TCA is crucial to ensuring that UK businesses remain competitive in the European market. A structured, multi-faceted approach is necessary.” To find out more about these findings, click here.

VR Simulation to Demonstrate the Danger of Snow Squalls

Since 2017, Dr. Jase Bernhardt, Hofstra associate professor of geology, environment, and sustainability, has been using virtual reality technology to teach the public about the dangers of rip currents, hurricanes, and flash flooding. His most recent award, a $100,000 Road to Zero Community Traffic Safety Grant from the National Safety Council, is enabling him to tackle another seasonal weather worry: driving in snow squalls. The National Safety Council received funding for this grant from the National Highway Traffic Safety Administration. Bernhardt’s project aims to share information about the onset of snow squalls, the importance of heeding emergency weather advisories, and what drivers should do if they are on the road when a snow squall occurs. Although squalls are infrequent, they are extreme and frightening winter weather events that can result in a rapid onset of heavy snow, low visibility, icy roadways, and frigid temperatures. “Snow squalls are a very specific type of weather phenomenon. They often occur on a clear, calm day, with no warning of precipitation,” Bernhardt said. “Seemingly out of nowhere, you’ll see clouds, followed by a quick burst of very heavy snow. For a short time, perhaps only 10, 15 minutes, there are whiteout conditions where drivers can barely see the road ahead of them.” According to the U.S. Department of Transportation website, 24% of weather-related vehicle crashes occur on snowy, slushy, or icy pavement, and 15% happen during snowfall or sleet. More than 1,300 people are killed and nearly 117,000 people are injured in vehicle crashes on snowy, slushy, or icy pavement annually. Because winters in the New York metropolitan area have been mild for the last few years, Bernhardt worries that people have been lulled into a false sense of security about driving during winter storms or squalls. “We’re not used to being in that kind of severe weather anymore,” he said. “Snow squalls can be deadly in terms of massive collisions and multi-vehicle chain collisions. The key thing to remember is that they come in rapidly, catching people by surprise.” Bernhardt is collaborating on the software for the snow squall VR simulation with Frank Martin ’22, ’23, who earned both a BS and an MS in Computer Science from Hofstra University. Users will wear a headset and hold a device – like a video game controller – in each hand to replicate the movements of a steering wheel. In this way, users will experience what it is like to drive from clear, pleasant conditions into a brutal wall of snow. Bernhardt said that if a warning for a snow squall is issued via emergency broadcast, he hopes people who have used the simulation will understand the urgency of getting off the road or pulling onto the shoulder and remaining in their vehicle. “We want people to have an experience that is as close to reality as possible. The idea is to simulate how sudden and terrifying snow squalls can be and give people an opportunity to learn what they should and should not do if they are caught in one,” Bernhardt said. In conjunction with the VR simulation, Bernhardt is developing a survey to determine people’s reactions to emergency messaging and how effective it is. He will work with the National Weather Service to have the simulation and surveys available by fall 2025 for use at training and outreach events throughout the Northeast. Like Bernhardt’s rip current project, there are plans to have a version of the snow squall simulation and corresponding literature available in Spanish. Dr. Sasha Pesci, Hofstra assistant professor of geology, environment, and sustainability, is co-principal investigator on the grant and is helping with the translation of materials. “More and more, the National Weather Service, state and federal governments, and other agencies recognize the importance of having this information available in other languages,” Bernhardt said. “There are a lot of drivers whose primary language is Spanish, and they include cab and Uber drivers, and truckers.” Jase Bernhardt is available to speak with media about this topic - simply click on his icon now to arrange an interview today.

#Expert Q and A: Disinformation and Elections

Question: Taylor Swift recently took to her Instagram page to “set the record straight” about an AI version of her that had “endorsed” Former President Donald Trump. What are some of the things people can look for to know if a celebrity has indeed endorsed a candidate? Answer: People can go to the celebrity’s social media page to see their recent social media activity. On the page, people can search for information regarding political endorsements. People should be aware that many fake and parody social media accounts exist for celebrities, so people need to make sure they locate the real social media accounts of the celebrity in question. Also, people can search reputable news sources to see if there is any verifiable information (i.e., the information has been verified by other reputable news sources) regarding celebrity endorsements. Question: In an era where it is too easy for anyone to alter images or video, what are some of the dangers that can be associated with these deep fakes? How can this negatively impact the election, and just life in general with having this kind of misinformation out there? Answer: There can be multiple concerns regarding disinformation and elections. One, if voters make decisions about whether to vote for a candidate based on disinformation/misinformation, this is a concern for elections because in a democracy the hope is that voters can make informed voting decisions based on accurate information. Second, if millions of people are exposed to disinformation/misinformation and only a small percentage of those are not aware that the disinformation/misinformation is false, this could have significant effects for elections. The reason is that in recent presidential elections, and likely in the upcoming election, the margin of victory in some swing states can be less than 1% of the total state vote in some cases. Thus, if only a small percentage of individuals who are exposed to disinformation/misinformation believe the information is true, and the disinformation/misinformation affects their voting decisions, that could have significant effects on the election outcome of a given swing state. Furthermore, we know that the election outcome of each swing state has important implications for the overall presidential election outcome. Question: Do celebrity endorsements still help or hurt candidates? Answer: The empirical evidence linking specific celebrity endorsements to election outcomes is mixed. Based on existing research, we can’t say that a specific celebrity endorsement led to an election victory or loss. However, there has been some interesting research from Harvard (2024) that shows that celebrity endorsements do matter for elections by potentially increasing voter interest, voter engagement and voter registration. One example is in September of 2023 when Taylor Swift made an Instagram post encouraging individuals to vote. Immediately afterward, 35,000 individuals registered to vote on the non-partisan voter registration website Vote.org . So, while we can’t say that a certain celebrity endorsement will directly affect an election outcome, celebrities can move the needle in terms of voter interest, voter registration, and potentially voter turnout, which can influence election outcomes. Interested in learning more - let us help. Lance Hunter, PhD, is a professor of political science with a background in international relations. He is available to speak with media about this important topic - simply click on his icon to arrange an interview today.

Putting a price tag on environmental projects

Unlike a grocery store, the goods and services in the environment — think clean water, tree cover, or flood control — don’t come with a price tag. Researchers in the University of Delaware Department of Applied Economics and Statistics have received a $1.5 million grant to assess the value of what is gained or lost from environmental projects. The three-year grant from the U.S. Army Engineer Research and Development Center, the chief research and development center for the federal environmental engineering agency U.S. Army Corps of Engineers, will pave the way for UD environmental economists to develop a web-based platform to help the Corps.  The research team is led by Maik Kecinski, associate professor in the Department of Applied Economics and Statistics and also includes department colleagues Kent Messer and Martin Heintzelman, as well as three graduate researchers. The team will create an online platform to help the Corps estimate the monetary value of the ecosystem impacts through its ongoing and proposed projects across the U.S. Kecinski said many of the Corps’ projects involve natural resources, such as building dams or restoring rivers. Those projects require labor hours and equipment, each with a market value. “But the big piece the Corps doesn’t have is what is the environmental value that’s created or lost through these projects?” Kecinski said. The project came about after ERDC representatives visited UD in 2023. Kent Messer, Professor of Applied Economics, presented research about behavioral aspects around water quality and conservation and learned about ERDC’s research needs. Messer said that the big takeaway from those discussions was that ERDC was interested in having a platform to show the ecosystem services value of its projects. “So that was an exciting opportunity to connect and partner with them on the development of a tool that could help them in this regard,” Messer said. Messer said the opportunity to work with the Corps to assess its projects nationwide is “huge” for the University and for UD’s College of Agriculture and Natural Resources. “It speaks enormously to our college’s prominence in environmental economics issues,” Messer said. Martin Heintzelman, chair of UD's Department of Applied Economics and Statistics, said the project will help raise the profile of the department. “This is really in our wheelhouse in terms of the kind of research we do,” Heintzelman said. “It’s a great opportunity for us to be applying research to policymakers, people who are going to use this work to make better decisions as they’re going about their work constructing, managing, and sometimes de-constructing water and related projects.” The researchers hope the web-based platform will play a role in policy and decision-making, helping the Corps make more informed decisions on environmental projects in the future. “One thing I hope is going to come from this is the choices we make today are going to create a better tomorrow. That’s what it is all about” Kecinski said.

Five ways going green can improve your bottom line: A guide for West Midlands SMEs

As sustainability becomes a central focus for businesses across the globe, small and medium-sized enterprises (SMEs) in the West Midlands are uniquely positioned to benefit from going green. Whether you're running a corner shop, a hairdressing salon, a manufacturing operation, or any other type of small business, sustainable practices can significantly enhance your bottom line. Here are five key ways that adopting green strategies can lead to financial gains. Reduced operational costs One of the most immediate and tangible benefits of going green is the reduction in operational costs. Energy efficiency, waste reduction, and resource conservation are all areas where small changes can lead to significant savings. For instance, simply switching to energy-efficient lighting can reduce electricity bills by up to 75 per cent—a substantial saving for any business, particularly for small retailers or service providers where margins can be tight. Additionally, the UK government offers incentives to help businesses transition to more energy-efficient operations, making it easier for SMEs to invest in these changes. Join Aston University’s workshop on 18 September and take advantage of a free energy assessment for your business. Learn practical steps to audit your energy use and uncover cost-saving opportunities tailored to your specific industry needs. Access to new markets and opportunities As the UK government and local authorities push for a greener economy, there are growing opportunities for businesses that align with these goals. SMEs that adopt sustainable practices may qualify for grants, tax reliefs, and other incentives designed to support green initiatives. For example, local councils in the West Midlands have programmes such as ‘BEAS and Decarbonisation Net Zero’ aimed at helping small businesses reduce their carbon footprint, which can be especially beneficial for almost all sectors where environmental impact is a growing concern. At the workshop, we’ll delve into the funding options and partnerships available to West Midlands SMEs committed to sustainability, helping you unlock new growth opportunities. Increased marketability Consumers are increasingly favouring businesses that demonstrate a commitment to sustainability. According to a study by Nielsen, 66 per cent of global consumers are willing to pay more for sustainable goods, and this trend is evident in the UK as well. By adopting green practices, SMEs in the West Midlands can enhance their brand reputation. This can translate to increased sales, customer loyalty, and even the ability to charge premium prices for sustainable products or services. In a competitive market, your environmental credentials can be a powerful differentiator. Attend Aston University’s workshop to learn from real-life success stories and see how businesses are already turning sustainability into a competitive advantage. Long-term resilience and competitiveness Sustainability isn’t just about immediate financial gains; it’s also about future-proofing your business. As regulations around carbon emissions and environmental impact become stricter, businesses that have already integrated green practices will find it easier to comply, avoiding potential fines and disruptions. For SMEs in sectors like manufacturing, where regulatory pressures are particularly high, adopting sustainable practices now can help ensure long-term competitiveness and resilience. A prime example of this shift is the NHS, which is actively working towards a Net Zero supply chain by 2045. The NHS is urging its suppliers to adopt sustainable practices, with a strong focus on reducing carbon emissions. Businesses that fail to align with these expectations risk losing contracts and falling behind competitors who are meeting these sustainability criteria. At the workshop, you'll learn more about sustainability strategy that can keep your business competitive and resilient in an ever-changing market. Enhanced employee engagement and productivity Increasingly, employees are seeking to work for companies that align with their personal values, including a commitment to sustainability. While this trend is more pronounced among larger companies, it’s also becoming relevant for small businesses, particularly those in industries where attracting and retaining talent is competitive. According to research, 74 per cent of employees feel more fulfilled when they work for a company that is making a positive impact on the environment. For small businesses, fostering a sustainable workplace can enhance employee morale, attract top talent, and reduce turnover rates. However, the degree to which this resonates can depend on your specific workforce. In sectors like tech, professional services, or among younger employees, sustainability is often a key consideration. On the other hand, in some more traditional industries, other factors like job security and compensation might be more important, though sustainability still adds value. Sign up for our workshop to discover how your small or medium business—regardless of sector—can implement effective sustainability practices and energy efficiency strategies to drive growth. This event is open to all SMEs across the West Midlands! Click here to register now. You'll also have the opportunity to book a free energy assessment on the spot and apply for match funding of up to £100,000 to make your business more energy efficient.

The Handshake Seen 'Round The World

More than 50 million viewers were expecting a cold standoff to start last night's debate between Vice President Kamala Harris and former president Donald Trump. University of Delaware experts say Trump was likely more shocked than they were when Harris walked to his podium for a cordial handshake. "It was a clearly planned move on Harris' part intending to assert some dominance over someone whose entire schtick is about being dominant. And it was successful, and I think it discomforted Trump," said David Redlawsk, professor of political science and international relations. Erin Cassese, professor of political science and international relations, said the move exuded confidence, especially given that President Biden and former-President Trump did not shake hands at the outset of their July debate. "Harris’s pursuit of the handshake showed off the bat that she would engage in this debate on her own terms, Cassese said. "It also had Trump on the back foot, as he seemed not to expect the gesture." Cassese said the handshake also offset any advantage Trump might have gained due to the podium setup, which could have highlighted their height differential. "But the handshake showed that Harris was not intimidated by the difference in stature," Cassese said. Redlawsk is a political psychologist who studies voter behavior and emotion, focusing on how voters process political information to make their decisions. He has written several books on politics, worked behind the scenes on campaigns and ran for local office. Cassese explores the behavior of women as voters and candidates for political office in the United States. Her areas of expertise are gender, abortion, public opinion, campaigns and elections. To set up an interview either either expert, reporters can visit their ExpertFile pages and clicking on the "contact" button.

#Expert Opinion: 'Gun laws need an overhaul'

In the aftermath of last week's school shooting in Georgia, Jennifer Necci Dineen and Kerri M. Raissian from UConn’s ARMS Center contributed this compelling piece to The Atlanta Journal-Constitution. The entirety of the article is available here: On Sept. 4, the United States experienced its 45th school shooting of 2024, this time at Apalachee High School in Winder, Georgia. Barrow County Sheriff Jud Smith called the shooting “pure evil” and reported the suspected shooter would be tried as an adult. Since then, the shooter’s father has also been charged. A criminal justice response is vital, but it cannot be our only response. Gun laws need an overhaul. The failure to do so means that we will continue charging shooters and their families and attending the funerals of those senselessly killed. Laws are the role of government. Should elected officials fail to act (again), we think it is also fair to hold them responsible for the firearm violence killing our nation’s children. Georgia lawmakers have passed legislation to protect children in other ways. Georgia requires that children be at least 16 years old and to have held a learner’s permit for a year before they can drive: minors under 16 cannot be employed in dangerous or harmful jobs; and those under 17 cannot marry. These restrictions recognize that children’s prefrontal cortex, the part of their brain responsible for reasoning, impulse control and decision-making, is not yet fully formed. Yet, despite firearms being the leading cause of death for children in the United States, Georgia has minimal regulations governing children’s firearm access. There is no minimum age for purchasing or possessing rifles or shotguns, no permit required for carrying firearms in public (whether open or concealed) and no mandate for secure firearm storage (such as unloading, locking and storing ammunition separately). Details of the shooting in Winder continue to emerge, but let’s start with what we know. Reports indicate that the shooter and his father were questioned by the Jackson County Sheriff’s Office in May 2023 following multiple anonymous tips about online threats, including images of guns. The suspect’s father claimed that his child did not have unfettered access to the guns. The authorities did not have probable cause for an arrest, and so they left and the guns stayed. And, in fact, the father bought his son a new gun — an AR-15 — as a Christmas present. Perhaps more disturbing is that this kind of negligence and indifference is not an anomaly. A similar set of facts surround the Nashville Waffle House shooter and the Michigan Oxford High School Shooter. In both cases, parents ignored warning signs and helped their sons keep or procure firearms that were used in mass shootings. Moreover, almost three-quarters of guns used in gun-related incidents at schools come from the home or someone the shooter knows. It’s fair to ask: Where are the parents? However, we also want to know where are the elected officials charged with keeping us and our children safe when they are at school, the movies, a parade or otherwise living their lives? Laws mandating secure firearm storage, permitting, minimum age requirements and background checks have been proven to lower firearm homicide rates. Emergency risk protection orders, or red-flag laws, which temporarily prevent individuals deemed a danger to themselves or others from possessing or purchasing firearms, have also been effective in reducing firearm homicides. Georgia’s failure to implement such regulations, allowing a child with underdeveloped decision-making skills to access a gun, means the state shares the blame for the gun-related injuries and deaths at Apalachee High School. Georgia Gov. Brian Kemp is right. It’s not the time to “talk about safety and policy.” The time was years ago, but it’s never too late to do the right thing. Kerri Raissian is an associate professor in the School of Public Policy at the University of Connecticut; director of the University of Connecticut's UConn’s Center for Advancing Research, Methods, and Scholarship (ARMS) in Gun Violence Prevention; and co-director of the Institute for Collaboration on Health, Intervention, and Policy (InCHIP) Gun Violence Prevention Research Interest Group. Her research focuses on child and family policy, with an emphasis on understanding how policies affect fertility, family formation, and family violence. She is available to speak to media about this important topic - simply click on her icon now to arrange an interview today.

In Ancient Egypt, One Villanova Professor Sees Modern Lessons

During the Old Kingdom (2700-2200 B.C.E.), Memphis was the epicenter of Egyptian civilization. A key strategic point in the Nile Delta region, it long served as the seat from which the Pharaoh ruled his domain, exerted his influence and marshaled his military might. Bustling with activity, it teemed with craftspeople, clerics and courtiers, and its whitewashed walls reverberated with the sounds of enterprise, exaltation and empire. Four-and-a-half millennia later, sifting through the silent sands near Mit Rahina, Villanova University associate teaching professor Kelly-Anne Diamond, PhD, is working to recover the last traces of this once-thriving metropolis. In collaboration with a team of academics, graduate students and Egyptian artisans, she hopes to shed new light on what life was like in the "lost city" of Memphis—and to explore its long-buried connections to the present day. The Memphis Kôm el-Fakhry Archaeological Project "We call our initiative the 'Memphis Kôm el-Fakhry Archaeological Project,' or 'MKAP' for short, and we're excavating one particular mound in a series that make up the ancient city," said Dr. Diamond, who co-directs the effort. "I was very excited when I was invited to join the project, especially at its inception. There aren't many settlement sites [like this one]. We could probably count them on one hand." With its focus on "settled" land, MKAP is contributing to a growing body of research in Egyptology, or the study of ancient Egyptian history, culture and society, that centers on the experiences of everyday people. It's an area of significant interest for Dr. Diamond, who's previously investigated mourning traditions and sex and gender in the pharaonic era. "Currently, most of our knowledge is about the king, his extended family and the people who worked for him," she said. "This is one of the reasons why I think working at Memphis is so fascinating. When you work at a settlement site, this is where you're going to find information about regular people—about women, about children, about the elderly, about family structure." Already, MKAP has yielded findings that could challenge contemporary understandings of life in ancient Egypt. In particular, the discovery of an Old Kingdom-aged adult skeleton, within the bounds of the excavated mound, has spurred questions. "What we found doesn't necessarily line up with what we currently believe about Old Kingdom burial practices, because other evidence suggests that where people lived and where people buried their dead were two separate locations," shared Dr. Diamond. "Generally, we say that they lived in Kemet—which is the 'black land,' or the land where there's very, very rich soil—and were interred in Deshret, or the 'desert.' "Now, we do know that there was a First Intermediate Period (2181-2055 B.C.E.) cemetery at the site, adjacent to the settlement. We also know that, as the town progressed and people continued to live there, access to the cemetery was cut off. As we were going deeper into the settlement, which means that we were going into earlier levels, this is where we found the adult skeleton. The pottery in the area seems to suggest that we hit Old Kingdom levels, which would take us earlier than the First Intermediate Period cemetery. "Potentially, we need to reevaluate what we know about Egyptian burial customs." From the Past to the Present For some, the significance of a centuries-old corpse might be lost. And, in an age of smartphones, electric cars and highspeed Internet, the world in which the Memphians lived might seem on its face absolutely foreign. But, in unearthing the contents of the MKAP mound and in studying the minutiae of ancient life, Dr. Diamond sees important lessons—lessons that echo throughout time. As she maintains, the remnants of communal meals, religious rituals and day-to-day work, and their existence in the distant past, serve as powerful reminders of our enduring humanity. "One of the things I find, with my students, is that they're surprised that ancient Egypt was such a complex civilization," said Dr. Diamond. "They're surprised when we talk about technologies and social mobility—that these early people, whether improving on weapons and farming tools or seeking promotions, had a sense of progress, efficiency and change. "But, most of all, they're surprised at how similar life in ancient Egypt was to what they experience on a regular basis today. And that's how I often introduce my courses: What you know about life, or life as you know it, started back in the ancient Near East, in Egypt and Mesopotamia. So, we can find the origins of all these things that we know by going back to the ancient Near East. "And history did not start in Greece and Rome. We have to go back earlier." Editor's note: Following the filming of the videos above, Dr. Diamond was promoted from assistant teaching professor to associate teaching professor. 

Calls for Trump Documents Case to be Reassigned to a New Judge

Professor of Constitutional Law James Sample is part of a group seeking to file an amicus brief with the 11th US Circuit Court of Appeals, criticizing the Judge Aileen Cannon’s handling of the classified documents case against former President Donald Trump. CNN.com reported that Professor Sample is one of two judicial ethics experts to join a retired federal judge and the government watchdog group, Citizens for Responsibility and Ethics in Washington, in this effort to reassign the case to a new judge. According to the article, an amicus brief, or “friend of the court” brief, is from someone who is not a party to the case and is merely meant to provide information to the court. It is up to the court how much legal weight — if any at all – is given to an amicus brief. James is available to speak with media - simply click on his icon now to arrange an interview today.

Aston University develops novel bone cancer therapy which has 99% success rate

Bioactive glasses, doped with gallium developed to create a potential treatment for bone cancer Lab tests have a 99 percent success rate of killing cancerous cells Method could also regenerate diseased bones. Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer. Tests in labs have found that bioactive glasses doped with the metal have a 99 percent success rate of eliminating cancerous cells and can even regenerate diseased bones. The research was conducted by a team of Aston University scientists led by Professor Richard Martin who is based in its College of Engineering and Physical Sciences. In laboratory tests 99% of osteosarcoma (bone cancer) cells were killed off without destroying non-cancerous normal human bone cells. The researchers also incubated the bioactive glasses in a simulated body fluid and after seven days they detected the early stages of bone formation. Gallium is highly toxic, and the researchers found that the ‘greedy’ cancer cells soak it up and self-kill, which prevented the healthy cells from being affected. Their research paper Multifunctional Gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma has been published in the journal Biomedical Materials. Osteosarcoma is the mostly commonly occurring primary bone cancer and despite the use of chemotherapy and surgery to remove tumours survival rates have not improved much since the 1970s. Survival rates are dramatically reduced for patients who have a recurrence and primary bone cancer patients are more susceptible to bone fractures. Despite extensive research on different types of bioactive glass or ceramics for bone tissue engineering, there is limited research on targeted and controlled release of anti-cancer agents to treat bone cancers. Professor Martin said: “There is an urgent need for improved treatment options and our experiments show significant potential for use in bone cancer applications as part of a multimodal treatment. “We believe that our findings could lead to a treatment that is more effective and localised, reducing side effects, and can even regenerate diseased bones. “When we observed the glasses, we could see the formation of a layer of amorphous calcium phosphate/ hydroxy apatite layer on the surface of the bioactive glass particulates, which indicates bone growth.” The glasses were created in the Aston University labs by rapidly cooling very high temperature molten liquids (1450o C) to form glass. The glasses were then ground and sieved into tiny particles which can then be used for treatment. In previous research the team achieved a 50 percent success rate but although impressive this was not enough to be a potential treatment. The team are now hoping to attract more research funding to conduct trials using gallium. Dr Lucas Souza, research laboratory manager for the Dubrowsky Regenerative Medicine Laboratory at the Royal Orthopaedic Hospital, Birmingham worked on the research with Professor Martin. He added: “The safety and effectiveness of these biomaterials will need to be tested further, but the initial results are really promising. “Treatments for a bone cancer diagnosis remain very limited and there’s still much we don’t understand. Research like this is vital to support in the development of new drugs and new methodologies for treatment options.” Notes to Editors Multifunctional Gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma Shirin B. Hanaei1, Raghavan C. Murugesan1, Lucas Souza1, Juan I.C. Miranda1, Lee Jeys2,3, Ivan B. Wall3, and Richard A. Martin1 1. College of Engineering and Physical Sciences. Aston University, Aston Triangle, Birmingham, B4 7ET, UK 2. Oncology Department, The Royal Orthopaedic Hospital, Birmingham, B31 2AP, UK 3. College of Health and Life Sciences. Aston University, Aston Triangle, Birmingham, B4 7ET, UK DOI 10.1088/1748-605X/ad76f1 About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming The Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk