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Findings point to potential new therapeutic targets for this highly aggressive, drug-resistant breast cancer subtype In breakthrough research at ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, scientists have discovered that a protein secreted by tumor cells can switch off the body’s natural defenses against triple negative breast cancer (TNBC). The study, led by Jennifer Sims-Mourtada, Ph.D., lead research scientist at the Cawley Center for Translational Cancer Research (CTCR), at the Graham Cancer Center, is reported in The Journal of Translational Medicine, available online. “What we found is that TNBC tumor cells can effectively shut down the body’s defense systems against the tumor by secreting a type of protein called IL-10,” Dr. Sims-Mourtada said. “The presence of this immune system protein forces the antibodies that would normally be created to attack the tumor to become non-reactive and not do what they are supposed to do.” The study was initiated in partnership with The Wistar Institute of Philadelphia, Pennsylvania, in collaboration with the late Raj “Shyam” Somasundaram, Ph.D., a cell biologist at the Melanoma Research Center. “Dr. Sims-Mourtada and her team have brought us tantalizingly close to understanding what drives the aggressive nature of triple negative breast cancer, a treatment-starved disease that disproportionately affects Delaware women,” said Nicholas J. Petrelli, M.D., Bank of America endowed medical director of the Helen F. Graham Cancer Center & Research Institute. “Their work underscores our belief that scientific collaborations such as this one between our Cawley CTCR clinicians and Wistar scientists can smooth the way for new findings to become effective therapies, especially for hard-to-treat and aggressive forms of cancer like TNBC.” Understanding the mechanism behind TNBC Delaware ranks highest in the nation for incidence of triple negative breast cancer. TNBC is an aggressive form that affects Black women at twice the rate of white women with poorer outcomes. Patients have higher rates of early recurrence than other breast cancer subtypes, particularly in the first five years after diagnosis. Currently there is no targeted therapy for TNBC. “One of our missions within the Cawley CTCR is to understand the mechanisms behind TNBC and find a treatment for it,” Dr. Sims-Mourtada said. “Our study sheds new light on what is prompting the body’s immune response to the cancer cells and offers clues to potential new therapeutic targets.” Normally it is the job of the B cells to regulate the immune response against foreign invaders like cancer. Among other jobs, they control inflammation at the site of an attack by releasing proteins including IL-10 to signal the defender cells to stand down. “Previously it was thought that the immune cells were the ones to express IL-10 to regulate themselves,” Dr. Sims-Mourtada said. “But our study shows that the tumor cells also release this protein, which means they are driving how the immune system behaves.” Within the tumor microenvironment, IgG4 is one of four antibody subclasses expressed and secreted by B cells. Whereas another type of antibody would urge the immune system to press on with the attack, activation of IgG4 signals the job is done. TNBC and activation of IgG4 “Our findings support that TNBC may create a tumor environment that supports activation of IgG4, and messaging from IL10 is triggering the switch,” Dr. Sims-Mourtada said. As previously reported with other cancers, such as melanoma, this study confirms that the presence of IgG4-positive B cells within the tumor associates with advanced disease increased recurrence and poor overall breast cancer survival. It is also possible that IL-10 expression by tumor cells may also be a cause of poor outcomes in TNBC, and this may be independent of IgG4+ B cells. “At this point, we don’t know what causes tumor cells to start secreting IL-10, but we know that B cell-tumor cell interactions are involved,” Dr. Sims-Mourtada said. “We still have to look at what is really going on in the B cell population to determine which subtypes of B cells are affected by this tumor crosstalk and why some forms of TNBC express IL-10 (the ones with poor outcomes) and others do not. “We think that the presence or absence of other immune cells in the microenvironment may affect how B cells interact with tumor cells to drive IL-10 expression,” she said. Resources for the study, including blood and tissue samples from consenting patients, were obtained through the Graham Cancer Center’s Tissue Procurement program. Interestingly, in a small subset of samples, the researchers found that IL-10 expression was significantly higher in Black patients than non-Hispanic white patients. These findings need to be confirmed in a larger more diverse population with different TNBC subtypes. Understanding tumor-infiltrating B cells “Our growing understanding of the contribution of IgG4+ cells to the immune microenvironment of TNBC and what drives IL-10 expression may reveal ways in which tumor-infiltrating B cells can contribute to tumor growth and provide new targets to increase the immune response to TNBC,” Dr. Sims-Mourtada said. As partners for more than a decade, Graham Cancer Center research clinicians and Wistar scientists collaborate across disciplines to translate cancer research into more effective therapies for patients everywhere. In addition to providing high-quality, viable tissue samples for Wistar research studies, Graham Cancer Center clinicians actively participate in concept development, sharing their unique understanding of the everyday patient experience.
Aston Institute of Health and Neurodevelopment officially launches new £2.8m MRI scanner
A new £2.8 million MRI scanner has been unveiled at Aston University. The showcase took place in Aston Institute of Health and Neurodevelopment on Monday 25 April. The event was attended by Aston University Interim Vice-Chancellor Saskia Loer Hansen and other members of the University executive team, together with academic researchers in the University’s College of Health and Life Sciences. After an official ribbon-cutting ceremony hosted by the Institute co-directors Professor Jackie Blissett and Professor Gavin Woodhall, guests were invited to take a tour of the new MRI scanner facilities where imaging researchers were on hand to showcase and discuss their research for which the new MRI scanner is a vital facility. Interim Vice-Chancellor Saskia Loer Hansen said: “I am delighted that Aston Institute of Health and Neurodevelopment is home to this state-of-the-art facility. Having a new MRI scanner on our campus will not only enable our scientists to undertake their neuroimaging research, but will also benefit so many patients in the region who urgently need this facility as part of their medical treatment. “Our new MRI scanner further highlights the world-class research that our scientists are undertaking at Aston University.” The new Siemens MAGNETOM Prisma 3T MRI scanner was installed over a period of four months starting in November 2021, including the work undertaken to remove the old machine from the building. The scanner has been made ‘child friendly’ with suitable images and the room which hosts the scanner has a wall mural of cherry blossom trees. The new MRI scanner will enhance the world-class neuroimaging research facilities within the Institute of Health and Neurodevelopment and support the development of the next generation of researchers. Professor Jackie Blissett, co-director of Aston Institute of Health and Neurodevelopment, said: “The new MRI scanner will enhance the world-class neuroimaging research facilities within the Institute of Health and Neurodevelopment. It will allow us to answer the questions that matter to children and young people, their families and the services that support them.” Aston University researchers use advanced neuroimaging techniques to examine brain health in children with neurological diseases and developmental disorders and are developing a research programme focused on children and young people to deliver a new understanding of development, disorder and disease and the interventions that will make a difference. The new scanner will also enable the Institute to provide the most recent innovations in MRI for patients visiting through the clinical service Aston University Imaging. Patients visiting for MRI scans come through private referrals, as well as from local institutions such as the Birmingham Royal Ballet and Aston Villa Football Club.
Aston University experts to co-chair The Spring Servitization Conference 2022
The Conference is dedicated to understanding how organisations can develop and adapt their business models through servitization and advances services The theme is Achieving Net-Zero through Servitization and it will be held in Florence, Italy on 9 and 10 May Professor Tim Baines and Dr Ali Z. Bigdeli, from the Advanced Services Group at Aston University, will be co-chairs. Two Aston University experts are set to co-chair a major conference around servitization in Italy in May. Professor Tim Baines and Dr Ali Z. Bigdeli, from the Advanced Services Group (ASG) at Aston University, will be co-chairs alongside Professor Mario Rapaccini (University of Florence), Professor Nicola Saccani and Dr Federico Adrodegari (both University of Brescia) while Jill Forrest (also ASG) will be conference administrator. The Spring Servitization Conference (SSC) was first launched more than 10 years ago at Aston University in Birmingham. It was created to build and formalise a research community around the topic of servitization, and to understand how organisations can develop and adapt their business models through servitization and advances services. Servitization is a term used to describe the process through which a business transitions from selling products alone to selling a combination of product and service, and ultimately outcomes. The theme of the 2022 edition of the conference will be Achieving Net-Zero through Servitization and will be held at Istituto degli Innocenti in Florence on Monday 9 and Tuesday 10 May. The event will bring together the world’s leading researchers, practitioners and doctoral students to debate and engage with the theory and practice of servitization. Professor Tim Baines, executive director of The Advanced Services Group at Aston University and co-chair The Spring Servitization Conference 2022, said: “Servitization has already helped to transform the fortunes of many UK manufacturing businesses and I am looking forward to showcasing what it can do for businesses abroad too. “SSC2022 will follow the now established format of a single stream where all contributors have an opportunity to present to the whole conference audience and engage in both structured and semi-structured panel sessions to discuss their work. “The programme is designed to encourage extensive debate and bridge research theory and industrial practice. “We have some fantastic keynote speeches from senior executives at leading manufacturing businesses including Tim Foreman, European R&D manager, OMRON Europe and Paolo Mauri, Electrolux Professional.” You can find out more about The Spring Servitization Conference 2022 here.
The research looked into the means for achieving higher sustainability performance through circular economy adoption The project was led by Professor Prasanta Dey and Professor Pawan Budhwar from Aston Business School Data was gathered from around 100 SMEs from Greece, France, Spain and the UK. New findings from an Aston University-led study have found Small and Medium Sized Enterprises (SMEs) are likely to achieve higher environmental performance through circular economy (CE) adoption. CE is a systemic approach to economic development designed to benefit businesses, society, and the environment. In contrast to the 'take-make-waste' linear model, a circular economy is regenerative by design and aims to gradually decouple growth from the consumption of finite resources. The project was led by Professor Prasanta Dey and Professor Pawan Budhwar from Aston Business School along with Soumyadeb Chowdhury (Toulouse Business School), Krishnendu Saha (Birmingham City University), Debashree De (University of Essex) and Chrysovalantis Malesios (Agricultural University of Athens). Data was gathered from around 100 SMEs from each of the four selected countries – Greece, France, Spain and the UK using a survey to study the current state of CE adoption, and subsequently, focus groups were organised which involved SMEs owners and managers, policymakers, SMEs' customers and suppliers, in each country to derive means for improving sustainability performance. The study reveals that SMEs in all the participating countries are likely to achieve higher environmental performance through CE adoption. SMEs in France were likely to achieve higher overall sustainability performance than other participating countries. It also found products, processes and facilities design is likely to help SMEs most in all the participating countries to adopt CE, while their waste management all needed improvement. Professor Budhwar, head of Aston Business School, said: “Although from prior research there is evidence of SMEs achieving superior environmental performance by adopting CE, economic and social performances are not assured. This motivated us to undertake empirical research to reveal the means for achieving higher sustainability performance (economic, environmental, and social) through CE adoption”. “The findings of this research enable us to continue CE adoption not only in other European countries but also in India, Thailand, Vietnam and Kenya”. Professor Dey, a professor in operations and information management at Aston Business School, said: “SMEs in the EU countries are likely to have sustainable design practices aligned with the CE philosophy. On the contrary, SMEs in the participating countries are likely to have worst recover function. “This implies that customers' pressure works for SMEs to adopt CE principles as design function in most of the SMEs' businesses is governed by SMEs' customers. Whereas effective recover function depends on SMEs' self-motivation and policymakers’ pressure.” “CE adoption needs a structured approach of analysing current state of CE through analysing correlation of organisational value functions with sustainability performance, identifying issues and challenges, and suggesting means for improvement across value functions.” You can read the full report here.
Aston University experts to take part in Pint of Science 2022
Pint of Science, the world’s largest festival of public science talks, will run from 9 – 11 May Experts from universities, including Aston University, will take part across 32 UK cities Aston University academics will appear in front of audiences at Birmingham venues: The Woodman, Grain & Glass and Café Artum at Hockley Social Club. Tickets have gone on sale for Pint of Science 2022 which is returning on its 10th anniversary. The festival will bring thousands of scientists and their research out of the lab and into our pubs, cafes and community halls from 9 to 11 May 2022. Experts from universities in Birmingham including Aston University, Birmingham City University and University of Birmingham, will take part in 16 events across the city. The festival will take place in 32 UK cities, with events in hundreds of cities across 25 countries. Each event will provide a unique line up of talks, demonstrations and live experiments, held in a relaxed and informal environment. Aston University academics taking part in Pint of Science will appear in front of audiences at a number of Birmingham venues, including, The Woodman, Grain & Glass and Café Artum at Hockley Social Club. They will host talks on topics around the Pint of Science themes of: Beautiful Mind; Atoms to Galaxies; Our Body; Planet Earth; Tech me out; Our Society. Seven Aston University experts are leading talks including ‘The science of swearing’, ‘How much microplastic is in your pint: does it matter?’ and ‘How facial expressions guide our eating behaviour’. Dr Robbie Love, a lecturer in English at Aston University, who is taking part in Pint of Science 2022 and who is hosting a talk about the science of swearing said: “I am really looking forward to an evening of linguistic libations at Café Artum for Pint of Science 2022. “Swearing might seem like a bit of fun, but the science behind swearing shows us that it plays a really important role in human communication. Plus, I’m looking forward to hearing everyone’s favourite swear words!” Katie Edwards, a PhD student at Aston University who is taking part in Pint of Science 2022 said: “I am really looking forward for this year’s Pint of Science festival to chat about eating behaviour. “I will be talking about how other people's food enjoyment can impact our eating. “It is a great opportunity to hear about current scientific research whilst relaxing with a drink.” You can find out more about full line up of events in Birmingham, which includes experts from the University of Birmingham and Birmingham City University, here.
Aston University appoints translator in residence to inspire future literary translators
Aston University and Writing West Midlands have appointed Sarah Letza, a professional translator from the region to the role She will be working on community engagement activities at Aston University and with the West Midlands community The project is funded by Arts Council England. Aston University has appointed a translator in residence as part of a project developed by the translators Daniel Hahn and Ros Schwartz, a new one-off literary translation residency for 2022 based in Birmingham. Sarah Letza, a professional translator from the region, has been appointed to the position until March 2023. The project is funded by Arts Council England and will be run in partnership with Aston University and Writing West Midlands. Sarah’s residency will encourage an interest in literary translation and translated literature, and the valuing of languages, among communities in and around Birmingham through workshops, talks and other public engagement and collaborative participation projects. Sarah Letza, translator in residence at Aston University, said: “I hope to draw attention to the opportunities that translation and language learning can lead to and capitalise on the wealth of talent that can be drawn from Midlands schools and universities. “There is the potential to be involved with the many translation research projects already under development at Aston University as well as promoting and supporting languages and translation pathways. “I want to showcase Birmingham as a city that has been built on cultural crossings, intellectual exchange and creativity, all of which are the bedrock of both translation and language learning.” Dr David Orrego-Carmona, a lecturer in English, languages and applied linguistics at Aston University, said: “Birmingham is an incredibly multilingual city and Aston University is particularly well-placed to raise awareness and showcase the value of languages, translation and intercultural exchanges. “We are certain the programme will provide inspiring experiences for our beneficiaries in Birmingham and the region, and we are looking forward to the engaging activities that Sarah is already planning.” For more information about our courses in translation click here.
With an estimated 1.5-million faculty in the US and a near 50,000 growth in UK-based academics in the last decade (to 225,000), universities and colleges have a whole range of interests and expertise on offer. In fact, despite rumours to the contrary, academia is a large and growing global ‘industry’. If you’re responsible for external relations, communications, marketing, civic engagement, knowledge exchange - or any other aspect of external engagement or “connectedness” in a university or college - then the ability to choose which faculty experts you selectively promote and publicise can be a very tough assignment. I’ve had first-hand experience with this. I was once in that very position - trying to keep up with the opportunities and the expectations afforded by 800 academics at just the one mid-sized UK institution where I worked. With the benefit of that firsthand experience and having since worked with more than 100 higher education institutions in the UK, Europe and North America, here are a few observations and also a few tips on how to organize your expertise: Approach #1: The Focus on Expertise Clusters An approach taken by some universities nowadays is to promote their expertise as a group of “grand challenges” or “beacons of excellence” - drawing together as many areas of research expertise under (usually) three or four headings. While identifying “token clusters” of expertise for focus and prioritisation may seem logical, this approach doesn’t really work. It may help with internal politics but it fails to generate enough precision to be relevant to various communities such as the media and industry. Approach #2: Selectively Promoting Key Experts One trap that universities can also fall into is to focus on a small group of academics who appear to be more suitable to promote. The reasoning for this approach is often driven by the need to have a manageable number for internal communications/press office staff to work with. The easy route to take is to just work with academics who are more keen to work with comms staff in promoting their work and who are already at ease in speaking to the media. Selection of experts on these factors, while important, isn’t the optimal way to build up the profile for the institution with key audiences. First off, this approach often doesn’t yield the diversity that audiences such as journalists and potential student and faculty recruits want to see represented. This approach will also miss the mark if it just plays to popular disciplines or hot topics. Being more inclusive to promote a wider range of disciplines and specialized topics is better value all round. Approach #3: The Faculty “Expertise Audit” I’ve seen institutions make many mistakes in positioning their faculty as experts, given it’s a proven way to differentiate brand, build profile and reputation. That’s why I’ve started to work with several universities on what I refer to as a “faculty expertise audit”. This brings a more structured process that helps prioritize key areas of research expertise and identify specialist experts. The audit also looks at the resources and overall capacity that universities have available to support an “expertise marketing” program that optimizes all these elements to significantly boost performance. Start with The Business Case for Expertise At the heart of this more structured, targeted audit approach is ensuring you are generating “return-on-investment” and “value-for-effort.” A good starting point is to ask: Where is the budget coming from? Where is current and expected demand for your programs? When starting this assessment, you have to think longer than a year out. Instead, look very hard and in detail at the next three to five years (the typical cycle of research investment and university strategies) and identify which expertise is most likely to solve the problems and consequential explorations that governments, industry, benefactors/donors, and funding agencies will want to support. I’m not saying that research areas without such sizable levels of predicted investment should be ignored - far from it - but we are in a competitive climate and universities now have to secure ‘orders’ (for applied and contracted expertise) that will ensure institutional sustainability and success. In turn, that success will allow investment in other areas that are socially vital but financially a weaker bet as regarded by funding sources. Having proven where research funding is most available, pressing and externally directed, then the audit is designed to identify and match the institution’s research talent to these requirements. These audits involve shortlisting, enlisting and then coaching the appropriate academic experts. The best results come from one-to-one sessions with academics which create buy-in and yield a more detailed marketing plan to leverage your experts. While more inclusive, this is an efficient process designed to create a “shared roadmap” for where the university and the academic both want to take their expertise. A large part of this roadmap then covers off other important activities such as creating a more discoverable and engaging online presence with enriched academic profiles that perform far better than the traditional “faculty directory.” Keeping online academic profiles fresh, content-rich, jargon-free, and compelling makes the job of expert ‘mining’ so much easier. Developing a sustained program of content with an organized lead generation process is also necessary. These extra steps are where many universities miss the mark. The result is a significant loss of inbound opportunities for research grants, consulting revenues, academic collaborations as well as local and global media coverage. I recently spoke with a Vice Chancellor of a prominent UK University who admitted that they as an institution deserved a failing grade when it came to promoting their faculty research achievements, saying that he “doubted any of their academics would be happy with the way their work was being promoted online.” This is an important aspect of the faculty audit. As a consultative process, it is non-threatening and we’re listening to staff and academics. That not only enriches the information the University has to promote its brand better, it also helps to enlist the support of the academic community who see that the university cares and that it is getting their input to put together a plan – both for the university and for individual academics. The academic is happy (they understand the value for them personally and for their institution); the University is happy (it is able to focus and prioritise its expertise in an evidence-based manner), and Communications and press office staff are happy (they have so more to work with in connecting the work of the University to a variety of local and global communities). The Benefits of A Faculty Audit Having completed many of these, I’ve seen very clearly, the results of a well run Faculty Audit process that without exception yield an excellent return on investment. Here are just some of the benefits to consider: Greater Insights: Gain a deeper understanding of the hidden strengths and opportunities within your academic ranks. Better Planning: A detailed report from a Faculty Audit enables a more strategic approach to planning where faculty research and expertise can support various programs within the University - such as industry engagement, media coverage and recruitment. Building Trust: When conducted by a third-party, a Faculty Audit is seen as more credible and less prone to perceptions of internal bias. More Engaged Faculty: Increased collaboration with faculty is gained through a more consultative process that builds “shared awareness” and enables more proactive support of their research. Increased Capacity: Producing more proactive content with faculty yields better results in terms of media coverage, research engagements, etc. Demonstrate Diversity: A better understanding of expertise that goes beyond the “usual suspects” to engaging a more diverse set of faculty to promote the University. News Coverage: Positioning your faculty and their research in a more relevant way aligns with the interests of the outside world and what's on the mind of outsiders. Less Stress: A more proactive, well structured plan helps everyone to synchronise activities better versus scrambling too much to meet deadlines in the “here and now.” Is a Faculty Audit Right for Your Institution? Here are some key considerations when evaluating the value of a Faculty Audit for your institution. You are ideally suited to undertake a faculty expertise audit if: You have a stretched workload where there's little capacity for proactive comms. You're tending to turn to the same academics for expert commentary in the media or elsewhere. You tend to get complaints (or mild mutterings) about not supporting academics enough. You don't have time to get to know the range of academic experts in your institution - especially new arrivals or eager early career academics. You've adopted an 'inside out approach' rather than one that engages with the interests of the outside world and what's on the mind of outsiders. There's weak management of expectations with the academic community - and a need for clarity and shared pathways for publicity. You're operating too much in the here and now and don't have the time to plan for future events, milestones and opportunities. You want to be more strategic in your comms and engagement - and make a real difference via attracting interest, income and investment. You don't have an integrated approach to comms (where content can be repurposed and recycled). You want more global reach and presence and can exploit digital tools to enable this. Additional Resources Academic Experts and the Media (PDF) This report, based on detailed interviews with some of the most media-experienced academics across the UK and United States draws on their experiences to identify lessons they can share in encouraging other academics to follow in their path. Download the UK Report Here Download the US Report Here The Complete Guide to Expertise Marketing for Higher Education (PDF) Expertise Marketing is the next evolution of content marketing. Build value by mobilizing the hidden people, knowledge and content you already have at your fingertips. This win-win solution not only gives audiences better quality content, but it also lets higher ed organizations show off their smarts. Download Your Copy Click Here for Additional Resources
Aston University MEG scanning facilities used by start-up to launch new brain health service
MEG scanning services at Aston Institute of Health and Neurodevelopment (IHN) have been used to launch the world’s first brain-imaging service to measure and assess brain health. Commercial brain imaging service Myndspan launched a service to assess brain health and identify concussions, with an event at Aston University. Start-up, MYndspan, was founded in 2020 by Caitlin Baltzer, former vice president of operations at functional brain imaging company Croton Healthcare and Janne Huhtala, previously chief executive of MEGIN, the global leader in functional brain imaging. The service was created to support brain health across populations, using cutting edge brain scanning technology to monitor and extend healthy cognitive lifespans. The brain imaging service is powered by a non-invasive brain scanning technology called Magnetoencephalography (MEG), which measures the electrical signals between neurons to form a highly detailed map of brain activity and function. The MEG scanner, which is located in the Aston Institute of Health and Neurodevelopment, at Aston University, identifies and observes functional ‘invisible injuries’ to the brain, such as concussion or PTSD, that can’t be seen from an MRI image of the brain. MYndspan’s service combines MEG scans with gamified tests of cognitive function, which measure a range of mental processes such as attention, memory, and visuospatial processing. Using these two measures of brain health, cognitive function and brain function, MYndspan provides a comprehensive overview, detailed in a thorough, easy-to-understand report of how a person’s brain is behaving and why. Among the service’s first customers are neuroscientist and author Dr Dean Burnett who is using MYndspan to monitor the effect increasing physical activity has on his brain over time and Vicky Macqueen former England Rugby player and chief executive of Didi Rugby, who is using the service to measure her pre-concussion baseline for playing contact sports safely. Through routine monitoring of personal brain activity, MYndspan helps people assess and understand their brain health. This helps to identify issues before symptoms emerge and supports optimal lifestyle and clinical intervention. Its first application is concussion, where the technology can support the recovery of an estimated 3.8 million athletes who experience sports-related concussion annually. Janne Huhtala, MYndspan co-founder said: “MYndspan’s technology can identify concussed brain activity and objectively identify and monitor recovery from a concussion. Currently, individuals are deciding to go back to play based on how they feel – a decision that can have life changing consequences. “We think athletes deserve to have objective information about where they are in their recovery, to make the best and most informed decisions.” MYndspan’s service will be available to the general public at Aston University’s Institute of Health and Neurodevelopment (IHN), an international leader in advanced technology to explore brains, development and healthy behaviours. IHN at Aston University is the first of many planned locations around the world where individuals will be able to access the service. MYndspan co-founder Caitlin Baltzer added: “The brain is hugely complex and exciting, and whilst there is a vast body of research and knowledge already available, there is still so much for us to learn about how it functions and changes over time. “In a world where we can track and optimise every part of our health, and our lives, the brain remains neglected. At MYndspan, we believe that every person has the right to better brain health and this begins with knowing our brains. “We are very excited to launch our brain scanning technology at Aston University as a demonstration for how digital health tools can support brain health and ultimately help more people recover and age better.” Dr Dean Burnett, neuroscientist and author, including of the Guardian blog ‘Brain Flapping’, said: “I'm a big proponent of anything that helps people understand their brains better, and MYndspan's new high-tech but easily accessible approach looks to be extremely useful in that regard.”
Aston University sets Meritics on course to become market leader in the bio-pharmaceutical sector
Aston University has completed a knowledge transfer partnership with Meritics Ltd to develop the company’s capability and underpinning knowledge to measure the size, concentration and distribution of biological entities, such as liposomes and exosomes, using proprietary particle analysers. The project will enable Meritics to enter the fast-growing biologics sector with their particle analysis instruments and services to significantly increase company turnover. It represented a significant change in direction for the company and focused on systems that would have the largest impact. Results provided Meritics with significant data and proof-of-concept applications required to widen the company’s product range into the biological market. It also broadened the company’s knowledge of biological applications and helped bridge gaps between the areas of interest and the limitations of the analysers. Meritics Ltd supplies and provides service support for a range of particle characterisation instrumentation to industrial, research and academic institutions in the UK. Additionally, it offers a range of consumables, analysis services and consultancy. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, called a KTP Associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. The project was led by Dr Alice Rothnie and Dr Alan Goddard from Aston University’s Aston Centre for Membrane Protein & Lipid Research (AMPL), a specialist research group with a track record of biological particle characterisation. Dr Rothnie has over 14 years of experience working with liposomes, viral and cellular systems, while Dr Goddard brought over a decade of experience in biological membranes and nanoparticles ¬– mainly focusing on liposomes. Also working on this partnership as KTP Associate was Dr Megan Cox, whose proven expertise in biochemistry drove the innovation and research behind the project. Following the completion of the project, Dr Cox has been employed by Meritics as a Technical Specialist, using biological expertise to assess instrument parameters for biological entities. Brian Miller, founding managing director of Meritics, said: “The project has sped up the company’s plan to move into more biological application areas and widen our customer base. Aston University’s extensive knowledge in biology and biological entities is crucial for our wider sales and technical staff and provided invaluable visibility of the biological markets”. Dr Alan Goddard said: “Working in partnership with Meritics has allowed us to transfer our extensive experience of biological particles into industry. We have formed an exciting partnership which has continued past the end of the formal project, enabling cutting-edge research to be performed at Aston using the latest equipment.”
New research to help manage excessive weight gain in patients being treated with antipsychotics
New research led by Dr Gurkiran Birdi and Dr Ian Maidment in the College of Health and Life Sciences at Aston University will explore ways of managing excessive weight gain in patients being treated with antipsychotics for mental health illnesses such as schizophrenia. The project, known as RESOLVE and funded by the National Institute for Health Research (NIHR), will study non-pharmacological interventions for antipsychotic-induced weight gain in people living with severe mental illness (SMI) by working directly with patients to understand and explain how, why, for whom, and in what contexts non-pharmacological interventions could help service users to manage antipsychotic-induced weight gain. Antipsychotics are widely used in the treatment of schizophrenia and other severe mental illnesses (SMI). Over the last 20 years, the first generation of antipsychotics has been replaced by the newer second generation of antipsychotics. There are over 220,000 people being treated for schizophrenia in the UK at any one point in time. Up to 80% of people with schizophrenia or bipolar disorder are overweight or obese. Weight gains of up to 33kg have been reported with antipsychotics. This weight gain has devastating consequences: life expectancy is reduced by 20 years in people with schizophrenia, partly related to the consequences of this weight gain. Diabetes has been reported to be a major issue with second-generation antipsychotics. In RESOLVE - which includes partners from University of East Anglia, Oxford, Cambridge, Birmingham Universities, the NHS and the McPin Foundation - the researchers will combine literature what has been written about the subject. The team will also interview volunteers, both people who have suffered from the weight and healthcare staff involved to understand their lived experience of weight gain. We also want to find out what works to help manage weight. At the end of the project, the team plans to develop guidance for service users and practitioners on the best ways to treat and manage weight gain. Dr Ian Maidment, reader in clinical pharmacy and lead researcher, said: “Prior to moving to academia, I spent 20 years working in mental health services. This is a really important issue, I have seen patients literally “balloon” weight with their weight increasing from 80 to 120kg. We need to find better ways to help them.” One member of the RESOLVE Lived Experience Advisory Group said: “The RESOLVE study could provide a tailored solution to my antipsychotic weight gain, that could benefit my unique needs as an individual. I have found that weight gain from taking anti-psychotics has been a real health problem. I find that this is often ignored or stigmatized by friends, family and healthcare professionals. Added to which there seems to be no currently available solution that works”.
