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It's a fabulous fall - and our expert can explain why all those colors come out this time of year featured image

It's a fabulous fall - and our expert can explain why all those colors come out this time of year

Autumn has arrived.  And as we all take time to welcome this wonderous palette that nature delivers year after year, those who are curious about all those colors are looking for answers. Why there are so many different shades, tints, and tones? What causes the colors to change? And where's the best place to find one of nature's finest displays of leaves? It's a topic that comes up every year, and recently Connecticut Public Radio connected with UConn's Bob Fahey to get some of the answers about autumn in New England. I ventured into a forest in northeastern Connecticut with two UConn tree experts. We met up at Horsebarn Hill, one of the best viewpoints in the state, surveying a rolling river valley showing off with fall colors. We see oaks just starting to turn red. Nearby hickories provide a dash of yellow – and, of course, the maples are already stealing the show, even on a cloudy day. Here’s what I found out: Our trees are diverse One reason the foliage is so good is simply due to the number of species we have. “We have a very diverse hardwood forest in this part of New England,” said Bob Fahey, an associate professor and forest ecologist at UConn. “We have both species that are more southern species and also some of the more northern species.” “In comparison to say, the Mid-Atlantic or other places that have lots of deciduous species, we have maples, which are just the best,” he said. “We also have a number of species that have nice yellow foliage,” he said. “Birches and beech. If you go a little bit farther south from here, mostly what you have is oaks. And oaks can have good fall foliage colors, but there are a lot of times they don't and they don't last for as long.” We have lots and lots of trees The diversity of species provides a diversity of color, said Tom Worthley, an associate extension professor and a forester at UConn. He asked me to remember the last time I flew over Connecticut. What did you see, he asked. Lots of trees, right? “Most of the ground is covered by a tree canopy,” Worthley said, noting that some estimates put that tree canopy cover at around 75% of the land area of the whole state. “Back where we were standing a few minutes ago, we had some cherry trees,” Worthley said, his eyes scanning the trees enveloping us. “There's a few remnant ash, there's some walnut around the edges here. And let's see, some hickory.” A walnut tree towers over us – and there are even some white pines. It’s that varied bioscape that sets New England forests apart. “Even in my two-acre forest behind my house, I have 22 different species of tree, which is more than some regions of the northern part of the U.S.,” Fahey said. Travel to the west, and what you’re likely to see are lots of evergreens and aspen trees. “Not that there aren't others, there are plenty of others, but not in the same abundance and not in the same kind of mix that we have around here,” Worthley said. Climate plays a role Across New England are rolling hills with microclimates that can contribute to vibrant fall colors. “You’ll see ... highly different color in different parts of the landscape, which has to do with temperature differences,” Fahey said. Combine that with Connecticut’s mix of southern and northern species and the colors here might not be as exciting and bright as what you would see in Vermont and New Hampshire, Fahey said. But our foliage season can sometimes last a little bit longer. One reason? Oaks. “We have so much more of that oak component,” Fahey said. “The oaks will hold their leaves until the end of October.” Moisture, temperature and the amount of daylight all contribute to how long it takes for a tree to shed its leaves. And, for each species, the calculation is different. “A tree makes an economic decision,” Worthley said. “It decides, ‘Well, it's costing more in energy to keep these leaves going than what they're producing for me and so it's time to shut them off.’” Why do leaves fall anyway? It’s when leaves are green that the most important work is happening, pulling carbon out of the atmosphere and giving us oxygen. And for that green color, we can thank the pigment chlorophyll. “The color that's in the leaves – is always there from the time the leaf is grown,” Worthley said. “As the growing season fades, the chlorophyll disappears,” he said. Then the other colors in the leaf can begin to show off. Pigments like anthocyanins (reds and purples) and carotenoids (yellows and oranges) peek out, tiny threads in an autumnal blanket transforming New England’s green forests into a richly colored landscape. The colors are out - but only for a limited time.  If you're a journalist looking to know more about this topic before all the leaves fall, then let us help. Dr. Fahey is an Associate Professor in the Department of Natural Resources and the Environment and Center for Environmental Sciences and Engineering at the University of Connecticut. He is also the George F. Cloutier Professor in Forestry, director of the UConn Forest, and associate director of the UConn Eversource Energy Center. Simply click on his icon now to arrange a time to talk today.

Robert T. Fahey, Ph.D. profile photo
4 min. read
Preparing the clean hydrogen workforce featured image

Preparing the clean hydrogen workforce

The University of Delaware will play a leading role in workforce development efforts associated with the Mid-Atlantic Clean Hydrogen Hub (MACH2), which has been selected by the U.S. Department of Energy to receive up to $750 million in funding through the historic Regional Clean Hydrogen Hubs program. MACH2 was chosen as one of seven hydrogen hubs, totaling up to $7 billion in grants, announced by the Energy Department on Oct. 13. In stiff national competition, MACH2 ranked among the most pro-labor and greenest hubs in the nation, according to the Delaware Sustainable Chemistry Alliance (DESCA), which brokered the proposal, involving industries, academic institutions, local governments and community partners from across Delaware, southeastern Pennsylvania and South Jersey. Hydrogen is the most abundant element in the universe, and the Energy Department is working to accelerate its use as a clean energy source and as a means to decarbonize heavy industry, transportation and energy storage to meet President Biden’s goal of a 100% clean electrical grid by 2035 and net-zero carbon emissions by 2050, with the regional hydrogen hubs leading the way. MACH2 will encompass a network of hydrogen producers, consumers, local connective infrastructure for hydrogen deployment, and the education and training needed to develop the region’s clean energy workforce. UD will lead the higher education component of MACH2’s workforce development with Cheyney University, Rowan University and the University of Pennsylvania. MACH2 is projected to create 20,000 well-paying jobs in the production, delivery and use of zero-emission hydrogen to repower the region’s industrial facilities, transportation systems and agriculture sectors. What kinds of jobs will MACH2 help prepare people for? There will be a need for technicians for hydrogen-powered vehicles, construction workers for installing hydrogen pipelines, fuel cell power system operators, hydrogen production plant managers, and directors of research and development (R&D) programs, to name a few. Some of these roles may require a high school diploma and an apprenticeship or specific credential; others may require a college degree, from bachelor’s to master’s to Ph.D. Yushan Yan, the Henry Belin du Pont Chair in Chemical and Biomolecular Engineering at UD, will direct the hub’s higher education workforce development efforts. This work will complement high school, vo-tech and community college training programs in energy and construction that will be expanded through the hub, along with pre-apprenticeship programs, particularly those that recruit from underserved communities, offered by building trade unions. “The University of Delaware and our collaborators at Cheyney, Rowan and Penn are well-poised to prepare students for rewarding careers in the new hydrogen economy,” Yan said. “Several engineering, energy and hydrogen programs are already in place at our institutions and will be expanded through the hub, offering students exciting opportunities.” UD will enhance hydrogen technology training at the master’s level through a new “4+1” master’s degree in electrochemical engineering, which would allow highly qualified undergraduate students to earn a bachelor’s degree in an area such as chemical and biomolecular engineering or mechanical engineering and then continue on to earn a master’s degree in electrochemical engineering in the fifth year.

Yushan Yan profile photo
3 min. read
From Sci-Fi to Reality: Nanoscale Materials Pave the Way for High Precision Disease Treatment featured image

From Sci-Fi to Reality: Nanoscale Materials Pave the Way for High Precision Disease Treatment

Imagine being able to create something smaller than the size of a single strand of hair that can help treat cancer at the cellular level. Sounds like something out of a science fiction novel or movie, right? Wrong.  Emily Day, with the Department of Biomedical Engineering at the University of Delaware is doing just that.  Her lab innovates nanomaterials (materials with single units measuring  between 1 and 100 nanometers) that enable more high precision treatment of cancer, blood disorders and other diseases. She also studies how these nanoparticle interact with with our bodies on both the subcellular-level and whole-organism level. Day has been recognized with an NSF CAREER Award along with dozens of other awards and grant honors. She is available to talk about her research and can be contacted by clicking her profile. 

1 min. read
Expert explainer - Storm Daniel and the Libya flooding featured image

Expert explainer - Storm Daniel and the Libya flooding

Expert: Dr Kiran Tota-Maharaj Reader in Civil & Environmental Engineering (Water and Environmental Engineering) College of Engineering and Physical Sciences, Aston University 1/ Do we have any basic measures on the volume of precipitation that triggered the collapse of the two dams that flooded Derna? How much rain over what period of time? Are there adequate records to put that in historical context? Were any records broken? Storm Daniel has the characteristics of a tropical depression, approximately 170 millimetres (6.7 inches) of rainfall occurred fell in Libya. Torrential rains of between 150 - 240 mm caused flash floods in several cities, including Al-Bayda, which recorded the highest rainfall rate of 414.1 mm. 2/ Do we know anything about the dams that failed? Where they old, near the end of their expected lifespan? Were they known to be fragile in any way? To what extent, in other words, might this have been a disaster waiting to happen? Flash floods, which is considered as one of the worst weather-related natural disasters are highly unpredictable following brief spells of heavy rain. This region in Libya is subjected to flash floods, where floods from the mountains causing heavy damage to hydraulic structures and features of Dams. These floods are made up of sudden, unexpected and heavy rains or a strong surge of water, which usually hit the steep sloped mountainous catchments and have inundated many regions in Libya. The sweeping flash floods also led to the death of many residents and great losses of property. Entire neighborhoods in Derna disappeared, along with their residents swept away by water after two ageing dams collapsed making the situation catastrophic and out of control, the city of Derna is surrounded by mountains, so the flash flooding occurred quite rapidly, taking over with surface-water levels rising as high as 3 metres (10 feet). Engineers have previously issued warnings about the risks of these dams bursting and the urgent need to strengthen their defenses, which unfortunately didn’t occur. Early Warning Systems (EWS)- which are effective ways to reduce the risks of flash floods have not been properly implemented. When EWS are issued before a flash flood event, additional time is created to take action and save lives and infrastructure. The unexpected arrival of a flash flood in Libya, combination with its force, limited understanding of the risks and small space-time scales provide explicit challenges for the development and implementation of an EWS system for flash floods. 3/ There is speculation about many thousands of deaths. Is this attributable almost entirely to the failed dams? Or was there massive and deadly flooding beside that? Thousands of people’s lives have been sadly lost after the massive flood ripped through the city of Derna as a result from the heave storm conditions and excessive rainfall. There have been several areas severely affected by widespread flooding, damage to infrastructure, and loss of life. The disastrous flooding event is likely the cause of the two dams’ collapses, making thousands of residents of the valley and the city of Derna, Libya vulnerable as a result of the storm. Entire neighbourhoods of Derna by the bank of the swollen river had been ravaged and washed away. For further details or to interview Dr Tota-Maharaj, contact Nicola Jones Press and Communications Manager, Aston University, Birmingham, UK n.jones6@aston.ac.uk or Mobile: (+44)7825 342091

3 min. read
National Science Foundation awards $2.5M Lifelong Learning Grant to support Georgia Southern computer science and IT departments, 161 scholarships featured image

National Science Foundation awards $2.5M Lifelong Learning Grant to support Georgia Southern computer science and IT departments, 161 scholarships

The National Science Foundation announced a $2.5 million award supporting Georgia Southern University researchers in addressing high-demand workforce needs in information technology and computer science fields. The funded project, “Enabling Lifelong Success in an Information Technology Workforce,” adapts and evaluates evidence-based student support activities within the IT Department, one of the units in the Allen E. Paulson College of Engineering and Computing. The goal of the project is to identify a group of highly qualified students and to render 161 scholarships over a six-year period in an effort to increase student retention and graduation rates. “This is great news for the IT program at Georgia Southern, and it will provide a positive impact to the surrounding area as businesses’ needs for IT professionals increase,” said interim Vice President of Research and Economic Development Chris Curtis, Ph.D. Georgia Southern Professor and Department of Information Technology Chair Yiming Ji, Ph.D., is taking the lead on the grant, which, he noted, has the potential to have a profound impact on students. “This project will train a pool of talented students, especially those with financial needs, and prepare them for successful careers in IT,” said Ji. “With scholarships from the grant, students will have time to focus on studying, instead of having to work to make ends meet. These students will also receive dedicated support, including academic advising, research opportunities, internship and career service and much more. The result is that these students will become confident and have a greater future in IT careers.” The project involves four researchers, including Lei Chen, Ph.D., (co-PI), professor of IT; Hayden Wimmer, Ph.D., (co-PI), associate professor of IT; Elise Cain, Ph.D., (co-PI), assistant professor of leadership’ and Kania Greer, Ed.D., (external evaluator), program coordinator of the Center for STEM education. The project also received support from the Allen E. Paulson College of Engineering and Computing (CEC) and the Georgia Southern Office of Research. The national and regional demand for computer and IT professionals remains high. “This project will directly benefit our local, regional and national economies,” said CEC Dean Craig Harvey, Ph.D. “High-tech industries are already in and being attracted to the Savannah area, and the locations of Georgia Southern University’s campuses provide unique opportunities to train high-quality computing and IT professionals who are in high demand.” The Department of Information Technology offers a wide range of undergraduate and graduate computer and IT programs at Georgia Southern, in addition to a new Ph.D. program in applied computing. This grant is the first of its kind to be received by the IT department. The department hopes that through the use of this grant, they will build stronger partnerships with businesses and federal or state government organizations, among others. Interested in knowing more? To arrange an interview with Yiming Ji or Chris Curtis, simply connect with Georgia Southern's Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to arrange an interview today.

2 min. read
Bioenergy experts welcome commitment to sustainability in UK’s new Biomass Strategy featured image

Bioenergy experts welcome commitment to sustainability in UK’s new Biomass Strategy

New strategy outlines role of biomass in UK’s transition to net zero, with sustainability as major theme Supergen Bioenergy Hub experts worked with government departments to provide scientific evidence and insight They welcome the holistic view of sustainability in the Biomass Strategy and call for action to deliver its ambitions. A group of bioenergy experts have welcomed the Government’s new UK Biomass Strategy, but say urgent action is now vital to shape its ambitions into deliverable policies. Researchers at the Supergen Bioenergy Hub - led by Aston University - worked closely with government departments to provide scientific evidence to inform the strategy, which outlines the role biomass will play in supporting the UK’s transition to net zero and how this will be achieved. Professor Patricia Thornley, who leads the Hub, says: “This is a comprehensive and considered biomass strategy that, rightly, places sustainability at the heart of UK bioenergy development. The challenge is now to produce actions that can deliver the sustainable system of biomass required to achieve net zero.” Sustainability is a major theme within the new strategy. It includes a review of how existing sustainability policies could be improved, as well as a commitment to developing a cross-sectoral sustainability framework (subject to consultation) to ensure sustainability across the many different applications of biomass. This follows previous work led by Dr Mirjam Rӧder, Systems Topic Group Lead in the Supergen Bioenergy Hub, calling for harmonised sustainability standards across different biomass applications, which is referenced in the strategy. Dr Rӧder says: “We need rigorous approaches to sustainability governance that go beyond emissions. Considering wider environmental, social and economic trade-offs is essential for true sustainability and building trust in bioenergy projects.” The strategy considers the amount of biomass resource that might be available to the UK in the future, highlighting the importance of both imported and domestically produced biomass resources. Professor Thornley comments: “It is important that the strategy recognises the potential of imported as well as indigenous biomass in achieving global greenhouse gas reductions. Sustainable systems should grow, convert and use biomass in the locations where they can deliver most impact, ensuring we take account of all supply chain emissions. We shouldn’t shy away from imports where the source is sustainable and the overall system makes environmental, economic and social sense.” The strategy also considers how biomass should be prioritised across a variety of applications to best support the transition to net zero. Biomass applications ranging from transport fuels and hydrogen to domestic and industrial heating are recognised as important, but in the medium to long term the focus is on integration of bioenergy with carbon capture and storage (BECCS). BECCS is an emerging technology where the CO2 that may be released during the production and use of electricity, fuels or products derived from biomass is captured and stored, potentially resulting in negative emissions. Professor Thornley comments: “The priority use framework outlined in the Biomass Strategy makes eminent sense. The UK (and the global energy system) needs carbon dioxide removals to deliver net zero. BECCS has an absolutely key role to play, as reflected in the strategy. Again, while this is encouraging to see, we must not underestimate the challenges of moving towards such a radically different system at scale.” “Relying on future BECCS deployment alone to counterbalance the current excess of greenhouse gas emissions would not enable the full potential and benefits of BECCS. BECCS should be deployed alongside measures to transition away from the use of fossil fuels, not instead of them,” adds Dr Joanna Sparks, Biomass Policy Fellow at the Supergen Bioenergy Hub, who engaged closely with government departments as they developed the strategy. Dr Sparks led an extensive policy engagement and knowledge transfer process to ensure that those developing the strategy had full access to the breadth and depth of UK scientific and engineering academic expertise, ensuring a robust, independent scientific base. Professor Thornley believes continued engagement between policymakers, academics and the wider sector is vital in achieving the next steps in the delivery of the Government’s strategy. She says: “The key to successful long-term results is a close partnership between academia, industry and policy stakeholders so that we can anticipate problems and plan the pathways to success.”

Patricia Thornley profile photoDr Mirjam Röder profile photo
3 min. read
Optical research illuminates a possible future for computing technology featured image

Optical research illuminates a possible future for computing technology

Nathaniel Kinsey, Ph.D., Engineering Foundation Professor in the Department of Electrical and Computer Engineering (ECE), is leading a group to bring new relevance to a decades-old computing concept called a perceptron. Emulating biological neuron functions of the messenger cells within the body’s central nervous system, perceptrons are an algorithmic model for classifying binary input. When combined within a neural network, perceptrons become a powerful component for machine learning. However, instead of using traditional digital processing, Kinsey seeks to create this system using light with funding from the Air Force Office of Scientific Research. This “nonlinear optical perceptron” is an ambitious undertaking that blends advanced optics, machine learning and nanotechnology. “If you put a black sheet outside on a sunny day, it heats up, causing properties such as its refractive index to change,” Kinsey said. “That’s because the object is absorbing various wavelengths of light. Now, if you design a material that is orders of magnitude more complex than a sheet of black plastic, we can use this change in refractive index to modify the reflection or transmission of individual colors – controlling the flow of light with light.” Refractive index is an expression of a material’s ability to bend light. Researchers can harness those refractive qualities to create a switch similar to the binary 1-0 base of digital silicon chip computing. Kinsey and collaborators from the U.S. National Institute of Standards and Technology, including his former VCU Ph.D. student Dhruv Fomra, are currently working to design a new kind of optically sensitive material. Their goal is to engineer and produce a device combining a unique nonlinear material, called epsilon-near-zero, and a nanostructured surface to offer improved control over transmission and reflection of light. Kinsey’s prior research has demonstrated that epsilon-near-zero materials combine unique features that allow their refractive index to be modified quite radically – from 0.3 to 1.3 under optical illumination – which is roughly equivalent to the difference between a reflective metal and transparent water. While an effective binary switch, the large change in index requires a lot of energy (~1 milli-Joules per square centimeter). By combining epsilon-near-zero with a specifically designed nanostructure exhibiting surface lattice resonance, Kinsey hopes to achieve a reduction in the required energy to activate the response. The unique response of a nanostructure exhibiting surface lattice resonance allows light to effectively be bent 90 degrees, arriving perpendicular to the surface while being split into two waves that travel along the surface. When a large area of the nanostructure is illuminated, the waves traveling along the surface mix, where they interfere constructively or destructively with each other. This interference can produce strong modification to reflection and transmission that is very sensitive to the geometry of the nanostructure, the wavelength of the incident light and the refractive index of the surrounding materials. The mixing of optical signals along the surface can also selectively switch regions of the epsilon-near-zero material thereby performing processing operations. A key aspect of Kinsey’s work is to build nonlinear components, like diodes and transistors, that use optical signals instead of electrical ones. Transistors and other traditional electronic components are nonlinear by default because electrical charges strongly interact with each other (for example, two electrons will tend to repel each other). Creating optical nonlinear components is challenging because photons do not strongly interact, they just pass through each other. To correct for this, Kinsey employs materials whose properties change in response to incident light, but the interaction is weak and thus requires large energies to utilize. Kinsey’s device aims to reduce that energy requirement while simultaneously shaping light to perform useful operations through the use of the nanostructured surface and lightwave interference. The United States Department of Defense sees optical computing as the next step in military imaging. Kinsey’s work, while challenging, has potential to yield an enormous payoff. “Let’s say you want to find a tank within an image,” Kinsey said, “Using a camera to capture the scene, translate that image into an electrical signal and run it through a traditional, silicon-circuit-based computer processor takes a lot of processing power. Especially when you try to detect, transfer, and process higher pixel resolutions. With the nonlinear optical perceptron, we’re trying to discover if we can perform the same kinds of operations purely in the optical domain without having to translate anything into electrical signals.” Linear optical systems, like metasurfaces and photonic integrated circuits, can already process information using only a fraction of the power of traditional tools. Building nonlinear optical systems would expand the functionality of these existing linear systems, making them ideal for remote sensing platforms on drones and satellites. Initially, the resolution would not be as sharp as traditional cameras, but optical processing built into the device would translate an image into a notification of tanks, troops on the move, for example. Kinsey suggests optical-computing surveillance would make an ideal early warning system to supplement traditional technology. “Elimination or minimization of electronics has been a kind of engineering holy grail for a number of years,” Kinsey said, “For situations where information naturally exists in the form of light, why not have an optical-in and optical-out system without electronics in the middle?” Linear optical computing uses minimal power, but is not capable of complex image processing. Kinsey’s research seeks to answer if the additional power requirement of nonlinear optical computing is worthwhile given its ability to handle more complex processing tasks. Nonlinear optical computing could be applied to a number of non-military applications. In driverless cars, optical computing could make better light detection and ranging equipment (better known as LIDAR). Dark field microscopy already uses related optical processing techniques for ‘edge detection’ that allows researchers to directly view details without the electronic processing of an image. Telecommunications could also benefit from optical processing, using optical neural networks to read address labels and send data packets without having to do an optical to electrical conversion. The concept of optical computing is not new, but interest (and funding) in theory and development waned in the 1980s and 1990s when silicon chip processing proved to be more cost effective. Recent years have seen many advancements in computing, but the more recent slowdown in scaling of silicon-based technologies have opened the door to new data processing technologies. “Optical computing could be the next big thing in computing technology,” Kinsey said. “But there are plenty of other contenders — such as quantum computing — for the next new presence in the computational ecosystem. Whatever comes up, I think that photonics and optics are going to be more and more prevalent in these new ways of computation, even if it doesn’t look like a processor that does optical computing.” Kinsey and other researchers working in the field are in the early stages of scientific exploration into these optical computing devices. Consumer applications are still decades away, but with silicon-based systems reaching the limit of their potential, the future for this light-based technology is bright.

5 min. read
Inspired by Palm Trees' Resilience, Florida Tech Researcher Seeks to Strengthen Made Materials   featured image

Inspired by Palm Trees' Resilience, Florida Tech Researcher Seeks to Strengthen Made Materials

Inspired by the tiny, circular vessels in the trunks of palm trees that allow the iconic plants to bend but not snap in strong winds, an assistant professor of aerospace engineering is researching how to recreate Mother Nature’s handiwork in additive manufacturing. Mirmilad Mirsayar received a three-year, $200,627 research grant from the National Science Foundation’s highly competitive Mechanics of Materials and Structures program under the Division of Civil, Mechanical and Manufacturing Innovation to study the mechanics and physics of crack propagation in functionally graded cellular structures made by additive manufacturing. That’s the process of creating an object by building it one layer at a time. Mirsayar is the sole principal investigator of the project, “Understanding Mixed-Mode Fracture Mechanics in Additively Manufacturable Functionally Graded Microcellular Solids.” His research is inspired by cellular patterns seen in palm trees and butterfly wings. For example, unlike oak trees and some others, the palm tree’s center contains those vessels, distributed non-uniformly throughout the trunk, that help it survive in Florida’s windy environment. Other biological systems, such as bone, honeycombs and marine sponges, also serve as inspirations from nature. “I’m enjoying this research because I’m learning from nature and I’m applying fundamentals of physics and mathematics to solve a very important engineering problem while training the next generation of engineers and researchers,” Mirsayar said. Materials with cellular structures, such as aircraft wings and artificial bones, are widely used in industries such as aerospace and biomedical. As additive manufacturing has advanced, materials with cellular structures and increasingly complex geometrical patterns can be precisely manufactured. Mirsayar is looking at ways to optimize these strong and light cellular structures made by additive manufacturing to achieve the highest resistance against failure under complex operational loading conditions, such as bending tension, compression and torsion. What could this mean for additive manufacturing? How could stronger materials change what or how we build? Contact Florida Tech Media Communications Director Adam Lowenstein at adam@fit.edu to schedule an interview with Dr. Mirsayar.

2 min. read
#Expert Research: Biodegradable ultrasound implant could improve brain tumour treatments featured image

#Expert Research: Biodegradable ultrasound implant could improve brain tumour treatments

One of the challenges in treating certain types of brain cancer is the way that the blood-brain barrier prevents chemotherapy drugs from reaching the tumors they're meant to target. UConn's Thanh Nguyen, a biomedical and mechanical engineer, is developing new technology that could improve how we are able to treat brain tumors.  He recently spoke with Physics World about this groundbreaking research: A new type of biodegradable ultrasound implant based on piezoelectric nanofibres could improve outcomes for patients with brain cancer. Researchers led by Thanh Nguyen from the the University of Connecticut’s department of mechanical engineering fabricated the devices from crystals of glycine, an amino acid found in the human body. Glycine is not only non-toxic and biodegradable, it is also highly piezoelectric, enabling the creation of a powerful ultrasound transducer that could help treat brain tumours. Brain tumours are particularly difficult to treat because the chemotherapy drugs that would be effective in tackling them are blocked from entering the brain by the blood–brain barrier (BBB). This barrier is a very tight junction of cells lining the blood vessel walls that prevents particles and large molecules from making their way through and damaging the brain. However, ultrasound can be safely used to temporarily alter the shape of the barrier cells such that chemotherapy drugs circulating in the bloodstream can pass through to the brain tissues. Currently, to achieve such BBB opening requires the use of multiple ultrasound transducers located outside the body, together with very high intensity ultrasound to enable penetration through the thick human skull bone. “That strong ultrasound can easily damage brain tissues and is not practical for multiple-time applications which are required to repeatedly deliver chemotherapeutics,” Nguyen tells Physics World. By contrast, the team’s new device would be implanted during the tumour removal surgery, and “can generate a powerful acoustic wave deep inside the brain tissues under a small supplied voltage to open the BBB”. The ultrasound would be triggered repeatedly as required to deliver the chemotherapy that kills off the residual cancer cells at tumour sites. After a set period of time following treatment the implant biodegrades, thereby eliminating the need for surgery to remove it. The research, reported in Science Advances, demonstrated that the team’s device used in conjunction with the chemotherapy drug paclitaxel significantly extended the lifetime of mice with glioblastomas (the most aggressive form of brain tumour) compared with mice receiving the drugs but no ultrasound treatment. This is fascinating research and if you are interesting in covering this topic, then let us help. Professor Nguyen focuses on biointegrated materials and devices at nano- and micro-scales for applications in biomedicine, and he's available to speak to media about his research. Simply click on his icon now to arrange an interview today.

Thanh Nguyen, Ph.D. profile photo
2 min. read
Florida Tech Shark Biologist
Stars in National Geographic Program on Shark Attacks featured image

Florida Tech Shark Biologist Stars in National Geographic Program on Shark Attacks

Toby Daly-Engel, the distinguished shark biologist and director of Florida Tech’s Shark Conservation Lab, is a featured expert on “When Sharks Attack…and Why,” an eight-episode program debuting this week as part of National Geographic’s SharkFest 2023. The series debuts July 6 at 9 p.m. Eastern on National Geographic with new episodes airing nightly through July 12. It is also now streaming on Disney+, Hulu and the National Geographic website. The series will air on Nat Geo Wild starting July 26 at 8 p.m. Eastern. As its name suggests, “When Sharks Attack…and Why” investigates shark encounters in America and around the world. “Many attacks are appearing in new and surprising places,” the network notes. Episodes explore incidents in New York, California, Hawaii, Indonesia, Australia and elsewhere. At Florida Tech, Daly-Engel conducts research using a combination of genomics, field ecology and modeling to study shark mating systems and habitat use, and the impacts of climate change on shark populations. On the program, she is our expert guide to anatomical and physiological aspects of sharks, many of which are unique to this species. We first meet Daly-Engel in Episode 1, New York Nightmare. Filmed in her lab, she talks viewers through key parts of a shark’s body using a small dogfish shark. She tells viewers that while a shark’s sense of smell is often touted, these apex predators also have powerful hearing, far better than humans. (In a later episode, she notes a shark’s vision in murky waters is about 10 times stronger than human vision in those conditions.) “I really enjoyed delving into the science behind shark-human interactions,” Daly-Engel said, “and busting the myths that make people afraid of the water.” Daly-Engel is no stranger to SharkFest. Last year she was featured in another SharkFest series, “Shark Attack File,” and she has been on SharkFest and Discovery’s Shark Week programing multiple times, including 2021 when she appeared on three programs across both networks. Looking to know more about shark encounters and attacks? Then let us help with your coverage and questions. Toby Daly-Engel is an assistant professor in the Department of Ocean Engineering and Marine Sciences department at Florida Tech. He's available to speak with media about this topic - simply click on his icon now to arrange an interview today.

Toby S. Daly-Engel, Ph.D. profile photo
2 min. read