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When Luis Quiroga-Nuñez, Ph.D was appointed director of Florida Tech’s Ortega Observatory and its primary tenant – a non-functioning, 32-inch telescope – in 2023, he decided it was time to provide astronomy students and others a window to space. The observatory is already a base for research across a spectrum of cosmic exploration through disciplines such as astronomy and astrophysics, heliophysics, planetary science and astrobiology. However, current students have yet to see the stars up close, as the aging telescope, commissioned in 2008, has sat dormant for the last several years. With restoration, the telescope could be a powerful tool to train students to use professional telescopes and make observations – critical skills that will help prepare them for their future careers. It soon became apparent, however, that this was no simple task. The restoration would necessitate reverse engineering on a large scale to even understand how to fix and upgrade the telescope, much less actually repair it. It would also, as Quiroga-Nuñez wisely recognized, be its own powerful educational opportunity, providing unique hands-on learning opportunities for students in the College of Engineering and Science. “We are an institute of technology. We have perfectly capable people, like these young students, ready to join hands-on projects, get crazy and start to be creative.” Luis Quiroga-Nuñez With various issues to tackle and eager to support home-grown expertise, Quiroga-Nuñez and Lee Caraway, Ph.D, an instructor in the department of electrical engineering and computer science, recruited students with varied backgrounds, from astronomy to electrical engineering and computer science. Students could apply what they learned in class and grow their portfolios with a real-world project, the sort of experiential learning that is a hallmark of a Florida Tech education. Some improvements have been made, but the project remains an exciting puzzle for students and faculty alike. Here’s how they are doing it. An Interdisciplinary Project In January 2023, Quiroga-Nuñez partnered with Caraway to rebuild the telescope from the inside out. They say the conversation started over lunch, sketching ideas on a napkin. With various issues to tackle and eager to support home-grown expertise, Caraway and Quiroga-Nuñez recruited students with varied backgrounds, from astronomy to engineering to computer science. “This is about as real-world as you can get without leaving school. We have this giant piece of technology that is not working. Figure out why,” said recent graduate Adrianna Agustin ’24, who helped update the telescope’s communication system. “All of those problem-solving skills will directly translate to wherever we go in the future.” The project’s multidisciplinary nature also boosts collaboration between both sides of the college. “We keep integrating different parts of the university and involving students in a project that we were blinded by,” Quiroga-Nuñez says. “We sit between the scientists and the engineers.” And there’s no shortage of tasks. In addition to the refurbishment, Quiroga-Nuñez and Caraway are also completing routine telescope maintenance, with students taking on adjacent projects around the observatory. With the telescope repair, each student is given their own task, such as redesigning a small clip that supports the dome’s electric current, reviewing the conditions of the finder’s lens or understanding how analog devices control the telescope’s focus. This allocation allows each student to claim their own individual contribution to the greater telescope puzzle. Opening a Time Capsule The telescope’s biggest issues were mechanical and electrical, all exacerbated by age. Its motors were decades old and naturally failing, Caraway said. These motors controlled the telescope’s right ascension and declination – essentially, its ability to move. The chaotic interior also involved multiple individual systems with dozens of wires. And the circuits controlling the motors, which dated back to the 1980s, were also failing due to age. As Caraway noted, his students are sweeping off “dust older than them.” “The technology back then simply did not exist to control the motors, run the diagnostics and make it all happen,” Caraway explained. “They’re not designed to run 30 years.” Additionally, the computer program that controlled the motors was outdated and did not meet to the university’s security requirements. Given all this, the team needed to develop a new communication system for the telescope, starting with the computer software. They decided instead of purchasing an upgraded computer system, they could build and program their own in-house from scratch. Next, once the new computer was up and running, it needed motors to command. Marisa Guerra ’24 worked on a senior design project involving a robotic arm whose motor structure was the same as the telescope’s. She crafted a blueprint for the telescope’s new motors using what she learned for her capstone project. At the same time, Agustin worked on developing a cleaner communication system between the computer to the motors. Her senior design research focused on electric vehicles and their internal circuit systems, and she could replicate something similar within the telescope – but not without digging through the decaying electronics first. “We had to reverse engineer and actually redraw the circuits, which was good practice because a lot of the time, for senior design at least, you don’t really have to design a new circuit. You are just kind of puzzle-piecing it together,” Agustin said. “But with this circuit, all of them were bad.” Using Guerra’s and Agustin’s senior design research, the team reprogrammed the telescope’s circuits. What once took 20 wires to operate now only takes two. They also reduced the weight of the telescope’s motors from 40 pounds to just 2 pounds. Once the communication system was finished, the team was just waiting for mobility. And on a day in Spring 2024, thanks to the refurbished system, they were able to create movement within the telescope for the first time in years. “I didn’t even know if that device could move internally,” Quiroga-Nuñez says. The moment was celebrated, but the team knew this success triggered a new challenge. It was time to tackle high astrometric precision – a crucial element of properly tracking movement in space. “We are pointing to tiny points in the sky. If we do not track that properly, we are going to be lost in the universe,” Quiroga-Nuñez says. The Value of Time Perfecting precise movement is expected to take some time, but that’s not a bad thing, Quiroga-Nuñez says. He believes that a lengthy timeline will offer more value in the long run because it will give even more students a chance to get involved. Besides, its primary purpose will be to teach students how to use a telescope and allow them to make observations and prepare for their future careers. Ultimately, Quiroga-Nuñez predicts that the telescope could pick up its first image from space in about a year if everything stays on track. However, the team still has a lot of ground within the telescope to uncover, with an unpredictable number of potential troubleshooting challenges. For example, while rebuilding the motor, they discovered that the internal mirror that illuminates the telescope’s visuals was in poor condition – it needed cleaning and new aluminum to reflect enough light to see the telescope’s imagery, Agustin explains. So, the team had to remove the mirror and ship it to New York for refurbishment – a process that took several months. Once the mirror is reinstalled, they can return to their quest for better precision. The mirror is just one example of unpredictability in reverse-engineering. Ultimately, dedicating more time to understanding and solving the unforeseen challenges allows more students to participate in the telescope’s journey, Quiroga-Nuñez says. “This is like a big Lego for them,” he says. “They are learning the process, and the students, I think, will have found a very valuable life experience.” If you're interested in connecting with Luis Quiroga-Nuñez, director of Florida Tech’s Ortega Observatory - simply contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology at adam@fit.edu to arrange an interview today.
A final disbursement of $8.8 million completes the $17.8 million grant awarded by the Department of Defense (DoD) to Virginia Commonwealth University’s (VCU) Convergence Lab Initiative (CLI). The funding allows CLI to continue advancing research in the areas of quantum and photonic devices, microelectronics, artificial intelligence, neuromorphic computing, arts and biomedical science. “The Convergence Lab Initiative represents a unique opportunity to drive innovation at the intersection of advanced technologies, preparing our students to tackle the critical challenges of tomorrow,” said Nibir Dhar, Ph.D., electrical and computer engineering professor and CLI director. “By combining cutting-edge research in electro-optics, infrared, radio frequency and edge computing, we are equipping the next generation of engineers with the skills to shape the future of both defense and commercial industries.” Working with Industry Partnership is at the heart of CLI and what makes the initiative unique. CivilianCyber, Sivananthan Laboratories and the University of Connecticut are among several collaborators focusing on cutting-edge, multidisciplinary research and workforce development. The lightweight, low-power components CLI helps develop are capable of transforming military operations and also have commercial applications. The Convergence Lab Initiative has 25 collaborative projects in this area focused on: Electro-optic and Infrared Technologies: Enhancing thermal imaging for medical diagnostics, search-and-rescue operations and environmental monitoring. This improves military intelligence, surveillance and reconnaissance capabilities. Radio Frequency and Beyond 5G Communication: Developing ultra-fast, low-latency communication systems for autonomous vehicles, smart cities and telemedicine. Accelerating advancements in this area also address electronic warfare challenges and security vulnerabilities. Optical Communication in the Infrared Wavelength: Increasing data transmission rates to create more efficient networks that support cloud computing, data centers, AI research and covert military communications. Edge Technologies: Creating low size, weight and low power-consuming (SWaP) computing solutions for deployment in constrained environments, such as wearables, medical devices, internet of things devices and autonomous systems. These technologies enhance real-time decision-making capabilities for agriculture, healthcare, industrial automation and defense. Benefits for Students College of Engineering students at VCU have an opportunity to engage with cutting-edge research as part of the DoD grant. Specialized workforce development programs, like the Undergraduate CLI Scholars Program, provide hands-on experience in advanced technologies. The STEM training also includes students from a diverse range of educational backgrounds to encourage a cross-disciplinary environment. Students can also receive industry-specific training through CLI’s Skill-Bridge Program, which facilitates direct connections between business needs and academic education. Unlike the DoD program for transitioning military personnel, the CLI Skill-Bridge is open to students from VCU and other local universities, creating direct connections between industry needs and academic training. This two-way relationship between academia and industry is unlike traditional academic research centers. With the College of Engineering’s focus on public-private partnerships, VCU becomes a registered partner with the participating businesses, collaborating to design individualized training programs focused on the CLI’s core research areas. This approach ensures students receive relevant, up-to-date training while companies gain access to a pipeline of skilled talent familiar with the latest industry trends and innovations. “The significance of this grant extends beyond immediate research outcomes. It addresses critical capability gaps for both the DoD and commercial sectors,” says Dhar. “This dual-use approach maximizes DoD investment impacts and accelerates innovation in areas that affect everyday life — from healthcare and environmental monitoring to communication networks and smart infrastructure. Breakthroughs emerging from these collaborations will strengthen national security while creating commercial spinoffs that drive economic growth and improve quality of life for communities both locally and globally. Advances in infrared technology, in particular, will position the VCU College of Engineering as a center for defense technologies and new ideas.”
New light technique could revolutionise non-invasive medical diagnostics Orbital Angular Momentum could be harnessed to improve imaging and data transmission through biological tissues Could eventually have potential to make procedures such as surgery or biopsies unnecessary. An Aston University researcher has developed a new technique using light which could revolutionise non-invasive medical diagnostics and optical communication. The research showcases how a type of light called the Orbital Angular Momentum (OAM) can be harnessed to improve imaging and data transmission through skin and other biological tissues. A team led by Professor Igor Meglinski found that OAM light has unmatched sensitivity and accuracy that could result in making procedures such as surgery or biopsies unnecessary. In addition it could enable doctors to track the progression of diseases and plan appropriate treatment options. OAM is defined as a type of structured light beams, which are light fields which have a tailored spatial structure. Often referred to as vortex beams, they have previously been applied to a number of developments in different applications including astronomy, microscopy, imaging, metrology, sensing, and optical communications. Professor Meglinski in collaboration with researchers from the University of Oulu, Finland conducted the research which is detailed in the paper “Phase preservation of orbital angular momentum of light in multiple scattering environment” which is published in the Nature journal Light Science & Application. The paper has since been named as one of the year’s most exciting pieces of research by international optics and photonics membership organisation, Optica. The study reveals that OAM retains its phase characteristics even when passing through highly scattering media, unlike regular light signals. This means it can detect extremely small changes with an accuracy of up to 0.000001 on the refractive index, far surpassing the capabilities of many current diagnostic technologies. Professor Meglinski who is based at Aston Institute of Photonic Technologies said: “By showing that OAM light can travel through turbid or cloudy and scattering media, the study opens up new possibilities for advanced biomedical applications. “For example, this technology could lead to more accurate and non-invasive ways to monitor blood glucose levels, providing an easier and less painful method for people with diabetes.” The research team conducted a series of controlled experiments, transmitting OAM beams through media with varying levels of turbidity and refractive indices. They used advanced detection techniques, including interferometry and digital holography, to capture and analyse the light's behaviour. They found that the consistency between experimental results and theoretical models highlighted the ability of the OAM-based approach. The researchers believe that their study’s findings pave the way for a range of transformative applications. By adjusting the initial phase of OAM light, they believe that revolutionary advancements in fields such as secure optical communication systems and advanced biomedical imaging will be possible in the future. Professor Meglinski added: "The potential for precise, non-invasive transcutaneous glucose monitoring represents a significant leap forward in medical diagnostics. “My team’s methodological framework and experimental validations provide a comprehensive understanding of how OAM light interacts with complex scattering environments, reinforcing its potential as a versatile technology for future optical sensing and imaging challenges.” ENDS https://www.nature.com/articles/s41377-024-01562-7 Light: Science & Applications volume 13, Article number: 214 (2024) August 2024 https://doi.org/10.1038/s41377-024-01562-7 Authors: Igor Meglinski, Ivan Lopushenko, Anton Sdobnov & Alexander Bykov About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming The Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk
New Aston University spin-out company will develop novel ways to treat non-healing wounds
EVolution Therapeutics (EVo) has been founded on the work of Professor Andrew Devitt into the causes of inflammatory disease A failure to control inflammation in the body, usually a natural defence mechanism, can cause chronic inflammation, such as non-healing wounds Non-healing wounds cost the NHS £5.6bn annually, so there is a vital need for new treatments. Aston University’s Professor Andrew Devitt, Dr Ivana Milic and Dr James Gavin have launched a new spin-out company to develop revolutionary treatments to treat chronic inflammation in patients. One of the most common inflammatory conditions is non-healing wounds, such as diabetic foot ulcers, which cost the NHS £5.6bn annually, the same cost as managing obesity. Such wounds are generally just dressed, but clinicians say there is a vital need for active wound treatments, rather than passive management. The spin-out, Evolution Therapeutics (EVo), will aim to create these vital active treatments. Inflammation in the human body helps to fight infection and repair damage following injury and occurs when the immune system floods the area with immune cells. Normally, this inflammation subsides as the damage heals, with the immune system signalling to the immune cells to leave. However, in some cases, the usual healing mechanism is not triggered and the inflammatory response is not turned off, leading to chronic inflammation and so-called inflammatory diseases. EVo is based on Professor Devitt’s work on dying cells in the body, known as apoptotic cells, and how they contribute to health. Dying cells release small, membrane-enclosed fragments called extracellular vesicles (EVs), which alert the immune system to the death of cells, and then trigger the body’s natural repair mechanism and remove the dead cells. It is estimated that 1m cells die every second. Professor Devitt and his team have identified the molecules within the EVs which control the healing process and are engineering new EVs loaded with novel healing enzymes, to drive the body’s repair responses to actively heal wounds. Much of the research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC) with additional support from the Dunhill Medical Trust. Professor Devitt, Dr Milic and Dr Gavin received Innovation-to-Commercialisation of University Research (ICURe) follow-on funding of £284,000 to develop the vesicle-based therapy with EVo. Most recently, in December 2023, Professor Devitt and Dr Milic were awarded £585,000 from the BBSRC Super Follow-on-Fund to develop engineered cells as a source of membrane vesicles carrying inflammation controlling cargo. The team, together with Professor Paul Topham, also received funding from the National Engineering Biology Programme (£237,000) to support polymer delivery systems for vesicles. EVo is one of the 12 projects being supported by SPARK The Midlands, a network which aims to bridge the gap between medical research discoveries of novel therapeutics, medical devices and diagnostics, and real-world clinical use. SPARK The Midlands is hosted at Aston University, supported by the West Midlands Health Tech Innovation Accelerator (WMHTIA), and was launched at an event on 31 January 2024. Professor Devitt, EVo chief technical officer, said: “Inflammation is the major driver of almost all disease with a huge contribution to those unwelcome consequences of ageing. We are now at a most exciting time in our science where we can harness all the learning from our research to develop targeted and active therapies for these chronic inflammatory conditions.” Dr Gavin, EVo CEO, said: “The chronic inflammation that results in non-healing wounds are a huge health burden to individuals affecting quality of life as we age but also to the economy. Our approach at EVo is to target the burden of non-healing wounds directly to provide completely novel approaches to wound care treatment. By developing a therapy which actively accelerates wound healing, we hope to drastically improve quality of life for patients, whilst reducing the high cost attached to long term treatment for healthcare systems worldwide.”
Nicholas Petrelli, M.D., Receives Lifetime Achievement Award
Nicholas Petrelli, M.D., Bank of America Endowed Medical Director of ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, has received the Lifetime Achievement Award from Tulane University School of Medicine in New Orleans, Louisiana. Petrelli is a 1973 graduate of the school. Dr. Petrelli, center, receives the Lifetime Achievement Award from Julius L. Levy, Jr., M.D., past president, Tulane Medical Alumni Association, left, and Lee Hamm, M.D., senior vice president & dean of the School of Medicine, and the James R. Doty Distinguished Professor and Chair, Tulane University School of Medicine, New Orleans, Louisiana. The award recognizes an alumnus of the school who has made significant contributions to the field of medicine and has offered outstanding leadership in the community. Under Petrelli’s leadership at ChristianaCare since 2001, the Helen F. Graham Cancer Center & Research Institute has become a national model for multidisciplinary cancer care and a top enroller in U.S. clinical research trials. The Graham Cancer Center is a National Cancer Institute Community Oncology Research Program and one of only five hybrid academic community cancer centers in the nation. Through the work of the Graham Cancer Center and partnerships with health care providers, community organizations and the state to improve the prevention, diagnosis and treatment of cancer, Delaware’s cancer mortality rate has dropped twice as fast as the national rate. In addition, the state is outpacing the nation in reducing deaths from a number of cancers. Delaware has gone from number one in cancer mortality 22 years ago to number 17 today. Petrelli has numerous achievements in cancer care and research. He has established several firsts for Delaware, including a multidisciplinary disease center site, the Cawley Center for Translational Cancer Research, a tissue procurement center, an adult genetic counseling program, a statewide high-risk family cancer registry consisting of more than 500,000 individuals and an innovative oncology express unit to provide patients with cancer a way to address urgent care needs without having to go to the emergency department. Among his accomplishments on the national level are the first primary care practice established at a cancer center and the first gene editing research program integrated into a community cancer center. Through a unique research partnership with the Ellen and Ronald Caplan Cancer Center of The Wistar Institute, he has brought cutting-edge cancer treatments and diagnostics to Delawareans. And in a ground-breaking collaboration among the government, community organizations and the Graham Cancer Center nearly 10 years ago, Delaware ended the disparity between Black and white people for colorectal cancer screenings and mortality, which continues to this day. Petrelli has received numerous awards and has authored 360 peer-reviewed manuscripts and 31 book chapters. He has served on advisory panels of the National Cancer Institute, the American Society of Clinical Oncology, the American Cancer Society and the Society of Surgical Oncology. He was president of the Society of Surgical Oncology from 2007 to 2008. In 2013 he received the Order of the First State Award, the highest honor in the state, from Delaware Gov. Jack Markell. In 2019 he received the James Tilton award (named for the first U.S. Army Surgeon General) from the Medical Society of Delaware.
Program addresses disparities in breast cancer between Black and white women ChristianaCare’s Helen F. Graham Cancer Center & Research Institute is partnering with Susan G. Komen®, the world’s leading breast cancer organization, in an expansion of Komen’s screening and diagnostics program to income-eligible residents of Delaware. Under the program, Delaware women who meet income qualifications will be able to access no-cost breast cancer screening mammograms and necessary diagnostic follow-up tests. Once approved by Susan G. Komen for care, they can select ChristianaCare for services. ChristianaCare is one of 20 health systems nationwide partnering with Susan G. Komen in the program, which seeks to reduce disparities in areas where the breast cancer mortality gap between Black and white women is the greatest. “The Graham Cancer Center is proud of its longstanding partnership with Susan G. Komen to bring breast cancer screenings to our community and to reduce disparities and save lives,” said Nicholas Petrelli, M.D., Bank of America endowed medical director of the Helen F. Graham Cancer Center & Research Institute. “This new partnership with Komen is an innovative way that we are stronger together as we continue to reduce barriers to care and help more Delaware women access timely breast imaging and treatment,” he said. “The screening and diagnostics program is critical for individuals who may have been putting off their breast cancer screening due to concerns about cost,” said Nora Katurakes, RN, OCN, manager of the Graham Cancer Center’s Community Outreach & Education program. “Early detection saves lives, and cost should not be a barrier to accessing high-quality health care services for anyone in need. This program seeks to achieve health equity for all.” “Early detection saves lives, and cost should not be a barrier to accessing high-quality health care services for anyone in need,” said Nora Katurakes, RN, OCN, manager of Community Outreach and Education According to the Delaware Division of Public Health, breast cancer is the most common cancer diagnosed among women in Delaware, and Black women are disproportionately more affected by breast cancer than white and Hispanic women and have a higher mortality rate. In addition, Black women in Delaware have among the highest incidence rates in the U.S. of triple negative breast cancer, an aggressive form of the disease that is harder to treat and more likely to return. The Komen screening and diagnostics program is a service provided through the Komen Patient Care Center. Last year, Susan G. Komen provided nearly 3,000 screening and diagnostics services. Komen hopes to serve another 3,000 individuals in 2023. To be eligible for the program, individuals must have a current annual household income at or below 300% of the Federal Poverty Level. For one person that is $43,740. A two-person family must have a $59,160 household income to be eligible. The Tatiana Copeland Breast Center at the Helen F. Graham Cancer Center & Research Institute is one of the few facilities in the region devoted exclusively to breast care, diagnosis and treatment, and was the first center in the state to offer high-definition 3D mammography imaging. About Breast Cancer Screening Screening mammography tests are used to find breast cancer before it causes any warning signs or symptoms. Regular screening tests along with follow-up tests and treatment, if diagnosed, reduce an individual’s chance of dying from breast cancer. Mammography is a test that uses X-rays to create images of the breast. These images are called mammograms. A radiologist trained to read mammograms studies the images and looks for signs of breast cancer. A mammogram may show: No signs of breast cancer. A benign (not cancer) condition or other change that does not suggest cancer. An abnormal finding that needs follow-up tests to rule out cancer. Income eligible people seeking access to a breast cancer screening mammogram or diagnostic service should contact the Komen Breast Care Helpline at 1-877-465-6636 or helpline@komen.org to learn more. Individuals who would like more information about breast cancer screening in Delaware can also call ChristianaCare Community Health Outreach & Education at 302-623-4661.
Birmingham MP officially opens £1.5 million healthcare simulation facilities at Aston University
Paulette Hamilton MP officially opens healthcare simulation facilities at Aston Medical School and School of Optometry State-of-the-art facilities including medical simulation room with high fidelity manikins for students to practise real life scenarios opens The first in Europe ocular simulation suite allows students to refine skills in examining the health of the eyes and experience a wide range of eye disease. New £1.5 million healthcare simulation facilities have officially opened at Aston Medical School and in the School of Optometry at Aston University. The state-of-the-art facilities were formally opened by Paulette Hamilton, member of parliament for Birmingham Erdington, on Friday 2 December at a ribbon cutting ceremony that was attended by Aston University Vice-Chancellor Professor Aleks Subic as well as other members of the University executive and staff from the College of Health and Life Sciences. Commenting on the new facilities Paulette Hamilton MP said: “It’s been brilliant to visit and officially open the new healthcare simulation facilities at Aston University. “I know from my time as a nurse how important it is to have access to good training and the latest equipment. These fantastic facilities will give students the best possible learning experience as they prepare to enter their profession, providing healthcare in Birmingham and beyond.” Hosted by Professor Anthony Hilton, Pro-Vice-Chancellor and Executive Dean of the College of Health and Life Sciences, guests were invited to take a tour of the new facilities including a clinical skills simulation room which allows students to practise in emergency settings and an ocular simulation unit facility, the only one in Europe. Professor Hilton said: "We are delighted these new facilities have opened in time for the start of the new term and that students can benefit from practising their clinical skills in a variety of scenarios. “The acute care simulation room will allow for simulated emergency resuscitation scenarios that are very difficult to teach in real life situations, such as heart attacks, acute breathlessness and severe allergic reaction and will be of great value in training students of medicine, pharmacy and optometry.” The healthcare simulation facilities will be used by students studying medicine, pharmacy and optometry, where they will be able to practise in emergency settings using high quality manikins where they will simulate treating patients for acute conditions such as a heart attack or learning how to intubate a patient onto a ventilator. Professor Aleks Subic, Vice-Chancellor, Aston University said: “The launch of the Aston University healthcare simulation facilities marks an important milestone in the development of our digital health precinct within the Birmingham Knowledge Quarter. By establishing world-class medical imaging, advanced visualisation, and digital diagnostics capabilities we are in fact bringing Industry 4.0 to healthcare. “Our students from the Aston Medical School and School of Optometry in particular, will benefit immensely from this development as they will be able to detect a wide range of clinical conditions and diseases and explore different interventions and scenarios, safely within a simulated environment.” The high-fidelity acute care simulation room will also be equipped with recording facilities, a debrief room and control room. The funding has allowed for the purchase of other training equipment such as a hospital grade bed and single task trainer simulation equipment. For example, male and female catheterisation models, pelvic and rectal trainers, venepuncture arms, breast trainers and abdominal trainers. The facilities were part funded by the Office for Students which awarded the University £806,226 to set up the ‘high fidelity’ simulation A&E room with further expenditure by Aston University on the ocular simulation unit. The ocular simulation facility is unique in Europe. It allows students to refine their skills in examining the health of the front and back of the eyes and to experience a wide range of eye disease. One of the simulators allows students to utilise their smartphones to practise at home. They can gain direct feedback and be assessed by the simulators, allowing more flexible, diverse and intensive learning than can be achieve with clinical practice placements. Professor Liz Moores, deputy dean of the College of Health and Life Sciences, said: “The College of Health and Life Sciences is thrilled with this investment. The enhanced facilities will help to support many of our healthcare students, including those now applying for our new nursing degree. It will also support us with the introduction of the new pharmacy and optometry education standards, providing a step change in our ability to simulate a wide range of clinical scenarios.” For more information about studying in the College of Health and Life Sciences please visit our website.
Aston University has teamed up with biotechnology company Biocleave Ltd in a new knowledge transfer partnership (KTP) to develop the company’s capacity to produce membrane-associated proteins on a competitive commercial scale. The partnership will see Aston University’s world-leading expertise provide next-level solutions to a complex problem and provide exciting breakthroughs from both commercial and scientific standpoints. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. Biocleave Ltd produces ‘Research Use Only’ (RUO) proteins. These are used widely in industry and academia to study and develop diagnostics and disease treatments. The process of manufacturing these proteins is known as ‘expression’, requiring host cells to produce them. The company is the first to engineer the non-pathogenic microbe Clostridia as a recombinant protein expression host, enabling them to overcome the typical expression challenges of production host toxicity and costly development cycles. Initial trials have demonstrated advantages to making membrane-associated proteins in Clostridia compared with established production systems. However, these proteins are associated with the fatty membrane that surrounds a cell and are not soluble in water. While Biocleave has well-established proprietary technology for manipulating the microbes, they want to extend their expertise for purifying these challenging membrane proteins, essential to commercialising their production. The Aston University team will be led by Dr Alan Goddard, senior lecturer in biochemistry in the School of Biosciences and founding member of Aston Membrane Proteins and Lipids (AMPL). Dr Goddard’s research focuses on the application of membrane biology to industrially relevant problems. He has nearly 20 years' experience working with membranes and their integral proteins. Dr Goddard will be joined by Professor Roslyn Bill, associate dean (research) for the College of Health and Life Sciences and director of AMPL. Professor Bill’s research focuses on the purification and characterisation of membrane proteins and she has published extensively on yeast as a recombinant expression host. Commenting on the project, Dr Goddard said: “This is a really exciting opportunity to leverage the decades of research experience Professor Bill and I have with expressing and purifying membrane proteins. It will allow Biocleave to enter new markets, many of which are important for drug development and healthcare. Hopefully, the products we make will have positive benefits not only for Biocleave’s customers but also wider society.” Dr Liz Jenkinson, chief executive of Biocleave Ltd, said: “We’ve made great progress in establishing the technology to work with Clostridia, a promising host, and although we’re constantly learning, so much is still unknown about the clostridial membrane. Through this KTP partnership with Aston University, we’re excited to develop the skills of our staff and expand our commercial offering to extend our range of RUO protein targets.” Because the Clostridial membrane adds a new level of complexity, successfully developing the required tools internally to resolve these issues, without input from experts, would take considerable time.
Toolkit is easily incorporated into any laboratory science course Wilmington, Del., April 1, 2021 – St. Georges Technical High School in southern New Castle County, Delaware is the first high school in the United States to use ChristianaCare Gene Editing Institute’s innovative CRISPR in a Box Educational Toolkit™ in a science class. CRISPR in a Box brings to life the much-heralded CRISPR gene editing technology – the “genetic scissors” that allow scientists to edit DNA. The toolkit is designed for educational sessions in secondary and post-secondary schools and is suitable for remote learning. “Gene editing is the future of medicine,” said Eric Kmiec, Ph.D., director of ChristianaCare’s Gene Editing Institute. “Our partnership with the Delaware Department of Education will help cultivate the next generation of genetic scientists and enhance Delaware’s position as a leader in the biosciences.” “We are thrilled that students at St. Georges Technical High School will be the first In the United States to experience a live demonstration of CRISPR gene editing using our Innovative CRISPR in a Box educational toolkit,” said Siobhan Hawthorne, Education and Community Outreach leader at ChristianaCare’s Gene Editing Institute. “This toolkit will provide STEM students with a visual understanding of how the exciting CRISPR technology can unlock medical treatments to improve lives.” Delaware Secretary of Education Susan Bunting praised her department's partnership with ChristianaCare's Gene Editing Institute to develop the “Seeds of STEM” course that teaches high school students about gene editing. “Gene editing approaches diseases in new ways and will have significant impact in the health care and agriscience fields,” Bunting said. “This is a great example of an industry and education partnership investing in youth by providing hands-on knowledge and skills around emerging technology.” “We are so fortunate that ChristianaCare’s Gene Editing Institute reached out to our program to plan a high school ‘first’ opportunity with this new CRISPR experiment,” said Danya Espadas, one of the St. Georges biotech teachers. “Giving students the chance to use a cutting-edge, 21st century tool for medicine in their own high school lab – to have that technology at their fingertips – transcends what they see in a textbook or a video. By being able to do it themselves, it makes it real for them.” Espada said the experiment focuses on editing a gene of a non-infectious E.coli bacteria to become resistant to an antibiotic, thereby allowing researchers to create a new class of antibiotics that cannot be overcome by bacteria that are gene resistant. “We’re talking about eventually saving lives, here,” she said. “What can be more important than that?” The tools in CRISPR in a Box have been designed based on the pioneering discoveries of the Gene Editing Institute that are currently being used to explore next-generation medical therapies and diagnostics for diseases, including lung cancer and sickle-cell anemia. Component items in the toolkit include the CRISPR/Cas complex, a target DNA molecule, a mammalian cell free extract and a synthetic DNA molecule. All materials in the kit are safe, synthetic materials. There are no live cultures or viruses involved. The kit is meant to provide a hands-on demonstration of CRISPR’s capabilities, and not allow for manipulations of living organisms. “The kit is easy and fun to use,” said Kristen Pisarcik, research assistant at the Gene Editing Institute who has taught students at Delaware Technical Community College which first used the toolkit. “In a short period of time students will reliably and successfully complete the laboratory activity and be able to see the results of gene editing,” she said. Since the foundations of the kit touch upon key themes in biology, it can be readily incorporated into practically any science or biology course with a laboratory component, “One of the beauties of CRISPR in a Box is that there is no need to purchase specialized equipment. If a teaching lab can support bacterial cultivation, it can perform the in vitro gene editing lab activity,” Pisarcik said. CRISPR in a Box is the evolution of a partnership between the Gene Editing Institute, Delaware Technical Community College and Rockland Immunochemicals that began in 2017 with a National Science Foundation grant to develop the first-ever gene editing curriculum for community college students. Video and photo collection of first class in U.S. to use CRISPR in a Box™ educational gene editing toolkit. About ChristianaCare’s Gene Editing Institute The Gene Editing Institute, a worldwide leader in CRISPR gene editing technology and the only institute of its kind based within a community health care system, takes a patient-first approach in all its research to improve the lives of people with life-threatening disease. Since 2015, researchers at the Gene Editing Institute have been involved in several ground-breaking firsts in the field, including the development of the first CRISPR gene editing tool to allow DNA repairs outside the human cell which will rapidly speed therapies to patients and a unique version of CRISPR called EXACT that reduces the number of off-target edits to other areas of the genome, which is vital for further research and patient applications. Its researchers are currently developing a patient trial for lung cancer using CRISPR and employing the technology to combat the COVID-19 pandemic. About the biotech program St. Georges Technical High School The Biotech career program of study at St. Georges Technical High School is the first such program offered in a Delaware high school. With two teachers and approximately 100 students in grades 10-12, the program presents advanced content in biology and chemistry with opportunities for students to learn basic laboratory techniques and procedures and to maintain and operate common instruments and equipment used in a biotechnology laboratory. St. Georges is a comprehensive career and technical high school with 1,100 students who study in one of 16 different career pathways.
Locking down your data. Are lawmakers finally waking up to the importance of privacy?
Data collection and data control are becoming international issues. As the lucrative and important pieces of customer data collection become a priority for major tech and software companies – privacy and protection is now emerging as the key issue for international legislators. Just recently, Microsoft had to update several of its agreements with cloud customers and re-classify its role in Europe. Last month, as part of an enquiry that opened earlier this year, the European Data Protection Supervisor (EDPS) expressed 'serious concerns' over whether the relevant contractual terms were compliant with GDPR, and over Microsoft's role as a data processor or data controller for EU institutions. The report followed the publication of a series of papers by the Dutch Ministry of Justice and Security, suggesting that Office 365 was breaching GDPR by collecting 'functional and diagnostics data', including email subject lines and text run through a spell-checker. Microsoft has now acknowledged its position as a data controller - which has a higher bar for ensuring user data - when it comes to the provision of enterprise services. "In the [Online Services Terms] OST update, we will clarify that Microsoft assumes the role of data controller when we process data for specified administrative and operational purposes incident to providing the cloud services covered by this contractual framework, such as Azure, Office 365, Dynamics and Intune," says Julie Brill, Microsoft's corporate vice president for global privacy and regulatory affairs and chief privacy officer. "This subset of data processing serves administrative or operational purposes such as account management; financial reporting; combating cyber attacks on any Microsoft product or service; and complying with our legal obligations." Forbes Magazine – November 18 Data collection and control are becoming big issues on a global scale as more and more governments are looking for consumer protection while companies are seeking the profit that comes from the information customers provide voluntarily and sometimes unwillingly . Are you a reporter covering technology, privacy and data collection and control? Did you know that there is value in the results of spell-checkers and document review tools? If you have questions or need an expert source for insight and perspective – let us help. Dr. Rachel Cummings is an expert in data privacy, algorithmic economics, optimization, statistics, and information theory. Dr. Cummings is available to speak with media regarding data privacy and other topics, simply click on her icon to arrange an interview.
