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Thousands of men to trial prostate cancer home testing kit

Thousands of men worldwide are to receive a home test kit for prostate cancer – thanks to pioneering research from the University of East Anglia and the Norfolk and Norwich University Hospital (NNUH). The research team are trialling a new home-testing ‘Prostate Screening Box’ to collect men’s urine samples at-home. The urine samples will be used to analyse the health of the prostate in 2,000 men in the UK, Europe and Canada. This simple urine test is intended to diagnose aggressive prostate cancer and in a pilot study predicted which patients required treatment up to five years earlier than standard clinical methods. Lead researcher Dr Jeremy Clark from the University of East Anglia 'unboxes' the new home testing kit live on Sky News. The Prostate Screening Box has been developed in collaboration with REAL Digital International Limited to create a kit that fits through a standard letterbox. It means that men can provide a urine sample in the comfort of their own home, instead of going into a clinic or having to undergo an uncomfortable rectal examination. The research team hope that it could revolutionise diagnosis of the disease. Lead researcher Dr Jeremy Clark, from UEA’s Norwich Medical School, said: “Prostate cancer is the most common cancer in men in the UK. However it usually develops slowly and the majority of cancers will not require treatment in a man’s lifetime. It is not a simple matter to predict which tumours will become aggressive, making it hard to decide on treatment for many men. “The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination (DRE), an MRI scan or a biopsy. “We have developed the PUR (Prostate Urine Risk) test, which looks at gene expression in urine samples and provides vital information about whether a cancer is aggressive or ‘low risk’. “The Prostate Screening Box part sounds like quite a small innovation, but it means that in future the monitoring of cancer in men could be so much less stressful for them and reduce the number of expensive trips to the hospital. “The prostate lies just below the bladder. It constantly produces secretions which naturally flow into the urethra - the tube through which urine passes from the bladder. The prostatic secretions carry cells and molecules from all over the prostate which are flushed out of the body on urination. We collect these and examine them. It’s a way of sampling the whole prostate in one go. “As the prostate is constantly secreting, the levels of biomarkers in the urethra will build up with time. Collecting from the first wee of the day means that overnight secretions can be collected which makes the analysis more sensitive.” The team have previously trialled the kit with a small group of participants, but in the next phase of the research study are rolling it out to thousands. Men taking part in the trial will receive a home urine-sampling kit and will be asked to provide two urine samples – one to be taken first thing in the morning and the second an hour later. The samples will then be sent back to the lab for analysis. Dr Clark said: “Feedback from early participants showed that the at-home collection was much preferred over sample collection in a hospital. “We hope that using our Prostate Screening Box could in future revolutionise how those on ‘active surveillance’ are monitored for disease progression, with men only having to visit the clinic after a positive urine result. “This is in contrast to the current situation where men are recalled to the clinic every six to 12 months for a range of tests including DRE, PSA tests, painful and expensive biopsies and MRI. We are working to develop the test to help patients in three years’ time. “A negative test could enable men to only be retested every two to three years, relieving stress to the patient and reducing hospital workload,” he added. Robert Mills, Consultant Clinical Director in Urology at NNUH, said: “This simple, non-invasive urine test has the potential to significantly change how we diagnose and manage early prostate cancer for the benefit of patients and health care systems. It may enable us to avoid unnecessary diagnosis of low risk disease as well as managing patients more appropriately with surveillance for those with low risk of progression and early curative treatment for those at high risk of progression.” Paul Villanti, executive director of programs at Movember, said: “The PUR test has great potential to transform the way prostate cancer is managed. Not only can it accurately predict when a man’s disease will become aggressive and require treatment, but it has the added advantage of allowing men to complete it at home. “We are proud to have supported the development of the PUR test from its early stages as part of our Global Action Plan on Biomarkers, through to this trial involving thousands of men across the world. “Through our Global Action Plan on active surveillance, we have been able to identify hundreds of men from the UK, Germany, Italy and Canada who are suitable to take part in this trial. “We hope it will speed up the trial’s progress and get this test included as part of clinical care for men as quickly as possible.” The research has been funded by a Movember and Prostate Cancer UK Innovation award, the Masonic Charitable Foundation, the Bob Champion Cancer Trust, the King family, the Andy Ripley Memorial Fund, the Hargrave Foundation, Norfolk Freemasons and the Tesco Centenary Grant.

New prostate cancer urine test shows how aggressive disease is and could reduce invasive biopsies

Researchers from the University of East Anglia have developed a new urine test for prostate cancer which also shows how aggressive the disease is. A new study shows how an experimental new test called ‘ExoGrail’ has the potential to revolutionise how patients with suspected prostate cancer are risk-assessed prior to an invasive biopsy. The research team say their new test could reduce the number of unnecessary prostate cancer biopsies by 35 per cent. Prostate cancer is the most common cancer in men in the UK. It usually develops slowly and the majority of cancers will not require treatment in a man’s lifetime. The most commonly used tests for prostate cancer include blood tests, a physical examination known as a digital rectal examination (DRE), an MRI scan or an invasive biopsy. However, doctors struggle to predict which tumours will become aggressive, making it hard to decide on treatment for many men. Lead researcher Dr Dan Brewer, from UEA’s Norwich Medical School, said: “While prostate cancer is responsible for a large proportion of all male cancer deaths, it is more commonly a disease men die with rather than from. “Therefore, there is a desperate need for improvements in diagnosing and predicting outcomes for prostate cancer patients to minimise over-diagnosis and overtreatment whilst appropriately treating men with aggressive disease, especially if this can be done without taking an invasive biopsy. “Invasive biopsies come at considerable economic, psychological and societal cost to patients and healthcare systems alike.” The research team developed the new ExoGrail urine test by combining two biomarker sources - measurements of a protein-marker called EN2 and the levels of gene expression of 10 genes related to prostate cancer risk. It builds on previously developed tests called PUR and ExoMeth. They tested it using urine samples from 207 patients who had been undergone a biopsy for prostate cancer at the Norfolk and Norwich University Hospital (NNUH). When the urine results were compared to biopsy results, the study showed that the test had successfully shown which patients had prostate cancer and which did not. The ExoGrail test also provided risk scores for patients and highlighted those for which an invasive biopsy would have been beneficial. The findings show that using information from multiple, non-invasive biomarker sources has the potential to greatly improve how patients with suspected prostate cancer are risk-assessed prior to an invasive biopsy. Dr Brewer said: “Our new urine test not only shows whether a patient has prostate cancer, but it importantly shows how aggressive the disease is. This allows patients and doctors to select the correct treatment. And it has the potential to reduce the number of unnecessary biopsies by 35 per cent.” The research team was led by Dr Shea Connell, Prof Colin Cooper, Dr Daniel Brewer and Dr Jeremy Clark, all from UEA’s Norwich Medical School, in collaboration with the Norfolk and Norwich University Hospital, the University of Surrey, the University of Bradford, The Earlham Institute, and The Movember GAP1 Urine Biomarker Consortium. The urine biomarker research was funded by the Movember GAP1 Urine Biomarker project, Prostate Cancer UK, The Masonic Charitable Foundation, The Bob Champion Cancer Trust, the King family, The Andy Ripley Memorial Fund, the Hargrave Foundation, Norfolk Freemasons and the Tesco Centenary Grant. Paul Villanti, executive director of programmes at Movember, said: “We are proud to have supported the development of the ExoGrail urine test as part of our Global Action Plan Urine Biomarker project. “Having non-invasive tests which can accurately show how aggressive a man’s prostate cancer is not only reduces the number of men having to undergo painful biopsies, but also ensures that the right course of treatment for the patient is selected more quickly.” ‘Integration of Urinary EN2 Protein & Cell-Free RNA Data in the Development of a Multivariable Risk Model for the Detection of Prostate Cancer Prior to Biopsy’ is published in the journal Cancers on Tuesday, April 27, 2021.

Novel coronavirus discovered in British bats

A coronavirus related to the virus that causes Covid-19 in humans has been found in UK horseshoe bats – according to new collaborative research from the University of East Anglia, ZSL (Zoological Society of London), and Public Health England (PHE). However, there is no evidence that this novel virus has been transmitted to humans, or that it could in future, unless it mutates. UEA researchers collected faecal samples from more than 50 lesser horseshoe bats in Somerset, Gloucestershire and Wales and sent them for viral analysis at Public Health England. Genome sequencing found a novel coronavirus in one of the bat samples, which the team have named ‘RhGB01’. Due to the rapid response nature of this research, it has not yet been peer reviewed. It is the first time that a sarbecovirus (SARS-related coronavirus) has been found in a lesser horseshoe bat and the first to be discovered in the UK. The research team say that these bats will almost certainly have harboured the virus for a very long time. And it has been found now, because this is the first time that they have been tested. Importantly, this novel virus is unlikely to pose a direct risk to humans, unless it mutates. A mutation could happen if a human infected with Covid-19 passes it to an infected bat, so anyone coming into contact with bats or their droppings, for example those engaged in caving or bat protection, should wear appropriate PPE. Prof Diana Bell, an expert in emerging zoonotic diseases from UEA’s School of Biological Sciences, said: “Horseshoe bats are found across Europe, Africa, Asia and Australia and the bats we tested lie at the western extreme of their range. “Similar viruses have been found in other horseshoe bat species in China, South East Asia and Eastern Europe. “Our research extends both the geographic and species ranges of these types of viruses and suggests their more widespread presence across more than 90 species of horseshoe bats. “These bats will almost certainly have harboured this virus for a very long time – probably many thousands of years. We didn’t know about it before because this is the first time that such tests have been carried out in UK bats. “We already know that there are different coronaviruses in many other mammal species too,” she said. “This is a case of ‘seek and you will find’. “Research into the origins of SARS-CoV-2, the virus that causes Covid-19 in humans, has focussed on horseshoe bats - but there are some 1,400 other bat species and they comprise 20 per cent of known mammals. “Our findings highlight the need for robust genotype testing for these types of viruses in bat populations around the world. And it raises an important question about what other animals carry these types of viruses.” Prof Andrew Cunningham, from the Zoological Society of London, said: “Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection have been underestimated. “This UK virus is not a threat to humans because the receptor binding domain (RBD) – the part of the virus that attaches to host cells to infect them - is not compatible with being able to infect human cells. “But the problem is that any bat harbouring a SARS-like coronavirus can act as a melting pot for virus mutation. So if a bat with the RhGB01 infection we found were to become infected with SARS-CoV-2, there is a risk that these viruses would hybridise and a new virus emerge with the RBD of SARS-CoV-2, and so be able to infect people. “Preventing transmission of SARS-CoV-2 from humans to bats, and hence reducing opportunities for virus mutation, is critical with the current global mass vaccination campaign against this virus.” Prof Bell added: “The main risks would be for example a bat rehabilitator looking after a rescued animal and infecting it with SARS-CoV2 - which would provide an opportunity for genetic recombination if it is already carrying another sarbecovirus. “Anyone coming into contact with bats or their droppings, such as bat rescuers or cavers, should wear appropriate PPE – in order to reduce the risk of a mutation occurring. “We need to apply stringent regulations globally for anyone handling bats and other wild animals,” she added. The new virus falls within the subgroup of coronaviruses called sarbecoviruses which contains both SARS-CoV-2 (responsible for the current pandemic) and SARS-CoV (responsible for the initial 2003 SARS outbreak in humans). Further analysis compared the virus with those found in other horseshoe bat species in China, South East Asia and Europe and showed that its closest relative was discovered in a Blasius’s bat from Bulgaria in 2008. Ivana’s story The UK discovery was made by undergraduate ecology student Ivana Murphy, from UEA’s School of Biological Sciences, who collected bat droppings as part of her final year research dissertation. Jack Crook conducted the genetic analyses in partnership with other researchers at PHE. A total of 53 bats were captured, and their faeces collected in sterile bags. The research was conducted under strict Health and Safety protocols. Full PPE was worn and Ivana was regularly tested for Covid-19 to avoid any chance of cross contamination. The bats were released immediately after their droppings had been collected. Ivana said: “I am very fortunate to be surrounded by so many experts in their fields, which has allowed me access to resources that many undergraduates wouldn’t have. I feel extremely lucky to have been able to conduct such an advanced study.” “We weren’t shocked by the results, but I am extremely eager to carry out further research. “I chose to study ecology at UEA as I have a passion for trying to protect and conserve nature. I wanted a better understanding of the global situation and so chose UEA to study ecology and conservation. “The plan after graduation is to do an extended study of viruses in UK bats, very similar to the one I carried out as an undergraduate. There is still a lot more to understand and I am extremely excited to see what else we can find out.” But she says that she doesn’t want her research to turn people against bats. “More than anything, I’m worried that people may suddenly start fearing and persecuting bats, which is the last thing I would want and would be unnecessary. As like all wildlife, if left alone they do not pose any threat.” ‘Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe’ is published on the Research Square pre-print server. Read the full story, including a Q&A with all you need to know.

COVID expert: Prof Lawrence Young, UK

Professor Lawrence Young of the University of Warwick is one of the go-to experts in the UK on COVID-19. A Professor of Molecular Oncology at Warwick Medical School, he can comment on many aspects of the pandemic -- from the nature of the virus itself and its effects in patients, to its impacts on hospitals and wider society. He regularly features on TV, radio, and newspapers in the UK and worldwide, including: If you would like to book an interview with Prof. Young, contact press@warwick.ac.uk or L.Walton.1@warwick.ac.uk 

Are America and Japan forming a strong western front when it comes to China?

Friday saw President Joe Biden host a foreign leader for the first time since being elected, with Japan’s Prime Minister Yoshihide Suga coming to the White House to discuss Asian policies, primarily, concerns about China.  Biden and Suga said they both aimed to tighten the relationship between the two countries during the daylong visit, and China was one of the biggest focuses of the day's meetings. "We committed to working together to take on the challenges from China and on issues like the East China Sea, the South China Sea, as well as North Korea, to ensure the future of a free and open Indo-Pacific," Biden said during remarks in the Rose Garden of the White House on Friday. Suga said he and Biden had "serious talks on China's influence over the peace and prosperity of the Indo-Pacific, and the world at large." "We agreed to oppose any attempts to change the status quo by force or coercion in the East and South China Seas and intimidation of others in the region," Suga said. "At the same time, we agreed on the necessity for each of us to engage in frank dialogue with China, and in so doing, to pursue stability of international relations, while upholding universal values." China sent 25 warplanes into Taiwan's air defense identification zone on Monday, which was the largest breach of that space since the island began regularly reporting such activity in September, Taiwan's Defense Ministry said. The fact that Suga was the first foreign leader to pay a visit to the White House showed the importance of the relationship between the two countries in promoting democracy in the region, Biden said earlier in the day. April 16 – CNN As China continues to flex its military and economic muscle in the region, the world is watching, and every move may have a global impact. If you are a journalist covering Asia and the political issues that are brewing in the region, then let us help with your coverage. Dr. Elizabeth Larus is an expert in the politics of China. She is available to speak to media, simply click on her icon to arrange an interview today.

Black Maternal Health Week – Infant mortality in Georgia is still high, what can be done to save more lives?

Earlier this week, President Joe Biden proclaimed that April 11 thru 17 would be Black Maternal Health Week in America. In Georgia, the state has consistently been ranked as one of the most dangerous places in this country to be a new mother. Approximately 26 Georgia women die from pregnancy complications for every 100,000 live births, compared to the national average of about 17 women. But even more devastating is the fact that about 60% of the state’s maternal deaths between 2012 and 2016 were found to be preventable, according to the Georgia Department of Public Health. And the mortality rates are much more tragic for Black women in Georgia. African American women are almost three times more likely to die from a pregnancy-related cause than white women in Georgia. Black mothers in rural areas of Georgia are at an even higher risk. “Maternal and infant mortality are really significant indicators of the quality of health in any area, so my colleagues around Georgia really felt challenged to do something that we hadn’t done in a long time in our state, which was to get the data,” says Dr. Chad Ray. “Because you can’t really fix something unless you know who and why. And then you assemble the stakeholders to formulate a plan to make a dent and to move the needle on something that is just so important.” This is an important topic that impacts mothers in Georgia and across the entire United States. And if you are a journalist looking to cover this topic – then let us help. Dr. Chad Ray is the Interim Section Chief of the Department of Obstetrics and Gynecology at the Augusta University Medical Center. He is an expert in the areas of maternal mortality & global women's health initiatives. Dr. Ray is available to speak with media about Black Maternal Health Week - simply click on his icon now to arrange an interview today.

Japan Society CEO offers insights on President Biden’s upcoming meeting with Prime Minister Yoshihide Suga

Much like the cherry blossoms that are reaching peak in DC and are just starting to bloom here in NYC, U.S.-Japan relations seem set to hit their peak with Prime Minister Yoshihide Suga set to become the first world leader to meet with President Biden at the White House this week. This marks the first time a Japanese leader—or any Asian leader—is the first to meet with a U.S. president, since traditionally this honor has been reserved for a neighboring country like Canada or Mexico, or a European ally such as the UK. What does this mean for geopolitics? How does this shift our relationship with Japan and other allies? What does this mean for the balance of global power in a world of ever-shifting alliances? According to Joshua Walker, President & CEO of Japan Society, this historic visit indicates the following: This visit highlights the shift from a Western Transatlantic to an Eastern Transpacific Asian century, where Japan plays a critical role as a frontline security ally of the United States against China as this competition dominates geopolitics. It emphasizes the importance of democratic allies like Japan, specifically the Quad formation of Australia, India, Japan, and the U.S. as a new multilateral framing of America’s engagement in Asia. Japanese leadership inaugurated this concept in the last decade, which has now been embraced by the Biden administration. Brings into focus the 70 years of security treaty alliance between the United States and Japan, where Biden and Suga have been key players for the last half century—since the opening to China that changed the character of U.S.-Japan relations. Represents a key bilateral opportunity for both new administrations to get to know each other on the world stage in advance of the G7 summit in England this summer, and a time to coordinate strategies between the first and third largest economies, from domestic COVID responses and infrastructure investment to global responses to climate change and authoritarian regimes from North Korea and Myanmar to Iran. As host of the Summer Olympics in Tokyo, Japan elevates global aspirations and hopes for a successful, albeit different, competition of the human spirit that, through its resiliency, can overcome COVID. America represents the largest Olympic delegation and TV market, while Japan is the only Asian country to host two Summer Olympics even as China plans for its own Winter Games in 2022.

The great global warming debate – our experts are being asked about the ethics behind controlling earth’s climate

Solar geoengineering - it’s a topic that has caused an ethical lightening storm in the science community. The concept is complex. Should the world take on the crisis of climate change by attempting to artificially attempting to cool the earth? It’s an idea that has the National Academies of Sciences, Engineering and Medicine seeking a billion dollars in the next five years to investigate the theory. It’s a topic that is somewhat controversial, and journalists are looking to leading experts from across America for expert insight, opinion and perspective. Prakash Kashwan, a political scientist at the University of Connecticut, said he felt the report could have better emphasized the seriousness of some concerns over others. Uncertainties about the impacts of solar geoengineering on global weather patterns have the potential to affect some regions of the world more severely than others, he pointed out. Some experts have raised concerns about potential effects of geoengineering on monsoon rainfall in parts of Asia and Africa, he said. More than 2 billion people around the world rely on these rainfall patterns to support their water and agricultural needs. These kinds of issues should be given special weight, Kashwan suggested. "Some uncertainties are much more highly consequential for the global society, and especially for the poor and vulnerable," he told E&E News. Kashwan also reiterated concerns about potential political effects. While the report makes clear that geoengineering is not a substitute for climate mitigation, he suggests that this doesn't necessarily prevent policymakers from using it in that way. "The problem is the extent to which researchers are really helpless in deciding how research is used in the political system," he said. "That part has yet to be fully appreciated." Kashwan suggests that more dialogue might be warranted before funding a national research program, with greater input from both the international community and political experts who can weigh in on the ways that geoengineering research might affect political decisions. March 26, Scientific American It's a captivating idea – but it could have political, social and ethical consequences. Dr. Kashwan has also been interviewed by The New York Times. If you are a journalist looking to learn more about solar geoengineering, its possibilities and the reasons some scientists are worried – then let us help with your coverage. Prakash Kashwan is an Associate Professor of Political Science at UConn and an expert in the areas of environmental and climate justice, planetary justice, global commons, climate governance, and climate geoengineering governance. Dr. Kashwan is available to speak with media regarding this topic – simply click on his icon now to arrange an interview today.

What’s it all mean as ‘Big-Tech’ pivots to privacy? Let our Experts help explain if you are covering

The business of the internet as we know it, is about to change. As companies in the past have thrived, boomed, and found serious cash and success harvesting your data – that model may soon be coming to an end. With companies like Google and Apple leading the way, odds are a serious transformation is about to come and the know that notice has been served, it is getting a lot of attention. The decision, coming from the world’s biggest digital advertising company, could help push the industry away from the use of such individualized tracking, which has come under increasing criticism from privacy advocates and faces scrutiny from regulators. Google’s heft means the change could reshape the digital ad business, where many companies rely on tracking individuals to target their ads, measure the ads’ effectiveness, and stop fraud. Google accounted for 52% of last year’s global digital ad spending of $292 billion, according to Jounce Media, a digital ad consultancy. About 40% of the money that flows from advertisers to publishers on the open internet—meaning digital advertising outside of closed systems such as Google Search, YouTube, or Facebook—goes through Google’s ad buying tools, according to Jounce. March 03 – The Wall Street Journal. But what will this mean for powerhouses like Facebook or the multitude of apps and carriers who rely on data, and the money that comes with it to succeed? What lies ahead will be interesting, and if you are a journalist looking to cover this topic – then let our experts help. Vilma Todri is an Assistant Professor of Information Systems & Operations Management at Emory University’s Goizueta Business School. Previously, she worked for Google where she was developing integrated cross-platform advertising strategies for large business clients that partnered with Google and recently wrote a comprehensive paper on this very topic. Vilma is available to speak with media about this subject – simply click on her icon now to arrange an interview today.

What We Can Learn From Celebrating Irish-American Heritage Month

About two weeks ago, President Joseph Biden declared March 2021 Irish-American Heritage Month. In an official statement, the president said, "We owe a debt of gratitude to the Irish-American inventors and entrepreneurs who helped define America as the land of opportunity... The fabric of modern America is woven through with the green of the Emerald Isle." As the director of the Center for Irish Studies at Villanova University, an institution founded by Irish Augustinians to educate the children of Irish immigrants, Joseph Lennon, PhD, agrees. He hopes to use this presidential declaration as an opportunity to expand the conversation around what it means to be of Irish descent beyond wearing green and watching the annual St. Patrick's Day parade. The way Dr. Lennon sees it, "there is much more to Irish America than a parade and parties." With such a rich history of Irish immigrants and their descendants living in and contributing to the development of the United States, Dr. Lennon sees March 2021 as an important time to reflect on the "contributions and travails of this ethnicity" in a way that reaches beyond "silly slogans and marketing schemes." He reminds us, "there are over 30 million Irish Americans. The Irish contributed massively to the infrastructure of industrial America and later to the civil, education and business worlds—not to mention the Catholic Church." Dr. Lennon also hopes this month will help redefine the larger notion of what it looks like to be Irish and American. He notes that "38% of African Americans have Irish ancestry," but acknowledges that "this is a complicated issue," since in some cases this may stem from abuses suffered during the American practice of slavery. It is important conversations like these that Dr. Lennon wants to bring to light during Irish-American Heritage Month, and he stresses that "more research is needed into understanding this history—as well as the unions between Irish immigrants and northern-bound African Americans during the late nineteenth century." Per Dr. Lennon, these historical events are tied to our present day. He sees a need for "the level of recent racist attachments to Irishness... to be confronted with historical knowledge and anti-racist understandings." With such important issues in mind, Dr. Lennon wants to impart that "the Irish diaspora is global and diverse and Irish culture runs much more deeply and broadly in America than we might guess by just attending the St. Patrick's Day celebrations." He adds, "I'm curious to see if the conversation continues past St. Patrick's Day this year." Despite most St. Patrick’s Day events and programs being virtual in 2021, there are many opportunities to celebrate Irish-American heritage this year. At Villanova, the Center for Irish Studies is hosting a virtual St. Patrick's Day Celebration called "Links Across the Atlantic" on Wednesday, March 17, from 10:00 a.m. to 9:00 p.m. This free celebration will include live entertainment segments, from an Irish breakfast tutorial with study abroad director Mary Madec to lunchtime laughs with actor Johnny Murphy, and will culminate with a streamed Irish music fèis (or festival) in partnership with Tune Supply, featuring We Banjo 3, the Friel Sisters and One for the Foxes! For more information or to register for this event, please click here.