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A Crisis of Caring

Laura Mauldin's rule of thumb is that if you think you're caregiving, you probably are. The University of Connecticut professor and author has a new book that just been released In Sickness and in Health, where an urgent argument is made that America’s caregiving crisis is not a private family matter, but a structural and political failure.  Mauldin isn't just a scholar in the field. She also speaks from personal experience about the impact of caregiving -- as well as how society views and values it -- on both caregivers and those that they care for. It may not have been the birthday present then 32-year-old Laura Mauldin wanted to buy herself, but purchasing long-term care insurance was something she knew she needed. Mauldin, an associate professor in UConn’s Department of Social and Critical Inquiry, had been caring for her sick partner the five years prior, watching as cancer destroyed the promise of a long life. “It’s not about being morbid, rather it’s about recognizing the inevitability of a completely typical, expectable part of life,” Mauldin says of her advanced planning. “Why not just go ahead and in a neutral way have a plan? Then it’s there, you don’t have to worry, and you can feel more prepared.” A detailed account of her caregiving experience is the launching point for her new book, “In Sickness and in Health,” released this month by HarperCollins’ Ecco Press, in which she tells the story of a handful of couples from around the country who she came to know over years of spending time with them, oftentimes days and nights. “I grew to love these people and to care about them,” she says. “Their stories tell us something bigger about our culture, about our society, and about our choices around care policy and care systems. Theirs are the hidden stories that are going on behind millions of closed doors.” In her quest to bring discussions about caregiving to the light of day, Mauldin sat with UConn Today recently to talk about the different forms that caregiving can take, the result of absent social safety nets, and how ableism permeates the culture. February 2026 - UConn Today Drawing from her new book, Mauldin blends her personal experience with sociological research to show how love, marriage, and devotion are routinely forced to compensate for weak public policy, limited Medicaid support, and a culture shaped by ableism. Her work reframes caregiving as essential labor, deeply gendered, largely invisible, and profoundly political, and challenges the notion that “love is enough” in a system that offers far too little support. It’s an old adage: when people get married, they promise to stick together “in sickness and in health.” But that’s easier said than done when you’re caregiving for a spouse or long-term partner, when systemic failures often lead to burnout. In her new book, In Sickness and in Health: Love Stories from the Front Lines of America’s Caregiving Crisis, University of Connecticut professor Laura Mauldin explores the relationships between caregivers and their disabled and sick spouses, and the underlying lack of structural support in the US that makes unpaid care an inescapable feature of most such relationships. The topic is personal for her: Maudlin’s partner’s leukemia came out of remission as they were getting closer in 2006. “Falling in love with J had called upon me to increasingly fill a role that required meeting nearly every one of her needs,” Mauldin writes in her introduction. “This was more than just providing emotional support when the person you love is suffering.” J passed away in 2010. I spoke to Mauldin about crafting this book based on her lived experiences, how systems fail both disabled people and their caregivers, and what is at stake with Medicaid cuts exacerbating the damage to an already broken system. February 2026 - Mother Jones Dr. Laura Mauldin, an associate professor in the Department of Social and Critical Inquiry at the University of Connecticut, blends rigorous scholarship with lived experience to challenge prevailing assumptions about caregiving, disability, and public policy. Her work exposes how cultural norms and policy gaps intersect to offload care onto private homes, obscuring the true costs of care and the human toll of under-resourced support systems. She is available to speak with media - simply click on her icon now to arrange an interview today.

Expert Q and A: Understanding "Punch," The Baby Monkey That Captured The World's Heart

A tiny Japanese macaque named Punch has unexpectedly become one of the internet’s most talked-about animals. Born at a zoo in Japan and rejected by his mother shortly after birth, the young monkey was hand-raised by staff and given a stuffed toy for comfort—an image that quickly ricocheted across social media worldwide. Videos showing Punch tentatively approaching other macaques, sometimes being pushed away or corrected as he tried to socialize, struck an emotional chord. What began as a local zoo update rapidly turned into international headlines, with audiences from North America to Europe weighing in on what they saw as loneliness, resilience and the universal need for belonging. But experts say the story is more nuanced than a viral clip suggests. The interactions that many viewers interpreted as bullying are, in fact, typical components of macaque social development, part of how young primates learn boundaries, hierarchy and group norms. While Punch’s early maternal separation makes his integration more delicate, gradual acceptance into the troop is a positive sign. As internet users continue to share and comment, the moment has sparked broader conversations about animal emotion, anthropomorphism and the realities of wildlife behavior in managed care settings. Florida Tech's Catherine Talbot offered insight into the complexities of animal behavior.  Catherine F. Talbot is an assistant professor in the School of Psychology at Florida Tech and co-director of the Animal Cognitive Research Center at Brevard Zoo. Her overarching research goal has been to study the ultimate (evolutionary) and proximate (behavioral, biological, and developmental) mechanisms underlying sociality. Q: Is it normal for mother macaques to abandon their babies, or is this an unusual occurrence? What circumstances can cause this to happen?  It’s not necessarily normal, but also not that uncommon in primates, unfortunately. It’s more common in first time mothers that are inexperienced and sometimes lower ranking mothers. A number of factors can increase the likelihood of abandonment including stress on the mother and unfavorable conditions such as limited resources. Q: How does abandonment affect development in young macaques?  Early maternal contact is critical for normal behavioral and emotional development. Infants rely on their mothers for nutrition, warmth, protection and learning how to navigate social dynamics. When infants do not have their mothers during critical developmental periods like infancy, in the short term, they tend to have elevated stress responses and difficulty with emotional regulation. In the long-term, it depends on whether the infant is able to form other types of attachment. In the worst-case scenario, they may have increased aggression, abnormal and/or self-injurious behavior, digestive issues and may lack social skills. But primates are resilient, and with social support and gradual integration into a troop, Punch can form new attachments, learn socially appropriate behavior and ultimately live a fairly normal monkey life. Q: Is it obvious to the rest of the troop when a young macaque has no mother? How does this affect integration?  Japanese macaques have really complex social worlds, so they are really in tune with the relationships they have with one another and recognize the relationships between other individuals. That can certainly make it more difficult for Punch to be accepted back into the troop – he needs to find some friends and possibly even a surrogate parent. With social support, he should be able to recover from the absence of a mother. It’s really great to see that the care staff stepped in to support Punch as he begins to recovery from the stress of this experience. It’s even more important that Punch is around other monkeys of the same species so that he can continue to learn from them and respond appropriately to social communication cues. I’m thrilled to see that Punch is now making friends. Q: Punch is obviously attached to his stuffed orangutan. We can understand how this happens from our own human experience, but can you explain, on a biological level, how he bonded with this stuffed animal? Primates, including humans, are neurobiologically wired to form strong social bonds with a caregiver very early in life. In many primate species, infants are born highly dependent on their mother. Punch’s attachment to the stuffed orangutan reflects this need for attachment. That physical touch – warmth, softness, graspable limbs, a stable physical presence – can partially activate those same calming biological pathways, including the release of oxytocin which regulates stress and promotes feelings of safety. Without activation in those pathways, Punch would likely experience stronger feelings of separation or loneliness and ultimately social withdrawal. These biological pathways are crucial to proper social and emotional development of any primate species. Any way we can help mitigate those effects for Punch is crucial for successful integration back into his troop. Q: How does sociality among Japanese macaques compare to that of similar species? Japanese macaques live in large multi-male, multi-female social groups that can range from roughly 50 to 150 individuals. Like many macaques species, they form stable, female-bonded societies. Females remain in their natal group (or the group they were born into) for life, inherit their mother’s rank, and form strong kin- based alliances whereas males emigrate to a new group at adolescence. Their societies are organized around matrilines or extended female family lines in which rank is very important. They have strong dominance hierarchies and generally high levels of aggression, but levels of aggression and tolerance can vary a good amount from group to group. Entire matrilines can outrank others, which dictates access to food, grooming partners, and coalitions. Within a single troop, you often see multiple matrilines with long-standing dominance competitions. I sometimes compare it to a Romeo and Juliet-style Montague and Capulet dynamic, where beneath the surface of daily grooming and foraging is a complex political landscape structured by kinship and status. Q: What behaviors can Punch expect from the rest of the monkeys as he continues to integrate with the troop? What behaviors can the troop expect to see from him? As Punch continues to integrate into his troop, I would expect to see some social testing by other members of the group to see how Punch responds- they may use mild aggression like open mouth threats or direct stares (which arethreatening is macaques), brief chases, and displacement from resources like food/resting spots. These will help clarify Punch’s rank and help form and maintain a stable hierarchy. Therefore, I hope to see Punch make at least a few strong social bonds (friends), to help defend him against more intense aggression. As long as he makes a few friends, he should begin to receive more affiliative behavior. Integration is usually gradual as these bonds form and strengthen and these skills develop. I would expect to see more play and grooming with conspecifics and less reliance on his stuffed orangutan as real social bonds start to form. Grooming is especially important for forming and maintaining social bonds and there are already videos showing Punch receiving some grooming from older monkeys, which bodes well for him. He also needs to respond in socially appropriate ways, like grooming others and showing submission to higher ranking individuals. Essentially, he needs to understand and follow the rules of Japanese macaque society. Q: What message do you have as people continue to root for Punch?  It's uplifting to see how much support Punch has gained across the world. And while Punch is clearly adorable and so vulnerable that you just want to love him and give him (or other monkeys like him) a home, it’s important to remember that more than anything else, he needs to live with other monkeys so that he can live a life that is true to his species and nature. Unfortunately, many people still have monkeys as pets. The illegal wildlife trade is a multi-billion-dollar industry, ranking as the fourth largest illegal trade after drugs, arms, and human trafficking. Within the United States, it is estimated that there are more than 15,000 nonhuman primates living in unsuitable conditions. Primates are intelligent, sentient beings that need complex communities and relationships to thrive. There currently is no federal legislation that protects primates from private ownership, but the Captive Primate Safety Act (H.R.3199/ S.1594) has been proposed to prohibit the private possession of nonhuman primates and the sale or transportation of nonhuman primates for the wild pet trade. If you're interested in connecting with Catherine and learning more about animal behavior,  let us help. Contact  Adam Lowenstein, Assistant Vice President for External Affairs at Florida Institute of Technology, at adam@fit.edu to arrange an interview today.

Target Market: Who Are They, What Do They Value, and Where Are They?

In last week’s column on Super Bowl ads, I stressed the importance of providing a value proposition when you are advertising or marketing your goods and services. As a reminder, a value proposition is a promise that you make to potential customers that provides them a compelling reason why they should buy your product rather than a product from one of your competitors. Prior to developing a value proposition, you first need to understand who you are trying to sell to and what product characteristics they value. This will ensure that your value proposition will be more likely convince these buyers (your target market) to buy from you. The most effective Super Bowl ads from last week did this important work well. Once the company has a good, valuable proposition, it then needs to communicate that valuable proposition to its target market. Fortunately for companies with Super Bowl ads, just about all target markets are watching the game. However, for pretty much all other advertising and marketing, it must communicate where the target market will see or hear it. In today’s column, I will walk you through how to determine who your target market is, what they value, and finally, where to distribute your marketing messages. You are probably asking yourself, why is a guy who teaches Operations and Supply Chain Management (O&SCM) writing about Marketing? The answer is simple, really. It is the job of the O&SCM function of the company to deliver on the value proposition. So, as marketing develops its value proposition, it must confer with O&SCM to determine if the firm can deliver on that value proposition. If marketing communicates a value proposition it cannot meet, the company will likely be unsuccessful. With that in mind, let us examine the target market/value proposition development process. As a firm begins to identify its target market for a particular product, it must first determine the various potential customers who might buy that product and attempt to partition those customers into groups who value similar things. For instance, looking at the automobile market, there are some customers who value low price most, some who value performance and aesthetics most, and others who value reliability, durability, and consistency. If we are either in the automobile market or thinking about entering the automobile market, we need to find a group that values some characteristics that we think we can provide better than other market entrants. As you can see, the identification of a target market and the development of a value proposition that will appeal to that target market are done concurrently and iteratively. As noted above, the O&SCM function of the company is also brought in during these iterations to determine if the physical good can be manufactured or a service can be delivered in such a way that it can meet the value proposition. One important thing to remember is that in most cases, you are not your target market. What I mean by that is that you are often biased by your own knowledge and taste/preferences, and this may differ significantly from what your target market values. Remember that you are a unique individual whose preferences for a price point and evaluation of other characteristics might differ from your target market. Be sure to develop a value proposition that reflects the buying habits of your target market customers. Once you have developed a strong value proposition that you know your O&SCM can deliver upon, it is time to message that value proposition in places where your target market is present. As noted above, this aspect of our process is like “shooting fish in a barrel” for Super Bowl advertisers because all target markets are typically watching the Super Bowl. It is not so trivial for the rest of us. We need to understand what forms of media our target markets consume (e.g., television, radio, social media), but also, with each of these media, which applications or types of shows do they frequent. While most think social media skews young, and that is true for the most part, Facebook skews older, while Instagram, Snapchat, and TikTok skew much younger. On television, much of network television skew older, but there are shows like “Dancing with the Stars” and The “Bachelor” that do particularly well with younger women. Many mornings when I am getting ready for the day, I listen to “Augusta’s Morning News” on WGAC radio, and it is clear that my fellow listeners are primarily in my age demographic. My advice is to do your homework and find out where your target market is consuming media. All the work above is not very easy, but doing it right will lead to big returns. If you can identify who you want to target, based on what they value, and then be sure they get the marketing message that you have what they value, your business will succeed!

Labubu success demonstrates the benefits of the ‘blind box’ business strategy

Labubu dolls have taken the world by storm. The viral collectable keychains that feature plush monster-like figurines, sold by the Chinese company Pop Mart, have been compared to other toys like Beanie Babies or the more recent Sonny Angels. Labubus come in a variety of colors and outfits, and they are sold in “blind boxes” — so customers never know which collectibles they will get when they buy them. The meteoric ascent of these toys raises the question: What exactly is the appeal of Labubus? According to Tianxin Zou, Ph.D., an assistant professor of marketing in the University of Florida Warrington College of Business, there are a few reasons behind Pop Mart’s success. “It’s a little bit like buying a lottery ticket,” Zou said about the blind box concept. “The uncertainty is giving another layer of enjoyment.” Zou compares the psychological experience of blind boxes to gambling, stating that some customers buy hundreds of boxes for the chance at winning big. Customers aren’t just buying the products; they’re buying the experience. Each Labubu release features 12 figurine designs, as well as a much rarer secret design, so customers are enticed by the possibility of getting that one rare doll. This can also come with monetary value, as Labubus have been resold for thousands of dollars on platforms like eBay. Recently, a first-generation Labubu toy sold for $150,000 in a Labubu-specific auction. The unboxing experience can also trigger social interaction. People often film themselves unboxing the products and posting the experiences online for millions to see, or they gather in person to open boxes with their friends. This brings people together, forming a sense of community and identity around Labubu ownership. “Unboxing the blind box together can become a joyful event,” Zou said. “It makes it so Labubu has a social value and can help form friendships.” The rarity of certain designs is also a key factor in the social aspect of Labubus. Within these communities, especially online, owning rare designs can become a form of social capital. This has contributed to the rise of “Lafufus,” or fake Labubu dolls sold by retailers separate from Pop Mart. The craze has become less about the item itself and more about what it represents socially. Even if a keychain is fake, it still shows that the owner is socially in the know. Pop Mart also aligns itself with well-known franchises, such as Star Wars and Marvel, for branded blind box designs. And celebrity interest has helped the popularity of Labubus skyrocket. The toy first gained momentum after it was seen on the bag of Lisa, a member of the K-pop group Blackpink. Since then, Labubus have been spotted on the bags and belt loops of public figures ranging from Rihanna to Tom Brady. Zou explains that this furthers the social impact of the toys, as people aim to replicate celebrities’ style. “This collaboration with celebrities gives Pop Mart synergy, which gives it this stronger social effect,” Zou said. While the success of Labubus may seem spontaneous, it is actually the result of highly strategic business strategies. However, other retailers are catching on, providing competition for Pop Mart as more companies enter the blind box game. The retailer also faces new challenges, with countries like China and Singapore creating regulations for the sale of blind boxes, especially to children. But for now, the monsters continue to dominate the market, giving the company time to formulate new strategies. And because the company’s strength lies in its research and planning, it likely will not be going into its next phase blind.

Beyond the field: New research highlights how NIL is reshaping college athlete identity

In an era of name, image and likeness, or NIL, many college athletes are thinking differently about who they are — seeing themselves not just as competitors or students, but also as influencers with distinct voices and causes, according to a new study from the University of Florida. Molly Harry, Ph.D., an assistant professor in the Department of Sport Management at the UF College of Health and Human Performance, surveyed 200 athletes from 21 Power Four universities to better understand how NIL, which refers to the rights of college athletes to earn money through endorsements, sponsorships, social media promotions and other commercial opportunities, has impacted the way athletes perceive their roles and identities. “Historically, we’ve viewed them (college athletes) through the lens of athletics or academics, but they’re daughters, brothers, role models, and increasingly, they’re now cultivating public personas and marketing skills.” —Molly Harry, Ph.D., an assistant professor in the Department of Sport Management The findings, published Friday in the Sociology of Sport Journal, reveal a growing recognition among athletes that they are more than the two-dimensional “student-athlete” model that is traditionally used in research and policy. “With the shift in NIL policies, athletes are starting to develop roles and identities related to that of the influencer,” Harry said. “Historically, we’ve viewed them through the lens of athletics or academics, but they’re daughters, brothers, role models, and increasingly, they’re now cultivating public personas and marketing skills.” Through survey responses across seven major sports — football, baseball, men’s and women’s basketball, gymnastics, volleyball and softball — Harry and UF doctoral student Hannah Kloetzer examined athletes' engagement with NIL opportunities, as well as the personal sacrifices they made to pursue them. They found that many athletes now view NIL as a platform to promote causes they care about, build connections with their communities and explore career pathways after college. One softball player described the value of NIL in a way that highlights the broader impact: “It’s been great to feel seen and have your hard work in a sport help in other parts of life. It’s really nice to use NIL on a resume as marketing experience.” Athletes surveyed said they found deals not just with big-name brands, but more often with local businesses like restaurants, boutiques and community partners. This entrepreneurial approach often required initiative and personal outreach, something many athletes had to learn on their own. “Some athletes told us they felt lost when trying to navigate NIL,” Harry said. “Others shared how they reached out to local businesses or organized their own camps.” One particularly striking finding, Harry said, was that some athletes were making athletic sacrifices — like spending less time training — to pursue NIL work, a shift that underscores the importance of these opportunities. Harry stressed that while no one reported skipping practices, athletes did acknowledge shifting their priorities to make room for NIL-related endeavors. “If you’re willing to give up something in your athletic routine, that speaks volumes about how central NIL — and influencer identities — could become for some athletes,” she said. Another key insight: football players of color from low socioeconomic backgrounds were most likely to self-identify as influencers. This emerging pattern stands in contrast to perceived broader trends in the social media world. “That was one of the most fascinating takeaways,” Harry said. “We have this unique subset of influencers — college football athletes — that are starting to enter this space.” Harry’s research builds on a growing conversation in the academic community about the evolving identity of college athletes. A few conceptual pieces have previously proposed the idea of a “student-athlete-influencer,” but Harry’s team is one of the first to gather empirical data to back it up. This new perspective has broad implications for how universities and organizations like the NCAA support college athletes, both during their playing years and as they prepare for life after sport. “As fans, we often see athletes as commodities on the field,” Harry said. “But they’re humans first, and they’re starting to recognize their own value and tap into their potential beyond the playing field.” In addition to academic and athletic support, Harry believes universities should invest in more targeted resources tailored to influencer pressures, like mentorship opportunities and training that goes beyond basic social media etiquette. “Athletes who take on influencer roles may deal with unique stressors, whether it’s comparing engagement numbers or coping with public scrutiny,” she said. “It would be valuable to provide opportunities where athlete-influencers can support each other, share strategies and protect their mental health.” A football player who participated in the study summed up the broader potential of NIL: “I’m very appreciative of NIL opportunities and the ability to continue to grow my camp and greater brand outside of my football program.” Looking ahead, Harry plans to explore this evolving identity through more qualitative research, with a focus on what it truly means to be an “influencer” in the context of college athletics. “Athletes are more than football players. They are more than swimmers,” she said. “They are people who we walk with on our college campuses, and they are people who bring value to our society in a host of ways.”

LSU astrophysicist weighs in on potential release of UFO records

Dr. Eric Burns is a leading researcher in high-energy astrophysics, he studies neutron star mergers and gamma-ray bursts and helped lead the first multimessenger discovery of a binary neutron star merger. "Given the vast size of the universe, most scientists think life beyond Earth likely exists, and we are actively searching for it. However, there is no credible evidence that extraterrestrials have visited Earth or made contact with humanity. Previous government reviews of UFO reports have not produced convincing proof of alien technology. Astronomers are terrible at keeping secrets — if even one of us had solid evidence of aliens, the entire world would know by lunchtime. I strongly support transparency and look forward to the release of additional information, but extraordinary claims require extraordinary evidence."

Why Nick Cave’s First Public Outdoor Sculpture Found Its Home at Meijer Gardens

The permanent installation of Amalgam (Origin), Nick Cave’s first public outdoor sculpture in the world, marks a major moment for contemporary art in the Midwest and a defining milestone for Frederik Meijer Gardens & Sculpture Park. As the curator who guided the project from concept to completion, Suzanne Ramljak offers essential insight into why this work matters now, how it fits within Cave’s evolving career, and what it signals about the growing role of public art in shaping cultural identity. The sculpture’s installation in October coincides with a pivotal period in Nick Cave’s career. On Feb. 13, he debuted “Nick Cave: Mammoth,” a monumental new body of work on view at the Smithsonian American Art Museum through Jan. 3, 2027. Not only is it Cave's first solo exhibition in Washington, D.C., but it is the museum’s largest ever single-artist commission. And this spring, the Obama Presidential Center in Chicago opens with a major, immersive installation by Cave, placing his work at the center of a national cultural moment. Against this timely backdrop, Meijer Gardens’ installation stands as a quiet but powerful first: the artist’s inaugural permanent outdoor public sculpture. Understanding the Significance of Nick Cave's Work The sculpture reflects the evolution of Nick Cave’s artistic practice, rooted in his groundbreaking Soundsuits series, a body of work first developed in response in the wake of Rodney King’s 1991 assault by police and designed to challenge viewers’ perceptions of identity, race, and community. Over decades, Cave’s work has moved from wearable performance art into public sculpture, allowing his socially engaged visual language to occupy shared civic space. The permanent presence of Amalgam (Origin) at Meijer Gardens highlights the institution’s commitment to showcasing art that resonates with broader cultural dialogues about resilience, protection, and collective identity. “Nick Cave’s art is deeply rooted - in his family, in community, in craft, and in nature. His work is also grounded in concerns of social justice. The power of Amalgam (Origin) stems from this fertile mix; a blend of the personal and communal, exceptional and traditional.” Suzanne Ramljak, Vice President of Collections & Curatorial Affairs, Frederik Meijer Gardens & Sculpture Park Suzanne Ramljak is Vice President of Collections & Curatorial Affairs at Frederik Meijer Gardens & Sculpture Park where she oversees the acquisition, siting and curation of engaging sculptural exhibitions. View her profile The timing also highlights Cave’s deep Midwest ties. He lives and works in Chicago and earned his master's degree at Cranbrook Academy of Art in Bloomfield Hills, Michigan. The Meijer Gardens installation connects those regional roots to a global artistic trajectory, reinforcing the Midwest’s influence on contemporary art at the highest level. Media Attention, Coverage and Cultural Momentum Since the installation was announced and unveiled, the sculpture has drawn significant regional, national and arts-focused media attention, underscoring its cultural weight and public resonance. Coverage has highlighted the work’s monumental scale, its distinction as Nick Cave’s first permanent outdoor public sculpture, and Meijer Gardens’ role as a national destination capable of supporting ambitious and timely contemporary art. Media narratives consistently framed the installation as both a major moment for Grand Rapids’ cultural landscape and a signal of Meijer Gardens’ growing influence within the national arts conversation. The range of coverage points to interest from music, arts, lifestyle, and cultural outlets, suggesting the installation’s appeal to a variety of audiences. That level of attention reflects not only the significance of the work itself, but also the curatorial vision guiding its placement and permanence, a process led by Suzanne Ramljak. Expert Insight: As Curator of Collections and Senior Curator of Sculpture, Ramljak brings expert perspective on: Why Meijer Gardens was the right home for Cave’s first outdoor public sculpture How this work fits within Cave’s broader artistic practice, particularly his engagement with performance, movement, and public space What permanence means in contemporary art, especially for works often associated with temporality and performance How landscape, scale, and audience interaction shape the experience of outdoor sculpture Her expertise situates the installation within both Cave’s career arc and Meijer Gardens’ long-standing commitment to presenting ambitious contemporary sculpture in dialogue with nature.

Discovery pinpoints potential Achilles’ Heel in HIV, opening new frontier in drug development

Scientists have long known that detecting HIV early is crucial in slowing and treating the virus. During the acute stage of infection, a single human cell can produce as many as 10,000 new HIV particles. A discovery led by the University of Delaware's Juan Perilla offers hope: A new drug target early in the virus's life cycle that could save millions of lives. In the surprising discovery, published Feb. 18 in Nature, Perilla and collaborators in the U.S. and the United Kingdom, have revealed a previously unknown role for the viral protein integrase. Scientists already knew that integrase helps HIV insert itself into human DNA. But this new study provides the first direct evidence that integrase plays a critical structural role earlier on in HIV’s life cycle — when the virus matures into an infectious force. Using high-resolution cryo-electron microscopy (cryo-EM), the research team – which also included UD doctoral student Juan S. Rey – found that integrase proteins form gluey filaments that line the inside of the capsid. Each segment of the filament slots neatly into the capsid’s hexagon-shaped tiles, while gripping tightly to HIV’s RNA genome. This zipper-like arrangement organizes and packs the virus, preparing it to hijack a cell and start making copies of itself. “Integrase plays a structural role inside the HIV capsid — nobody expected that,” Perilla said. “This protein forms filaments that anchor the RNA to the capsid. Without these filaments, the virus is non-infective.” Seeing inside HIV is no small feat. The capsid is only about 120 nanometers wide —roughly 1/800th the thickness of a human hair. It is incredibly small, fragile, densely packed and constantly changing, Perilla said. To reveal its hidden architecture, the researchers relied on deep collaboration and a combination of sophisticated microscopy, molecular modeling and experimentation. Read more about the science behind the study here. “The thing with HIV is that people are chronically living with it,” Perilla said. “Treatments are effective, but patients always need new therapeutics. We want to help develop the next generation of inhibitors and hope to have a significant contribution.” To reach Perilla directly and arrange an interview, visit his profile page. Interested reporters can also email MediaRelations@udel.edu.

School District Faces an Impossible Choice in Fight Over Mascot Name

Education Professor Alan Singer was interviewed by Newsday about the Connetquot School District on Long Island being threatened with funding cuts if it does not reinstate its old mascot name, the Thunderbirds. The name change to T-Birds was made in 2022 to comply with the state’s ban on Native American mascots and other imagery in public schools.

Rethinking AI in the classroom: A literacy-first approach to generative technology

As schools nationwide navigate the rapid rise of generative artificial intelligence, educators are searching for guidance that goes beyond fear, hype or quick fixes. Rachel Karchmer-Klein, associate professor of literacy education at the University of Delaware, is helping lead that conversation. Her latest book, Putting AI to Work in Disciplinary Literacy: Shifting Mindsets and Guiding Classroom Instruction, offers research-based strategies for integrating AI into secondary classrooms without sacrificing critical thinking or deep learning. Here is how she is approaching the complex topic.  Q: Your new book focuses on AI in disciplinary literacy. What is the central message? Karchmer-Klein: Rather than positioning AI as a shortcut or replacement for student thinking, the book emphasizes a literacy-first approach that helps students critically evaluate, interrogate, and apply AI-generated information. This is important because schools and universities are grappling with rapid AI adoption, often without clear guidance grounded in learning theory, literacy research, or classroom practice. Q: What inspired this research? Karchmer-Klein: The book grew directly out of my work with preservice teachers, practicing educators, and school leaders who were asking practical but complex questions about AI: How do we use it responsibly? How do we prevent over-reliance? How do we teach students to question what AI produces? I also saw a gap between public conversations about AI which often focused on fear or efficiency and what teachers actually need: research-informed strategies that support deep learning. My long-standing research in digital literacies provided a natural foundation for addressing these questions. Q: What are some of the key findings from your work? Karchmer-Klein: AI is most effective when it is embedded within strong instructional design and disciplinary literacy practices, not treated as a stand-alone tool. The research and classroom examples illustrate that AI can support student learning when it is used to prompt reasoning, reveal misconceptions, provide feedback for revision, and encourage multiple perspectives. Another important development is the emphasis on teaching students to evaluate AI outputs critically by recognizing bias, inaccuracies, and limitations, rather than assuming correctness. Q: How could this work impact schools, teacher education programs and the broader public? Karchmer-Klein: For educators, this work provides concrete, evidence-based literacy strategies coupled with AI in ways that strengthen, not dilute, student thinking. For teacher education programs and school districts, it offers a research-based framework for professional development and policy conversations around AI use. More broadly, the work speaks to a public concern about how emerging technologies are shaping learning, helping to reframe AI as something that requires human judgment, ethical consideration, and strong literacy skills to use well. ABOUT RACHEL KARCHMER-KLEIN Rachel Karchmer-Klein is an associate professor in the School of Education at the University of Delaware where she teaches courses in literacy and educational technology at the undergraduate, graduate, and doctoral levels. She is a former elementary classroom teacher and reading specialist. Her research investigates relationships among literacy skills, digital tools, and teacher preparation, with particular emphasis on technology-infused instructional design. To speak with Karchmer-Klein further about AI in literacy education, critical evaluation of AI-generated content and teacher preparation in the era of generative AI, reach out to MediaRelations@udel.edu.