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3D-printed lung model helps researchers study aerosol deposition in the lungs
Treating respiratory diseases is challenging. Inhalable medicines depend on delivering particles to the right lung areas, which is complicated by factors like the drug, delivery method and patient variability, or even exposure to smoke or asbestos particles. University of Delaware researchers have developed an adaptable 3D lung model to address this issue by replicating realistic breathing maneuvers and offering personalized evaluation of aerosol therapeutics. “If it's something environmental and toxic that we're worried about, knowing how far and how deep in the lung it goes is important,” said Catherine Fromen, University of Delaware Centennial Associate Professor for Excellence in Research and Education in the Department of Chemical and Biomolecular Engineering. “If it's designing a better pharmaceutical drug for asthma or a respiratory disease, knowing exactly where the inhaled aerosol lands and how deep the medicine can penetrate will predict how well that works.”that can replicate realistic breathing maneuvers and offer personalized evaluation of aerosol therapeutics under various breathing conditions. Fromen and two UD alumni have submitted a patent application on the 3D lung model invention through UD’s Office of Economic Innovation and Partnerships (OEIP), the unit responsible for managing intellectual property at UD. In a paper published in the journal Device, Fromen and her team demonstrate how their new 3D lung model can advance understanding of how inhalable medications behave in the upper airways and deeper areas of the lung. This can provide a broader picture on how to predict the effectiveness of inhalable medications in models and computer simulations for different people or age groups. The researchers detail in the paper how they built the 3D structure and what they’ve learned so far. Valuable research tool The purpose of the lung is gas exchange. In practice, the lung is often approximated as the size of a tennis court that is exchanging oxygen and carbon dioxide with the bloodstream in our bodies. This is a huge surface area, and that function is critical — if your lungs go down, you're in trouble. Fromen described this branching lung architecture like a tree that starts with a trunk and branches out into smaller and smaller limbs, ranging in size from a few centimeters in the trachea to about 100 microns (roughly the combined width of two hairs on your head) in the lung’s farthest regions. These branches create a complex network that filters aerosols as they travel through the lung. Just as tree branches end in leaves, the lung’s branches culminate in delicate, leaf-like structures called alveoli, where gases are exchanged. “Those alveoli in the deeper airways make the surface area that provides this necessary gas exchange, so you don't want environmental things getting in there where they can damage these sensitive, finer structures,” said Fromen, who has a joint appointment in biomedical engineering. Mimicking the complex structure and function of the lung in a lab setting is inherently challenging. The UD-developed 3D lung model is unique in several ways. First, the model breathes in the same cyclic motion as an actual lung. That’s key, Fromen said. The model also contains lattice structures to represent the entire volume and surface area of a lung. These lattices, made possible through 3D printing, are a critical innovation, enabling precise design to mimic the lung's filtering processes without needing to recreate its full biological complexity. “There's nothing currently out there that has both of these features,” she explained. “This means that we can look at the entire dosage of an inhaled medicine. We can look at exposure over time, and we can capture what happens when you inhale the medication and where the medicine deposits, as well as what gets exhaled as you breathe.” The testing process Testing how far an aerosol or environmental particle travels inside the 3D lung model is a multi-step process. The exposure of the model to the aerosol only takes about five minutes, but the analysis is time-consuming. The researchers add fluorescent molecules to the solution being tested to track where the particles deposit inside the model’s 150 different parts. “We wash each part and rinse away everything that deposits. The fluorescence is just a molecule in the solution. When it deposits, we know the concentration of that, so, when we rinse it out, we can measure how much fluorescence was recovered,” Fromen said. This data allows them to create a heat map of where the aerosols deposit throughout the lung model’s airways, which then can be validated against benchmarked clinical data for where such aerosols would be expected to go in a human under similar conditions. The team’s current model matches a healthy person under sitting/breathing conditions for a single aerosol size, but Fromen’s team is working to ensure the model is versatile across a much broader range of conditions. “An asthma attack, exercise, cystic fibrosis, chronic obstructive pulmonary disorder (COPD) — all those things are going to really affect where aerosols deposit. We want to make sure our model can capture those differences,” Fromen said. The ability to examine disease features like airway narrowing or mucus buildup could lead to more personalized care, such as tailored medication doses or redesigned inhalers. Currently, inhaled medicines follow a one-size-fits-all approach, but the UD-developed model offers a tool to address these issues and understand why many inhaled medicines fail clinical trials.
Santa Ana Winds: Nature's Power and Its Impacts on Communities
The Santa Ana Winds, a defining phenomenon of Southern California, are more than just a weather pattern—they are a powerful force shaping the region's environment, safety, and culture. These hot, dry winds can dramatically exacerbate wildfire risks, affect air quality, and even influence human behavior. Understanding the Santa Ana Winds is vital for addressing broader issues of climate change, disaster preparedness, and community resilience. Their far-reaching effects provide journalists with a range of compelling story angles, such as: The meteorological science behind the Santa Ana Winds and why they occur Their role in intensifying wildfires and efforts to mitigate these risks Health impacts, including effects on air quality and respiratory conditions Psychological and behavioral studies linked to wind-driven stress and aggression Historical and cultural significance of the Santa Ana Winds in Southern California How climate change might alter the frequency and intensity of these winds If you're covering the massive fires in California, let us help with your ongoing coverage. Connect with an expert about the Santa Ana Winds: To search our full list of experts visit www.expertfile.com
Los Angeles wildfires: Experts address health concerns and evacuation strategies
Major wildfires are once again raging in California, this time in Los Angeles County. According to news reports, they have so far been responsible for two deaths, 1,000 damaged structures and the evacuation of more than 30,000 residents. Experts from the University of Delaware's Disaster Research Center can comment on health impacts, evacuation strategies and how to manage pets and animals during disasters. Below are three of the Disaster Research Center core faculty and the topics they can discuss related to the current wildfires: Jennifer Horney, founding director of UD’s epidemiology program: Health impacts of disasters (mental and physical) as well as evacuation. Additionally, exposure to wildfire smoke which increases risk of respiratory infections; the scale of these fires during a very high period for these infectious diseases (flu, RSV, COVID) may also put pressure on public health and health care systems. Tricia Wachtendorf, co-director of the Disaster Research Center and professor of sociology and criminal justice: Disaster donations, social vulnerability and evacuation. Sarah DeYoung, associate professor of sociology and criminal justice: Pets and animals during evacuations.
Ask the Expert: Understand the latest on COVID-19 and mpox
As the university physician at Michigan State, Michael Brown advises the president and other leaders on major health policy or programs that impact life on campus or education abroad programs. He is also chair of the Department of Emergency Medicine in the MSU College of Human Medicine. Here, Brown shares the latest guidance about two viruses that are making news — COVID-19 and mpox, which was formerly called monkeypox. Is COVID-19 changing? COVID-19 will be with us for years to come. It seems to come and go in waves and now, it’s surging again across the United States. We’re seeing more cases, but the number of severe cases is much lower than the peaks we saw during the height of the pandemic. This is good news. Just a small fraction of the people who get COVID-19 actually become sick enough to go to the emergency department. We have to keep that in perspective. How can people stay healthy? The virus does mutate — that’s what viruses do — and a couple recent variants have become predominant. Ideally, the next vaccine will target the latest prevalent variants. I expect the Food and Drug Administration to release a new vaccine very soon, and I definitely will be in line to get one when it’s available. In fact, I highly encourage everyone to get a vaccine this fall. The effectiveness peaks about four weeks after you receive it and lasts at least four to six months — maybe longer. The people who are most protected are those who have had a bout of COVID-19, built up their immunity and received a vaccine. This combination is the best protection from getting an illness that’s severe enough to send you to the hospital. What symptoms are associated with this strain of COVID-19? The symptoms are much like what we’ve seen from COVID-19 in the past. It is an upper respiratory illness, so you may have a sore throat, congestion and a cough, but there can be other symptoms like headache. Some people experience nausea, vomiting or diarrhea. Fever and muscle aches are also common. What if someone tests positive for COVID-19? False positives are very rare with COVID-19 tests so if you get a positive result, you should take care of yourself and protect those around you. The Centers for Disease Control and Prevention recommend that you stay home and wear a mask around others. You should also treat your symptoms, stay hydrated and take acetaminophen for fever and muscle aches. After 24 hours of feeling better and being fever-free (with no acetaminophen), you can go out in public. It’s advised that you wear a mask for an additional five days to protect people who are vulnerable. And what about mpox? Mpox is a viral disease largely found in the Democratic Republic of the Congo in Central Africa. The people there are accustomed to living with it. But it mutates, and we have seen a change in the disease patterns in the past few years. One of the new variants is more severe and is now spreading in the Congo region. It has become a critical situation there, but we have not seen the more severe variant here in the United States. Mpox is not as transmissible as COVID-19 because it requires close contact — usually intimate contact or other close physical proximity like sharing a towel. Symptoms include a rash that may start on the face or genital area along with fever and body aches. A vaccine is available, and an experimental drug can be prescribed as treatment. The World Health Organization has asked developed countries like the United States to assist with research to better understand the new variant. Looking to know more - we can help. Michael Brown is available to speak with media - simply connect with Dalin Clark now to arrange an interview today.
Expert Insight: Training Innovative AI to Provide Expert Guidance on Prescription Medications
A new wave of medications meant to treat Type II diabetes is grabbing headlines around the world for their ability to help people lose a significant amount of weight. They are called GLP-1 receptor agonists. By mimicking a glucagon-like peptide (GLP) naturally released by the body during digestion, they not only lower blood sugar but also slow digestion and increase the sense of fullness after eating. The two big names in GLP-1 agonists are Ozempic and Wegovy, and both are a form of semaglutide. Another medication, tirzepatide, is sold as Mounjaro and Zepbound. It is also a glucose-dependent insulinotropic polypeptide (GIP) agonist as well as GLP-1. Physicians have been prescribing semaglutide and tirzepatide with increasing frequency. However, both medications come with a host of side effects, including nausea and stomach pain, and are not suitable for every patient. Many clinics and physicians do not have immediate access to expert second opinions, as do the physicians at Emory Healthcare. Creating a Digital Twin That lack of an expert is one of the reasons Karl Kuhnert, professor in the practice of organization and management at Emory University’s Goizueta Business School, is using artificial intelligence to capture the expertise of physicians like Caroline Collins MD through the Tacit Object Modeler™, or TOM. By using TOM, developed by Merlynn Intelligence Technologies, Kuhnert and Collins can create her “decision-making digital twin.” This allows Collins to reveal her expertise as a primary care physician with Emory Healthcare and an Assistant Professor at Emory School of Medicine, where she has been leading the field in integrating lifestyle medicine into clinical practices and education. Traditional AI, like ChatGPT, uses massive amount of data points to predict outcomes using what’s known as explicit knowledge. But it isn’t necessarily learning as it goes. According to Kuhnert, TOM has been designed to learn how an expert, like Collins, decides whether or not to prescribe a drug like semaglutide to a patient. Wisdom or tacit knowledge is intuitive and rooted in experience and context. It is hard to communicate, and usually resides only in the expert’s mind. TOM’s ability to “peek into the expert’s mind makes it a compelling technology for accessing wisdom.” “Objective or explicit knowledge is known and can be shared with others,” says Kuhnert. "For example, ChatGPT uses explicit knowledge in its answers. It’s not creating something new. It may be new to you as you read it, but somebody, somewhere, before you, has created it. It’s understood as coming from some source." Karl Kuhnert “Tacit knowledge is subjective wisdom. Experts offer this, and we use their tacit know-how, their implicit knowledge, to make their decisions. If it were objective, everyone could do it. This is why we hire experts: They see things and know things others don’t; they see around corners.” Mimicking the Mind of a Medical Expert Teaching TOM to see around the corners requires Collins to work with the AI over the course of a few days. “Essentially what I do is I sit down with, in this case, a physician, and ask them, ‘What are thinking about when you make this decision?'” says Kuhnert. “The layperson might think that there are hundreds of variables in making a medical decision like this. With the expert’s tacit knowledge and experience, it is usually between seven and twelve variables. They decide based on these critical variables,” he says. "These experts have so much experience, they can cut away a lot of the noise around a decision and get right to the point and ask, ‘What am I looking at?’" Karl Kuhnert As TOM learns, it presents Collins with more and different scenarios for prescribing semaglutide. As she makes decisions, it remembers the variables present during her decision-making process. “Obviously, some variables are going to be more important than other variables. Certain combinations are going to be challenging,” says Collins. “Sometimes there are going to be some variables where I think, yes, this patient needs a GLP-1. Then there may be some variables where I think, no, this person really doesn’t need that. And which ones are going to win out? That’s really where TOM is valuable. It can say, okay, when in these difficult circumstances where there are conflicting variables, which one will ultimately be most important in making that decision?” The Process: Trusting AI After working with TOM for several hours, Collins will have reacted to enough scenarios for TOM to learn to make her decision. The Twin will need to demonstrate that it can replicate her decision-making with acceptable accuracy—high 90s to 100 percent. Once there, Collins’ Twin is ready to use. “I think it’s important to have concordance between what I would say in a situation and then what my digital twin would say in a situation because that’s our ultimate goal is to have an AI algorithm that can duplicate what my recommendation would be given these circumstances for a patient,” Collins says. “So, someone, whether that be an insurance company, or a patient themselves or another provider, would be able to consult TOM, and in essence, me, and say, in this scenario, would you prescribe a GLP-1 or not given this specific patient’s situation?” The patient’s current health and family history are critical when deciding whether or not to prescribe semaglutide. For example, according to Novo Nordisk, the makers of Ozempic, the drug should not be prescribed to patients with a history of problems with the pancreas or kidneys or with a family history of thyroid cancer. Those are just the start of a list of reasons why a patient may or may not be a good candidate for the medication. Kuhnert says, “What we’re learning is that there are so many primary care physicians right now that if you come in with a BMI over 25 and are prediabetic, you’re going to get (a prescription). But there’s much more data around this to suggest that there are people who are health marginalized, and they can’t do this. They should not have this (medication). It’s got to be distributed to people who can tolerate it and are safe.” Accessing the Digital Twin on TOM Collins’s digital twin could be available via something as easy to access as an iPhone app. “Part of my job is to provide the latest information to primary care physicians. Now, I can do this in a way that is very powerful for primary care physicians to go on their phones and put it in. It’s pretty remarkable, according to Colllins.” It is also transparent and importantly sourced information. Any physician using a digital twin created with TOM will know exactly whose expertise they are accessing, so anyone asking for a second opinion from Colllins will know they are using an expert physician from Emory University. In addition to patient safety, there are a number of ways TOM can be useful to the healthcare industry when prescribing medications like semaglutide. This includes interfacing with insurance companies and the prior approval process, often lengthy and handled by non-physician staff. “Why is a non-expert at an insurance company determining whether a patient needs a medication or not? Would it be better to have an expert?” says Collins. “I’m an expert in internal medicine and lifestyle medicine. So, I help people not only lose weight, but also help people change their behaviors to optimize their health. My take on GLP-1 medications is not that everyone needs them, it’s that they need to be utilized in a meaningful way, so patients will get benefit, given risks and benefits for these medications.” The Power of a Second Opinion Getting second, and sometimes third, opinions is a common practice among physicians and patients both. When a patient presents symptoms to their primary care physician, that physician may have studied the possible disease in school but isn’t necessarily an expert. In a community like Emory Healthcare, the experts are readily available, like Collins. She often serves as a second opinion for her colleagues and others around the country. “What we’re providing folks is more of a second opinion. Because we want this actually to work alongside someone, you can look at this opinion that this expert gave, and now, based on sourced information, you can choose. This person may be one of the best in the country, if not the world, in making this decision. But we’re not replacing people here. We’re not dislocating people with this technology. We need people. We need today’s and tomorrow’s experts as well,” according to Kuhnert. But also, you now have the ability to take an Emory physician’s diagnosing capabilities to physicians in rural areas and make use of this information, this knowledge, this decision, and how they make this decision. We have people here that could really help these small hospitals across the country. Caroline Collin MD Rural Americans have significant health disparities when compared to those living in urban centers. They are more likely to die from heart disease, cancer, injury, chronic respiratory disease, and stroke. Rural areas are finding primary care physicians in short supply, and patients in rural areas are 64 percent less likely to have access to medical specialists for needed referrals. Smaller communities might not have immediate access to experts like a rheumatologist, for example. In addition, patients in more rural areas might not have the means of transportation to get to a specialist, nor have the financial means to pay for specialized visits for a diagnosis. Collins posits that internal medicine generalists might suspect a diagnosis but want to confirm before prescribing a course of treatment. “If I have a patient for whom I am trying to answer a specific question, ‘Does this patient have lupus?’, for instance. I’m not going to be able to diagnose this person with lupus. I can suspect it, but I’m going to ask a rheumatologist. Let’s say I’m in a community where unfortunately, we don’t have a rheumatologist. The patient can’t see a rheumatologist. That’s a real scenario that’s happening in the United States right now. But now I can ask the digital twin acting as a rheumatologist, given these variables, ‘Does this patient have lupus?’ And the digital twin could give me a second opinion.” Sometimes, those experts are incredibly busy and might not have the physical availability for a full consult. In this case, someone could use TOM to create the digital twin of that expert. This allows them to give advice and second opinions to a wider range of fellow physicians. As Kuhnert says, TOM is not designed or intended to be a substitute for a physician. It should only work alongside one. Collins agreed, saying, “This doesn’t take the place of a provider in actual clinical decision-making. That’s where I think someone could use it inappropriately and could get patients into trouble. You still have to have a person there with clinical decision-making capacity to take on additional variables that TOM can’t yet do. And so that’s why it’s a second opinion.” “We’re not there yet in AI says Collins. We have to be really careful about having AI make actual medical decisions for people without someone there to say, ‘Wait a minute, does this make sense?’” AI Implications in the Classroom and Beyond Because organizations use TOM to create digital twins of their experts, the public cannot use the twins to shop for willing doctors. “We don’t want gaming the system,” says Collins. “We don’t want doctor shopping. What we want is a person there who can utilize AI in a meaningful way – not in a dangerous way. I think we’ll eventually get there where we can have AI making clinical decisions. But I don’t think I’d feel comfortable with that yet.” The implications of using decision-making digital twins in healthcare reach far beyond a second opinion for prescription drugs. Kuhnert sees it as an integral part of the future of medical school classrooms at Emory. In the past, teaching case studies have come from books, journals, and papers. Now, they could come alive in the classroom with AI simulation programs like TOM. "I think this would be great for teaching residents. Imagine that we could create a simulation and put this in a classroom, have (the students) do the simulation, and then have the physician come in and talk about how she makes her decisions." Karl Kuhnert “And then these residents could take this decision, and now it’s theirs. They can keep it with them. It would be awesome to have a library of critical health decisions made in Emory hospitals,” Kuhnert says. Collins agreed. “We do a lot of case teaching in the medical school. I teach both residents and medical students at Emory School of Medicine. This would be a really great tool to say, okay, given these set of circumstances, what decision would you make for this patient? Then, you could see what the expert’s decision would have been. That could be a great way to see if you are actually in lockstep with the decision-making process that you’re supposed to be learning.” Kuhnert sees decision-making twins moving beyond the healthcare system and into other arenas like the courtroom, public safety, and financial industries and has been working with other experts to digitize their knowledge in those fields. "The way to think about this is: say there is a subjective decision that gets made that has significant ramifications for that company and maybe for the community. What would it mean if I could digitize experts and make it available to other people who need an expert or an expert’s decision-making?" Karl Kuhnert “You think about how many people aren’t available. Maybe you have a physician who’s not available. You have executives who are not available. Often expertise resides in the minds of just a few people in an organization,” says Kuhnert. “Pursuing the use of technologies like TOM takes the concept of the digital human expert from simple task automation to subjective human decision-making support and will expand the idea of a digital expert into something beyond our current capabilities,” Kuhnert says. “I wanted to show that we could digitize very subjective decisions in such areas as ethical and clinical decision-making. In the near future, we will all learn from the wisdom codified in decision-making digital twins. Why not learn from the best? There is a lot of good work to do.” Karl Kuhnert is a Professor in the Practice of Organization & Management and Associate Professor of Psychiatry, School of Medicine and Senior Faculty Fellow of the Emory Ethics Center. If you're looking to connect with Karl to know more - simply click on his icon now to arrange a time to talk today.
300 million tonnes of rice straw are burned after harvest in Asia every year Aston University will be contributing to new international project to unlock renewable energy potential Its researchers will lead on calculating the greenhouse gas emissions savings of new systems. Aston University researchers are helping to make rice straw processing in India and the Philippines less environmentally damaging. The University will be contributing to a new international collaboration, the Renewable, Inclusive Carbon-negative Energy (RICE) project, funded by Innovate UK Energy Catalyst programme to unlock renewable energy for rice farmers. Already the University has worked with UK company Straw Innovations in the Philippines and now the two are expanding their collaboration to benefit more of the continent. Aston University working with UK company Straw Innovations and Indian enterprise, Takachar Rice straw is a crop waste byproduct and each year across Asia 300 million tonnes of it go up in smoke when burnt after harvest. This releases emissions and air pollutants that triple risks of increased respiratory diseases and accelerate climate change. India and the Philippines are the world’s second and eighth largest rice producers respectively and together they produce 130 million tonnes of both rice and straw per year. Aston University and Straw Innovations and will be collaborating with an Indian award winning small and medium sized enterprise, Takachar. The firm has developed small scale, low-cost, portable equipment which can convert agricultural waste on-site into higher value bioproducts such as fertilizer blends, chemicals and biofuels. "The company will develop a super-sized version which is 10 times bigger than their current device, make it adaptable to rice mills, and will send it to Straw Innovations, so the two firms can test out different business models for farmer adoption/benefit. Straw Innovations will also send their machines from the Philippines to India mid-project and the two countries will test out different business models for farmer adoption/benefit. And for the first time they will tap into the heat produced in the waste process to dry rice, instead of using diesel or kerosene. University researchers will lead on assessing the sustainability of the project, calculating the greenhouse gas emissions savings of the new systems introduced by Straw Innovations and Takachar. Sustainability expert Dr Mirjam Röder will also engage with the farming community and rural stakeholders to quantify how the systems can increase farmer incomes, equality of opportunity, food security and decarbonisation benefits, whilst highlighting any trade-offs. Dr Röder who is based at Aston University’s Energy & Bioproducts Research Institute (EBRI) said: “Environmentally, rice produces 48% of all global crop emissions, due to methane from flooded fields. This is halved when the straw is removed and reduced further when its carbon is stored in biochar. We are aiming for carbon negative which means removing carbon dioxide (CO₂) from the atmosphere or sequestering more CO₂ than is emitted. “Our new research leads on from our rice straw bio gas hub project with Straw Innovations, SEARCA and Koolmill and we’re pleased to be building further relationships with new partners in India. In January Biomass and Bioenergy published a paper about the topic written by Dr Röder, the director of EBRI Professor Patricia Thornley and Craig Jamieson of Straw Innovations called The greenhouse gas performance and climate change mitigation potential from rice straw biogas as a pathway to the UN sustainable development goals. Craig Jamieson from Straw Innovations said "We’ve been pioneering rice straw work with the team at Aston University for the past seven years. We're delighted to continue that strong partnership and widen it to include Takachar in this new project. “Takachar is a leader in making biochar from crop residues and our partnership with them is very strategic. We look forward to combining our new improved straw harvesting technology with their scaled-up biochar production. It will be a step change, creating a new, more efficient system for carbon negative energy and soil improvement for rural communities across Asia." Vidyut Mohan who founded Takachar said: “We are excited to partner with Aston University and Straw Innovations. “Our combined solutions can significantly move the needle in reducing crop residue collection costs and biochar production costs for carbon removal." Notes to Editors Rice straw is a crop waste byproduct and each year across Asia 300 million tonnes of it go up in smoke when burnt after harvest https://tinyurl.com/2afjhhsj To read The greenhouse gas performance and climate change mitigation potential from rice straw biogas as a pathway to the UN sustainable development goals visit https://www.sciencedirect.com/science/article/pii/S0961953424000254, Biomass and Bioenergy Volume 182, March 2024, 107072 Mirjam Röder and Patricia Thornley Energy & Bioproducts Research Institute (EBRI), College of Engineering and Physical Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, United Kingdom Craig Jamieson Straw Innovations Ltd., Lawes Open Innovation Hub, Rothamsted Research, West Common, Harpenden, HERTS, AL5 2JQ, United Kingdom https://doi.org/10.1016/j.biombioe.2024.107072 About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming The Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk
Healthy Environment, Healthy People: The Intersection Between Climate and Health
How is climate change influencing our health? Why does climate change have a greater impact on vulnerable populations and low-income people? How does the U.S. health care system affect the climate? How can health care systems improve their impact on the climate and the environment? ChristianaCare’s inaugural Climate and Health Conference addressed these topics and raised possible solutions at the John H. Ammon Medical Education Center on the Newark, Delaware, campus on April 12. At the conference, the common denominator was this: An unhealthy environment can lead to illnesses and deaths from air pollution, high heat, contaminated water and extreme weather events. Health systems, government entities, community organizations and individuals all have a role to play in decreasing these effects. “Climate, the environment and health care systems are intertwined,” said Greg O’Neill, MSN, APRN, AGCNS-BC. “We need to pay close attention to this relationship so we can improve health for everyone.” O’Neill is director of Patient & Family Health Education and co-chair of the Environmental Sustainability Caregiver Committee at ChristianaCare. Climate change and intensifying health conditions Negative health effects are so closely tied to the environments where people live, work and play that The Lancet called climate change “the greatest global health threat facing the world in the 21st century [and] the greatest opportunity to redefine the social and environmental determinants of health.” At the conference, speakers addressed specific areas of concern. Asthma. Air pollutants, while largely invisible, are associated with asthma. What’s more, people who live in urban areas with little green space are more likely to have uncontrolled asthma, said speaker Robert Ries, M.D., an emergency medicine resident at ChristianaCare. And there’s the rub, he said: When people with asthma spend time in green spaces, it may improve their health. “In Canada,” he said, “some doctors prescribe nature – two hours a week for better overall health outcomes. Could we do that here?” Heat-related illness. Temperatures worldwide have been rising, increasing the likelihood of heat-related health incidents. Heat waves may be harmful to children and older adults, particularly those who don’t have access to air conditioning, swimming pools or transportation to the beach, said speaker Alan Greenglass, M.D., a retired primary care physician. Children visit the emergency room 20% more frequently during heat waves. Weather-related illness. Climate change is causing more floods, which may result in respiratory problems due to mold growth; and droughts, which may threaten water safety and contribute to global food insecurity, said speaker Anat Feingold, M.D., MPH, an infectious disease specialist at Cooper Health. Stress and anxiety. Climate change can affect mental health, even leading to “solastalgia,” which is distress about environmental change and its effect on one’s home, said speaker Zachary Radcliff, Ph.D., an adolescent psychologist at Nemours. He encouraged clinicians in the audience to keep this mental health concern in mind when seeing patients as it may become more prevalent. Cardiovascular disease risk. Frequent consumption of red meat increases the risk of cardiovascular disease, the top cause of death in the U.S. It’s also unhealthy for the environment, said speaker Shirley Kalwaney, M.D., an internal medicine specialist at Inova. Livestock uses 80% of available farmland to produce only 17% of calories consumed, creating a high level of greenhouse gas emissions. By comparison, plant-based whole foods decrease the risk of cardiovascular disease and diabetes. They use only 16% of available farmland, producing 82% of calories consumed. This makes reducing red meat in our diets one of the most powerful ways to lower the impact on our environment. Health equity and the environment People in low-income communities are more likely to live in urban areas that experience the greatest impacts of climate change, including exposure to air pollutants and little access to green space, said speaker Abby Nerlinger, M.D., a pediatrician for Nemours. A Harvard study in 2020 demonstrated that air pollution was linked with higher death rates from COVID-19 — likely one of the many reasons the pandemic has disproportionally harmed Black and Latino communities. Similarly, access to safe, affordable housing is essential to a healthy environment, said Sarah Stowens, Ed.D., manager of State Policy and Advocacy for ChristianaCare, who advocated for legislation including the Climate Solutions Act, another bill that increased oversight regarding testing and reporting of lead poisoning and a policy to reduce waste from topical medications. Opportunities for change in health care Reduce emissions from pharmaceuticals and chemicals. These emissions are responsible for 18% of a health system’s greenhouse gas emissions. One way to reduce this number is for clinicians to prescribe a dry-powder inhaler (DPI) instead of a metered-dose inhaler (MDI) when applicable and safe for the patient and to give patients any inhalers that were used in the hospital at discharge if they are going home on the same prescription. Hospitals have opportunities to reduce greenhouse gases while caring for patients, said Deanna Benner, MSN, APRN, WHNP, women’s health nurse practitioner and co-chair of ChristianaCare’s Environmental Sustainability Caregiver Committee. The health care sector is responsible for 8.5% of U.S. greenhouse gas emissions, the highest per person in the world. U.S. greenhouse gas emissions account for 27% of the global health care footprint. One way to significantly reduce the carbon footprint is to use fewer anesthetic gases associated with greater greenhouse gas emissions, Benner said. Limit single-use medical devices. Did you know that one surgical procedure may produce more waste than a family of four produces in a week? Elizabeth Cerceo, M.D., director of climate health at Cooper Health, posed this question during her talk. Sterilizing and reusing medical devices, instead of using single-use medical devices, she said, may meaningfully reduce hospital waste. ChristianaCare’s commitment to healthy environments and healthy people As one of the nation’s leading health systems, ChristianaCare is taking a bold, comprehensive approach to environmental stewardship. ChristianaCare reduced its carbon footprint by 37% in 2023 by purchasing emission-free electricity. ChristianaCare joined the White House Climate Pledge to use 100% renewable energy by 2025, reduce greenhouse gas emissions by 50% by 2030 and achieve zero net emissions by 2050. ChristianaCare has created an Environmental, Social and Governance structure to help advance a five-year strategic plan that delivers health equity and environmental stewardship. Nearly 150 staff members have become Eco-Champions, an opportunity to be environmental change-leaders in the workplace. In 2023, ChristianaCare’s successful environmental stewardship included: Reducing our carbon footprint by 37% by purchasing emission-free electricity. Recycling 96,663 pounds of paper, which preserved 11,485 trees. Reducing air pollution by releasing an estimated 33,000 fewer pounds of nitrogen oxides and sulfur oxides through the use of a cogeneration energy plant on the Newark campus. Donating 34,095 pounds of unused food to the Sunday Breakfast Mission in Wilmington, Delaware. Donating 1,575 pounds of unused medical equipment to Project C.U.R.E., ChristianaCare’s Virtual Education and Simulation Training Center and Delaware Technical Community College. “In quality improvement, they say you improve the things that you measure,” O’Neill said in expressing goals for continued success. In looking ahead, said Benner, “I really hope that this conference is the catalyst for positive change with more people understanding how climate is connected to health, so that we can protect health from environmental harms and promote a healthy environment for all people to thrive.”
Dangerous new COVID variant could overwhelm hospitals, weaken immunity
Two new studies have found that the new COVID variant BA.2.86 could lead to more severe diseases than other Omicron variants. Jennifer Horney, one of the leading experts on the COVID-19 pandemic, can discuss the new variant and its potential impact on the healthcare system. Horney, professor and founding director of the University of Delaware's epidemiology program, made the following points: There are spikes now in all respiratory infections across the U.S. High rates of COVID-19 and seasonal infuenza especially among children and older adults could stress healthcare systems. New subvariants of COVID-19 could be severe. High hospitalization rates are occurring in countries with far higher vaccination rates in the US, perhaps due to reduced immunity. We need to continue to track new variants and focus on developing updated vaccines. Continued mutations will mean less protection from infection among those who have prior infections and vaccinations. To set up an interview, visit Horney's profile and click on the contact button.
Ask Our Expert: Why it’s important to get a flu vaccination
As cold and flu season approaches, it’s time to take proactive steps to ensure the health and well-being of everyone. Getting a flu vaccination is be the best defense in staying healthy this time of year. Klaus Ley, MD, founding co-director of the Immunology Center of Georgia, part of the Medical College of Georgia at Augusta University, emphasizes the significance of getting vaccinated against the flu. “The flu can have serious consequences and by getting vaccinated, you protect yourself and those around you,” Ley said. “It’s a simple yet effective way to prevent the spread of this contagious virus.” Flu vaccination is not only a responsible choice but also a crucial step in maintaining public health. The World Health Organization records about 1 billion cases of influenza each year. Severe cases often result in hospitalizations, contributing to up to 650,000 respiratory-related deaths globally. Worried about potential side effects from the vaccine? Ley said that’s a minor concern compared to the effects of the full-blown flu. According to the Centers for Disease Control and Prevention, life-threatening allergic reactions to flu shots are very rare. While severe reactions are uncommon, it’s important to let your health care provider know if you have a history of allergy or severe reaction to vaccines before getting a flu shot. “Common side effects from a flu shot could include soreness or swelling at the site of the injection, headache, low-grade fever, nausea, muscle aches or fatigue. Those minor side effects are an indication your immune system is responding as it should to the vaccination. You will experience much more severe fever, aches and other symptoms if you catch the flu without being vaccinated against it,” said Ley. Klaus Ley, MD, is the Georgia Research Alliance Bradley Turner Eminent Scholar in Immunology, founding co-director of the Immunology Center of Georgia, and a professor in the Department of Physiology at the Medical College of Georgia at Augusta University. He's available to speak with media regarding flu season and vaccinations - simply click on his icon now to arrange an interview today.
• Rice straw could be a fuel of the future in rural Philippines • Across Asia 300 million tonnes of rice straw go up in smoke every year • New proposals includes scaling up harvesting system with straw removal, biogas-powered rice drying and storage and efficient milling. An Aston University bioenergy researcher has been explaining how rice straw could be a fuel of the future in rural Philippines. Dr Mirjam Roeder who is based at the University’s Energy & Bioproducts Research Institute (EBRI) is collaborating with the UK company Straw Innovations Ltd, Southeast Asian Regional Center for Graduate Study and Research in Agriculture (SEARCA) and Koolmill Systems Ltd to showcase their research. The Food and Agriculture Organisation (FAO) states that rice is the number one food crop globally and 91% of it is produced and consumed in Asia. As a crop it is responsible for 48% of global crop emissions and for every kilogram of rice, a kilo of straw is produced. Across Asia 300 million tonnes of rice straw go up in smoke every year when burnt after harvest, releasing emissions and air pollutants that triple risks of increased respiratory diseases and accelerate climate change. To raise awareness of sustainable uses for rice straw Dr Roeder has travelled to the sixth International Rice Congress in Manila, Philippines to explain the potential of the emerging technology. Rice straw is an underdeveloped feedstock and can be collected and digested to produce biogas, unlocking sustainable straw management options and renewable energy for farmers using anaerobic digestion (AD) from rice straw. Dr Roeder has been working with Straw Innovations on their UK Innovate project demonstration facility in the Philippines, the Rice Straw Biogas Hub, which is scaling up a complete harvesting system with straw removal, biogas-powered rice drying and storage, together with efficient milling. Craig Jamieson, Straw Innovations said: “The International Rice Congress is only held every four years and is a key event for coordinating and tracking progress in rice research. “Our partnership with Aston University and SEARCA adds independent, scientific rigour to the work we do and amplifies our message to government policy makers. We are grateful to Innovate UK for their ongoing support through the Energy Catalyst Programme, which is accelerating our development.” At the conference Dr Roeder has been explaining how independent environmental and social research can increase farmer incomes, equality of opportunity, food security and decarbonisation benefits. She said: “Engaging with stakeholders and working in partnership across organisations is vital to the successful adoption of new technologies. I am delighted to have had the opportunity to host an event with our project partners at this prestigious conference, bringing the cutting-edge research of using rice straw for clean energy to the forefront of the rice research community and supporting the pathway to net zero.” Dr Glenn B Gregorio, Center Director of SEARCA, added: "We are gaining insights into the environmental impact of rice straw utilisation and implementing policies to unleash its potential to empower us to make informed decisions that are instrumental to climate change mitigation and decarbonisation," Professor Rex Demafelis, University of the Philippines, is also working with SEARCA and is leading the project on life cycle analyses and measurements of rice straw greenhouse gas emissions. He said: “Rice straw is a valuable resource, and we are grateful to be part of this team which seeks to harness its full potential and promote circularity, which would ultimately contribute to our goal of reducing our greenhouse gas emissions.” ENDS The Supergen Bioenergy Hub works with academia, industry, government and societal stakeholders to develop sustainable bioenergy systems that support the UK’s transition to an affordable, resilient, low-carbon energy future. The Hub is funded jointly by the Engineering and Physical Sciences Research Council (EPSRC) and the Biotechnology and Biological Sciences Research Council (BBSRC) and is part of the wider Supergen Programme. For further information contact Rebecca Fothergill and Catriona Heaton supergen-bioenergy@aston.ac.uk Follow us on Twitter @SuperBioHub Visit our website at supergen-bioenergy.net Visit our YouTube Channel to watch the video on Carbon Balance FAO: RICE PRODUCTION IN THE ASIA-PACIFIC REGION: ISSUES AND PERSPECTIVES - M.K. Papademetriou* (fao.org) https://www.fao.org/3/x6905e/x6905e04.htm About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming The Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk