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LSU Launches Louisiana’s Most Advanced Microscope at Research Core Facility
LSU’s Advanced Microscopy and Analytical Core (AMAC) facility gives Louisiana researchers access to 16 state-of-the-art instruments, including a new Spectra 300 Scanning Transmission Electron Microscope (S/TEM) for atomic-scale imaging and analysis. The new microscope—the most advanced in Louisiana—was installed with $10 million in support from the U.S. Army. Standing almost 13 feet tall on a platform isolated from vibration, the S/TEM required major renovations, including a raised ceiling, acoustic wall panels, and a magnetic field cancellation system to ensure the instrument’s stability and performance. The microscope offers magnification up to 10 million times, powerful enough to enlarge a single grain of Mississippi River silt to the size of Tiger Stadium. “This is a transformational moment for LSU and for the future of research in Louisiana,” Interim LSU President Matt Lee said. “With the installation of the most advanced microscope in the state, LSU is once again demonstrating how we’re delivering on our promises—leading in research, innovation, and service to the state and nation.” The launch of the AMAC and S/TEM demonstrates LSU’s increased investment in providing its faculty and partners with the best possible equipment for research and discovery, including for national defense, energy, and health. “Winning in research is no different than winning in athletics—the best facilities attract the best talent, and you need the best of both to win,” LSU Vice President of Research and Economic Development Robert Twilley said. “Today’s launch is about a state-of-the-art microscope but also the launch of the AMAC as our first research core facility at LSU—the first of more to come to attract, train, and supply the best research talent for Louisiana and build research teams that win.” Using a finely focused electron beam and techniques such as energy dispersive X-ray spectroscopy (EDS) and electron energy loss spectroscopy (EELS), the S/TEM can reveal both structure and chemistry at atomic resolution. These capabilities drive advances in materials science—improving semiconductors, solar cells, batteries, catalysts, coatings, and alloys—while supporting biomedical research by mapping drug delivery, uncovering the structures of viruses and bacteria, and improving medical implant design. LSU’s AMAC research core facility was recently rebranded, changing its name from the Shared Instruments Facility (SIF). Learn more about how AMAC instruments help unlock millions in federal research funding to Louisiana and deliver solutions.
First scientific paper on 3I/ATLAS interstellar object
When the news started to spread on July 1, 2025, about a new object that was spotted from outside our solar system, only the third of its kind ever known, astronomers at Michigan State University — along with a team of international researchers — turned their telescopes to capture data on the new celestial sighting. The team rushed to write a scientific paper on what they know so far about the object, now called 3I/ATLAS, after NASA’s Asteroid Terrestrial-impact Last Alert System, or ATLAS. ATLAS consists of four telescopes — two in Hawaii, one in Chile and one in South Africa — which automatically scans the whole sky several times every night looking for moving objects. MSU’s Darryl Seligman, a member of the scientific team and an assistant professor in the College of Natural Science, took the lead on writing the paper. “I heard something about the object before I went to bed, but we didn’t have a lot of information yet,” Seligman said. “By the time I woke up around 1 a.m., my colleagues, Marco Micheli from the European Space Agency and Davide Farnocchia from NASA’s Jet Propulsion Laboratory, were emailing me that this was likely for real. I started sending messages telling everyone to turn their telescopes to look at this object and started writing the paper to document what we know to date. We have data coming in from across the globe about this object.” The discovery Larry Denneau, a member of the ATLAS team reviewed and submitted the observations from the European Southern Observatory's Very Large Telescope in Chile shortly after it was observed on the night of July 1. Denneau said that he was cautiously excited. “We have had false alarms in the past about interesting objects, so we know not to get too excited on the first day. But the incoming observations were all consistent, and late that night it looked like we had the real thing. “It is especially gratifying that we found it in the Milky Way in the direction of the galactic center, which is a very challenging place to survey for asteroids because of all the stars in the background,” Denneau said. “Most other surveys don't look there.” John Tonry, another member of ATLAS and professor at the University of Hawaii, was instrumental in design and construction of ATLAS, the survey that discovered 3I. Tonry said, “It's really gratifying every time our hard work surveying the sky discovers something new, and this comet that has been traveling for millions of years from another star system is particularly interesting.” Once 3I/ATLAS was confirmed, Seligman and Karen Meech, faculty chair for the Institute for Astronomy at the University of Hawaii, both managed the communications flow and worked on getting the data pulled together for submitting the paper. “Once 3I/ATLAS was identified as likely interstellar, we mobilized rapidly,” Meech said. “We activated observing time on major facilities like the Southern Astrophysical Research Telescope and the Gemini Observatory to capture early, high-quality data and build a foundation for detailed follow-up studies.” After confirmation of the interstellar object, institutions from around the world began sharing information about 3I/ATLAS with Seligman. What scientists know about 3I/ATLAS so far Though data is pouring in about the discovery, it’s still so far away from Earth, which leaves many unanswered questions. Here’s what the scientific team knows at this point: It is only the third interstellar (meaning from outside our solar system) object to be detected passing through our solar system. It’s potentially giving off gas like other comets do, but that needs to be confirmed. It’s moving really fast at 60 kilometers per second, or 134,000 miles per hour, relative to the sun. It’s on an orbital path that is shaped like a boomerang or hyperbola. It’s very bright. It’s on a path that will leave our solar system and not return, but scientists will be able to study it for several months before it leaves. The James Webb Space Telescope and the Hubble Space Telescope are expected to reveal more information about its size, composition, spin and how it reacts to being heated over the next few months. “We have these images of 3I/ATLAS where it’s not entirely clear and it looks fuzzier than the other stars in the same image,” said James Wray, a professor at Georgia Tech. “But the object is pretty far away and, so, we just don’t know.” Seligman and his team are specifically interested in 3I/ATLAS’s brightness because it informs us about the evolution of the coma, a cloud of dust and gas. They’ve been tracking it to see if it has been changing over time as the object moves and turns in space. They also want to monitor for sudden outburst events in which the object gets much brighter. “3I/ATLAS likely contains ices, especially below the surface, and those ices may start to activate as it nears the sun,” Seligman said. “But until we detect specific gas emissions, like H₂O, CO or CO₂, we can’t say for sure what kinds of ice or how much are there.” The discovery of 3I/ATLAS is just the beginning. For Tessa Frincke, who came to MSU in late June to begin her career as a doctoral student with Seligman, having the opportunity to analyze data from 3I/ATLAS to predict its future path could lead to her publishing a scientific paper of her own. “I’ve had to learn a lot quickly, and I was shocked at how many people were involved,” said Frincke. “Discoveries like this have a domino effect that inspires novel engineering and mission planning.” For Atsuhiro Yaginuma, a fourth-year undergraduate student on Seligman’s team, this discovery has inspired him to apply his current research to see if it is possible to launch a spacecraft from Earth to get it within hundreds of miles or kilometers to 3I/ATLAS to capture some images and learn more about the object. “The closest approach to Earth will be in December,” said Yaginuma. “It would require a lot of fuel and a lot of rapid mobilization from people here on Earth. But getting close to an interstellar object could be a once-in-a-lifetime opportunity.” “We can’t continue to do this research and experiment with new ideas from Frincke and Yaginuma without federal funding,” said Seligman, who also is a postdoctoral fellow of the National Science Foundation. Seligman and Aster Taylor, who is a former student of Seligman’s and now a doctoral candidate in astronomy and astrophysics and a 2023 Fannie and John Hertz Foundation Fellow, wrote the following: “At a critical moment, given the current congressional discussions on science funding, 3I/ATLAS also reminds us of the broader impact of astronomical research. An example like 3I is particularly important to astronomy — as a science, we are supported almost entirely by government and philanthropic funding. The fact that this science is not funded by commercial enterprise indicates that our field does not provide a financial return on investment, but instead responds to the public’s curiosity about the deep questions of the universe: Where did we come from? Are we alone? What else is out there? The curiosity of the public, as expressed by the will of the U.S. Congress and made manifest in the federal budget, is the reason that astronomy exists.” In addition to MSU, contributors to this research and paper include European Space Agency Near-Earth Objects Coordination Centre (Italy), NASA Jet Propulsion Laboratory/Caltech (USA), University of Hawaii (USA), Auburn University (USA), Universidad de Alicante (Spain), Universitat de Barcelona (Spain), European Southern Observatory (Germany), Villanova University (USA), Lowell Observatory (USA), University of Maryland (USA), Las Cumbres Observatory (USA), University of Belgrade (Serbia), Politecnico di Milano (Italy), University of Michigan (USA), University of Western Ontario (Canada), Georgia Institute of Technology (USA), Universidad Diego Portales, Santiago (Chile) and Boston University (USA).
Georgia Southern University’s Allen E. Paulson College of Engineering and Computing and College of Education are teaming up to bring the latest innovative research on renewable energy to STEM educators and their classrooms across Georgia. That’s all thanks to a $600,000 grant from the National Science Foundation to establish the Engaging Educators in Renewable Energy (ENERGY) program. The funds will support a three-year-long initiative that will bring Valentin Soloiu, Ph.D.’s energy research into high school and technical college classrooms. Soloiu and engineering graduate students from Georgia Southern will conduct research related to renewable energy, reducing greenhouse gas emissions, and mitigating climate change, covering topics like renewable and alternative energy (solar and wind), climate change, enhanced energy technologies and the development of sensors and controls for energy applications and smart grids. Soloiu, the Allen E. Paulson Distinguished Chair of Renewable Energy, will be joined by mechanical engineering professor Mosfequr Rahman, Ph.D. and Elise Cain, Ph.D., director of the Educational Leadership Program in the College of Education, in developing the program. “The core requirement is to conduct state-of-the-art, transformative research in science and engineering,” explained Soloiu. “After that is complete, we bring high school and technical college teachers in to translate this research into classroom-ready modules.” Teachers will be selected from a large pool of statewide applicants to work alongside faculty and graduate students from the College of Engineering and Computing. They’ll also receive funds to incorporate that research into their curriculum. Soloiu will oversee the program as the principal investigator, with Cain serving as the education lead, bringing a multidisciplinary approach to the program. “I think interdisciplinary collaborations are vital in academic work,” noted Cain. “Faculty from the Allen E. Paulson College of Engineering and Computing contribute their technical knowledge and skills related to renewable energy, while I bring my College of Education perspectives on educational contexts and pedagogy. Working together allows us to create a robust program with immediate and lasting impacts.” Educators will visit local companies and interact with leaders in renewable energy, such as Gulfstream Aerospace in Savannah, Georgia, and Rolls-Royce Power Systems in Aiken, South Carolina. These experiences are designed to help teachers share career opportunities with students they might not otherwise encounter. “This program reflects the essence of our institutional mission,” said Cain. “It’s about discovery, teaching, and community engagement—all grounded in excellence and innovation.” Soloiu echoed those sentiments. “Many teachers and students in rural areas don’t even know what we do here at Georgia Southern,” explained Soloiu. “By engaging with educators directly, we’re creating awareness, inspiration, and pipelines to higher education and high-tech careers. This is reflective of the University’s dedication to our communities as we move towards R1 status.” Looking to know more about this important research happening at Georgia Southern - Valentin Soloiu is available to speak with media. Simply click on his icon now to arrange an interview today.
If the first few frames are any indicator of a blockbuster movie, hold the 2035 Best Picture Oscar for the Vera C. Rubin Observatory and its ambitious new 10-year project. On June 23, 2025, scientists at the state-of-the-art facility in the mountains of north-central Chile gave the public its first glimpses into the capabilities of its 8.4-meter Simonyi Survey Telescope, equipped with the world’s largest digital camera—a 3.2 megapixel, 6,600-pound behemoth that can photograph the whole southern sky every few nights. Its task is a decade-long lapse record-called the Legacy Survey of Space and Time (LSST). The first shots on that journey have left both the general public and astronomical community in awe, revealing in rich detail a mind-boggling number of galaxies, stars, asteroids and other celestial bodies. “The amount of sky it covers, even in just one image, is unprecedented,” said David Chuss, PhD, chair of the Department of Physics, who viewed the first images with colleagues at an organized watch party. “It’s such high-precision, beautiful detail,” added Kelly Hambleton Prša, PhD, associate professor of Astrophysics and Planetary Sciences. “It’s just mind-blowing.” What Makes Rubin and LSST So Unique? Simply, this revolutionary instrument, embarking on an equally revolutionary initiative, will observe half the sky to a greater depth and clarity than any instrument ever has before. Consider this: "The Cosmic Treasure Chest” image released by Rubin contains 1,185 individual exposures, taken over seven nights. Each one of those individual exposures covers 10 square degrees of night sky, which is about the same as looking up at 45 full moons positioned around one another. It may seem like a small size, but click the image yourself, and zoom in and out. The amount of sky captured in that range—enough to show roughly 10 million galaxies—is astounding. Per the Observatory, “it is the only astronomical tool in existence that can assemble an image this wide and deep so quickly.” “At the end of 10 years, Rubin will have observed 20 billion galaxies, and each night in that time frame it will generate 20 terabytes of data,” Dr. Hambleton Prša said. “And, because Rubin has so many different filters, we get to see the same objects in so many different ways.” According to Dr. Hambleton Prša and Dr. Chuss, the power and precision of the Rubin LSST, combined with the shear area of the sky that will be observed, will allow for an incredibly in-depth study of myriad objects, processes and events in ways nobody has ever studied them before. “For example, in our galaxy, we expect to observe only two supernovae per century,” Dr. Hambleton Prša said. “But we're observing 20 billion galaxies. For someone studying this phenomenon, the number of supernovae that they’re going to observe will be off the charts. It is an exquisite survey.” It will also provide insight into the universe’s oldest and most puzzling enigmas. “Rubin is able to look back into our universe at times when it was much smaller during its expansion and really address some of these incredible mysteries out there, like dark energy,” Dr. Chuss said. “We know the universe is expanding and that this expansion is accelerating. Rubin will trace the history of that acceleration and, from that, provide insight into the physics of the mysterious dark energy that appears to be driving it.” To enhance the technological capabilities of its instrument, scientists were invited to contribute towards the selection of the observing strategy of the telescope. The Rubin team took into consideration continual input from the astrophysics community, separated into what they call “science collaborations.” To achieve this, the Rubin team generated proposed simulations for collecting observations, which the science collaborations then assessed for their specific science goals. “The Rubin team then iterated with the science collaborations, taking into account feedback, to ultimately obtain the best strategy for the largest number of science cases,” Dr. Hambleton Prša said. Dr. Hambleton Prša is the primary contact for the Pulsating Star Subgroup, which is part of the Transients and Variable Stars Science Collaboration, the science collaboration that focuses on objects in the sky that change with time. She was the lead author among 70 co-authors on the roadmap for this science collaboration, underscoring the significant scale of community participation for each of these areas. Joined Under One Sky Dr. Hambleton Prša, Dr. Chuss and other members of the Astrophysics and Planetary Sciences Department and Department of Physics at Villanova have a vested interest in Rubin and the LSST project. In April, the two departments joined forces to launch The Villanova One Sky Center for Astrophysics, co-directed by the two faculty members. With goals to elevate the University's longstanding record of research eminence in astronomy and astrophysics and create opportunities for more students to access the disciplines, the Center partnered with the Rubin Observatory to help realize the mission. Both Villanova and Rubin share a similar vision on expanding access to this broad field of study. Fortuitously, the launch of The Villanova One Sky Center coincided with the initial data released from Rubin. What will result, Dr. Chuss says, will be a “truly awesome impact on both our Center and institution.” Dr. Hambleton Prša will advance her own research of pulsating stars, and Andrej Prša, PhD, professor of Astrophysics and Planetary Science and the primary contact for the Binary Star Subgroup, will broaden his study of short-period binary stars. Joey Neilsen, PhD, associate professor of Physics, will expand his research in black hole astrophysics. Becka Phillipson, PhD, an assistant professor of Physics, who recently led a proposal for Villanova to join the Rubin LSST Discovery Alliance, aims to increase the scope of her study of chaotic variability of compact objects. Dr. Chuss, who generally works on infrared and microwave polarimetry, which is “outside the wavelength ranges of Rubin” is interested in its complementarity with other observations, such as those of the cosmic microwave background—the oldest light in the universe—and the evolution of the large-scale structure of the universe. Subjects, he says, which are “exactly in the wheelhouse for Rubin.” Other faculty members are interested in topics such as how Rubin’s observations may change the knowledge of both the history and structure of our solar system and the population of Milky Way satellite galaxies. That is not to mention, Dr. Hambleton Prša points out, the daily 20 terabytes of data that will become available for students and postdoctoral researchers under their tutelage, who will be heavily involved in its analysis for their own projects and ideas. “This partnership is going to greatly increase our opportunities and elevate our profile,” Dr. Chuss said. “It will make our program even more attractive for faculty, postdocs and students to come and to share their knowledge and expertise. “Together, we will all have access to an incredible movie of this epoch of our universe, and the knowledge and surprises that come with it along the way.”
LSU’s Jill Trepanier Educating K-12 Louisiana Students About the Environment
What began in 2018 as a single rooftop weather station on LSU’s campus as a tool to help freshmen connect to the science happening around them, has grown into an educational network in the southern part of the state, connecting K-12 students with the sky through real-time data, interactive technology, and hands-on learning. Trepanier, a professor and department chair in LSU’s Department of Geography & Anthropology, leads a project that now includes 10 weather stations installed at or near K–12 schools from Lake Charles to Grand Isle. “The environment is harsh in Louisiana. Beautiful, but harsh,” Trepanier said. “The more students know about it, the better they can protect themselves and their families. For me, that’s what it is all about.” The project all started to help college students in Trepanier’s meteorology and physical geography classes connect more deeply with the material by using weather data collected from the air around them. “These were 400 freshmen every semester who were not geography majors, so they didn't really love the science of the atmosphere. But they were able to connect with the information because they could see the data on an app on their phone as they were living in it.” Installed across South Louisiana, each weather station is solar-powered and connected to a console that uploads data to an online web platform and displays it on a dashboard. Then an app shows the local students the current conditions and records for the day. “When we look at data from the community, it might be many miles from where you are. And most people live within a few miles or less of their schools. It allows them a close-up view of what is happening, instead of relying on something miles away,” she said. Teachers can use the data with certain lessons or during a passing storm. But the available data also educates them on things like solar radiation, “It also helps aid things like seasonality and our relationship with the sun. It extends well beyond just rain.” The material is also aligned with the Louisiana Student Science Standards for environmental and Earth sciences. “By allowing students to compare real data across space and time, it helps them to understand how systems are connected. And most of these science standards have them focusing on system theory, in one way or another,” Trepanier said. Read the full story here.
BATON ROUGE – Since the Big Bang, the early universe had hydrogen, helium, and a scant amount of lithium. Later, some heavier elements, including iron, were forged in stars. But one of the biggest mysteries in astrophysics is: How did the first elements heavier than iron, such as gold, get created and distributed throughout the universe? A new answer has come from an unexpected place – magnetars. Neutron stars are the collapsed cores of stars that have exploded. They are so dense that one teaspoon of neutron star material, on Earth, would weigh as much as a billion tons. A magnetar is a neutron star with an extremely powerful magnetic field. On rare occasions, magnetars release an enormous amount of high-energy radiation when they undergo “starquakes,” which, like earthquakes, fracture the neutron star’s crust. Starquakes may also be associated with powerful bursts of radiation called magnetar giant flares, which can even affect Earth’s atmosphere. Only three magnetar giant flares have been observed in the Milky Way and the nearby Large Magellanic Cloud, and seven from other nearby galaxies. Astrophysicist Eric Burns and his team of researchers at Louisiana State University in Baton Rouge study magnetars extensively through the observation of gamma-rays. These are the most energetic photons, most famous for turning Bruce Banner into the Incredible Hulk. Burns joined with researchers at Columbia University and other institutions to see if we could use gamma-rays to understand if magnetar giant flares forge the heaviest elements, and unexpectedly found the smoking-gun signature in decades-old data. The study, led by Anirudh Patel, a doctoral student at Columbia University in New York, is published in The Astrophysical Journal Letters. “It’s answering one of the questions of the century and solving a mystery using archival data that people had just forgotten about, demonstrating something that occurred when the Universe was younger,” said Burns. “Giant flares should occur just after the first stars died, meaning we have identified what could be the origin of the first gold in the universe.” How could gold be made at a magnetar? Patel and colleagues, including his advisor Brian Metzger, Professor at Columbia University and senior research scientist at the Flatiron Institute in New York, have been thinking about how radiation from giant flares could correspond to heavy elements forming there. This would happen through a “rapid process” of neutrons forging lighter atomic nuclei into heavier ones. Protons define the element’s identity on the periodic table: hydrogen has 1 proton, helium has 2, lithium has 3, and so on. Atoms also have neutrons which do not affect identity, but do add mass. Sometimes when an atom captures an extra neutron the atom becomes unstable and a nuclear decay process happens that converts a neutron into a proton, moving the atom forward on the periodic table. This is how, for example, a gold atom could take on an extra neutron and then transform into mercury. In the unique environment of a disrupted neutron star, in which the density of neutrons is extremely high, something even stranger happens: single atoms can rapidly capture so many neutrons that they undergo multiple decays, leading to the creation of a much heavier element like uranium. When astronomers observed the collision of two neutron stars in 2017 using NASA telescopes and the gravitational wave observatory LIGO, they confirmed that this event could have created gold, platinum, and other heavy elements. “LIGO tells us there was a merger of compact objects, and Fermi tells us there was a short gamma-ray burst. Together, we know that what we observed was the merging of two neutron stars, dramatically confirming the relationship,” said Burns. But neutron star mergers happen too late in the universe’s history to explain the earliest gold and other heavy elements. Finding secrets in old data At first, Metzger and colleagues thought that the easiest signature to study from the creation and distribution of heavy elements at a magnetar would appear in the visible and ultraviolet light, and published their predictions. But Burns in Louisiana wondered if there could be a gamma ray signal bright enough to be detected, too. He asked Metzger and Patel to work out what that signal could look like. Burns looked up the gamma ray data from the last giant flare that was observed, which was in December 2004. He realized that while scientists had explained the beginning of the outburst, they had also identified a smaller signal from the magnetar, in data from ESA (European Space Agency)’s INTEGRAL, a retired mission with NASA contributions. “It was noted at the time, but nobody had any conception of what it could be,” Burns said. Metzger remembers that Burns thought he and Patel were “pulling his leg” because the prediction from their team’s model so closely matched the mystery signal in the 2004 data. In other words, the gamma ray signal detected over 20 years ago corresponded to what thought it should look like when heavy elements are created and then distributed in a magnetar giant flare. "This is my favorite discovery I've contributed to,” said Burns. “My colleagues found this signal in the past, but nobody knew what it could be at the time. Once these models were ready, everything fit like a perfect puzzle, which is extremely rare in science." Researchers supported their conclusion using data from two NASA heliophysics missions: the retired RHESSI (Reuven Ramaty High Energy Solar Spectroscopic Imager) and the ongoing NASA Wind satellite, which had also observed the magnetar giant flare. Other collaborators on the new study included Jared Goldberg at the Flatiron Institute. Next steps in the magnetar gold rush Patel’s study estimates that magnetar giant flares could contribute about 10% of the total abundance of elements heavier than iron in the galaxy. Since magnetars existed relatively early in the history of the universe, the first gold could have been created this way. LSU PhD candidate Aaron Trigg, a NASA FINESST (Future Investigators in NASA Earth and Space Science and Technology) fellow, who works with Burns, is responsible for finding more magnetar giant flares to study. “These are gargantuan outbursts of energy from the strongest magnets in the Universe, which are powerful enough to affect Earth’s atmosphere,” said Burns. Trigg’s work will help us better understand these sources.” NASA’s forthcoming COSI (Compton Spectrometer and Imager) mission can follow up on these results. COSI, a wide-field gamma ray telescope, is expected to launch in 2027 and will study energetic phenomena in the cosmos, such as magnetar giant flares. COSI will be able to identify individual elements created in these events, providing a new advancement in understanding the origin of the elements. LSU is one of the lead science institutes for COSI. Burns and LSU Assistant Professor Michela Negro have key responsibilities in the mission, and Trigg is working through how best to study giant flares with COSI. These LSU astrophysicists will be growing their research group as they approach launch in 2027. “I have so many questions about the cosmos and our place in it,” said Trigg. “This research allows me to explore those questions and share the answers with the world.”
Chemical and Life Science Engineering Professor Michael “Pete” Peters, Ph.D., is investigating more efficient ways to manufacture biologic pharmaceuticals using a radial flow bioreactor he developed. With applications in vaccines and other personalized therapeutic treatments, biologics are versatile. Their genetic base can be manipulated to create a variety of effects from fighting infections by stimulating an immune response to weight loss by producing a specific hormone in the body. Ozempic, Wegovy and Victoza are some of the brand names for Glucagon-Like Peptide-1 (GLP-1) receptor agonists used to treat diabetes. These drugs mimic the GLP-1 peptide, a hormone naturally produced in the body that regulates appetite, hunger and blood sugar. “I have a lot of experience with helical peptides like GLP-1 from my work with COVID therapeutics,” says Peters. “When it was discovered that these biologic pharmaceuticals can help with weight loss, demand spiked. These drug types were designed for people with type-2 diabetes and those diabetic patients couldn’t get their GLP-1 treatments. We wanted to find a way for manufacturers to scale up production to meet demand, especially now that further study of GLP-1 has revealed other applications for the drug, like smoking cessation.” Continuous Manufacturing of Biologic Pharmaceuticals Pharmaceuticals come in two basic forms: small-molecule and biologic. Small-molecule medicines are synthetically produced via chemical reactions while biologics are produced from microorganisms. Both types of medications are traditionally produced in a batch process, where base materials are fed into a staged system that produces “batches” of the small-molecule or biologic medication. This process is similar to a chef baking a single cake. Once these materials are exhausted, the batch is complete and the entire system needs to be reset before the next batch begins. “ The batch process can be cumbersome,” says Peters. “Shutting the whole process down and starting it up costs time and money. And if you want a second batch, you have to go through the entire process again after sterilization. Scaling the manufacturing process up is another problem because doubling the system size doesn’t equate to doubling the product. In engineering, that’s called nonlinear phenomena.” Continuous manufacturing improves efficiency and scalability by creating a system where production is ongoing over time rather than staged. These manufacturing techniques can lead to “end-to-end” continuous manufacturing, which is ideal for producing high-demand biologic pharmaceuticals like Ozempic, Wegovy and Victoza. Virginia Commonwealth University’s Medicines for All Institute is also focused on these production innovations. Peters’ continuous manufacturing system for biologics is called a radial flow bioreactor. A disk containing the microorganisms used for production sits on a fixture with a tube coming up through the center of the disk. As the transport fluid comes up the tube, the laminar flow created by its exiting the tube spreads it evenly and continuously over the disk. The interaction between the transport medium coming up the tube and the microorganisms on the disk creates the biological pharmaceutical, which is then taken away by the flow of the transport medium for continuous collection. Flowing the transport medium liquid over a disc coated with biologic-producing microorganisms allows the radial flow bioreactor to continuously produce biologic pharmaceuticals. “There are many advantages to a radial flow bioreactor,” says Peters. “It takes minutes to switch out the disk with the biologic-producing microorganisms. While continuously producing your biologic pharmaceutical, a manufacturer could have another disk in an incubator. Once the microorganisms in the incubator have grown to completely cover the disk, flow of the transport medium liquid to the radial flow bioreactor is shut off. The disk is replaced and then the transport medium flow resumes. That’s minutes for a production changeover instead of the many hours it takes to reset a system in the batch flow process.” The Building Blocks of Biologic Pharmaceuticals Biologic pharmaceuticals are natural molecules created by genetically manipulating microorganisms, like bacteria or mammalian cells. The technology involves designing and inserting a DNA plasmid that carries genetic instructions to the cells. This genetic code is a nucleotide sequence used by the cell to create proteins capable of performing a diverse range of functions within the body. Like musical notes, each nucleotide represents specific genetic information. The arrangement of these sequences, like notes in a song, changes what the cell is instructed to do. In the same way notes can be arranged to create different musical compositions, nucleotide sequences can completely alter a cell’s behavior. Microorganisms transcribe the inserted DNA into a much smaller, mRNA coded molecule. Then the mRNA molecule has its nucleotide code translated into a chain of amino acids, forming a polypeptide that eventually folds into a protein that can act within the body. “One of the disadvantages of biologic design is the wide range of molecular conformations biological molecules can adopt,” says Peters. “Small-molecule medications, on the other hand, are typically more rigid, but difficult to design via first-principle engineering methods. A lot of my focus has been on helical peptides, like GLP-1, that are a programmable biologic pharmaceutical designed from first principles and have the stability of a small-molecule.” The stability Peters describes comes from the helical peptide’s structure, an alpha helix where the amino acid chain coils into a spiral that twists clockwise. Hydrogen bonds that occur between the peptide’s backbone creates a repeating pattern that pulls the helix tightly together to resist conformational changes. “It’s why we used it in our COVID therapeutic and makes it an excellent candidate for GLP-1 continuous production because of its relative stability,” says Peters. Programming The Cell Chemical and Life Science Engineering Assistant Professor Leah Spangler, Ph.D., is an expert at instructing cells to make specific things. Her material science background employs proteins to build or manipulate products not found in nature, like purifying rare-earth elements for use in electronics. “My lab’s function is to make proteins every day,” says Spangler. “The kind of proteins we make depends entirely on the project they are for. More specifically I use proteins to make things that don’t occur in nature. The reason proteins don’t build things like solar cells or the quantum dots used in LCD TVs is because nature is not going to evolve a solar cell or a display surface. Nature doesn’t know what either of those things are. However, proteins can be instructed to build these items, if we code them to.” Spangler is collaborating with Peters in the development of his radial flow bioreactor, specifically to engineer a microorganismal bacteria cell capable of continuously producing biologic pharmaceuticals. “We build proteins by leveraging bacteria to make them for us,” says Spangler. “It’s a well known technology. For this project, we’re hypothesizing that Escherichia coli (E. coli) can be modified to make GLP-1. Personally, I like working with E. coli because it’s a simple bacteria that has been thoroughly studied, so there’s lots of tools available for working with it compared to other cell types.” Development of the process and technique to use E. coli with the radial flow bioreactor is ongoing. “Working with Dr. Spangler has been a game changer for me,” says Peters. “She came to the College of Engineering with a background in protein engineering and an expertise with bacteria. Most of my work was in mammalian cells, so it’s been a great collaboration. We’ve been able to work together and develop this bioreactor to produce GLP-1.” Other Radial Flow Bioreactor Applications Similar to how the GLP-1 peptide has found applications beyond diabetes treatment, the radial flow bioreactor can also be used in different roles. Peters is currently exploring the reactor’s viability for harnessing solar energy. “One of the things we’ve done with the internal disc is to use it as a solar panel,” says Peters. “The disk can be a black body that absorbs light and gets warm. If you run water through the system, water also absorbs the radiation’s energy. The radial flow pattern automatically optimizes energy driving forces with fluid residence time. That makes for a very effective solar heating system. This heating system is a simple proof of concept. Our next step is to determine a method that harnesses solar radiation to create electricity in a continuous manner.” The radial flow bioreactor can also be implemented for environmental cleanup. With a disk tailored for water filtration, desalination or bioremediation, untreated water can be pushed through the system until it reaches a satisfactory level of purification. “The continuous bioreactor design is based on first principles of engineering that our students are learning through their undergraduate education,” says Peters. “The nonlinear scaling laws and performance predictions are fundamentally based. In this day of continued emphasis on empirical AI algorithms, the diminishing understanding of fundamental physics, chemistry, biology and mathematics that underlie engineering principles is a challenge. It’s important we not let first-principles and fundamental understanding be degraded from our educational mission, and projects like the radial flow bioreactor help students see these important fundamentals in action.”
Executive Order - Energy and Power Perspective
The tariffs imposed by the Executive Order (EO) are expected to significantly impact the energy and infrastructure sectors. New build energy projects in the United States heavily depend on importing components such as inverters, transformers, cabling, solar panels, mounting racks, and batteries from regions such as Southeast Asia, China, and the European Union. These tariffs are likely to affect all energy and infrastructure projects. We are seeing large capital projects across the United States impose caveats within their EPC contracts; allowing for steep and continual price adjustments upward. This is impacting billions of dollars of critical material and contractual obligated componentry. This also includes all materials with high volatility (steel, copper, aluminum). Not only are projects costs on the rise but so are supply chain disruptions, potentially causing delays in project timelines and/or project cancellations. The United States continues to grow in energy demand requirements, provided the vast deployment of data centers. Because of this grid reliability, modernization and new build implementation is critical in the coming decade. The tariffs are likely to have a large impact on these projects as well, given their requirement for componentry from all the regions impacted. As this situation continues to develop, the full implications and responses for the energy and infrastructure industry will become more apparent. Jeremy Erndt is a seasoned power development, engineering, and operations professional, with experience in power generation, infrastructure, and the sector with J.S. Held. He has led utility-scale power, transmission, port, and water projects from early development and conceptual design through NTP and eventual operation. He is an international development expert and supports a variety of programs for capital project development. Jeremy is a subject matter expert in project due diligence, engineering, and constructability for large-scale projects. Jeremy has been involved in various project-related and company mergers and acquisitions, thus providing a comprehensive track record and perspective of financial transactions at all stages. He has nearly two decades of experience in the development, engineering, construction, and operations of energy and infrastructure projects, spanning more than 30 GW within energy projects and over $60B of capital expenditures within infrastructure. Looking to know more or connect with Jeremy Erndt? Simply click on the expert's icon now to arrange an interview today. For any other media inquiries - contact : Kristi L. Stathis, J.S. Held +1 786 833 4864 Kristi.Stathis@JSHeld.com
Weird and complex life emerged on Earth as the planet's magnetic field gave way
The Earth’s magnetic field plays a key role in making the planet habitable. It shields lifeforms from harmful solar and cosmic radiation. It helps limit erosion of the atmosphere and keeps water from escaping into space. But new data show a prolonged near collapse of Earth’s magnetic field that took place some 575-565 million years ago coincided with the blossoming of macroscopic complex animal life. We now face the possibility of a new, unexpected twist in how life might relate to the magnetic field, says John A. Tarduno, the William R. Kenan Professor of Geophysics and the dean of research at the School of Arts and Sciences and the Hajim School of Engineering and Applied Sciences at the University of Rochester. “That twist could reach deep into Earth’s inner core,” says Tarduno, who recently wrote about the findings for Physics Today magazine. Tarduno is frequently cited by news outlets, like CNN, The Washington Post, and Smithsonian magazine, on matters related to the Earth’s inner core, or dynamo, and magnetic field. He can be reached at john.tarduno@rochester.edu.
'Chemtrails' and other climate conspiracies: Florida Tech's expert sets the record straight
When Florida Today columnist Tim Walters wanted to 'clear the air' about a popular conspiracy theory, he connected with Michael Splitt, an assistant professor at Florida Institute of Technology's College of Aeronautics with a focus on meteorology. The "chemtrail" conspiracy follows the erroneous belief that condensation trails (contrails) that trail behind jets are actually being used on a large scale to manage radiation and combat global warming. In the column, Splitt argued against the conspiracy by explaining what might happen if that level of "climate engineering" was actually going on. I recently wrote a column about the “chemtrail” conspiracy theory, and to say it caused quite a stir would be a serious understatement. My motivation for writing the piece came because there is a bill being looked at by the Florida legislature to address concerns of people who think the skies are being seeded by commercial airplanes with poisonous, weather-manipulating substances. Some of those raising concerns claim there are vague amorphous operatives in the federal government leading this charge. I decided I’d try to find answers, and I did so by asking someone credible in the field of weather sciences. Answers from climate expert Can the climate be altered by humans? The idea of trying to manipulate weather is called “climate engineering.” There is a form of this called solar geoengineering. “We've been doing things like this for decades in terms of, for example, fog management products. People have used this kind of methodology of adding things to the air to help get rid of fog, like the ice fog problem in Salt Lake City. So, there are places where people try to manage a local cloud layer,” Splitt said. However, it’s not done to a scale that would impact the country or globe. That’s where conspiracy theorists take climate engineering a step too far. There are those who say commercial airliners are spraying other substances like aluminum and barium (and other metallic) nano particles to reflect the sun's heat to reduce global warming. Splitt said if this were real, it might have the opposite effect. “When you have more contrails, it actually ends up warming the planet. The cirrus clouds created by aircraft and their reflective power isn't as much as let's say, the warming impact from below, from infrared radiation, so they end up being warmer." March 20 - Florida Today In the full column, Splitt also takes on other common misconceptions such as, "Why do some contrails last longer than others?" And, "Are ‘chemtrails’ steering, strengthening storms?" It's a worthwhile read for those interested in meteorology or conspiracy theories. Are you curious or looking to know more about those chasing clouds? Michael Splitt is available to speak with media. Contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology, at adam@fit.edu to arrange an interview today.
