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Simple 20-20-20 screen rule really does help with eye strain, research shows

Scientists find that a short break to look away from screen every 20 minutes improves symptoms of eye strain for computer users Aston University researchers used special software to monitor participants’ gaze for two weeks, measuring symptoms before and after First time that guidance has been scientifically validated. It’s long been recommended as a way of easing eye strain while working at a computer screen. Now the 20-20-20 rule – taking a break of at least 20 seconds, every 20 minutes, to look at least 20 feet away - has been confirmed by scientists at Aston University to help ease some of the symptoms of prolonged computer use. It’s estimated that at least half of people using computers in their regular work have some form of digital eye strain, resulting in eye surface problems including irritation and dryness, or vision issues such as headaches or blurred vision. Humans normally blink around 15 times each minute. When staring at screens, this number decreases generally to half that rate or less. That can lead to dry, irritated, and tired eyes, but twenty seconds focusing elsewhere is long enough for the eyes to relax enough to reduce the strain. This is the first time that the 20-20-20 guidance rule has been properly validated. Researchers at Aston University’s College of Health and Life Sciences set up their study with the help of 29 participants who suffer from symptoms of eye strain. Special software downloaded onto the participants’ own laptop computers used the built-in laptop camera both to check if a user was sitting at the screen and to monitor their gaze direction every few seconds. After 20 minutes of continuous screen viewing, the programme flashed up a message, asking users to rest for 20 seconds while looking at any distant target around 20 feet away, such as out of the window or across a room. The message couldn’t be removed until the task was performed correctly, as measured by the app. Participants’ digital eye strain symptoms were measured before and after two weeks of using the reminders, and one week after completing the study. Results showed a marked decrease in symptoms including dryness, sensitivity and discomfort. Professor James Wolffsohn, Professor of Optometry at Aston University, who led the research in collaboration with the University of Valencia, Spain, said: “The one previous study merely asked people to carry out the suggestions; but here the access control on the software meant we could be sure that participants really had looked away every 20 minutes. We saw a consequent improvement in the symptoms of the group as a whole.” Researchers noted that after the study, the participants’ eye symptoms returned to what they had been before the intervention. Professor Wolffsohn says: “We are planning to conduct longer term studies to see whether we can teach eyelid muscle memory impulses to blink more often during digital viewing, to help mitigate this chronic issue without long term use of reminders.” The findings confirm that people should try and take breaks from their screens. He added: “Although we used sophisticated software, it’s easy for others to replicate the effect by setting a timer on their phone, or downloading a reminder app. It’s a simple way of reminding yourself to take regular breaks for the good of your eyes.” The effects of breaks on digital eye strain, dry eye and binocular vision: Testing the 20-20-20 rule was published in Contact Lens and Anterior Eye journal.

Aston University welcomes minister for tech and the digital economy for tour of new Institute of Technology Hub

The minister for tech and the digital economy met with representatives from Aston University’s College of Engineering and Physical Sciences and Solihull College & University Centre during a visit to the new Greater Birmingham and Solihull Institute of Technology (GBSIoT) Hub on 2 August. Damian Collins MP was given a tour of the new facility by Rosa Wells, executive director for employment and skills and IoT at Solihull College & University Centre. The Institute of Technology focuses on engineering and advanced manufacturing and is a partnership between local further education colleges, universities and industry partners. It will support learners from across the region to progress to high-skill technical jobs in industry through clear, supported pathways. Construction of the GBSIoT Hub building is nearing completion and will be welcoming students in the coming weeks. During the visit, the minister was shown the cyber physical manufacturing rig, a scaled-down version of a factory of the future, which will create a simulated working environment for IoT learners. The minister then met with executive dean Professor Stephen Garrett and deputy dean Professor Kate Sugden for a tour of Aston University’s Advanced Prototyping Facility conducted by senior project manager Paul Gretton. The facility supports businesses by increasing awareness of the opportunities available through 3D printing to improve the efficiency and effectiveness of existing designs, and to develop new products all the way through to producing prototypes. The visit also included a showcase of Aston University’s Autopod, a state-of-the-art autonomous vehicle funded by the Greater Birmingham and Solihull Local Enterprise Partnership and the Institute of Technology which is used for research and as a teaching tool. Professor Garrett said: “Aston University has a proud history of delivering high-quality technical education and world-leading research. We were delighted to be able to showcase our facilities to Damian Collins MP, whilst discussing our commitment to equipping students with the knowledge and skills they need to succeed in STEM careers.” Damian Collins MP said: “It’s been brilliant to visit the pioneering facilities at Aston University today, especially seeing the cyber rig which will give students first class training to enter the industry with confidence. “Having these opportunities will help young people gain skills they need for future jobs, supporting the UK’s world leading advanced manufacturing and digital industries.” The minister toured the facilities at Aston University as part of his wider visit to the Birmingham 2022 Commonwealth Games. For more information about the College of Engineering and Physical Sciences please visit our website.

Babies react to taste and smell in the womb – new research

Scientists have recorded the first direct evidence that babies react differently to various smells and tastes while in the womb Study took 4D ultrasound scans of 100 pregnant women to see how their unborn babies responded to flavours from foods eaten by their mothers The research team, which also included scientists from Aston University, scanned some mothers to see fetal facial reactions to the kale and carrot flavours. Scientists have recorded the first direct evidence that babies react differently to various smells and tastes while in the womb by looking at their facial expressions. A study led by Durham University’s Fetal and Neonatal Research Lab, UK, took 4D ultrasound scans of 100 pregnant women to see how their unborn babies responded after being exposed to flavours from foods eaten by their mothers. Researchers looked at how the fetuses reacted to either carrot or kale flavours just a short time after the flavours had been ingested by the mothers. Fetuses exposed to carrot showed more “laughter-face” responses while those exposed to kale showed more “cry-face” responses. Their findings could further our understanding of the development of human taste and smell receptors. The researchers also believe that what pregnant women eat might influence babies’ taste preferences after birth and potentially have implications for establishing healthy eating habits. The study is published in the journal Psychological Science. Humans experience flavour through a combination of taste and smell. In fetuses it is thought that this might happen through inhaling and swallowing the amniotic fluid in the womb. Lead researcher Beyza Ustun, a postgraduate researcher in the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, said: “A number of studies have suggested that babies can taste and smell in the womb, but they are based on post-birth outcomes while our study is the first to see these reactions prior to birth. “As a result, we think that this repeated exposure to flavours before birth could help to establish food preferences post-birth, which could be important when thinking about messaging around healthy eating and the potential for avoiding ‘food-fussiness’ when weaning. “It was really amazing to see unborn babies’ reaction to kale or carrot flavours during the scans and share those moments with their parents.” The research team, which also included scientists from Aston University, Birmingham, UK, and the National Centre for Scientific Research-University of Burgundy, France, scanned the mothers, aged 18 to 40, at both 32 weeks and 36 weeks of pregnancy to see fetal facial reactions to the kale and carrot flavours. Mothers were given a single capsule containing approximately 400mg of carrot or 400mg kale powder around 20 minutes before each scan. They were asked not to consume any food or flavoured drinks one hour before their scans. The mothers also did not eat or drink anything containing carrot or kale on the day of their scans to control for factors that could affect fetal reactions. Facial reactions seen in both flavour groups, compared with fetuses in a control group who were not exposed to either flavour, showed that exposure to just a small amount of carrot or kale flavour was enough to stimulate a reaction. Co-author Professor Nadja Reissland, head of the Fetal and Neonatal Research Lab, Department of Psychology, Durham University, supervised Beyza Ustun’s research. She said: “Previous research conducted in my lab has suggested that 4D ultrasound scans are a way of monitoring fetal reactions to understand how they respond to maternal health behaviours such as smoking, and their mental health including stress, depression, and anxiety. “This latest study could have important implications for understanding the earliest evidence for fetal abilities to sense and discriminate different flavours and smells from the foods ingested by their mothers.” Co-author Professor Benoist Schaal, of the National Centre for Scientific Research-University of Burgundy, France, said: “Looking at fetuses’ facial reactions we can assume that a range of chemical stimuli pass through maternal diet into the fetal environment. “This could have important implications for our understanding of the development of our taste and smell receptors, and related perception and memory.” The researchers say their findings might also help with information given to mothers about the importance of taste and healthy diets during pregnancy. They have now begun a follow-up study with the same babies post-birth to see if the influence of flavours they experienced in the womb affects their acceptance of different foods. Research co-author Professor Jackie Blissett, of Aston University, said: “It could be argued that repeated prenatal flavour exposures may lead to preferences for those flavours experienced postnatally. In other words, exposing the fetus to less ‘liked’ flavours, such as kale, might mean they get used to those flavours in utero. “The next step is to examine whether fetuses show less ‘negative’ responses to these flavours over time, resulting in greater acceptance of those flavours when babies first taste them outside of the womb.”

Aston University joins Birmingham Health Partners alliance

Aston University becomes second university member to join Birmingham Health Partners (BHP) BHP brings together excellence from University of Birmingham and four regional NHS trusts The alliance brings together translational medicine, encompassing health data and academic excellence. Aston University has joined Birmingham Health Partners (BHP), becoming the second university to join the city’s university-NHS partnership. BHP brings together academic, clinical and translational excellence from the University of Birmingham, Aston University and four regional NHS trusts: University Hospitals Birmingham NHS Trust; Birmingham Women’s and Children’s NHS Trust; and more recently Sandwell and West Birmingham NHS Trust, the Royal Orthopaedic NHS Foundation Trust, as well as the regional Academic Health Science Network. BHP is known for its unique ecosystem which enables a full spectrum of translational medicine: encompassing health data, an established local health system, academic excellence and an extensive clinical trials capability – to help bring about answers to complex healthcare issues for the direct benefit of people worldwide. Aston University will be represented at board level by Professor Aleks Subic, Vice-Chancellor and Chief Executive of Aston University. While Professor Anthony Hilton, Pro-Vice-Chancellor & Executive Dean College of the College of Health and Life Sciences will join the executive group of BHP. Professor Hilton said: “We are excited to join BHP because it gives Aston University the chance to develop cross institutional collaborations under one umbrella of BHP. It provides an important forum for engagement with our regional NHS trusts and beneficiaries for both research, education and knowledge exchange. “We are keen to see how the alliance will support the funding of future research, enabling us to share innovation at the boundaries of each institutional expertise. “By having a unified West Midlands approach, we can harness key skills, expertise and our resources to have an impact on health in the region.” Managing Director at BHP, John Williams said: "It gives me great pleasure to welcome Aston University to be part of Birmingham Health Partners. “Alongside our NHS partners we will make use of our shared capabilities as employers, educators and researchers to positively impact the health and economic growth of our region."

Planet 9 Doesn’t Exist, So Why Does It Matter How We Get There? Let Our Expert Explain.

Planet 9 is an oft-discussed hypothetical planet in the outer region of the solar system. A new study involving Florida Tech astrobiologist Manasvi Lingam helps illustrate how we could possibly get there. The study, “Can We Fly to Planet 9?” is from Lingam and researchers Adam Hibberd and Andreas Hein. The team discovered that using current, unmanned transportation methods, it would take 45 to 75 years to get to Planet 9, which is about 42 billion miles away from Earth. By comparison, Pluto, which is the ninth object from the Sun, is roughly three billion miles from Earth. The research and work of Lingam, Hibberd and Hein is also getting a lot of attention from websites like UniverseToday.com. The team also studied near-future transportation methods nuclear thermal propulsion and laser sails. Using nuclear thermal propulsion, it would take approximately 40 years to reach Planet 9. It would take merely six to seven years to reach Planet 9 using laser sail propulsion, which involves using light from lasers to propel the vehicle. In its research, the team used the principles of orbital mechanics, sometimes called spaceflight mechanics. They inputted the complex and nonlinear mathematical equations into a computer, and then solved those equations with some optimization constraints. “What I mean by the latter is that ideally you want to maximize or minimize some quantity as much as possible,” Lingam said. “You might say, ‘Well, I want to minimize the flight time of the spacecraft as much as possible.’ So, what we did is that we put in an optimization constraint. In this case, it happens to be minimizing the time of journey. You solve the mathematical equations for a spacecraft with this condition, and then you end up with the results.” Lingam is inspired by the trendsetting Voyager spacecraft missions of the late 1970s, and one of his goals is to gain additional information about other worlds in our solar system, in addition to Planet 9 Voyager still provides valuable information regarding the outer solar system, though by 2025 it is expected that there may no longer be sufficient power to operate its science instruments. “Any mission to Planet Nine would likewise not just provide valuable information about that hypothetical planet, but it would also yield vital information about Jupiter, because what we do in some of the trajectories is a slingshot or powered flyby around Jupiter,” Lingam said. “It could also provide valuable information about the Sun because we also do a maneuver around the Sun, so you would still be getting lots of interesting data along the journey. And the length of the journey is comparable to that of the functioning time of the Voyager spacecraft today.” If you're a reporter looking to know more - then let us help get you connected to an expert. Manasvi Lingam is an Assistant Professor in the Department of Aerospace, Physics and Space Sciences at the Florida Institute of Technology. He is an author and go-to expert for media when it comes to anything in outer space or out of this world - just recently he was featured in Astronomy.com where he was asked to answer the illusive question - Are we alone?  Manasvi is available to speak with media - simply click on his icon now to arrange an interview today.

Physical models of a patient’s brain help researchers treat neurological disorders and diseases

Brain phantoms are a creative solution for a challenging question: How do you tune an electromagnetic field to a patient without testing on the actual patient? Transcranial magnetic stimulation (TMS) is an application of electromagnetic research with the potential to change the way we treat migraines, depression, obsessive compulsive disorder and even conditions like schizophrenia and Parkinson’s disease. Ravi Hadimani, Ph.D., associate professor of mechanical and nuclear engineering, leads a team of researchers who seek to use TMS to excite or inhibit brain neurons to alter specific brain functions and treat these conditions. This team includes faculty from VCU Health, including Mark Baron, M.D., professor of neurology and Kathryn Holloway, M.D., professor of neurosurgery, as well as outside collaborators like Joan Camprodon, M.D., associate professor of psychiatry at Harvard Medical School. “The brain phantom is a first step,” says Hadimani, “Our ultimate goal is to 3D print a brain fabricated with biomaterial scaffolds and printed neurons that produce a stimulation response similar to neurons in our brain. This model would behave more realistically than current brain phantoms. Our future work involves collaborating with researchers who are able to print lab-grown neurons on biomaterial scaffolds or researchers who directly fabricate artificial neurons onto any scaffold.” Coils used in TMS are responsible for generating the electromagnetic field used in treatment. Individual coils are designed to treat specific diseases, but additional settings like current strength, number of pulses and coil direction are unique to each patient. Refining these settings on the actual patient is not feasible. Computer modeling is also inefficient because creating head models and running simulations from MRI scans of the brain’s complex structure are not spontaneous. Hadimani and his team developed the brain phantom as a novel solution to this problem. In 2018, the first model was created by Hamzah Magsood, one of Hadimani’s Ph.D. students. The brain phantom is a physical model of a patient’s brain designed to specifications obtained from MRI scans. Materials used in brain phantom construction are designed to replicate the electrical conductivity and electromagnetic permeability of different brain sectors. The result is a representation that, when connected to electrodes, provides instantaneous feedback to researchers calibrating TMS coils. Elements of material science, electromagnetics and mechanical prototyping come together to create each brain phantom. The process starts with an MRI, which serves as a map for researchers designing the customized model. This is a careful process. Unlike other areas of the body with clear distinguishing features, like skin, muscle and bone, the brain has subtle differences between its many regions. Researchers must carefully distinguish between these areas to create an accurate brain phantom that will simulate a patient’s skin and skull as well as the brain’s gray and white matter. A composite material of polymer and carbon nanotubes that exhibits electric properties similar to the human brain is the foundation for the brain phantom. Additive manufacturing, more commonly known as 3D printing, is used to create shells for different brain regions based on the patient’s MRI. This shell becomes a mold for the polymer and carbon nanotube solution. Once the brain phantom takes shape within the mold, it is placed within a solution that dissolves the casing, leaving only the brain phantom behind. The conductive parts of the brain phantom are dark because of the carbon nanotubes and non-conductive parts are lighter in color. Electrodes are easily inserted into the brain phantom and provide feedback when an electromagnetic field from the TMS coil is applied. Adjustments to the strength, number of pulses of the field, and coil direction can then be made before applying the treatment to a patient. Having recently received a patent for the brain phantom, Hadimani and Wesley Lohr, a senior biomedical engineering undergraduate, formed Realistic Anatomical Model (RAM) Phantom. The pair have been awarded both the Commonwealth Commercialization Fund Award and the Commonwealth Cyber Initiative Dreams to Reality Incubator Grant. RAM Phantom’s goal is to market brain phantom technology to the growing neuromodulation market, which also includes transcranial direct current stimulation and deep brain stimulation. The company will also aid in the development of advanced brain models that more accurately simulate the properties of the human brain.

How will debates affect upcoming elections? Expert examines Walker-Warnock Senate matchup

Mid-term elections are nearly here and it is debate season for candidates. In Georgia, Sen. Raphael Warnock is set to debate Herschel Walker in Savannah on Oct. 14. This may be the only time the two candidates face off in a debate. But can these events sway a voter one way or another? Augusta University’s Mary-Kate Lizotte is an expert in political and voter behavior and said research shows debates do not have a substantial influence on election outcomes. “Most individuals who watch debates are well informed and therefore very likely to already have a party identification,” Lizotte said. “Sometimes debates do lead to a bump in the polls for a candidate if various news outlets agree that the candidate won. Most of the times, such bumps do not last that long.” But when it comes to a particular issue, she said there is some research that shows if it’s a newer topic, then it can influence public opinion. There has been a lot of attention on this particular debate since Warnock has unsuccessfully tried to engage Walker in other debates. Walker has said he’s not the polished speaker Warnock is and has downplayed the debate during recent speeches. “Walker is probably doing what others have done against a candidate with established oratory skills," adds Lizotte. "George H.W. Bush, George W. Bush, Sarah Palin and Mitt Romney, or their people, worked to lower expectations by conceding that their opponent was a fantastic debater/speaker; then the news media positively covered their debate performance when they performed moderately well or when their opponent does not trounce them.” “This could work in Walker’s favor if they only have one debate. If he gets positive coverage for doing better than expected, then he likely won’t agree to another debate.” With the mid-term elections inching closer and each Senate race crucial to determining the balance of power in Washington, these campaigns will get attention from state and national media. And if you're a reporter looking to cover the race in Georgia, then let us help. Dr. Mary-Kate Lizotte is an expert in political and voter behavior. She is available to talk about the upcoming midterm and gubernatorial elections in Georgia. Click on her name to schedule an interview.

Aston University to launch Aston Centre for Applied Linguistics

The Centre is an interdisciplinary, multilingual group of researchers made up of academic staff and research students It aims to build on Aston University’s longstanding expertise in research into language education, languages, and applied linguistics The hybrid launch event will take place at the University on 14 September Aston University is launching a new research centre within its College of Business and Social Sciences. The Aston Centre for Applied Linguistics (ACAL), formerly known as the Centre for Language Research at Aston (CLaRA), aims to build on Aston University’s longstanding expertise in research into language education, languages, and applied linguistics by promoting interdisciplinary collaboration and establishing national and international networks and partnerships. ACAL is an interdisciplinary, multilingual group of researchers – academic staff and research students – who work in the field of language and language education research. The Centre will officially be launched through a hybrid event at the University on 14 September 2022. There will be talks by Aston University’s Dr Lucia Busso & Dr Marton Petyko, Dr Marcello Giovanelli, Dr Megan Mansworth and Dr Emmanuelle Labeau as well as guest lectures from Professor Zhu Hua (IOE faculty of education and society, UCL) and Terry Lamb (professor of languages and interdisciplinary pedagogy, University of Westminster and Aston University language graduate). The event will conclude with a celebration of the major publications of ACAL members in 2021-22. Dr Emmanuelle Labeau, director of ACAL, said: “Language actually is all around us: we use it to articulate all our human activities. “Languages actually are all around us: over 100 languages are spoken in Birmingham “My recent AHRC-funded project BRUM (Birmingham Research for Upholding Multilingualism) has shown that research in language(s) is needed in local schools, businesses, public services and culture. “ACAL wants to put the ‘applied’ into linguistics to serve the University, the city, region and beyond. Our researchers are a great asset to the University’s ambitions, and we cannot wait informing and helping shape the Aston University 2030 Strategy.”

UConn insect expert David Wagner on the troubling decline of the mayfly

One of the world's oldest flying insects is in trouble. Mayflies are in serious decline and, after 300 million years in existence, their dwindling population should be an alarm bell for all of us. More than just a bug with a short life span flying masterfully near creeks, rivers, and ponds, the mayfly plays a serious role in local ecosystems and the environment at large. A key component in the food chain, the mayfly nymph feeds off of algae, plants, and rotting leaves, cleaning up nature's mess while growing large enough to become a meal itself -- for fish, amphibians, lizards, birds, and even humans. Without mayflies, the ripple effect upwards could mean calamity for the planet. In a recent Washington Post Magazine deep-dive, UConn insect expert David Wagner offered his perspective on the on the plight of the mayfly: I reached out to David Wagner, a biologist and lepidopterist at the University of Connecticut, for context, thinking that perhaps the problems were isolated or overblown. He has studied insects for decades and reviewed numerous scientific studies about them from around the globe. He did not provide much comfort. There’s a growing body of research suggesting that the world is in the midst of its sixth mass extinction, he said. The losses of all kinds of creatures appear to be driven by climate change, habitat degradation, pollution and other ecological stressors. In a paper for the Proceedings of the National Academy of Sciences last year, “Insect Decline in the Anthropocene: Death by a Thousand Cuts,” Wagner and several other scientists delivered a stark warning about the disappearance of insects. The report did not focus on mayflies, but Wagner told me they are among the most vulnerable of the world’s insects because of their need for clean, well-oxygenated water. “Mayflies are reliable ‘canaries in the coal mines’ for freshwater systems,” he explained. “And their future prospects, especially in areas that are drying or warming, are bleak.” September 19 - Washington Post Magazine Dr. David Wagner is an expert in caterpillars, butterflies, moths, and insect conservation, and he's commented extensively on the current decline of insects worldwide. Click his icon to arrange an interview today.

Researchers explore alternate delivery method for potential Alzheimer’s treatment

“Traditionally, the nose has been used as a route for delivery of locally acting drugs,” Laleh Golshahi, Ph.D., explained. “But recently, there has been a great deal of interest in the direct pathway through the olfactory region. That’s the same region where we smell, and that route is a direct pathway to the brain.” Golshahi, associate professor in VCU’s Department of Mechanical and Nuclear Engineering, leads the collaboration. Other members of the group are Worth Longest, Ph.D., the Louis S. and Ruth S. Harris Exceptional Scholar and Professor in the Department of Mechanical and Nuclear Engineering; Michael Hindle, Ph.D., the Peter R. Byron Distinguished Professor in VCU’s Department of Pharmaceutics; and Arya Bazargani, a Ph.D. student in VCU’s Interdisciplinary Center for Pharmaceutical Engineering and Sciences. The project is supported by a $200,000 internal grant from VCU Breakthroughs, a new internal funding mechanism as part of the Optimizing Health thrust of the One VCU Research Strategic Priorities Plan being implemented by the university’s Office of the Vice President for Research and Innovation. Hindle said that studies of nasally administered insulin have shown some promise for reducing the effects of Alzheimer’s. Unfortunately, delivery by injection, the most common way to deliver insulin, is ineffective for Alzheimer’s and other cerebral conditions because of the blood-brain barrier. Bazargani explained that nose-to-brain delivery of pharmaceuticals circumvents the blood-brain barrier, the lining of the blood vessels that surround the brain, guarding the central nervous system against a host of pathogens. “It’s usually a good thing,” he said. “But not when you’re trying to induce therapeutic effects into the brain.” Bazargani explained that insulin molecules are so large that the blood-brain barrier filters out most of the insulin. Hindle pointed out that even though the VCU team is avoiding the blood-brain barrier, insulin delivery still presents a number of challenges. “Insulin is a pretty fragile molecule, you know. It’s stored in the fridge,” Hindle said. “We need to include insulin in some sort of stable formulation — either a powder or a liquid nasal spray. We have to create the right particle or droplet size to get it into the right area of the nose.” Formulation development is only half of a two-pronged challenge, Golshahi said. The second aspect is the creation of a device that can deliver a dose way up to the olfactory region. “The nose is a challenge, because it’s designed as a filter to keep aerosols out of the body,” said Longest, who, along with Golshahi and Hindle, brings expertise in computational fluid dynamics to the team. “And the olfactory region is an especially troubling or difficult region to target, because it’s designed just to let a few molecules of what we inhale deposit.” Chief among the nasal filtering defenses, Golshahi said, is mucociliary clearance. Nasal passages are lined with mucous-coated cilia — moving microscopic projections on cells — sweeping foreign substances out of the air we breathe. The cilia do an excellent job, she said, but their efficiency makes it difficult to achieve a consistent delivery to the olfactory region. Another challenge, she added, lies in the fact that all noses are different. The collaborators are using in vitro and in silico methodologies. For the in vitro work, they have an array of 3D printed nose models, based on computed tomography (CT) scans. Golshahi said they have multiple anatomical casts of human nasal airways to test likely device/formulation combinations for their insulin/Alzheimer’s initiative. “We are going to use three of those nasal casts as our starting point,” she said. “We’ll connect the casts to a breathing simulator, which is basically a machine you can program to add the air going through — sort of bringing them to life.” Golshahi added that data from the casts will inform the in-silico component of the work — computational analysis that is expected to verify or challenge observations from the lab. Hindle said that once the team has developed a satisfactory formulation-device system, they can tackle the next challenge: identifying the dominant pathway from the olfactory region to the brain. “There are a variety of theories out there,” he said. “It could go along the nerve passageway. It could go between the nerve walls and the cells linking them.” “We have all the equipment and all the expertise necessary to be able to develop a formulation, and to put it in a device that leads to the highest amount of delivery to the target region,” Golshahi said. “And we are able to quantify how successful that combination of formulation and device is.”