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The CRISPR Dilemma: A Road To Saving Lives Riddled with Roadblocks

The New York Times recently published an Op-Ed by Dr. Fyodor Urnov unpacking the incredible advancement and possibilities of CRISPR gene editing technology on human lives. It also addressed some of the roadblocks and challenges preventing this "not so new" technology from getting to the finish line of promise.  Dr. Eric Kmiec, the director of ChristianaCare's Gene Editing Institute, whose unparalleled research has led to over 18 patents that have advanced medical research, also shared his concern in a follow-up letter published by the New York Times about the many roadblocks standing in the way of life-saving opportunities with gene editing and CRISPR technology. Dr. Kmiec (above) in the lab "If we were able to safely and effectively approve a COVID vaccine in a year, we must do the same by pooling public and private funds and seek ways to speed science. Why can’t we support the most promising solutions to some of the longest running and most intractable of cancers or rare diseases?" The advancement of gene editing has not only been stalled by the outdated processes of medical reviews and policies, but many have introduced political and religious barriers. The idea of "playing God" or even Dr. Frankenstein when people hear the term "gene editing" raises ethical questions based on a lack of understanding. Some of these concerns are shared in this recent article in Futurism.  Ask one of the 100 people afflicted with a gene defect that could cost them their lives at age 7 and the perspective may be a little different. Nature makes mistakes, often imperfect, and impacted by the ever-changing landscape, impacted by external factors that are either known or unknown. Gene editing, simply put, can fix typos in genes that have experienced a glitch. As Dr. Kmiec puts it, "It allows us to correct mutations that are inbred in the genome, it's correcting nature's mistakes — and nature does make a bunch of mistakes." Whether gene editing fits into a belief system or is too otherworldly for some to grapple with, Dr. Kmiec asserts that speeding up the delays put onto science by process, politics or fear will result in saving lives, saving pain and advancing possibility. Dr. Urnov agrees, "Scientists owe them and their families honesty about the ‌‌chasm between a test tube in a lab and an IV line in a hospital. The greatest obstacles are not technical but legal, financial and organizational." Gene editing is a pioneering technology that can help humans, plants and animals alike. When it comes to putting it into action, at the very least, if science is there to help, everyone should have the choice to use it. 

Aston University computer scientist joins first UK-wide Young Academy

The new UK Young Academy is a network of early career researchers and professionals It has been established to tackle local and global issues Dr Alina Patelli is a senior lecturer in computer science at Aston University. Aston University is delighted to announce that Dr Alina Patelli, a senior lecturer in computer science in the College of Engineering and Physical Sciences, is among the first members of the new UK Young Academy – a network of early career researchers and professionals established to help tackle local and global issues and promote meaningful change. Dr Patelli specialises in evolutionary computation, specifically, genetic programming and its applications in smart cities, with a focus on traffic modelling and prediction. Her interests also include autonomic, knowledge-based systems, as well as self-adaptation and self-organisation in computing. As part of the first cohort of 67 members, announced on 10 January by UK and Ireland National Academies, Dr Patelli will have the opportunity to help shape the strategy and focus of this new organisation, based on areas that matter to them. Along with their fellow members from across academia, charity organisations and the private sector, they will have the chance to inform local and global policy discussions, galvanising their skills, knowledge, and experience to find innovative solutions to the challenges facing societies now and in the future. The UK Young Academy has been established as an interdisciplinary collaboration with prestigious national academies: the Academy of Medical Sciences, British Academy, Learned Society of Wales, Royal Academy of Engineering, Royal Irish Academy, Royal Society of Edinburgh, and the Royal Society. It joins the global initiative of Young Academies, with the UK Young Academy becoming the 50th to join the Young Academy movement. Dr Alina Patelli said: “I am anticipating the start of my service as a member of the UK Young Academy with great enthusiasm. I highly value the opportunity to collaborate with colleagues from across the spectrum of science and governance in order to make a significant impact on the UK’s approach to tackling national and international challenges. “The UK Young Academy is perfectly placed to substantively improve the life of human communities everywhere and I am honoured to contribute towards the achievement of that goal.” Professor Stephen Garrett, executive dean of the College of Engineering and Physical Sciences at Aston University, said: “I would like to congratulate Alina on being selected as one of the first members of the UK Young Academy. It is a fantastic achievement to have been selected to join this talented and diverse cohort. “I wish her every success and look forward to seeing the fruits of her work with the Young Academy.” The successful applicants officially took up their posts on 1 January 2023, and membership runs for five years. It is expected that the next call for applications will open in 2023.

Interested in the true pursuit of greatness? Take a look at what Florida Tech has to offer

If you are up for the challenge and want to begin your own relentless pursuit of greatness, let us help. The Florida Tech campus is located in the heart of Florida’s Space Coast. That means proximity to key agencies and operations, such as NASA-Kennedy Space Center, SpaceX, Embraer, L3Harris Corporation, Northrop Grumman and more. Oh, and did we mention there are miles and miles of Atlantic Ocean beaches just moments away?  Learn more about all Florida Tech has to offer. Get in touch today! Simply contact: Adam Lowenstein Director of Media Communications (321) 674-8964 adam@fit.edu

Researchers seek to find new ways of building permanent magnets, reducing dependency on rare-earth elements

Permanent magnets play an indispensable role in renewable energy technologies, including wind turbines, hydroelectric power generators and electric vehicles. Ironically, the magnets used in these “clean energy” technologies are made from rare earth elements such as neodymium, dysprosium and samarium that entail environmentally hazardous mining practices and energy-intensive manufacturing processes, according to Radhika Barua, Ph.D., mechanical and nuclear engineering assistant professor. Access to these rare earth magnets is also heavily reliant on China and demand for them is expected to grow as the U.S. seeks to meet net-zero carbon emissions by 2050. “That anticipated demand poses a challenge to U.S. decarbonization goals as the rare earth elements are characterized by substantial market volatility and geopolitical sensitivity,” Barua says. “This is where our project comes in.” Barua and fellow VCU professors Afroditi Filippas, Ph.D., and Everett Carpenter, Ph.D., are part of a team of VCU researchers working to create new types of magnets. By using additive manufacturing, more commonly known as 3D printing, they hope to create replacements for those permanent magnets composed of rare earth elements that are made from materials readily available in the U.S. China mines 58 percent of the global supply of rare earth elements used to make neodymium magnets that are widely used in consumer and industrial electronics, the U.S. Department of Energy (DOE) noted in a February 2022 report. That dominance grows throughout the manufacturing process with China accounting for 92 percent of global magnet production, the DOE estimates. “It would be ideal if we could manufacture the same magnets with the same characteristics without using rare earth elements,” says Filippas, who teaches electromagnetics at VCU. “It would be even better if we could make these magnets using additive manufacturing techniques.” VCU researchers are trying to do that in collaboration with the Commonwealth Center for Advanced Manufacturing (CCAM), which brings university, industry and government officials together to tackle manufacturing challenges. The professors are conducting much of their work at CCAM’s lab in Disputanta, Virginia. “We have access to equipment that we would not have access to at VCU,” Filippas says of the benefits of the CCAM partnership. “They provide that level of expertise using the equipment and understanding the process.” The project is funded by the VCU Breakthroughs Fund and CCAM. Barua is working with Carpenter, a chemistry professor, on the materials science part of the project. Filippas is focusing on data analytics and is helping develop a monitoring process to ensure the newly-crafted replacement magnets are viable. In addition to providing a more stable source of supply, Barua says the replacement magnets could also bring environmental benefits. Providing an alternative to rare earth magnets would involve less hazardous mining techniques while also reducing emissions and energy consumption. The replacement magnets are made by filtering particles of iron, cobalt, nickel and manganese through a nozzle where a laser fuses them together through a process known as direct energy deposition. That metal 3D printing approach can make complex shapes while minimizing raw material use and manufacturing costs, Barua says. “Right now, we’re printing straight lines just to see what we’re going to get and see if we can even print them,” Filippas says. “Are we getting the composition of the materials that we want? It’s a slow painstaking process towards freedom from reliance on rare earth materials.” Barua says using additive manufacturing allows researchers to create a unique microstructure layer-by-layer instead of simply making magnets from a cast. Researchers do not expect their replacements to mimic the full strength of rare earth magnets, but they hope to produce mid-tier magnets that are as close as possible to current magnets. Carpenter adds their new magnets could potentially be smaller and weigh less than rare earth magnets, which could lead to numerous benefits. “This reduction would be a big savings to the automobile manufacturing industry, for example, where every ounce matters,” Carpenter says. “In an S-Class Mercedes, there are over 130 magnets used in sensors, actuators or motors. This approach could save pounds of weight which translates into fuel efficiency.” Barua says the team is working to establish the feasibility of their new magnet-making process. They are trying to get the microstructure of the new magnets just right and are using additive manufacturing to fine-tune their magnetic properties, Barua says. “When artificial diamonds, cubic zirconia, was synthetically produced in the lab, it changed the entire diamond industry,” Barua says. “That’s exactly what we’re trying to do. We’re trying to make synthetic magnets.”

Researcher to build fuel database to improve nuclear reactor sustainability

Braden Goddard, Ph.D., assistant professor in the Department of Mechanical and Nuclear Engineering, has received a grant from the U.S. Department of Energy’s Nuclear Energy University Program (NEUP) to create a database for use in nuclear material control of pebble bed reactors (PBR). Advances in material science and technology have revitalized the nuclear energy industry, allowing for the design and construction of advanced nuclear reactors. New high-temperature materials developed by researchers allow ideas from as early as 1970, like pebble bed reactors, to be re-explored and make nuclear power more efficient and sustainable. Pebble bed reactors are one of many ideas from as early as 1970 that researchers are once again exploring to make nuclear power more efficient and sustainable now that science has developed new high-temperature materials. “Imagine a gumball machine,” said Goddard, “A pebble bed reactor functions similarly. The pebbles are the gumballs, which are fed into a reservoir. As they make their way through the reactor, heat generated from the radiation is removed by a gas which then spins an electrical turbine to generate electricity. The pebbles then exit from the bottom of the reservoir and those that can be reused are returned to the top of the reservoir.” Each pebble contains thousands of microscopic uranium particles encased in silicon-carbide cladding. As the pebble passes through the PBR, the path it follows affects how much fissioning occurs within the uranium. This means pebbles deplete at different rates based on how they travel through the reactor. Goddard’s database seeks to characterize the state of a pebble after it leaves the PBR by determining precisely how much plutonium and uranium remains in the pebble. This informs PBR operators if the pebble can be reused or if it needs to be sent off as waste. Better characterizing these pebbles improves the sustainability and security of PBRs while reducing the amount of waste generated. Measuring gamma radiation from the radioactive isotope cesium-137 created from the fission of uranium is the traditional method of determining how much nuclear fuel is still viable. However, this system does not work for PBRs because the correlation between the uranium fuel and the gamma radiation it emits is not consistent between pebbles. To remedy this, Goddard will measure both gamma and neutron radiation emitted by all radioactive isotopes in the pebble, which varies depending on the route the pebble takes through the reactor. Partners like Brookhaven National Laboratory and similar institutions within the United States will assist in the research by applying machine learning techniques to the gamma and neutron radiation signature. “Nuclear reactor operators have instruments that tell them what’s going on inside the reactor, but it’s not the same as knowing how much uranium mass you have in fuel going into or coming out of the reactor,” said Goddard. Goddard and his colleague, Zeyun Wu, Ph.D., will use computer modeling to run countless simulations and map every possible course a pebble can take through a PBR. The resulting catalog of data will allow PBR operators to characterize the state of any pebble leaving the PBR and assess if it can be reused or if it is ready to be stored at a nuclear waste facility. The catalog also serves as a material inventory, allowing nuclear facilities to better track waste material.

#Expert Research: New National Science Foundation and NASA-Funded Research Investigates Martian Soil

Studies have shown crops can grow in simulated Martian regolith. But that faux material, which is similar to soil, lacks the toxic perchlorates that makes plant growth in real Red Planet regolith virtually impossible. New research involving Florida Tech is examining how to make the soil on Mars useful for farming. Andrew Palmer, co-investigator and ocean engineering and marine sciences associate professor, along with Anca Delgado, principal investigator and faculty member at Arizona State University’s Biodesign Swette Center for Environmental Biotechnology, and researchers from the University of Arizona and Arizona State University, are participating in the study, “EFRI ELiS: Bioweathering Dynamics and Ecophysiology of Microbially Catalyzed Soil Genesis of Martian Regolith.” This National Science Foundation and NASA-funded project will use microorganisms from bacteria to remove perchlorates from Martian soil simulants and produce soil organic matter containing organic carbon and inorganic nutrients. Martian regolith contains high concentrations of toxic perchlorate salts that will impede plant cultivation in soil, jeopardizing food security and potentially causing health problems for humans, including cancer. Researchers will look at different bacterial populations and how well they are able to process and break down the perchlorates, as well as what kind of materials they produce when they do. They’ll also look at different temperatures and moisture conditions, as well as in the presence or absence of oxygen. Students in the Palmer Lab will receive the simulants after this process, try to replicate it, and then test how well the perchlorate-free regolith is able to grow plants. A challenge the researchers face is how they remove the toxic salts, as well as if they can remove all of them. Palmer cautioned that the possibility that removing the perchlorates does not necessarily mean the regolith is ready for farming. “You can’t make the cure worse than the disease, so we have to be ending up with regolith on the other side that’s better than when we started,” Palmer said. “We can’t trade perchlorates for some other toxic accumulating compound. Just because we’re removing the perchlorates doesn’t necessarily mean that we’re going to make the regolith better for plants. We might just make it not toxic anymore. How much does it improve is really what we’re trying to figure out.” Even without perchlorates, there are significant challenges to growing crops in Martian soil. While researchers have grown plants in simulated regolith, the regolith is not good for plant growth, as in addition to a lot of salts, it has a high pH and is very fine, which means it can ‘cement’ when wet, suffocating plant roots. Being able to grow in the soil instead of using hydroponics could also provide a more efficient, cost-effective solution. “There is always the option of hydroponic growth of food crops, but with a significant distance to Mars and the lack of readily available water, we need a different kind of plan,” said ASU’s Delgado. “If there is a possibility to grow plants directly in the soil, there are benefits in terms of water utilization and resources to get supplies to Mars.” Some of the microbial solutions the team is proposing could also help with studies of soils on Earth. “The best soils for agriculture on earth, they were taken up decades ago, and so now we’re trying to farm on new land that’s not really meant for agriculture, if you think about it,” Palmer said. “So, as we think about ways to convert it into better soil, I think this research helps teach us how to do that, but it also inspires.” The research will also allow Florida Tech students to get hands-on space agriculture experience. “We’re going to be training the grad students and the undergraduates who are going to be the researchers who take on those new challenges, so I think one of our most important products are going to be the students we train,” Palmer said. “We’ll deliver Mars soil, but we also deliver, I think, a future group of researchers.” If you're a reporter looking to know more about this topic - then let us help with your coverage. Dr. Andrew Palmer is an associate professor of biological sciences at Florida Tech and a go-to expert in the field of Martian farming. Andrew is available to speak with media regarding this and related topics. Simply click on his icon now to arrange an interview today.

Aston University photonics expert elected as Fellow of Optica

• Professor Edik Rafailov is head of the Optoelectronics and Biomedical Photonics Research Group • He is a member of Aston Institute of Photonic Technologies, a world-leading photonics research centre • Optica is the leading organisation for researchers and others interested in the science of light. A photonics expert at Aston University has been elected as a Fellow of Optica (formerly OSA), Advancing Optics and Photonics Worldwide. Professor Edik Rafailov is head of the Optoelectronics and Biomedical Photonics Research Group in the College of Engineering and Physical Sciences at Aston University and a member of Aston Institute of Photonic Technologies (AIPT), one of the world’s leading photonics research centres. He was elected for his ‘contributions to novel gain media for semiconductor lasers at wavelengths from 750nanometres to1300nanometres’. Optica is the society dedicated to promoting the generation, application, archiving and dissemination of knowledge in the field of photonics. Founded in 1916, it is the leading organisation for scientists, engineers, business professionals, students and others interested in the science of light. Fellows are selected based on several factors, including outstanding contributions to business, education, research, engineering and service to Optica and its community. Satoshi Kawata, 2022 Optica president, said: “I am pleased to welcome the new Optica Fellows. These members join a distinguished group of leaders who are helping to advance the field optics and photonics. Congratulations to the 2023 Class.” Director of AIPT, Professor Sergei Turitsyn said: “I am delighted that Edik has received this prestigious fellowship. “AIPT has one more Optica Fellow, that is a high honour in the field of photonics. “Edik joined Aston University in 2014 and since then his research has contributed to the Institute’s world-leading position in the fields of fibre and semiconductor lasers and bio-medical photonics, making impact on industry, scientific communities and society.” Fellows are Optica members who have served with distinction in the advancement of optics and photonics. As they can account for no more than 10 percent of the total membership, the election process is highly competitive. Candidates are recommended by the Fellow Members Committee and approved by the Awards Council and Board of Directors. The new Optica Fellows will be honoured at the Society’s conferences and events throughout 2023.

Gene Editing Institute Travels to Salem for ‘Innovation Days’ Workshop

Education sessions bring CRISPR gene editing to high school students from diverse backgrounds Scientist-educators from ChristianaCare’s Gene Editing Institute held a workshop using CRISPR in a BoxTM at Salem Academy during Innovation Days in October at the school, located in Winston-Salem, North Carolina. These sessions followed a previous gene editing education workshop with Salem Academy students in January 2022. CRISPR in a BoxTM is a revolutionary toolkit that allows students to carry out a hands-on gene editing experiment while learning and analyzing the steps involved in a typical gene editing reaction. Scientists from the Gene Editing Institute also taught a condensed lesson about CRISPR gene editing’s utility in medicine and fielded questions from students about jobs in biotechnology, bioethics and sustainability in the lab. “It’s a really special opportunity that I know I wouldn’t get anywhere else,” said Mathilda Willenborg, a sophomore boarding student from Germany. “And I do feel like I’m learning a lot about gene editing that I definitely didn’t know before. The team makes it really easy and walks us through all the steps.” Last winter, Salem Academy became the first school in North Carolina to offer CRISPR in a Box as it pivoted its academic focus to STEAM (Science, Technology, Engineering, Art and Math). That first innovative workshop originated as a result of an idea from a ChristianaCare board member who attended Salem Academy. Gene Editing Institute Founder and Lead Scientist Eric Kmiec, Ph.D., made a virtual appearance as part of the latest sessions to encourage the students to pursue careers and pathways in biotechnology. “We’re so appreciative of our partnership with Salem Academy,” said Kmiec. “We want to take every chance we get to encourage more women to pursue careers in STEM. Women around the nation, and around the world, should have access to this groundbreaking technology, which will ultimately drastically change the way we treat and cure diseases. If we don’t have young women in that discussion, we’re missing out on valuable experiences and perspectives.” Salem Academy is the only all-female boarding and day high school on a college campus in the U.S. with a STEM focus. Women are achieving significant progress in STEM fields, representing 45% of students majoring in STEM, according to the Integrated Postsecondary Education Data System. However, women only represent 27% of STEM workers, with wide disparities in income in post-graduation employment. As of 2019, less than 30% of the world’s researchers were women, according to the UNESCO Institute for Statistics. The Gene Editing Institute commits to a mission of diversity and equity in its approach. This workshop reached 10 women, two of whom are international students. “Our ongoing partnership with the ChristianaCare Gene Editing Institute will help position our aspiring women scientists for future careers in biotechnology, science and medicine,” said Summer McGee, Ph.D., president of Salem Academy and College. “This is the type of experience that sets Salem Academy apart as a national leader in building the next generation of women leaders in STEAM.” The Gene Editing Institute itself is a national leader in female researchers. Women make up over 80% of scientists within the Institute and fill 75% of the principal investigator roles. The Institute pushes to address the gender gap and promote inclusivity through local outreach and state-spanning programs, like CRISPR in a Box. “We’re not here to do lip service,” said Brett Sansbury, Ph.D., principal investigator of the Discovery Branch of the Gene Editing Institute. “Too many companies make a plan or promise without any actionable steps. We’re taking those steps and bringing in opportunities for students who otherwise wouldn’t have had them.” To learn more about how to bring CRISPR in a Box to your school, visit https://geneeditinginstitute.com/products/education. About CRISPR in a BoxTM CRISPR in a BoxTM is the leading educational toolkit to teach gene editing. The exercise features a hands-on gene editing experiment, including a live readout within non-infectious E. coli bacteria. These experiments follow a gene editing reaction from beginning to end while teaching students the techniques scientists use to perform these reactions in real laboratory environments. CRISPR in a Box is distributed by Carolina Biological. To learn more, visit https://geneeditinginstitute.com/products/education.

Ask our expert - Economy, inflation and interest rates, where do we stand as we close in on the end of the year?

Everyone is keeping a close eye on the economy. Whether on a global scale or at the kitchen table - it's a topic that is at the top of everybody's mind these day. Simon Medcalfe, PhD is  the Cree Walker Chair in the Hull College of Business at Augusta University and resident expert on the economy, and he shared his thoughts on where the economy stands as the final months of the year approach. Q: The Gross Domestic Product report was up, what should we take out of that? “The GDP was interesting because it was actually up. The first two quarters were negative growth, so the economy had shrank. This time, the growth figure came in at 2.6%, but closer reading suggested it was actually a worse reading then the negative readings we had because consumer spending by firms was essentially flat. The growth was seen in net exports or government spending or things like. Consumers were kind of pulling back a little, which is why earnings were a little lower as well.” Q: The economy needs to slow down a little, doesn’t it? “I mean, yes, if you’re thinking about the Fed, that’s what they are worried about right now, inflation, because the economy is so incredibly hot, particularly with regards to prices. They’re raising interest rates with the aim at slowing down the economy. Unemployment is historically very, very low, if not at record levels in different places, so we could probably sustain a little slowing of the economy without impacting the labor market too much and try to get this general inflation under control.” Q: The economy could use a little unemployment, it’s that kind of counter intuitive? “Some unemployment is not bad. Economist use to suggest in the long run, the natural rate of unemployment is about 5-6%. Now we have unemployment in the 2-3% range in places. We have a little bit of wiggle room to see that increase.” Q: What's the difference between frictional and structural unemployment? "Economist talk about frictional unemployment and structural unemployment. Frictional unemployment is more of a job match or job search problem. So it’s a lack of information. Structural unemployment is because of the changing nature of industry within an economy. An example being people working in textile manufacturing and it’s hard for them to go straight into computer science coding because they don’t have the skills. This is more long term than frictional and in some cases can be quite detrimental to regions and people.” Q: The Fed is likely to raise interest rate by .75%, are there signs of this slowing down? “I think they’ll start slowing that down over time, but I think their projection is about 4.6% and we’re like 3.25% now. They’re looking at all the economic indicators. Not looking at any one or two, but everything. They’re looking at inflation, and have different measure of that. They’re look at the breakdown of inflation like how much of it is due to the war in Ukraine, and what areas of the economy it may be impacting. They’re looking at the labor market, definitely looking at manufacturing output, etc. The one thing they don’t generally look at is financial markets. They would look at the housing market though and different sectors of the real economy, not the financial economy.” Dr. Simon Medcalfe is a highly regarded economics expert in the Hull College of Business at Augusta University. Medcalfe is available to speak with media regarding the economy and its outlook – simply click on his icon now to arrange an interview today.

One of the crowd or one of a kind? New artificial intelligence research indicates we're a bit of both

Evidence that behaviour follow a two-step process when we’re in a crowd We are likely to imitate the crowd first and think independently second Findings will increase understanding of how humans make decisions based on others’ actions. An Aston University computer scientist has used artificial intelligence (AI) to show that we are not as individual as we may like to think. In the late 1960s, famous psychologist Stanley Milgram demonstrated that if a person sees a crowd looking in one direction, they’re likely to follow their gaze. Now, Dr Ulysses Bernardet in the Computer Science Research Group at Aston University , collaborating with experts from Belgium and Germany, has found evidence that our actions follow a two-step process when we’re in a crowd. Their results, Evidence for a two-step model of social group influence, published in iScience show that we go through a two-stage process, where we’re more likely to imitate a crowd first and think independently second. The researchers believe their findings will increase the understanding of how humans make decisions based on what others are doing. To test this idea the academics created an immersive virtual reality (VR) experiment set in a simulated city street. Each of the 160 participants was observed individually as they watched a movie within the virtual reality environment that had been created for the experiment. As they watched the movie, 10 computer-generated ‘spectators’ within the VR simulated street were operated by AI to attempt to influence the direction of the gaze of the individual participants. During the experiment, three different sounds such as an explosion were played coming from either the left or right of the virtual street. At the same time, a number of the ‘spectators’ looked in a specific direction, not always in the direction of the virtual blast or the other two sounds. The academics calculated a direct, and an indirect, measure of gaze-following. The direct measure was the proportion of trials in which participants followed the gaze of the crowd. The indirect measure took into account the reaction speed of participants dependent on whether they were instructed to look in the same or opposite direction as the audience. The experiment’s results support the understanding that the influence of a crowd is best explained by a two-step model. Dr Bernardet, said: “Humans demonstrate an initial tendence to follow others – a reflexive, imitative process. But this is followed by a more deliberate, strategic processes when a person will decide whether to copy others around them, or not. “One way in which groups affect individuals is by steering their gaze. “This influence is not only felt in the form of social norms but also impacts immediate actions and lies at the heart of group behaviours such as rioting and mass panic. “Our model is not only consistent with evidence gained using brain imaging, but also with recent evidence that gaze following is the manifestation of a complex interplay between basic attentional and advanced social processes.” The researchers believe their experiments will pave the way for increased use of VR and AI in behavioural sciences.