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UF astrobiologist partakes in her second NASA mission to Mars

By Halle Burton NASA’s Mars Perseverance rover mission is no easy task, yet its distinguished team has discovered signs of organic molecules, containing chemicals known for making life possible on Earth. One of these long-term planners is University of Florida astrobiologist, Amy Williams. “Organics make up life as we know it,” Williams said. “Seeing organic carbon on Mars sets us up to understand if the building blocks for life were present on the planet in the past through the lens of how life evolved on Earth.” Williams and the Perseverance team were published in November’s Science magazine for their organic molecules analysis, after finding numerous organic carbons on the Jerezo crater floor. Through NASA’s Jet Propulsion Laboratory, Perseverance is studying the crater with collected rock samples planned to be sent to Earth during the Mars Sample Return mission. Upon further research and testing on Earth, these rocks could determine compelling evidence of past life on Mars. Several of the rock samples indicate altercations by water, making scientists propose that a water-infused Mars could have supported ancient life. The Jerezo crater itself serves as an intriguing site to study past life on the terrestrial planet. The creation of the crater implies Mars contained a primitive river streaming into a lake billions of years ago. Now, Williams is no stranger to working with the detection of organic molecules on Mars. In 2015, she worked with the Curiosity rover which also found organic carbon on the inner planet. With her work diversified on the Perseverance team, evidence is closer than ever to proving the omnipresence of organic carbon on Mars. “Seeing a consistent story is always reassuring as a scientist,” Williams said.

Gene Editing Institute Opens a Unique Learning Lab for High School and College Students

Free program uses CRISPR in a Box™ toolkit to teach the power of gene editing To inspire the next generation of students to pursue careers in STEM (science, technology, engineering and math) and learn about the power of genomic science, ChristianaCare’s Gene Editing Institute has launched a new Learning Lab on its premises that offers educational programming about revolutionary CRISPR gene editing technology. Located next to the Gene Editing Institute’s lab on the University of Delaware’s STAR Campus, the Learning Lab is a physical space that provides an immersive field trip experience for upper-level high school students and college undergraduates who may not have access at their schools to a laboratory to conduct gene editing experiments. There is no cost for schools to use the lab or for the materials to conduct the experiment. The Gene Editing Institute wants to ensure that all schools have equal opportunity to participate in educational programming at the lab. Students using the lab can perform a gene editing experiment in a single day using the Gene Editing Institute’s innovative CRISPR in a Box™ educational toolkit. All materials in the kit are safe, synthetic materials, and allow students to perform CRISPR gene editing with non-infectious E. coli bacteria. They will be able to see an appearance change indicating gene editing has occurred at the end of their experiment. “Students around the country, no matter where they go to school, have the potential to be scientists, researchers and laboratory technicians,” said Eric Kmiec, Ph.D., executive director and chief scientific officer of ChristianaCare’s Gene Editing Institute. “Our hope is that by creating access and space for students to explore, we can inspire the next generation of students to pursue STEM careers. The Learning Lab allows us to help cultivate the next generation of genetic scientists and strengthen Delaware and our region as a leader in biotechnology.” Education Program Manager Amanda Hewes, MS, developed the Learning Lab after noticing a problem that was undercutting the opportunities of teachers to bring gene editing experiments into the classroom — a lack of space and equipment. Amanda Hewes, education program coordinator, assists students from Wilmington Charter School with their samples of DNA during a Learning Lab experiment. “We don’t want anything to hinder the way students learn about CRISPR gene editing,” Hewes said. “If a student feels like there are too many steps, or a teacher doesn’t have an essential piece of equipment, then we’ve lost an opportunity to bring the next generation of scientists into the lab. We’re striving to break down as many barriers as possible for students.” Learning real-world applications of gene editing The Learning Lab also allows students to speak directly with experts in the field about careers in biotechnology and gene editing as they learn the difference between such things as phenotypic and genotypic readouts in their gene editing experiments. This gives students the chance to ask about the real-world application of genome experiments in a research lab. It also lets them think about their place in a lab setting. “I’ve never been in an actual lab setting before,” said Shiloh Lee, a junior at the Charter School of Wilmington, at a recent class. “I think it is very, very cool to be able to experience it.” “I’ve learned a lot of new skills with the micropipetting,” said Pauline Zhuang, a senior at The Charter School of Wilmington. “We don’t have the same resources at our school. The CRISPR in a Box is such a great resource. My classmates and I have been able to experience, firsthand, what it is like to actually do gene editing.” Through the program, the Gene Editing Institute hopes to educate 1,000 students by spring 2024. Currently, the lab is on track to engage more than 200 students by the end of the spring 2023 semester. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the hallmark of a bacterial defense system that forms the basis for CRISPR-Cas 9 genome editing technology. The CRISPR technology enables researchers to modify genes in living cells and organisms and may make it possible to correct mutations at precise locations in the human genome in order to treat genetic causes of disease. For more information about the Learning Lab and the educational program, email geneeditinginstitute@christianacare.org.

MEDIA RELEASE: CAA Insurance Launches the CAA Head Start Discount™, Helping Young Drivers Save on Insurance Costs

CAA Insurance Company is excited to announce the launch of the CAA Head Start Discount™, a program designed to help young drivers save on their insurance costs. The discount is available to the children or dependents of CAA Insurance auto policyholders in good standing. Effective April 15 for new business and June 15 for renewals, the CAA Head Start Discount offers 25 per cent savings to youth in Ontario under the age of 25 with a clean driving record. This discount is part of CAA Insurance's commitment to innovation and offering the best possible options to its customers. "We are proud to be the first company to bring 25 per cent savings to market for young drivers in good standing," says Matthew Turack, group president CAA Insurance. "This new discount is another way that we can help Ontario families save money." CAA Insurance has always made decisions with the best interests of its customers in mind. When designing programs, products, or initiatives, CAA Insurance makes data-driven decisions by polling both policyholders and the public and by asking ourselves the question, "What would a customer like and benefit from?" This question helps the company stay modern and relevant. "We are confident that continuing to innovate and offer savings and programs that cater to the lifestyles of our customers is a strong business decision," says Turack. "The CAA Head Start Discount gives CAA Insurance the ability to be responsive to the needs of our customers and to ensure that we are there for them in every stage of life." Parents or legal guardians of safe drivers who are CAA Insurance policyholders in Ontario can talk to an agent or broker to see if their children or dependents are eligible for the discount.

Pharmacy researchers investigating drug optimisation for severe mental illness hold workshop for people with lived experience

Members of the Lived Experience Stakeholder Group meet at Aston University for the first time to give feedback on the project MEDIATE investigated how medication for severe mental illness can be optimised Research funded by the National Institute for Health Research (NIHR). Researchers from Aston Pharmacy School welcomed people with lived experience involved in the MEDIATE research project to campus for a one-day workshop on 17 March to enable these members of the Lived Experience Stakeholder Group - who all live with and take medication for severe mental illness (SMI) - to meet in person to give feedback and discuss their participation in the project. The group members have participated in the National Institute for Health Research (NIHR) funded project since January 2022 until its conclusion in March 2023. The MEDIATE project investigated how medication can be best optimised (safely getting the right drug at the right dose to the individual at the right time) for people living with SMI. The first part of the workshop allowed participants to discuss with the research team their involvement as people with lived experience of severe mental illness in the project. Dr Jo Howe, MEDIATE project researcher at Aston University, said: “Although this group was formed to help us as researchers, we became aware that involvement in the group has also helped group members. They enjoyed linking with their peers, despite having had different lives and journeys, they discovered shared experiences, which helped them feel less isolated. “Importantly some members said that their involvement in our research improved their self-confidence and helped them to speak about their medication concerns with their healthcare team.” The second part of the workshop bought the group together to gauge opinions on three separate research projects currently being planned by the MEDIATE research team. The group were able to give useful insights to help shape the research teams future project proposals. Max Carlish, MEDIATE group member, said: “Our participation throughout this project has really made us feel that we have been influencing the direction of the research. With our unique service user perspectives helping to make the research findings practicable and applicable to the vitally important - and often overlooked - area of medication optimisation.” Mustak Mirza, MEDIATE group member, added: “People will trust their leaders when the leaders do the thing that make them feel psychologically safe. And I believe and feel you (the MEDIATE Team) have done that. Many thanks for being so kind.” Dr Jo Howe added: “Input from the group has been invaluable for this project. Their involvement has shaped the trajectory of our research and they have been instrumental in identifying gaps in the research evidence. “It really was fantastic to meet everyone in person, I felt like we connected at a deeper level and I’m really looking forward to working with everyone again on future research.” Professor Ian Maidment, MEDIATE project lead at Aston University, said: “It is vital that the people who this research affects are actively involved in the process. We aimed to do this in MEDIATE and working with this group has really helped inform the research. For example, any guidance or outputs we produce will be centred on real world experience and are therefore much more likely to have an impact.”

Aston University develops software to untangle genetic factors linked to shared characteristics among different species

• Has potential to help geneticists investigate vital issues such as antibacterial resistance • Will untangle the genetic components shared due to common ancestry from the ones shared due to evolution • The work is result of a four-year international collaboration. Aston University has worked with international partners to develop a software package to help scientists answer key questions about genetic factors associated with shared characteristics among different species. Called CALANGO (comparative analysis with annotation-based genomic components), it has the potential to help geneticists investigate vital issues such as antibacterial resistance and improvement of agricultural crops. This work CALANGO: a phylogeny-aware comparative genomics tool for discovering quantitative genotype-phenotype associations across species has been published in the journal Patterns. It is the result of a four year collaboration between Aston University, the Federal University of Minas Gerais in Brazil and other partners in Brazil, Norway and the US. Similarities between species may arise either from shared ancestry (homology) or from shared evolutionary pressures (convergent evolution). For example, ravens, pigeons and bats can all fly, but the first two are birds whereas bats are mammals. This means that the biology of flight in ravens and pigeons is likely to share genetic aspects due to their common ancestry. Both species are able to fly nowadays because their last common ancestor – an ancestor bird - was also a flying organism. In contrast, bats have the ability to fly via potentially different genes than the ones in birds, since the last common ancestor of birds and mammals was not a flying animal. Untangling the genetic components shared due to common ancestry from the ones shared due to common evolutionary pressures requires sophisticated statistical models that take common ancestry into account. So far, this has been an obstacle for scientists who want to understand the emergence of complex traits across different species, mainly due to the lack of proper frameworks to investigate these associations. The new software has been designed to effectively incorporate vast amounts of genomic, evolutionary and functional annotation data to explore the genetic mechanisms which underly similar characteristics between different species sharing common ancestors. Although the statistical models used in the tool are not new, it is the first time they have been combined to extract novel biological insights from genomic data. The technique has the potential to be applied to many different areas of research, allowing scientists to analyse massive amounts of open-source genetic data belonging to thousands of organisms in more depth. Dr Felipe Campelo from the Department of Computer Science in the College of Engineering and Physical Sciences at Aston University, said: “There are many exciting examples of how this tool can be applied to solve major problems facing us today. These include exploring the co-evolution of bacteria and bacteriophages and unveiling factors associated with plant size, with direct implications for both agriculture and ecology.” “Further potential applications include supporting the investigation of bacterial resistance to antibiotics, and of the yield of plant and animal species of economic importance.” The corresponding author of the study, Dr Francisco Pereira Lobo from the Department of Genetics, Ecology and Evolution at the Federal University of Minas Gerais in Brazil, said: “Most genetic and phenotypic variations occur between different species, rather than within them. Our newly developed tool allows the generation of testable hypotheses about genotype-phenotype associations across multiple species that enable the prioritisation of targets for later experimental characterization.” For more details about studying computer since at Aston University visit https://www.aston.ac.uk/eps/informatics-and-digital-engineering/computer-science

Going green: Solar and wind power remain the best alternatives to fossil fuels

Find video for use here.  In the U.S., more and more individuals, and even corporations, are making it a priority to go green in an effort to reduce the nation's dependence on fossil fuels. Studies have proven carbon dioxide is a main contributor to human-caused climate change, so we're tapping into natural elements more often to reduce the use of fossil fuels. From solar farms to solar panels on houses and wind turbines, it’s tough not to find efforts to go green, and that’s a move in the right direction, according to Jessica Reichmuth, PhD, professor in the Department of Biological Sciences in the College of Science and Mathematics at Augusta University. She said we’re heading in the right direction, but more can be done. “We are taking the right steps, but I’m not sure if we will be entirely able to be green energy, but we definitely need to be more green than we are today,” said Reichmuth. “Fossil fuels will eventually run out and are a non-renewable resource.” Homeowners and municipalities are tapping into solar panels most often as a green resource. Some concerns include the costs involved and the fact that in most cases, the panels are permanently attached to a house. Reichmuth points to California as an example of a state trying to ease that burden. Some people who are moving into rental houses and know they aren’t going to be there for a long period of time can have a company attach removable panels. There are other companies jumping into the business of leasing solar panels as well. Even small panels the size of a binder located in a backyard can make a big difference in producing a noticeable amount of electricity. These are great steps, said Reichmuth, but more progress can still be made. “We are at a point within society with green technology that we know and understand how to make solar panels, the infrastructure is there to support them, we just need a movement to get them so they’re used everywhere,” Reichmuth said. Wind turbines remain a big source of discussion. Yes, they provide an alternative electric source, but at what cost? A big negative is the possibility of bird strikes. “Birds will learn to navigate around wind turbines. They are not built in a way that they are impervious to long-distance migration.” Hydroelectricity and geothermal energy are two other green sources of energy. There are not a lot of areas in the U.S. that offer geothermal resources, and as far as hydroelectricity goes, there’s still concern in Reichmuth’s eyes. “I think it would be great to see if dams are going to be used for hydroelectricity, but not as a water containment system. There are portions of the U.S., especially in the southwest, that are dealing with water issues because we have dammed them. Hydroelectricity is good if the dam is used specifically for that purpose and not water containment.” Renewable energy, cost savings and ESG are top of mind for corporations, governments and populations as we look to the future, and if you're a journalist covering this topic, then let us help. Jessica Reichmuth is available to speak with media. Simply click on her icon now to arrange an interview today.

Aston University teams up with eye care provider to reduce NHS patient backlog

Aston University and Eye Docs Ltd enter Knowledge Transfer Partnership to establish new shared-care regimes for eye care patients The new model will help patients access Eye Docs surgeons It will help reduce NHS waiting lists, outpatient clinic backlogs, improve patient care and deliver profits of over £8.8 million Aston University has teamed up with private ophthalmic services clinic, Eye Docs, to undertake a 32-month Knowledge Transfer Partnership (KTP), to help clear NHS surgery waiting-lists and outpatient backlogs. In the West Midlands, average NHS waiting times have increased to over 12 months due to the impact of the Covid-19 pandemic, with waiting list contracts ranging from 100 to 1,500 patients. A cross-disciplinary team from Aston University’s School of Optometry and Aston Business School will work with West Midlands-based company Eye Docs to create a ‘shared-care’ model as part of the KTP. A KTP is a three-way collaboration between a business, an academic partner and a highly qualified researcher, known as a KTP associate. The working model will encompass clinical optometry and management science expertise to identify which patient appointments could be undertaken in community practices and which need to be seen by Eye Docs surgeons. It is hoped this way of working will also help reduce pressure on the NHS - creating a more efficient and cost-effective model that will benefit all stakeholders from patients to clinicians. The Aston University team will be led by Professor Shehzad Naroo, professor of optometry, who brings expertise in leading multidisciplinary groups and managing projects that improve eye care service delivery. Professor Naroo has a long history of working with private clinics to improve delivery of eye care, increasing efficiency and widening the role of private clinics to support the NHS. He will be supported by Professor Prasanta Dey, professor in operations and information management, whose research interests are in project management, service operations management, supply chain management and applications of multi-criteria decision making in industry. Completing the team will be Dr Yang Zhao, senior lecturer in operations and information management, whose research interests are in business model design, digital business models, platform business models, digital innovation, digital healthcare and digitalisation in aging societies. Professor Shehzad Naroo, professor of optometry at Aston University, said: “It is a privilege to be involved in this KTP, which will enable Eye Docs to increase patient numbers to fully utilise theatre capacity by receiving more surgical referrals from local optometrists. “We’re thrilled to be able to help Eye Docs to offer community-based services to patients and help to reduce the burden on the NHS.” Professor Shah, consultant ophthalmic surgeon and co-owner of Eye Docs, said: “This partnership will allow us to adopt the latest research and expertise from a world-leading academic institute to develop new patient pathways and shared-care regimes, enabling us to grow our business and profitability, develop new services and improve patient care. “Working with a multidisciplinary team of clinical and business experts from Aston University will help us to achieve the aims of this project.”

Researchers fight cybercrime with new digital forensic tools and techniques

Irfan Ahmed, Ph.D., associate professor of computer science, provides digital forensic tools — and the knowledge to use them — to the good guys fighting the never-ending cyber-security war. Ahmed is director of the Security and Forensics Engineering (SAFE) Lab within the Department of Computer Science and VCU Engineering. He leads a pair of interrelated projects funded by the U.S. Department of Homeland Security (DHS) aimed at keeping important industrial systems safe from the bad guys — and shows the same tools crafted for investigating cyber attacks can be used to probe other crimes. The goal of cyber attacks on physical infrastructure may be to cause chaos by disrupting systems and/or to hold systems for ransom. The SAFE lab focuses on protecting industrial control systems used in the operation of nuclear plants, dams, electricity delivery systems and a wide range of other elements of critical infrastructure in the U.S. The problem isn’t new: In 2010, the Stuxnet computer worm targeted centrifuges at Iranian nuclear facilities before getting loose and infecting “innocent” computers around the world. Cyber attacks often target a portion of the software architecture known as the control logic. Control logic is vulnerable in that one of its functions is to receive instructions from the user and hand them off to be executed by a programmable logic controller. For instance, the control logic monitoring a natural gas pipeline might be programmed to open a valve if the system detects pressure getting too high. Programmers can modify the control logic — but so can attackers. One of Ahmed’s DHS-supported projects, called “Digital Forensic Tools and Techniques for Investigating Control Logic Attacks in Industrial Control Systems,” allows him to craft devices and techniques that cyber detectives can use in their investigations of attacks on sensitive critical infrastructure. Their investigation capabilities, he explains, is an under-researched area, as most of the emphasis to date has been on the prevention and detection of their cyber attacks. “The best scenario is to prevent the attacks on industrial systems,” Ahmed said. “But if an attack does happen, then what? This is where we try to fill the gap at VCU. And the knowledge that we gain in a cyber attack investigation can further help us to detect or even prevent similar attacks.” In the cat-and-mouse world of cyber security, the way cybercriminals work is in constant evolution, and Ahmed’s SAFE lab pays close attention to the latest developments by malefactors. For instance, an attacker may go for a more subtle approach than modifying the original control logic. An attack method called return-oriented programming sees the malefactor using the existing control logic code, but artfully switching the execution sequence of the code. Other attackers might insert their malware into another area of the controller, programmed to run undetected until it can replace the function of the original control logic. Attackers are always coming up with new methods, but each attack leaves evidence behind. The SAFE lab examines possible attack scenarios through simulations. Scale models of physical systems, including an elevator and a belt conveyor system, are housed at the SAFE lab to help facilitate this. The elevator is a four-floor model with inside and outside buttons feeding into a programmable logic controller. The conveyor belt is more advanced, equipped with inductive, capacitive and photoelectric sensors and able to sort objects. The tools and methods applied in cybercrime can be useful in tracking down other malefactors. That’s where Ahmed’s second DHS-funded project comes in. It’s called “Data Science-integrated Experiential Digital Forensics Training based-on Real-world Case Studies of Cybercrime Artifacts.” Ahmed is the principal investigator, working with co-PI Kostadin Damevski, Ph.D., associate professor of computer science. The goal is to keep law enforcement personnel abreast of the latest trends in the field of cybercrime investigation and to equip them with the latest tools and techniques, including those developed in the SAFE lab. “For example, investigators often have to go through thousands of images, or emails or chats, looking for something very specific,” Ahmed said. “We believe the right data science tools can help them to narrow down that search.” The FBI and other law enforcement agencies already have dedicated cybersleuthing units; the Virginia State Police have a computer evidence recovery section in Richmond. Ahmed and Damevski are arranging sessions showing investigators how techniques from data science and machine learning can make investigations more efficient by sorting through the mounds of digital evidence that increasingly is a feature of modern crime.

UC Irvine NATO expert available to discuss Finland membership

Heidi Hardt, associate professor of political science at UC Irvine, is a scholar whose expertise is in transatlantic security, US foreign policy, national security and European security and defense, including NATO, the EU and OSCE. She is the author of the book, NATO's Lessons in Crisis: Institutional Memory in International Organizations (Oxford UP, 2018). She recently completed a 2021-2022 Council on Foreign Relations International Affairs Fellowship for Tenured International Relations Scholars (IAF-TIRS). During the year, she worked for the US State Department (NATO Desk). Professor Hardt can be reached via email at hhardt@uci.edu.

Aston University establishes new independent investment company

Aston University is part of a group of eight universities which has established a new investment company Midlands Mindforge will accelerate the commercialisation of university research It aims to raise up to £250 million from investors. Aston University is one of eight research intensive universities in the Midlands to establish a new investment company to accelerate the commercialisation of university spinouts and early-stage IP rich businesses in the region.  Midlands Mindforge Limited has been co-founded by Aston University, University of Birmingham, Cranfield University, Keele University, University of Leicester, Loughborough University, University of Nottingham and University of Warwick, collectively Midlands Innovation. This ambitious, patent capital investment company plans to raise up to £250 million from strategic corporate partners, institutional investors and qualifying individuals. It aims to transform ground-breaking science and technology into successful businesses with real-world impact. Midlands Mindforge will help to address the significant funding deficit for early-stage technology businesses in the region. Through the combination of additional capital and company-building skills, Midlands Mindforge will lay the foundations of a more vibrant ecosystem for emerging science-backed companies in areas such as Clean Technology, AI and Computational Science, Life Sciences and Health Tech. Professor Aleks Subic, Vice-Chancellor of Aston University, said: "Aston University has a strong track record in bringing together industry and academia to solve real world problems and drive innovation through applied and translational research. Â Investment raised through Midlands Mindforge will enable a step change that will ensure we get the very best outcomes for our research. "The impact of increased investment in research translation will be felt widely, with Midlands Mindforge supporting the growth of high value added businesses and jobs in the region and creating the right conditions to build future global companies. This is a hugely exciting time for Aston University and the wider Midlands Innovation group of universities, and I look forward to seeing the benefits that this strategic development will bring." Collectively, the eight founding universities have the most postgraduate students, the highest levels of annual income, more research disclosures and patents generated per unit of research spend in the last three years, in comparison to any other UK university grouping. Minister of State for Science, Research & Innovation George Freeman MP said: "Commercialising UK science & technology for global industrial adoption has never been more urgent for both the UK economy and the global resource challenges facing us. The Midlands Innovation universities are driving a new era of innovation from robotics and advanced manufacturing to life science and autonomous vehicles and much more. "As we in Government increase UK public R&D to a record £20 billion a year, the key is private finance backing spinouts and scale-ups. The Midlands is rapidly becoming a world class UK cluster of excellence and Midlands Mindforge will play a key role in bringing global investors to help back world class companies." Chairman of the Midlands Engine Partnership, Sir John Peace, said: "The Midlands has always been associated with exceptional invention and creativity, but has long experienced significant underinvestment and consequently productivity levels have lagged behind the rest of the UK. "This bold and ambitious initiative led by the Midlands Innovation universities has the potential to help close the investment gap, supporting our region to reach its true potential for sustainable economic growth. Midlands Mindforge will help to further fast-track commercialisation of research ideas, creating a more resilient economy and playing an important role in levelling up the Midlands." Andy Street, Mayor of the West Midlands, said: "A key part of my mayoral mission is to drive our regional recovery forward and help generate the high-quality jobs of the future in order to improve quality of life for local people. This exciting new investment vehicle will very much support that mission planting the seeds for long-term sustainable economic growth here in the West Midlands. "Many brilliant ideas and top businesses have spun out from Midlands universities and this new venture will help us to advance that agenda and retain more of our innovative success stories within our region. "Together we can better nurture the enterprising talent on our doorstep and this new endeavour creates a wonderful opportunity to do just that." For more information about Midlands Mindforge visit www.midlandsmindforge.com