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Aston University professor elected Fellow of Royal Microscopical Society
Professor Igor Meglinski is a physicist, scientist and biomedical engineer He pioneered the application of circularly polarised light for cancer detection His research is at the interface of physics, optics and imaging modalities. Igor Meglinski, professor of mechanical, biomedical and design engineering in the College of Engineering and Physical Sciences at Aston University, has been elected as a Fellow of the Royal Microscopical Society (RMS). Professor Meglinski is a physicist, scientist, and biomedical engineer whose research interests are at the interface between modern physics, optics and imaging modalities, focusing on the exploration of novel photonics-based phenomena and their implementation to practical applications in medicine, biology, life sciences and health care industries. Among other achievements, Professor Meglinski pioneered the application of circularly polarised light for cancer detection. best known for his development of fundamental studies and translation research dedicated to imaging of cells and biological tissues utilising polarised light, dynamic light scattering and computational imitation of light propagation within complex tissue-like scattering medium. His current research projects include the application of coherent polarised light for cancer diagnosis, functional imaging of blood and lymph flows, neuroimaging and brain malformation studies. He is also exploring human visual perception of polarised light and helical wave fronts, the fundamentals of shaped light with orbital angular momentum and quantum entanglements transfer in turbid tissue-like scattering medium, screening of cells, cell’s organelles and cells interaction. He has authored and co-authored more than 400 scientific papers and presented over 800 presentations at major international conferences in the field, including over 200 keynote and plenary talks and invited lectures. The Royal Microscopical Society is a learned society dedicated to the promotion and development of microscopy and imaging. Its members come from a wide range of backgrounds, including undergraduates, research students, users of microscopy in industry and academia, microscopy manufacturers and suppliers and research leaders in their various fields within the biological and physical sciences. Professor Igor Meglinski said: “I was delighted to be invited to become a Fellow of the Royal Microscopical Society. “It is always a pleasure to be recognised for your work, such as my recent research which could provide a more accurate method of blood flow diagnosis in skin to help people with diabetes.”
Professor Corinne Spickett will explain how oxygen can cause damage to cells and lead to diseases Her inaugural lecture will take place on Thursday 26 January 2023 at 6.30 pm Members of the public may attend in person or online. A leading biochemist at Aston University is to give an inaugural lecture on the concept of oxidative stress and how failure to control it leads to diseases on Thursday 26 January 2023. During her public lecture, ‘Oxygen: can’t live without it, but stressful to live with it’, Professor Corinne Spickett will explain how oxygen can cause damage to cells, how damaged molecules such as “sticky lipids” can be measured using advanced technology, and what their biological effects are. Corinne moved to Aston University in 2011 from the University of Strathclyde. Her first degree was in biochemistry at Oxford University and she went on to gain a DPhil from Oxford on the application of NMR to study yeast bioenergetics in vivo. After postdoctoral work using NMR to investigate stress responses in plants and glutathione metabolism in pre-eclamptic toxaemia, she became a Glaxo-Jack research lecturer in the Department of Immunology at the University of Strathclyde and subsequently a senior lecturer in the Department of Biosciences. Since then, she has been working on the analysis of phospholipid oxidation by mass spectrometry and the biological effects of oxidized lipids, especially as relating to atherosclerosis and inflammation, and has published extensively in this field. She has also applied her expertise in analysis of phospholipids to lipidomic studies of LDL in chronic kidney disease and the study of changes in yeast membranes in biotechnology applications. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation. She is an internationally recognized researcher in the field of redox biology with extensive involvement in international research. Professor Spickett said: “We tend to take oxygen for granted as something essential for life, but actually it is highly reactive and its role in biochemistry poses a challenge for organisms from yeast to man. “Through a synopsis of my career, I will explain how oxygen can cause damage to cells and, in parallel, I will illustrate how academic research careers are often non-linear and often depend on serendipity.” The lecture will take place at Aston University at 6.00 pm for 6.30 pm on Thursday 26 January 2023. It will be followed by a wine reception from 7.30 pm to 8.00 pm. It is open to the public and free to attend, but places must be booked in advance via Eventbrite.
Professor of biotechnology appointed as new executive editor of prestigious journal
A biotechnology professor in the College of Health and Life Sciences at Aston University has been appointed as the new executive editor of the journal, BBA Biomembranes. Professor Roslyn Bill is sharing the role with Professor Burkhard Bechinger of the University of Strasbourg and will be jointly responsible for the editorial direction of the journal, including overseeing the peer review process of submissions. Roslyn's own area of research focuses on membrane protein structure, function and regulation. She is particularly interested in the regulation of aquaporin water channels in the brain and their development as drug targets to prevent life-threatening brain swelling. BBA Biomembranes is part of a family of 10 Biochimica et Biophysica Acta (BBA) journals, which are celebrating their 75th year of continuous publication in 2022. They were the first international journals to cover the joint fields of biochemistry and biophysics. Commenting on her appointment, Roslyn said: “I am delighted and honoured to join BBA Biomembranes as Executive Editor in BBA’s 75th anniversary year. “The journal has an international reputation for publishing high-quality articles in all aspects of membrane biology and biophysics. I look forward to working with the BBAMEM team to drive the journal’s continuing success.” Areas of research covered by BBA Biomembranes include: membrane structure, function and biomolecular organization, membrane proteins, receptors, channels and anchors, fluidity and composition, model membranes and liposomes, membrane surface studies and ligand interactions, transport studies and membrane dynamics. For more information on Professor Bill’s research, visit the research pages. For more information about studying in the School of Biosciences at Aston University, please visit our website.
Aston University sets Meritics on course to become market leader in the bio-pharmaceutical sector
Aston University has completed a knowledge transfer partnership with Meritics Ltd to develop the company’s capability and underpinning knowledge to measure the size, concentration and distribution of biological entities, such as liposomes and exosomes, using proprietary particle analysers. The project will enable Meritics to enter the fast-growing biologics sector with their particle analysis instruments and services to significantly increase company turnover. It represented a significant change in direction for the company and focused on systems that would have the largest impact. Results provided Meritics with significant data and proof-of-concept applications required to widen the company’s product range into the biological market. It also broadened the company’s knowledge of biological applications and helped bridge gaps between the areas of interest and the limitations of the analysers. Meritics Ltd supplies and provides service support for a range of particle characterisation instrumentation to industrial, research and academic institutions in the UK. Additionally, it offers a range of consumables, analysis services and consultancy. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, called a KTP Associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. The project was led by Dr Alice Rothnie and Dr Alan Goddard from Aston University’s Aston Centre for Membrane Protein & Lipid Research (AMPL), a specialist research group with a track record of biological particle characterisation. Dr Rothnie has over 14 years of experience working with liposomes, viral and cellular systems, while Dr Goddard brought over a decade of experience in biological membranes and nanoparticles ¬– mainly focusing on liposomes. Also working on this partnership as KTP Associate was Dr Megan Cox, whose proven expertise in biochemistry drove the innovation and research behind the project. Following the completion of the project, Dr Cox has been employed by Meritics as a Technical Specialist, using biological expertise to assess instrument parameters for biological entities. Brian Miller, founding managing director of Meritics, said: “The project has sped up the company’s plan to move into more biological application areas and widen our customer base. Aston University’s extensive knowledge in biology and biological entities is crucial for our wider sales and technical staff and provided invaluable visibility of the biological markets”. Dr Alan Goddard said: “Working in partnership with Meritics has allowed us to transfer our extensive experience of biological particles into industry. We have formed an exciting partnership which has continued past the end of the formal project, enabling cutting-edge research to be performed at Aston using the latest equipment.”
Why pollen season arrives earlier each year: Q&A with Georgia Southern biology professor Alan Harvey
As a seasonal allergy sufferer, Alan Harvey, Ph.D., biology professor in Georgia Southern University's College of Science and Mathematics, was curious what types of pollen were causing his sniffles and sneezes. As a scholar and educator, Harvey did what any curious mind would do — he began exploring the types of pollen in the region while trying to narrow down the culprit of his symptoms. What he didn’t expect to find was an interesting narrative that led to a collaborative art-science project and soon a full exhibit on pollen at the Georgia Southern Museum. Read on to learn more about Harvey’s research on pollen, upcoming exhibit, “Pollen Nation,” and why pollen season begins earlier each year. Q: Tell us about yourself — Who are you? What do you teach? How long have you been a professor here? A: I’m a professor and faculty member at Georgia Southern. This is my 23rd year here and I teach a variety of biology courses including field biology, invasive species and evolutionary ecology. Q: How long have you studied pollen and what interested you in studying this? A: I’ve not actually studied pollen for that long. I really wanted to figure out how to deal with my own severe allergies to it. Q: What is the most common pollen in our region? A: The most common pollen depends on the time of year. Any plant that produces flowers will produce pollen. But if you’re looking at a plant with nice, pretty flowers, that pollen is not going to be what you’d normally encounter or notice causing your allergies because that pollen is being transmitted by insects or other pollinators who are specifically being attracted by the pretty flowers. The kind of pollen that you do encounter is from plants that you wouldn’t even notice have flowers like pine, oak, maple and birch trees. Those are all wind-pollinated, so they don’t need pretty flowers. They’re not trying to attract anybody, they just have to produce a lot of pollen for the wind to blow around. This time of year, pine and oak are going to be the two common pollens. Q: When does pollen season usually begin in our region? A: It starts in the early spring and ends in late fall. And again, it’s different plants blooming during the course of that year. So this time of year, as I mentioned, is going to be pines and oaks. In the middle of the year, it will be more grasses, and toward the end of the year, it’s going to be things like ragweed. What scientists have discovered is that every year the pollen season starts earlier and lasts longer. Q: Why will it begin early this year? A: This is where we get into a sort of controversial subject, but basically, climate change issues are the main culprit in a couple of ways. First of all, plant growth is tied to temperature. So the earlier temperatures get warmer, the earlier in the year the plant is going to start actively growing and producing pollen. So, warmer temperatures are leading to earlier seasonal starts. Temperatures are warmer than they were at this time a few decades or 100 years ago. Q: Why is pollen important? A: It’s an essential component of sexual reproduction in plants, so in the absence of pollen, we would lose many, if not virtually all of the plants around us that we depend upon. It’s fundamentally important to life on Earth that those plants are able to continue to reproduce. In terms of its impact on known pollinators, when a bee visits a flower, it is, of course, looking for nectar that the plants produce, but they also are looking for pollen. So it’s a food source for a lot of animals as well. Q: What is an interesting fact or little-known fact about pollen? A: Pollen plays a role in some various religious ceremonies of other cultures. The one I’m most familiar with is in the Navajo Nation. In particular, corn pollen is at the core of a great many, if not virtually all, of the Navajo religious ceremonies. It’s also been used to solve crimes and there is a whole field of forensic pollen analysis. It’s also an important tool for paleontologists, anthropologists and archaeologists who are trying to understand past civilizations. Because pollen is incredibly resilient, it may be small, but it is darn near indestructible. You would need a pretty powerful microscope to see any of these, but with that tool, you can study pollen grains that are hundreds of millions of years old. They will last that long. They’re so, so tough. Q: Tell us about the new mural in the Biological Sciences Building — What inspired it? Who helped work on it? A: A number of years ago, a colleague in the Betty Foy Sanders Department of Art, Jeff Shmucki, and his wife Wendy Deschene and I came together and started collaborating on art-science projects because we realized we both are observers of the natural world, we just approach it from somewhat different ways. One of those projects was creating a mural of ecologically or environmentally important organisms surrounding students that they may not be aware of. For the first mural, we looked at salamanders of Georgia. We got a bunch of photographs of the salamanders and we cut them away from the background, blew them up and installed the murals. It was a big community project and students got involved in all phases of it. So I thought, ‘Well, that was really successful.’ What can we do next? And because I was in the middle of allergy attacks, I thought, ‘Well, what about pollen?’ Q: Tell us how the mural inspired your upcoming exhibit, “Pollen Nation,” at the Georgia Southern Museum. A: There are a lot of interesting layers to this basic idea of pollen that can’t really be shown in a mural, and the Georgia Southern Museum is a perfect place to explore those kinds of ideas in one common theme. Q: What can people expect to see at the “Pollen Nation” exhibit? A: There’ll be a lot of big, spectacular images of pollen and the plants that produce them. It’s going to be a mix of striking imagery and some interactive sort of game-like activities. You’ll also have the opportunity to look at some of the pollen in a microscope. Interested in learning more? Let us help. Allan Harvey, Ph.D., is available to answer your questions - simply reach out to Georgia Southern Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to arrange an interview today.
Senior lecturer at Aston University appointed as a Champion of the Microbiology Society
Dr Jonathan Cox, a senior lecturer in microbiology at Aston University, has been made a Champion of the Microbiology Society for the Midlands area, U.K. Microbiology Society Champions are members who help to raise the Society’s profile in their local area by initiating activities and events of their own or participating in Society-led events. They are appointed because of their passion for their subject matter and an enthusiasm to communicate it widely. Jonathan’s research interests surround the discovery of new antibiotics. He leads the Mycobacterial Research Group at Aston University, a multidisciplinary team spanning microbiology, biochemistry, molecular genetics, structural biology and drug discovery. The team’s main focus is to study the physiology of various pathogenic mycobacteria and to discover new ways to treat infections. He also teaches at Aston University and currently leads the teaching for first year microbiology on courses in biomedical science, biology and biochemistry, Jonathan also regularly engages with the press to comment on news stories and issues related to microbiology, infectious diseases and antibiotic resistance. He has been a full member of the Microbiology Society for 10 years and has already contributed in many ways, including hosting the Microbiology Society Roadshow at Aston University in 2021. He has also been featured in Microbiology Today discussing his research. Speaking of his appointment, Jonathan said: “Anti-microbial resistance (AMR) accounts for around 700,000 deaths per annum globally and that number is predicted to rise to 10 million by 2050. The current economic burden of AMR is estimated to be at least €1.5 billion per year in the EU. New antibiotics and an improved understanding of how to use them will help to slow the progression of AMR, saving countless lives in the future. “I am delighted to have been appointed as a Microbiology Society Champion and to use this opportunity to raise the profile of the Society and, in particular, the importance of research into AMR.”
Aston University has teamed up with biotechnology company Biocleave Ltd in a new knowledge transfer partnership (KTP) to develop the company’s capacity to produce membrane-associated proteins on a competitive commercial scale. The partnership will see Aston University’s world-leading expertise provide next-level solutions to a complex problem and provide exciting breakthroughs from both commercial and scientific standpoints. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. Biocleave Ltd produces ‘Research Use Only’ (RUO) proteins. These are used widely in industry and academia to study and develop diagnostics and disease treatments. The process of manufacturing these proteins is known as ‘expression’, requiring host cells to produce them. The company is the first to engineer the non-pathogenic microbe Clostridia as a recombinant protein expression host, enabling them to overcome the typical expression challenges of production host toxicity and costly development cycles. Initial trials have demonstrated advantages to making membrane-associated proteins in Clostridia compared with established production systems. However, these proteins are associated with the fatty membrane that surrounds a cell and are not soluble in water. While Biocleave has well-established proprietary technology for manipulating the microbes, they want to extend their expertise for purifying these challenging membrane proteins, essential to commercialising their production. The Aston University team will be led by Dr Alan Goddard, senior lecturer in biochemistry in the School of Biosciences and founding member of Aston Membrane Proteins and Lipids (AMPL). Dr Goddard’s research focuses on the application of membrane biology to industrially relevant problems. He has nearly 20 years' experience working with membranes and their integral proteins. Dr Goddard will be joined by Professor Roslyn Bill, associate dean (research) for the College of Health and Life Sciences and director of AMPL. Professor Bill’s research focuses on the purification and characterisation of membrane proteins and she has published extensively on yeast as a recombinant expression host. Commenting on the project, Dr Goddard said: “This is a really exciting opportunity to leverage the decades of research experience Professor Bill and I have with expressing and purifying membrane proteins. It will allow Biocleave to enter new markets, many of which are important for drug development and healthcare. Hopefully, the products we make will have positive benefits not only for Biocleave’s customers but also wider society.” Dr Liz Jenkinson, chief executive of Biocleave Ltd, said: “We’ve made great progress in establishing the technology to work with Clostridia, a promising host, and although we’re constantly learning, so much is still unknown about the clostridial membrane. Through this KTP partnership with Aston University, we’re excited to develop the skills of our staff and expand our commercial offering to extend our range of RUO protein targets.” Because the Clostridial membrane adds a new level of complexity, successfully developing the required tools internally to resolve these issues, without input from experts, would take considerable time.
Prof Rachel Warren on the impacts of climate change at COP26
A number of climate experts from the University of East Anglia will be available for interview during the COP26 climate conference in Glasgow. Their areas of expertise range from the impact of climate change on biodiversity, climate geoengineering and carbon removal, to the impact of climate change on sovereign credit ratings, carbon uptake by the oceans, and gender and climate change. Among them is Prof Rachel Warren, Professor of Global Change and Environmental Biology, from UEA's School of Environmental Sciences and Tyndall Centre for Climate Change Research. Her research areas and expertise cover the impacts of climate change on biodiversity. She is an IPCC author and available for interview on topics including climate change policy and modelling, climate change mitigation and adaptation, the impact of climate on ecosystems and species, and sustainability in the context of the Paris Agreement goals to limit global warming to well below 2oC.
UCI scientists study the effects of an oil spill on Orange County's coastline
Joana Tavares and Melissa Brock, a Ph.D student in ecology and evolutionary biology, are spearheading the newly formed Southern California Oil Spill Project at UCI. They are analyzing the composition and health of the phytoplankton and bacterial communities in the ocean and inland waterways, using samples collected before, during, and ultimately after the oil spill situation has played out. Also, the cleanup of the oil spill off the coast of Huntington Beach earlier this month is essentially complete, but responsibility for the spill has yet to be assigned. In the coming months, and possibly years, it will be the legal system that determines liability — and damages. Michael Robinson-Dorn, a clinical professor of law, co-associate dean for experiential education at the law school and director of UCI’s Environmental Law Clinic, joins the UCI Podcast to discuss how this spill compares to past ones, why simply shutting down offshore drilling is more challenging than it may seem and how society’s values will shape the future of oil drilling in California. For more information or to contact the researchers, email Brian Bell at bpbell@uci.edu.
How rabbits help restore unique habitats for rare species
European wild rabbits are a ‘keystone species’ that hold together entire ecosystems – according to researchers at the University of East Anglia. Our campus is home to hundreds of rabbits and Prof Diana Bell, from our School of Biological Sciences, has been researching them for more than 30 years. Now, she is one of the lead researchers on a new report which aims to restore and protect at-risk wildlife habitats which are rabbit dependent. The report shows how their grazing and digging activity keeps the ground in a condition that is perfect for sustaining other species that would otherwise move on – or die out. But their numbers are declining regionally, nationally and globally. And they are even being classed as endangered in their native region, the Iberian Peninsula. The findings come as efforts to save England’s most threatened species from extinction are turning the tide for wildlife in Norfolk and Suffolk thanks to the Shifting Sands project. Shifting Sands is one of 19 projects across England that make up the national Back from the Brink initiative. Together, these projects aim to save 20 species from extinction and benefit over 200 more. Lead partner of the rabbit work-stream and rabbit expert Prof Diana Bell, from UEA’ School of Biology, said: “The Breckland-based Shifting Sands project was set up to save some of the region’s rarest wildlife. “After several years of hard work by this multi-partner project, the fortunes of species classed as declining, rare, near-threatened or endangered are now improving in the Brecks. “The project has seen species recover in record numbers – including endangered beetle and plants, one of which is found nowhere else in the world. “Rabbits are incredibly important because their grazing and digging activity keeps the ground in a condition that is perfect for sustaining other species. “Sadly, rabbit populations have declined dramatically in the UK and across Europe, and the European wild rabbit is now listed as endangered in its ancestral Iberian Peninsula range. Their decline is largely due to a spill-over of new viruses from commercially bred rabbits. “The Shifting Sands project has shown us how important rabbits are to entire ecosystems, and it is vital that these habitats are conserved and protected. “We encouraged a rabbit revolution in the Brecks and we have produced a toolkit in partnership with Natural England to help landowners of similar rabbit-dependent habitats to do the same.” “Simple cost-effective ways of encouraging rabbits include creating piles of felled branches, known as brush piles, and banks of soil.” Monitoring over the past three years has shown the interventions are working, with evidence of significantly higher amounts of rabbit activity. Prof Bell said: “Our work resulted in evidence of rabbit activity in significantly higher numbers. 91 per cent of brush piles showed paw scrapes and 41 per cent contained burrows. Even when burrows did not form, the brush piles helped expand the range of rabbit activity.” The UEA research team worked in collaboration with Natural England, Forestry England, Plantlife, Breckland Flora Group, Norfolk Wildlife Trust, Suffolk Wildlife Trust, Butterfly Conservation, Buglife, the Elveden Estate and the RSPB to deliver this ambitious partnership project. It has seen five kilometres of ‘wildlife highways’ created, more than 100 specimens of rare plants re-introduced, habitat created and restored across 12 sites, species encouraged, and landscape-management practices improved. As a result, seven species of plant, bird and insect are increasing in number and many more are benefiting in turn. Among those species recovering are rare plants such as the prostrate perennial knawel that is unique to the Brecks, basil thyme and field wormwood. The endangered wormwood moonshiner beetle, lunar yellow underwing moth and five-banded digger tailed wasp are also increasing. All these species are identified in the UK’s Biodiversity Action Plan as being priorities for conservation. The open habitat maintained by rabbits supports two rare plants: the prostrate perennial knawel – found nowhere else in the world – and field wormwood. Pip Mountjoy, Shifting Sands project manager at Natural England, said: “The Brecks were described by Charles Dickens as “barren”. They are anything but. Their 370 square miles of sandy heathland, open grassland and forest support almost 13,000 species, making it one of the UK’s most important areas for wildlife. “That wildlife is under threat. Felling trees and encouraging a species that is often considered a pest may seem a strange solution. But in this instance, carefully managed ‘disturbance’ is exactly what this landscape and its biodiversity needs.” “The project’s interventions have provided a lifeline for this unique landscape, and shown how biodiversity can be promoted by ‘disturbing’ places – not just by leaving them alone. “ “These rare habitats are becoming overgrown and species are declining as a result of changing land management practices and human impacts. It’s our responsibility to restore and maintain these spaces for nature. Some of these species exist only here and, if lost, will be lost forever.” Established in 2017 with £4.7m from the Heritage Lottery Fund and £2.1m from other bodies, Back from the Brink was the first nationwide co-ordinated effort to bring together charities, conservation organisations and government bodies to save threatened species. More information about the Brecks, Shifting Sands, Back from the Brink and a toolkit to help rabbit conservation is available via www.naturebftb.co.uk.