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University of Delaware biomedical engineer helps develop first immune-capable cervix-on-a-chip
A major breakthrough in biomedical engineering is changing how scientists study sexually transmitted infections (STIs) – and a researcher from the University of Delaware is at the forefront. Published in Science Advances, the study introduces the first immune-capable “cervix-on-a-chip,” a cutting-edge microphysiological system that replicates the human cervical environment. The platform allows researchers to observe how infections, the immune system and the vaginal microbiome interact in real time – something not previously possible with traditional lab models. Co-lead author Jason Gleghorn, associate professor in the College of Engineering, led the development of the model. His work highlights how engineering-driven approaches are advancing critical research in women’s health. By integrating engineering with biology, we can now simulate complex human systems more accurately and make these tools accessible to a wider range of researchers, Gleghorn said. The model recreates key features of the cervix using human cells, immune components and naturally occurring microbiomes within a dynamic system that mimics physiological conditions. When tested with infections such as chlamydia and gonorrhea, the platform revealed how protective bacteria can reduce infection risk – while imbalanced microbiomes can worsen outcomes. These findings could help accelerate the development of new therapies, including probiotics and other preventative strategies aimed at strengthening the body’s natural defenses. The research underscores the growing impact of the College of Engineering, where interdisciplinary collaboration is driving innovation across biomedical engineering and beyond. By combining expertise in engineering, microbiology and immunology, the team has created a powerful new tool that could reshape how STIs – and other complex diseases – are studied. To speak with Gleghorn further about this advancement, email mediarelations@udel.edu.
UF professor to expand proven disease-prediction dashboard to monitor Gulf threats
After deploying life-saving cholera-prediction systems in Africa and Asia, a University of Florida researcher is turning his attention to the pathogen-plagued waters off Florida’s Gulf Coast. In the fight to end cholera deaths by 2030 – a goal set by the World Health Organization – UF researcher and professor Antar Jutla, Ph.D., has deployed his Cholera Risk Dashboard in about 20 countries, most recently in Kenya. Using NASA and NOAA satellite images and artificial intelligence algorithms, the dashboard is an interactive web interface that pinpoints areas ripe for thriving cholera bacteria. It can predict cholera risk four weeks out, allowing early and proactive humanitarian efforts, medical preparation and health warnings. Cholera is a bacterial disease spread through contaminated food and water; it causes severe intestinal issues and can be fatal if untreated. The US Centers for Disease Control reports between 21,000 and 143,000 cholera deaths each year globally. Make no mistake, the Cholera Risk Dashboard saves lives, existing users contend. His team now wants to set up a similar pathogen-monitoring and disease-prediction system for pathogenic bacteria in the warm, pathogen-fertile waters of the Gulf of America. “Its timeliness, its predictiveness and its ease of access to the right data is a game changer in responding to outbreaks and preventing potentially catastrophic occurrences.” - Linet Kwamboka Nyang’au, a senior program manager for Global Partnership for Sustainable Development Data Closer to home Jutla is seeking funding to develop a pathogen-prediction model to identify dangerous bacteria in the Gulf to warn people – particularly rescue workers – to use protective gear or avoid contaminated areas. He envisions post-hurricane systems for the Gulf that will help the U.S. Navy/Coast Guard and other rescue workers make informed health decisions before entering the water. And he wants UF to be at the forefront of this technology. “If we have enough resources, I think within a year we should have a prototype ready for the Gulf,” said Jutla, an associate professor with UF’s Engineering School Sustainable Infrastructure and Environment. “We want to build that expertise here at UF for the entire Gulf of America.” Jutla and his co-investigators have applied for a five-year, $4 million NOAA RESTORE grant to study pathogens known as vibrios off Florida’s West Coast and develop the Vibrio Warning System. These vibrios in the Gulf can cause diarrhea, stomach cramps, nausea, vomiting, fever and chills. One alarming example is Vibrio vulnificus, commonly known as flesh-eating bacteria, a bacterium that often leads to amputations or death. The Centers for Disease Control and Prevention (CDC) has reported increases in vibrio infections in the Gulf region, particularly from 2000 to 2018. The warm and ecologically sensitive Gulf waters provide a thriving habitat for harmful pathogens. “The grant builds directly on the success of our cholera-prediction system," Jutla noted. "By integrating AI technologies into public health decision-making, we would not only lead the nation but also become self-reliant in understanding the movement of environmentally sensitive pathogens, positioning ourselves as global leaders.” Learning from preparing early Jutla’s dashboards are critical tools for global health and humanitarian officials, said Linet Kwamboka Nyang’au, a senior program manager for Global Partnership for Sustainable Development Data. “Its timeliness, its predictiveness and its ease of access to the right data is a game changer in responding to outbreaks and preventing potentially catastrophic occurrences,” Kwamboka Nyang’au said. Over the last few years, Jutla and several health/government leaders have been working to deploy the cholera-predictive dashboard. “Our partnership with UF, the government of Kenya and others on the cholera dashboard is a life-saving mission for high-risk, extremely vulnerable populations in Africa. By predicting potential cholera outbreaks and coordinating multi-stakeholder interventions, we are enabling swift action and empowering local governments and communities to prevent crises before they unfold,” said Davis Adieno, senior director of programs for the Global Partnership for Sustainable Development Data. The early warnings for waterborne pathogens also allows the United Nations time to issue early assistance to residents in the outbreak’s path, said Juan Chaves-Gonzalez, a program advisor with the United Nations’ Office for the Coordination of Humanitarian Affairs. “There are several things we do with the money ahead of time. We provide hygiene kits. We repair and protect water sources. We start chlorination, we set up hand-washing stations, train and deploy rapid-response teams. At the community level, we try to inject funding to procure rapid-diagnostic tests,” he said. “We identify those very, very specific barriers and put money in organizations’ hands in advance to remove those barriers.” Eyes on the Gulf In the United States, hurricanes stir up vibrios in the Gulf, posing a high risk of infection for humans in the water. There has been a nearly 200% increase in these cases over the last 20 years in the U.S., according to the CDC. “After Hurricane Ian, we saw a very heavy presence of these vibrios in Sarasota Bay and the Charlotte Bay region. Not only that, but they were showing signs of antibiotic-resistance. Last year, we had one of the largest number of cases of vibriosis in the history of Florida,” Jutla said. Samples from 2024 hurricanes Helene and Milton are being analyzed with AI and complex bioinformatics algorithms. “If there is a risky operation by rescue personnel, not using personal protective equipment, then we would want them to know there is a significant concentration of these bacteria in the water,” Jutla said. “As an example, Navy divers operating in contaminated waters are at risk of infections from vibrios and other enteric pathogens, which can cause severe gastrointestinal and wound infections.” Safety and economics “Exposure to vibrios and other enteric pathogens,” Jutla added, “can disrupt economic activities, particularly in coastal regions that are dependent on tourism and fishing. And vibrios may be considered potential bioterrorism agents due to their ability to cause widespread illness and panic.” In developing the Vibrio Warning System, Jutla noted, he and his team want to significantly enhance public health safety and preparedness along the Gulf Coast. By leveraging advanced AI technologies, satellite datasets and predictive modeling, they plan to mitigate the risks posed by environmentally sensitive pathogenic bacteria, ensuring timely interventions and safeguarding human health and economic activities. “Hospital systems and healthcare providers in the Gulf region will have a tool for anticipatory decision making on where and when to anticipate illness from these environmentally sensitive vibrios, and issue a potential warning to the general public,” he said. “With the potential to become a leader in environmental pathogen prediction, UF stands at the forefront of this critical research, poised to make a lasting impact on local, regional, national and global health and safety.”
LSU Launches Louisiana’s Most Advanced Microscope at Research Core Facility
LSU’s Advanced Microscopy and Analytical Core (AMAC) facility gives Louisiana researchers access to 16 state-of-the-art instruments, including a new Spectra 300 Scanning Transmission Electron Microscope (S/TEM) for atomic-scale imaging and analysis. The new microscope—the most advanced in Louisiana—was installed with $10 million in support from the U.S. Army. Standing almost 13 feet tall on a platform isolated from vibration, the S/TEM required major renovations, including a raised ceiling, acoustic wall panels, and a magnetic field cancellation system to ensure the instrument’s stability and performance. The microscope offers magnification up to 10 million times, powerful enough to enlarge a single grain of Mississippi River silt to the size of Tiger Stadium. “This is a transformational moment for LSU and for the future of research in Louisiana,” Interim LSU President Matt Lee said. “With the installation of the most advanced microscope in the state, LSU is once again demonstrating how we’re delivering on our promises—leading in research, innovation, and service to the state and nation.” The launch of the AMAC and S/TEM demonstrates LSU’s increased investment in providing its faculty and partners with the best possible equipment for research and discovery, including for national defense, energy, and health. “Winning in research is no different than winning in athletics—the best facilities attract the best talent, and you need the best of both to win,” LSU Vice President of Research and Economic Development Robert Twilley said. “Today’s launch is about a state-of-the-art microscope but also the launch of the AMAC as our first research core facility at LSU—the first of more to come to attract, train, and supply the best research talent for Louisiana and build research teams that win.” Using a finely focused electron beam and techniques such as energy dispersive X-ray spectroscopy (EDS) and electron energy loss spectroscopy (EELS), the S/TEM can reveal both structure and chemistry at atomic resolution. These capabilities drive advances in materials science—improving semiconductors, solar cells, batteries, catalysts, coatings, and alloys—while supporting biomedical research by mapping drug delivery, uncovering the structures of viruses and bacteria, and improving medical implant design. LSU’s AMAC research core facility was recently rebranded, changing its name from the Shared Instruments Facility (SIF). Learn more about how AMAC instruments help unlock millions in federal research funding to Louisiana and deliver solutions.
New path to combating global malnutrition found in soil
A new University of Delaware study has found that a naturally occurring soil microbe can boost protein-building amino acids in wheat. The finding by UD's Harsh Bais and others could pave the way for nutrient-rich staple crops — helping combat global malnutrition as fluctuations in weather reduce crop quality. In the study, published in the journal Frontiers in Microbiology, Bais and a team of researchers from UD, Stroud Water Research Center and the Rodale Institute investigated how a bacteria naturally found in the soil that is beneficial to human health can enhance the levels of the amino acid and antioxidant ergothioneine in spring wheat. The researchers grew the spring wheat — one of the most widely consumed cereal crops — in a laboratory. After letting the seeds germinate and grow for seven days, they added a strain of bacteria called Streptomyces coelicolor M145 to the spring wheat roots. After combining the bacteria and the plant, they separated the plant’s leaves and roots. Then, they extracted the amino acid ergothioneine from the samples, working to determine how much protein was in the plant’s roots and shoots. They found that 10 days after S. coelicolor had been added to the spring wheat roots, the bacteria was able to inhabit spring wheat’s roots and shoots, producing ergothioneine, bypassing the plant’s innate defense mechanisms, and fortifying the spring wheat. Wheat roots were inoculated with the benign bacteria Streptomyces coelicolor. The image shows the presence of bacteria on the root hairs on day 5. “It’s unusual," Bais said. “Unless there is a mutual advantage for either the plant or the microbe.” The findings suggest that an alternative plant breeding approach could be utilized to associate plants with benign microbes to increase protein content in staple crops. All of our cereal crops are very low in protein. Think rice and breakfast cereals, common foods people eat, derived from these crops. “This approach of harnessing a natural association of microbes with plants may facilitate fortifying our staple crops, enhancing global nutritional security,” Bais said. Bais said he believes using microbes to transport nutrients depends on the microbes’ relationship with plants’ roots. He continues to work to catalyze the colonization of plant roots by beneficial microbes. "Establishing a partnership with the appropriate types of microbes or microbial consortia for plants represents a method of engineering the rhizosphere — the region of the soil near plant roots — to foster a more favorable environment for either microbial associations that stimulate plant growth traits or enhance nutrient availability, which is the path forward,” Bais said. Bais, a professor of plant biology who was named a UD Innovation Ambassador earlier this year, said plants’ “below-ground” traits, such as how nutrient-dense they are, have long been overlooked. “As far as food security, we will have significant challenges by 2050 when the world’s population doubles,” Bais said. “We incentivize our farmers for crop yield; we don’t incentivize them for growing nutrient-dense crops. Growing nutrient-dense plants will enable the population to be fed better and avoid any potential nutrient deficiencies.” The study was funded by the U.S. Department of Agriculture and the Foundation for Food and Agriculture Research. Scientists have become more interested in soil bacteria as a means to solve issues with malnutrition and nutrient deficiencies. Alex Pipinos, the lead author and a UD Class of 2025 graduate with a master’s in microbiology, said environmental conditions are one factor diminishing protein content in plants. “Essentially, crops are becoming less nutrient-dense,” Pipinos said. “The more nutrients in crops, the more healthy humans can be.” Pipinos points to a strong link between soil microbes, plant health and human health. Ergothioneine, she said, has already been shown to lower the risk of cardiovascular disease. It’s also been shown to combat cognitive decline, with a strong link to healthy cognitive aging. “By enhancing ergothioneine in plants, we can improve human health,” Pipinos said. To reach Bais directly and arrange an interview, visit his profile and click on the contact button. Reporters can also contact UD's Media Relations Department.
Are raw oysters safe to eat? A seafood expert has answers
Two people recently died in Louisiana after eating raw Gulf oysters contaminated with the flesh-eating bacteria Vibrio vulnificus. Now that we have returned to the “r” months of autumn, a period historically considered safer to consume the mollusks on the half shell, seafood lovers are rightfully on edge about enjoying what many consider a saltwater delicacy. Evelyn Watts, a seafood extension specialist with the LSU AgCenter and Louisiana Sea Grant, has spent the better part of her adult life working with the seafood industry on the best ways to process and work through regulations about their catches. She wants to set the record straight about the safety of eating Gulf oysters throughout the year. According to the U.S. Centers for Disease Control and Prevention, vibrio is a type of bacteria that thrives in warm, brackish waters, especially between May and October. Watts said that while Louisiana is observing some above-average cases, it is important to remember that vibrio is a seasonal pathogen with most infection cases linked to wound exposure or ingestion. On July 31, the Louisiana Department of Health reported four deaths and 17 hospitalizations from vibrio infections this year. The number of hospitalizations had risen to 22 as of the last week of August. Watts emphasized safe handling and cooking of all Louisiana seafood. Thoroughly cooking oysters and other shellfish eliminates any vibrio risk, she said. “The Louisiana seafood industry follows strict safety protocols, including cold-chain management and traceability systems, which includes the use of tags,” she said. “The tag color indicates if harvest refrigeration times have been followed.” Watts said white-tagged oysters may be consumed raw while those with green tags must be sold for processing and cannot be purchased for raw consumption. “Restaurants are required to post consumer advisories about raw shellfish risks, especially for those with liver disease or weakened immune systems,” she said. “Consumers may purchase oysters either as shellstock — live molluscan shellfish still in the shell — or shucked, where the meat has been removed from the shell.” Watts explained that if consumers intend to purchase shellstock oysters for raw consumption, they must look for the white tag, which confirms the product has followed proper refrigeration protocols. This tag includes key information such as the harvester’s name, the dealer’s name and address, certification number, date of harvest and harvest location. Conversely, pre-shucked oysters or half-shell oysters sold in tubs, bags or trays — whether refrigerated or frozen — are not intended for raw consumption unless the label explicitly states otherwise. “While vibrio is more common in warmer months, it’s important to remember that it can be present year-round," Watts said. "The good news is that by staying informed and choosing properly cooked oysters, consumers can enjoy seafood safely in any season.” According to LSU AgCenter and Louisiana Sea Grant economist Rex Caffey, oysters are the third-most lucrative seafood commodity in the state, behind shrimp and crab. Thus, the recent uptick in illnesses could adversely affect the state’s economy if the public isn’t properly informed on how to mitigate potential infections. “Louisiana is the national leader in oyster production and accounts for more than 75% of Gulf oyster landings,” Caffey said. “The value of Louisiana’s oyster crop has varied in recent years, with an average of $65 million annually from 2022 to 2024.” For additional information about oysters as it relates to handling and production, Watts suggests visiting https://louisianadirectseafood.com/oyster/. Article originally posted here
Aston University researcher investigates safety risks of secondhand cosmetics sold online
As second-hand beauty products grow in popularity, so do questions about their safety. At Aston University, Dr Amreen Bashir, senior lecturer in biomedical science, is leading an academic investigation into the microbiological risks associated with pre-owned cosmetics being sold through online platforms like Vinted and Facebook Marketplace. The project, which has received ethical approval from the University’s Health and Life Sciences Ethics Committee, will assess the types of bacteria and potential contaminants found in used cosmetics – such as makeup and skincare – when they are resold and reused by new owners. “Second-hand beauty is trending for sustainability and affordability,” said Dr Bashir. “But very little research has explored what’s actually living in those products — and what kind of risk that might pose to everyday users.” Why this matters Pre-owned beauty items are often marketed as sustainable and cost-effective, but without careful handling they can harbour microorganisms – from bacteria to mould – that may cause infections, allergic reactions, or worse. Without knowing when a product was first opened or its expiry date, buyers could be unknowingly using unsafe cosmetics. Dr Bashir’s study will be among the first in the UK to analyse not just contamination, but also expiry timelines, and how low consumer awareness of these dates adds to the risk. The study will explore: • Types of microbiological contamination found in used products • Risks posed by product type (e.g., mascaras vs. powders) • Storage conditions and packaging integrity • Expiry dates and consumer awareness, for example: - Cosmetics have expiry timelines printed as either a date or a small jar symbol with a number (e.g., 6M, 12M, 24M, 36M), indicating months after opening. - Products can be contaminated long before the expiry date if not stored properly. - Dr Bashir’s previous research found that many makeup users didn’t know where to find the expiry date on the packaging and often kept products for years past their safe-use period. Potential to shape consumer safety and regulation With second-hand beauty sales on the rise, the findings could help shape public health messaging, consumer awareness campaigns, and online marketplace guidelines. Results could also support industry discussions on product labelling, returns, and hygiene standards. The project bridges the gap between digital consumer behaviour and health science, with implications for how individuals make purchasing decisions and how regulations adapt to a fast-changing beauty market. ⸻ Want to learn more or collaborate? Updates will be shared through academic publications and public-facing channels once data collection and sample testing are complete. Click on the icon below to connect with: Dr Amreen Bashir, senior lecturer in biomedical sciences Areas of expertise: Clinical microbiology, antimicrobial resistance, bacteria found in food, makeup products, food and water microbiology
Research Matters: Targeting ‘jumping genes’ holds promise for treating age-related diseases
A growing number of clinical trials gauging the effects of inhibiting transposons, so-called “jumping genes,” have yielded encouraging results for treating Alzheimer’s and a wide range of other conditions. Vera Gorbunova, a molecular biologist at the University of Rochester whose research on the causes of aging and cancer is widely regarded as pioneering, says researchers tackling aging “need something new, and inhibiting transposons shows great promise.” Gorbunova’s comments were recently featured in Science magazine, a leading news outlet for cutting-edge research in all areas of science. Researchers say clinical trials of transposon inhibitors are important not just to identify potential treatments, but also to test whether jumping genes do, in fact, drive human diseases, as many suspect. Transposon genes are found in a diverse variety of organisms, from miniscule bacteria to humans, and they are known in biological terms as “transposable elements” because they literally jump around the genome. Their vagrancy has been implicated in illnesses such as lupus, Parkinson’s disease, cancer, and aging. Gorbunova is a recognized expert in aging and cancer whose research has been featured in high-profile publications ranging from Nature to The New York Times. Reach out to Gorbunova by clicking on her profile.
Chemical and Life Science Engineering Professor Michael “Pete” Peters, Ph.D., is investigating more efficient ways to manufacture biologic pharmaceuticals using a radial flow bioreactor he developed. With applications in vaccines and other personalized therapeutic treatments, biologics are versatile. Their genetic base can be manipulated to create a variety of effects from fighting infections by stimulating an immune response to weight loss by producing a specific hormone in the body. Ozempic, Wegovy and Victoza are some of the brand names for Glucagon-Like Peptide-1 (GLP-1) receptor agonists used to treat diabetes. These drugs mimic the GLP-1 peptide, a hormone naturally produced in the body that regulates appetite, hunger and blood sugar. “I have a lot of experience with helical peptides like GLP-1 from my work with COVID therapeutics,” says Peters. “When it was discovered that these biologic pharmaceuticals can help with weight loss, demand spiked. These drug types were designed for people with type-2 diabetes and those diabetic patients couldn’t get their GLP-1 treatments. We wanted to find a way for manufacturers to scale up production to meet demand, especially now that further study of GLP-1 has revealed other applications for the drug, like smoking cessation.” Continuous Manufacturing of Biologic Pharmaceuticals Pharmaceuticals come in two basic forms: small-molecule and biologic. Small-molecule medicines are synthetically produced via chemical reactions while biologics are produced from microorganisms. Both types of medications are traditionally produced in a batch process, where base materials are fed into a staged system that produces “batches” of the small-molecule or biologic medication. This process is similar to a chef baking a single cake. Once these materials are exhausted, the batch is complete and the entire system needs to be reset before the next batch begins. “ The batch process can be cumbersome,” says Peters. “Shutting the whole process down and starting it up costs time and money. And if you want a second batch, you have to go through the entire process again after sterilization. Scaling the manufacturing process up is another problem because doubling the system size doesn’t equate to doubling the product. In engineering, that’s called nonlinear phenomena.” Continuous manufacturing improves efficiency and scalability by creating a system where production is ongoing over time rather than staged. These manufacturing techniques can lead to “end-to-end” continuous manufacturing, which is ideal for producing high-demand biologic pharmaceuticals like Ozempic, Wegovy and Victoza. Virginia Commonwealth University’s Medicines for All Institute is also focused on these production innovations. Peters’ continuous manufacturing system for biologics is called a radial flow bioreactor. A disk containing the microorganisms used for production sits on a fixture with a tube coming up through the center of the disk. As the transport fluid comes up the tube, the laminar flow created by its exiting the tube spreads it evenly and continuously over the disk. The interaction between the transport medium coming up the tube and the microorganisms on the disk creates the biological pharmaceutical, which is then taken away by the flow of the transport medium for continuous collection. Flowing the transport medium liquid over a disc coated with biologic-producing microorganisms allows the radial flow bioreactor to continuously produce biologic pharmaceuticals. “There are many advantages to a radial flow bioreactor,” says Peters. “It takes minutes to switch out the disk with the biologic-producing microorganisms. While continuously producing your biologic pharmaceutical, a manufacturer could have another disk in an incubator. Once the microorganisms in the incubator have grown to completely cover the disk, flow of the transport medium liquid to the radial flow bioreactor is shut off. The disk is replaced and then the transport medium flow resumes. That’s minutes for a production changeover instead of the many hours it takes to reset a system in the batch flow process.” The Building Blocks of Biologic Pharmaceuticals Biologic pharmaceuticals are natural molecules created by genetically manipulating microorganisms, like bacteria or mammalian cells. The technology involves designing and inserting a DNA plasmid that carries genetic instructions to the cells. This genetic code is a nucleotide sequence used by the cell to create proteins capable of performing a diverse range of functions within the body. Like musical notes, each nucleotide represents specific genetic information. The arrangement of these sequences, like notes in a song, changes what the cell is instructed to do. In the same way notes can be arranged to create different musical compositions, nucleotide sequences can completely alter a cell’s behavior. Microorganisms transcribe the inserted DNA into a much smaller, mRNA coded molecule. Then the mRNA molecule has its nucleotide code translated into a chain of amino acids, forming a polypeptide that eventually folds into a protein that can act within the body. “One of the disadvantages of biologic design is the wide range of molecular conformations biological molecules can adopt,” says Peters. “Small-molecule medications, on the other hand, are typically more rigid, but difficult to design via first-principle engineering methods. A lot of my focus has been on helical peptides, like GLP-1, that are a programmable biologic pharmaceutical designed from first principles and have the stability of a small-molecule.” The stability Peters describes comes from the helical peptide’s structure, an alpha helix where the amino acid chain coils into a spiral that twists clockwise. Hydrogen bonds that occur between the peptide’s backbone creates a repeating pattern that pulls the helix tightly together to resist conformational changes. “It’s why we used it in our COVID therapeutic and makes it an excellent candidate for GLP-1 continuous production because of its relative stability,” says Peters. Programming The Cell Chemical and Life Science Engineering Assistant Professor Leah Spangler, Ph.D., is an expert at instructing cells to make specific things. Her material science background employs proteins to build or manipulate products not found in nature, like purifying rare-earth elements for use in electronics. “My lab’s function is to make proteins every day,” says Spangler. “The kind of proteins we make depends entirely on the project they are for. More specifically I use proteins to make things that don’t occur in nature. The reason proteins don’t build things like solar cells or the quantum dots used in LCD TVs is because nature is not going to evolve a solar cell or a display surface. Nature doesn’t know what either of those things are. However, proteins can be instructed to build these items, if we code them to.” Spangler is collaborating with Peters in the development of his radial flow bioreactor, specifically to engineer a microorganismal bacteria cell capable of continuously producing biologic pharmaceuticals. “We build proteins by leveraging bacteria to make them for us,” says Spangler. “It’s a well known technology. For this project, we’re hypothesizing that Escherichia coli (E. coli) can be modified to make GLP-1. Personally, I like working with E. coli because it’s a simple bacteria that has been thoroughly studied, so there’s lots of tools available for working with it compared to other cell types.” Development of the process and technique to use E. coli with the radial flow bioreactor is ongoing. “Working with Dr. Spangler has been a game changer for me,” says Peters. “She came to the College of Engineering with a background in protein engineering and an expertise with bacteria. Most of my work was in mammalian cells, so it’s been a great collaboration. We’ve been able to work together and develop this bioreactor to produce GLP-1.” Other Radial Flow Bioreactor Applications Similar to how the GLP-1 peptide has found applications beyond diabetes treatment, the radial flow bioreactor can also be used in different roles. Peters is currently exploring the reactor’s viability for harnessing solar energy. “One of the things we’ve done with the internal disc is to use it as a solar panel,” says Peters. “The disk can be a black body that absorbs light and gets warm. If you run water through the system, water also absorbs the radiation’s energy. The radial flow pattern automatically optimizes energy driving forces with fluid residence time. That makes for a very effective solar heating system. This heating system is a simple proof of concept. Our next step is to determine a method that harnesses solar radiation to create electricity in a continuous manner.” The radial flow bioreactor can also be implemented for environmental cleanup. With a disk tailored for water filtration, desalination or bioremediation, untreated water can be pushed through the system until it reaches a satisfactory level of purification. “The continuous bioreactor design is based on first principles of engineering that our students are learning through their undergraduate education,” says Peters. “The nonlinear scaling laws and performance predictions are fundamentally based. In this day of continued emphasis on empirical AI algorithms, the diminishing understanding of fundamental physics, chemistry, biology and mathematics that underlie engineering principles is a challenge. It’s important we not let first-principles and fundamental understanding be degraded from our educational mission, and projects like the radial flow bioreactor help students see these important fundamentals in action.”
Expert Research: The Surprising Source of Next-Gen Antibiotics: Oyster Blood
Antimicrobial resistance (AMR) is a growing concern across the world and it has doctors worried and scientists working hard to find a solution Basically, AMR is when bacteria and viruses no longer respond to antimicrobial medicines. The result is making infections harder to treat and increases the risk of spreading disease. Recently, Texas Christian University researcher Shauna McGillivray commented on exciting new research in this area that was featured in the media: The search for a solution to antimicrobial resistance found something. And researchers found it in a true “it’s always the last place you look” location. Australian oysters. Or more specifically, Australian oyster blood. Antimicrobial proteins and peptides (AMPPs) “… are an exciting area with a lot of potential,” said Shauna McGillivray, professor of biology at TCU with an emphasis on host-pathogen interactions. “[They] are by themselves very potent but, as has been noted in multiple studies, they can also synergize with existing antibiotics, thereby improving efficacy of antibiotics, even in some cases to antibiotics to which there are high levels of resistance.” Feb. 22 -Phamed.com This is an amazing find and could be groundbreaking for the pharmaceutical industry and health care. And if you're looking to know more about this research and what it means for health care - then let us help. Shauna McGillivray, associate professor of biology is available to speak with media about her recent research - simply click on her icon now to arrange an interview today.
More than half of U.S. states allow the sale of raw milk directly from farms to consumers, a number that would likely increase if Robert F. Kennedy Jr. – a raw milk advocate – is confirmed to lead the Department of Health and Human Services (DHHS). Kali Kniel, a professor of microbial food safety at the University of Delaware, can discuss the dangers and potential benefits of drinking raw milk. Some have celebrated the legalization of raw milk around the country, claiming it tastes better and has some nutritional benefits. Meanwhile, the U.S. Food and Drug Administration, one of the DHHS agencies Kennedy would lead, cautions against drinking raw milk, which comes directly from cows, sheep or goats and has been banned from being sold across state lines since the 1980s. Concerns regarding raw milk have been elevated as a deadly strain of bird flu is infecting dairy farms around the country. In the following Q&A, Kniel talks about the pathogens that may be present in raw milk, ways to communicate food safety to the public and other topics. Milk and other dairy products that sit on shelves at the grocery store are pasteurized. What does this process involve and why is it important for dairy products? Pasteurization of milk is a process of heating milk and passing it between heated stainless steel plates until it reaches 161 degrees Fahrenheit. It is held at that temperature for around 15 seconds before it is quickly cooled to 39 degrees Fahrenheit. This process is intended to kill the pathogenic bacteria that could make a person sick. How does this process affect milk’s quality and nutritional value? Scientific studies have shown that pasteurization does not significantly change the nutritional value of milk. Unpasteurized milk may have more vitamin C, which does not survive the pasteurization process, but milk is not considered a good source of vitamin C, as it contains less than 10% of the Recommended Dietary Allowance (RDA), the average amount of nutrients it takes to meet a healthy person’s needs. There are no beneficial bacteria in raw milk. Milk (pasteurized or raw) is not a good source of probiotic or potentially beneficial bacteria, so for that consumers should choose yogurt and other fermented dairy products as well as other fermented products. Scientific studies using animal models have shown no difference in how calcium in raw milk and pasteurized milk is absorbed by the human body. Popularity in drinking raw milk is increasing, despite the U.S. Food and Drug Administration advising that it’s not safe to drink. What are the health risks that come with drinking raw milk? Raw milk may contain pathogenic bacteria, including Campylobacter, Salmonella, pathogenic types of E. coli, Listeria and Brucella, as well as the protozoan parasite Cryptosporidium. These are all zoonotic microbes, which means they can be transmitted from animals to humans. Often the animal does not appear ill, so it is not possible to determine if an ill animal is shedding these pathogens in its feces that can contaminate milk. Microbial testing of the finished product and environmental monitoring programs may be helpful, but do not guarantee that the raw milk is absent of these pathogens. Milk can be contaminated with these pathogens from direct contamination with feces or from environmental conditions. Cross-contamination from dairy workers can also happen, even when people are trying their best to reduce the risk of cross-contamination. The likelihood of a disease outbreak occurring associated with a person consuming raw milk is relatively high given that others may also be exposed. Unpasteurized milk will have a relatively short shelf life and may not be available for testing. Following good hygiene practices on the farm and during milking such as biosecurity around the farm, appropriately sanitizing equipment and monitoring the health of animals can reduce the chance of milk contamination, but not eliminate it. There have been numerous outbreaks of illness associated with raw milk as well as cheese made from raw milk. Persons most at risk of illness associated with drinking raw milk include children, in particular 5 years of age and under, individuals aged 65 and over, pregnant women and immunocompromised individuals. It should be noted that all outbreaks of illness associated with raw milk have included individuals under 19 years of age. Children may be most vulnerable, as they cannot voice an opinion on consumption and risk of raw milk if it is in their household. The Center for Disease Control and Prevention (CDC) collects data on foodborne disease outbreaks voluntarily reported by state, local or territorial health departments. According to the CDC from 2013 to 2018 there were 75 outbreaks of illness linked to raw milk consumption. These outbreaks include 675 illnesses and 98 hospitalizations. Most of these illnesses were caused by Campylobacter, shiga-toxigenic E. coli, or Salmonella. An increase in outbreaks has been correlated with changes in the availability of raw milk. For example, between 2009 and 2023, there were 25 documented outbreaks in the state of Utah, which has 16 raw milk retailers licensed by the Utah Department of Agriculture and Food. In all of these outbreaks, the raw milk was contaminated with the bacteria Campylobacter, which typically causes gastroenteritis symptoms like diarrhea and nausea, but may also cause chronic illness, including Guillain-Barré syndrome which can cause paralysis. How likely are these illnesses to happen from drinking raw milk? It is difficult to say. Foodborne illness is often underreported, depending on how severe people’s symptoms are. According to one study, only about 3.2% of the U.S. population drinks raw milk, while about 1.6% eats cheese made from raw milk. But compared with consumers of pasteurized dairy products, they are 840 times more likely to experience an illness and 45 times more likely to be hospitalized. The authors of this work used the CDC’s national reporting system to analyze data from 2009 to 2014. Despite health risks, why do some people still drink raw milk? Some people feel a nostalgic connection to raw milk, and others may feel that foods that are not treated with heat retain certain nutrients and enzymatic activity. I am not aware of any peer-reviewed rigorous scientific studies that indicate the nutritional benefits of consuming raw milk over time, given the risks of potential for illness, combined with a well balanced diet full of healthful food choices. It remains that raw milk is particularly risky for children to consume, as children can get sick from consuming fewer bacterial cells compared to adults. More than 900 cases of highly pathogenic avian influenza — the disease commonly known as bird flu — have been detected in dairy cattle across 16 states, and at least 40 people have been infected with the disease from close contact with dairy cows. Raw milk is being tested for the virus. With raw milk gaining interest among consumers, what are the possible consequences? Does it elevate the risk of bird flu spreading further to people? There remain clear risks of transmission of pathogenic bacteria through consumption of raw milk, and now with the potential for contamination of raw milk with avian influenza, it is even more important that consumers protect themselves by drinking pasteurized milk. The people most at risk right now are those involved with the milking process and in the handling of dairy cattle. So it is important that those individuals be aware of the risks and take appropriate precautions, including hand washing and wearing appropriate personal protective equipment like protective clothing, gloves, face shields and eye protection. As of December, the U.S. Department of Agriculture is requiring 13 states to share raw milk samples so the agency can test for bird flu viruses. How could this testing better help us understand the virus? I think it is very smart that USDA is leading the National Milk Testing Strategy, which will help us understand the extent of infected herds. Surveillance of microorganisms is an important way to assess risk so we can develop appropriate strategies to reduce and control these risks.
