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Chemical and Life Science Engineering Professor Michael “Pete” Peters, Ph.D., is investigating more efficient ways to manufacture biologic pharmaceuticals using a radial flow bioreactor he developed. With applications in vaccines and other personalized therapeutic treatments, biologics are versatile. Their genetic base can be manipulated to create a variety of effects from fighting infections by stimulating an immune response to weight loss by producing a specific hormone in the body. Ozempic, Wegovy and Victoza are some of the brand names for Glucagon-Like Peptide-1 (GLP-1) receptor agonists used to treat diabetes. These drugs mimic the GLP-1 peptide, a hormone naturally produced in the body that regulates appetite, hunger and blood sugar. “I have a lot of experience with helical peptides like GLP-1 from my work with COVID therapeutics,” says Peters. “When it was discovered that these biologic pharmaceuticals can help with weight loss, demand spiked. These drug types were designed for people with type-2 diabetes and those diabetic patients couldn’t get their GLP-1 treatments. We wanted to find a way for manufacturers to scale up production to meet demand, especially now that further study of GLP-1 has revealed other applications for the drug, like smoking cessation.” Continuous Manufacturing of Biologic Pharmaceuticals Pharmaceuticals come in two basic forms: small-molecule and biologic. Small-molecule medicines are synthetically produced via chemical reactions while biologics are produced from microorganisms. Both types of medications are traditionally produced in a batch process, where base materials are fed into a staged system that produces “batches” of the small-molecule or biologic medication. This process is similar to a chef baking a single cake. Once these materials are exhausted, the batch is complete and the entire system needs to be reset before the next batch begins. “ The batch process can be cumbersome,” says Peters. “Shutting the whole process down and starting it up costs time and money. And if you want a second batch, you have to go through the entire process again after sterilization. Scaling the manufacturing process up is another problem because doubling the system size doesn’t equate to doubling the product. In engineering, that’s called nonlinear phenomena.” Continuous manufacturing improves efficiency and scalability by creating a system where production is ongoing over time rather than staged. These manufacturing techniques can lead to “end-to-end” continuous manufacturing, which is ideal for producing high-demand biologic pharmaceuticals like Ozempic, Wegovy and Victoza. Virginia Commonwealth University’s Medicines for All Institute is also focused on these production innovations. Peters’ continuous manufacturing system for biologics is called a radial flow bioreactor. A disk containing the microorganisms used for production sits on a fixture with a tube coming up through the center of the disk. As the transport fluid comes up the tube, the laminar flow created by its exiting the tube spreads it evenly and continuously over the disk. The interaction between the transport medium coming up the tube and the microorganisms on the disk creates the biological pharmaceutical, which is then taken away by the flow of the transport medium for continuous collection. Flowing the transport medium liquid over a disc coated with biologic-producing microorganisms allows the radial flow bioreactor to continuously produce biologic pharmaceuticals. “There are many advantages to a radial flow bioreactor,” says Peters. “It takes minutes to switch out the disk with the biologic-producing microorganisms. While continuously producing your biologic pharmaceutical, a manufacturer could have another disk in an incubator. Once the microorganisms in the incubator have grown to completely cover the disk, flow of the transport medium liquid to the radial flow bioreactor is shut off. The disk is replaced and then the transport medium flow resumes. That’s minutes for a production changeover instead of the many hours it takes to reset a system in the batch flow process.” The Building Blocks of Biologic Pharmaceuticals Biologic pharmaceuticals are natural molecules created by genetically manipulating microorganisms, like bacteria or mammalian cells. The technology involves designing and inserting a DNA plasmid that carries genetic instructions to the cells. This genetic code is a nucleotide sequence used by the cell to create proteins capable of performing a diverse range of functions within the body. Like musical notes, each nucleotide represents specific genetic information. The arrangement of these sequences, like notes in a song, changes what the cell is instructed to do. In the same way notes can be arranged to create different musical compositions, nucleotide sequences can completely alter a cell’s behavior. Microorganisms transcribe the inserted DNA into a much smaller, mRNA coded molecule. Then the mRNA molecule has its nucleotide code translated into a chain of amino acids, forming a polypeptide that eventually folds into a protein that can act within the body. “One of the disadvantages of biologic design is the wide range of molecular conformations biological molecules can adopt,” says Peters. “Small-molecule medications, on the other hand, are typically more rigid, but difficult to design via first-principle engineering methods. A lot of my focus has been on helical peptides, like GLP-1, that are a programmable biologic pharmaceutical designed from first principles and have the stability of a small-molecule.” The stability Peters describes comes from the helical peptide’s structure, an alpha helix where the amino acid chain coils into a spiral that twists clockwise. Hydrogen bonds that occur between the peptide’s backbone creates a repeating pattern that pulls the helix tightly together to resist conformational changes. “It’s why we used it in our COVID therapeutic and makes it an excellent candidate for GLP-1 continuous production because of its relative stability,” says Peters. Programming The Cell Chemical and Life Science Engineering Assistant Professor Leah Spangler, Ph.D., is an expert at instructing cells to make specific things. Her material science background employs proteins to build or manipulate products not found in nature, like purifying rare-earth elements for use in electronics. “My lab’s function is to make proteins every day,” says Spangler. “The kind of proteins we make depends entirely on the project they are for. More specifically I use proteins to make things that don’t occur in nature. The reason proteins don’t build things like solar cells or the quantum dots used in LCD TVs is because nature is not going to evolve a solar cell or a display surface. Nature doesn’t know what either of those things are. However, proteins can be instructed to build these items, if we code them to.” Spangler is collaborating with Peters in the development of his radial flow bioreactor, specifically to engineer a microorganismal bacteria cell capable of continuously producing biologic pharmaceuticals. “We build proteins by leveraging bacteria to make them for us,” says Spangler. “It’s a well known technology. For this project, we’re hypothesizing that Escherichia coli (E. coli) can be modified to make GLP-1. Personally, I like working with E. coli because it’s a simple bacteria that has been thoroughly studied, so there’s lots of tools available for working with it compared to other cell types.” Development of the process and technique to use E. coli with the radial flow bioreactor is ongoing. “Working with Dr. Spangler has been a game changer for me,” says Peters. “She came to the College of Engineering with a background in protein engineering and an expertise with bacteria. Most of my work was in mammalian cells, so it’s been a great collaboration. We’ve been able to work together and develop this bioreactor to produce GLP-1.” Other Radial Flow Bioreactor Applications Similar to how the GLP-1 peptide has found applications beyond diabetes treatment, the radial flow bioreactor can also be used in different roles. Peters is currently exploring the reactor’s viability for harnessing solar energy. “One of the things we’ve done with the internal disc is to use it as a solar panel,” says Peters. “The disk can be a black body that absorbs light and gets warm. If you run water through the system, water also absorbs the radiation’s energy. The radial flow pattern automatically optimizes energy driving forces with fluid residence time. That makes for a very effective solar heating system. This heating system is a simple proof of concept. Our next step is to determine a method that harnesses solar radiation to create electricity in a continuous manner.” The radial flow bioreactor can also be implemented for environmental cleanup. With a disk tailored for water filtration, desalination or bioremediation, untreated water can be pushed through the system until it reaches a satisfactory level of purification. “The continuous bioreactor design is based on first principles of engineering that our students are learning through their undergraduate education,” says Peters. “The nonlinear scaling laws and performance predictions are fundamentally based. In this day of continued emphasis on empirical AI algorithms, the diminishing understanding of fundamental physics, chemistry, biology and mathematics that underlie engineering principles is a challenge. It’s important we not let first-principles and fundamental understanding be degraded from our educational mission, and projects like the radial flow bioreactor help students see these important fundamentals in action.”
MEDIA RELEASE: CAA survey finds cannabis-impaired driving remains a concern in Manitoba
As 4/20 approaches, a survey conducted on behalf of CAA Manitoba reveals a trend: while most drivers in the province recognize the risks of cannabis-impaired driving, a significant number continue to drive after consuming cannabis—often in combination with other substances like alcohol or prescription medication. “Manitobans who decide to drive after consuming cannabis often underestimate the risks associated with this action,” said Ewald Friesen, manager, government relations, CAA Manitoba. “People still seem to believe that they have no alternative but to drive home or that the drive is short enough that it doesn’t matter. We are here to remind Manitobans that while cannabis use is legal and can be safely consumed, you should never do it before driving.” Forty-seven per cent of Manitoba drivers used cannabis in 2024; 36 per cent tried cannabis this year for the first time since legalization. Despite growing awareness of the risks, 18 per cent of Manitoba drivers admit to driving after using cannabis, with the majority doing so within just three hours of consumption. Half of those surveyed are driving within three hours of consumption. The survey also revealed that 53 per cent of recent cannabis-impaired drivers reported driving shortly after consumption, with 36 per cent feeling high while behind the wheel. Alarmingly, 79 per cent expressed confidence in their driving ability while impaired, though 71 per cent expressed concern about being caught. “There is a common misconception on how cannabis affects drivers,” says Friesen, “however, it has been proven that cannabis use can impact a driver’s reaction time, judgement, coordination and decision-making.” Driving after consuming edibles has been a growing trend since last year. While smoking remains the primary mode of cannabis use, the survey highlights a growing trend of driving after consuming edibles, which can have delayed and unpredictable effects. Solid edibles (67 per cent) and joints (61 per cent) are the most used formats, and more than half of cannabis users prefer edibles over any other format. "Unlike other forms of cannabis, edibles often have delayed and unpredictable effects, which can significantly impair judgment and reaction times,” adds Friesen. “It is crucial for individuals to recognize these differences and prioritize safety, not only for themselves but for everyone sharing the road." There is a disconnect between what people believe and how they behave when it comes to cannabis and driving. Although 93 per cent of Manitoba drivers agree that cannabis-impaired driving is a serious road safety issue, many still view it as less dangerous than alcohol or prescription opioids. This disconnect between perception and behaviour underscores the need for continued education and enforcement. The penalties for impaired driving are serious and can include: • Immediate 24-hour licence suspension (up to 60 days pending further testing) • Three-day vehicle impoundment • A $400 fine • Mandatory Impaired Driver Assessment • Additional administrative penalties, ignition interlock program requirements, and possible charges under the Criminal Code of Canada CAA Manitoba encourages all motorists to make safe, informed choices: • Know the rules and understand how different cannabis products affect the body. • Don’t drive impaired—whether by cannabis, alcohol, or any combination of substances. • Plan ahead by arranging a rideshare, taxi, or designated driver, especially if planning to consume cannabis during upcoming events like 4/20. The online survey was conducted by DIG Insights from July 5 to July 18, 2024, with 504 Manitoba drivers aged 19 and older. Based on the sample size of n=504 and with a confidence level of 95%, the margin of error for this research is +/- 3%.)
AI-powered model predicts post-concussion injury risk in college athletes
Athletes who suffer a concussion have a serious risk of reinjury after returning to play, but identifying which athletes are most vulnerable has always been a bit of a mystery, until now. Using artificial intelligence (AI), University of Delaware researchers have developed a novel machine learning model that predicts an athlete’s risk of lower-extremity musculoskeletal (MKS) injury after concussion with 95% accuracy. A recent study published in Sports Medicine details the development of the AI model, which builds on previously published research showing that the risk of post-concussion injury doubles, regardless of the sport. The most common post-concussive injuries include sprains, strains, or even broken bones or torn ACLs. “This is due to brain changes we see post-concussion,” said Thomas Buckley, professor of kinesiology and applied physiology at the College of Health Sciences. These brain changes affect athletes’ balance, cognition, and reaction times and can be difficult to detect in standard clinical testing. “Even a minuscule difference in balance, reaction time, or cognitive processing of what’s happening around you can make the difference between getting hurt and not,” Buckley said. How AI is changing injury risk assessment Recognizing the need for enhanced injury reduction risk tools, Buckley collaborated with colleagues in UD’s College of Engineering, Austin Brockmeier, assistant professor of electrical and computer engineering, and César Claros, a fourth-year doctoral student; Wei Qian, associate professor of statistics in the College of Agriculture and Natural Resources; and former KAAP postdoctoral fellow Melissa Anderson, who’s now an assistant professor at Ohio University. To assess injury risk, Brockmeier and Claros developed a comprehensive AI model that analyzes more than 100 variables, including sports and medical histories, concussion type, and pre- and post-concussion cognitive data. “Every athlete is unique, especially across various sports,” said Brockmeier. “Tracking an athlete’s performance over time, rather than relying on absolute values, helps identify disturbances, deviations, or deficits that, when compared to their baseline, may signal an increased risk of injury.” While some sports, such as football, carry higher injury risk, the model revealed that individual factors are just as important as the sport played. “We tested a version of the model that doesn’t have access to the athlete’s sport, and it still accurately predicted injury risk,” Brockmeier said. “This highlights how unique characteristics—not just the inherent risks of a sport—play a critical role in determining the likelihood of future injury,” said Brockmeier. The research, which tracked athletes over two years, also found that the risk of MSK injury post-concussion extends well into the athlete’s return to play. “Common sense would suggest that injuries would occur early in an athlete’s return to play, but that’s simply not true,” said Buckley. “Our research shows that the risk of future injury increases over time as athletes compensate and adapt to small deficits they may not even be aware of.” The next step for Buckey’s Concussion Research Lab is to further collaborate with UD Athletics’ strength and conditioning staff to design real-time interventions that could reduce injury risk. Beyond sports: AI’s potential in aging research The implications of the UD-developed machine-learning model extend far beyond sports. Brockmeier believes the algorithm could be used to predict fall risk in patients with Parkinson’s disease. Claros is also exploring how the injury risk reduction model can be applied to aging research with the Delaware Center for Cognitive Aging. “We want to use brain measurements to investigate whether baseline lifestyle measurements such as weight, BMI, and smoking history are predictive of future mild cognitive impairment or Alzheimer’s disease,” said Claros. To arrange an interview with Buckley, email UD's media relations team at MediaRelations@udel.edu
Researchers race to detect Alzheimer's sooner using $3.9M grant
Too often, people learn they have Alzheimer’s disease when it’s too late. The changes in the brain that lead to the disease manifesting with symptoms have already been occurring for decades. Researchers at the University of Delaware will attempt to detect the disease sooner through a new study that examines changes in the arteries and brain tissue in midlife adults in their 50s and 60s. The findings of this work, funded by a nearly $4 million grant from the National Institute on Aging (NIA), could identify the earliest mechanisms linking vascular aging to the loss of brain tissue integrity, leading to new targets for interventions aimed at preventing age-related cognitive impairment. “People who develop high blood pressure or stiffening of the aorta and carotid arteries in midlife are at a much higher risk for developing cognitive impairment or dementia in late life,” said Christopher Martens, the principal investigator of the study. Martens, an associate professor of kinesiology and applied physiology in UD's College of Health Sciences and director of the Delaware Center for Cognitive Aging (DECCAR), is working closely with Curtis Johnson, an associate professor of biomedical engineering in the College of Engineering and leader of the neuroimaging biomarker core within DECCAR, on research funded by a nearly $4 million grant from the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH). “A lot happens as we age, so we’re aiming to pinpoint the timing and exact mechanisms that cause these changes in midlife adults,” Martens said. This latest grant extends DECCAR’s ongoing Delaware Longitudinal Study for Alzheimer’s Prevention (DeLSAP), which seeks to study how risk and protective factors for dementia are related and change over time. Those eligible for DeLSAP could also meet the criteria for participating in the new study. In his Neurovascular Aging Laboratory, Martens studies mechanisms leading to the stiffening of arteries, while Johnson is specifically interested in measuring the stiffness of the brain. “As a person ages, the brain gets softer and breaks down, and we’re looking to see whether changes in arterial stiffness and patterns of blood flow in the brain cause this decline,” Johnson said. Changes in blood flow to the brain come from controllable factors. Smoking, cardiovascular health, diet and exercise all impact blood flow positively and negatively. “A lot of aging research is done at the end of life,” Johnson said. “We want to look at midlife and try to predict what happens later in life so we can prevent it.” While the brain gets softer with age, arteries get stiffer. “We hypothesize that midlife increases in stiffness in blood vessels cause damaging pulsatile pressure to enter the brain,” Martens said. “We believe this is one of the reasons we start to develop cognitive issues at an older age because the brain is exposed to increased pressure; that pressure is likely inflicting damage on surrounding brain tissue.” In Johnson’s Mechanical Neuroimaging Lab, researchers will use high-resolution magnetic resonance elastography (MRE) to determine where brain damage occurs and what specific brain structures may be affected. “From an MRI perspective, most researchers look at AD and other neurodegenerative diseases like multiple sclerosis with an emphasis on detection in a hospital setting,” Johnson said. “Using highly specialized techniques we’ve developed, we focus on the earlier side and how these changes progress into disease from the neuroscience side, emphasizing prevention.” Together, they’ll seek to learn whether arterial stiffness causes the kind of cognitive impairment seen in AD or whether the decline is associated with a loss in the integrity of brain tissue. “If we can prove arterial stiffness is playing a causal role in cognitive aging, that would provide further support for focusing on blood vessel health as an intervention for delaying AD or other forms of dementia versus solely focusing on the brain,” Martens said.
The annual Healthy Georgia Report has been released by Augusta University’s Institute of Public and Preventive Health and it gives a snapshot of how Georgians stack up against not only neighboring states, but the country when it comes to a variety of health topics. This year’s report has added information on adult dental health, poor mental health, skin cancer and overdose deaths. Information on HIV risk behaviors, breast cancer screenings and colon cancer screenings have also returned. The report has been delivered to lawmakers, community leaders and researchers in Georgia to provide them with tangible figures on how Georgia is faring in numerous topics. The goal is to stimulate conversations about public health needs and, in turn, promote action, such as policy changes, greater community engagement and the appraisal of funds. Biplab Datta, PhD, assistant professor in the IPPH and the Department of Health Management, Economics and Policy, has collaborated with other IPPH faculty and staff to update the report. Datta has seen the impact this can have with state leaders. “They have a good appetite for data driven policy changes. I think this report actually helps them in that direction,” said Datta. “We tried to present data in a way that policy makers may find helpful in deciding on appropriate policy choices.” Overdose deaths is one of the new categories this year and is a hot topic nationwide. The report shows Georgia has the sixth lowest rate of overdose deaths in the country. Datta said that’s good, but the number is trending upwards and now should be the time to take steps to prevent it from getting worse. “We cannot be satisfied. We are doing a good job but need to be on our toes to prevent it from further ascending,” Datta said. Another category that Georgia is trending in a good direction is cigarette smoking. But the opposite is true for the obesity rate in the Peach State. The data shows Georgia has the 14th highest rate of obesity in all of the U.S. and the number is on the rise. The data also shows it’s related to household income and education. Adults who are below the federal poverty line and without a college degree are significantly more likely to be obese. Also, those in the 18-to-49 age group have a high rate of obesity compared to the national and regional average. “That is problematic because if someone is developing some cardiometabolic conditions in this age group, they will be at high risk for adverse cardiovascular events at an older age. So we need to focus on food habits, physical exercise, and other health promoting behaviors to prevent and control obesity,” Datta said. Another interesting topic is those in Georgia who have health insurance coverage. While coverage in adults is second lowest in the nation, there is a slight uptick in the number of people who have coverage from the past few years. The number is much better for children with health insurance. He points out that many state programs like PeachCare for Kids may account for the differences. Datta said one topic that definitely needs to be investigated more is cancer rates. He said we observe a low prevalence rate, despite the common perception and other data sources suggest a relatively higher incidence rate of cancer in Georgia. He believes we may be seeing lower survival rates that are not included in the survey. “I think we need more investigation into this particular issue,” said Datta. “Why are we seeing so low numbers of cancer prevalence when we know that cancer incidence rates are very high in Georgia?” The Healthy Georgia Report is the only report of its kind in the state Looking to know more or connect with Biplab Dhatta? Then let us help. Biplab is available to speak with media regarding this important topic. Simply click on his icon now to arrange an interview today.
In a recent survey conducted by CAA South Central Ontario (CAA SCO), alarming trends indicate a significant rise in cannabis-impaired driving, particularly involving edibles. Key findings from the 2023 survey revealed that 38 per cent of cannabis-impaired drivers in Ontario consumed edibles before driving—a 12 per cent increase from the previous year and more than double the rate in 2019. “The data shows us that while drivers primarily engage in cannabis-impaired driving after smoking a joint, the prevalence of driving under the influence of edibles is on the upswing, and that poses a greater risk to road safety,” says Michael Stewart, community relations consultant at CAA SCO. “Edibles are harder to detect and can take up to two hours for the effects to kick in.” According to the survey, 7 per cent (approximately 750,000 Ontario drivers) admit to driving after consuming some form of cannabis in the past three months. The survey also found that almost three-quarters (70 per cent) of the cannabis-impaired drivers admitted to getting behind the wheel within 3 hours of consumption, and nearly half (45 per cent) have felt high while driving. “Despite the misconception that cannabis may not impair driving ability, it affects coordination, reaction time, attention, judgment, and decision-making. We want to emphasize our commitment to public education, urging motorists to stay informed about the risks and penalties of impaired driving,” says Stewart. The consequences of impaired driving are evident, with 6 per cent of Ontario drivers admitting having ever been charged— an increase from the previous year. Collisions caused by impaired driving also rose to 6 per cent in 2023, compared to 4 per cent in the preceding year. During this holiday season, CAA reminds drivers to make alternate arrangements, such as utilizing rideshare services, to ensure a safe journey home. “While edibles may be legal, CAA emphasizes that they are incompatible with responsible driving,” adds Stewart. Dig Insights conducted an online survey on behalf of CAA SCO between June 22 to July 5, 2023, of 1,518 Ontario drivers aged 19-75 who had access to a vehicle. Based on the sample size and the confidence level (95 per cent), the margin of error for this study was +/- 2 per cent.
#Expert Q&A: Amid the Wildfire Haze, NJIT's Alexei Khalizov Explains What's in the Air
The soot that permeated the air in New Jersey and New York this summer — courtesy of massive wildfires in Canada — is exactly what a New Jersey Institute of Technology professor is studying to determine its impact on climate change. Alexei Khalizov, an associate professor of chemistry and environmental science, is partnering with Associate Professor Gennady Gor on the three-year project, which began last year and is supported by a $620,000 grant from the National Science Foundation. Specifically, they’re examining the soot created by wildfires and the burning of fossil fuels in hopes of better predicting its impact on climate. Khalizov, who’s been at NJIT since 2013, took time out from his research to explain what millions of residents of N.J. and N.Y. are experiencing as a result of the wildfires hundreds of miles to the north. Q: What’s in the smoke? Small particles and some gas chemicals. These particles and chemicals were released by wildfires and they were picked up by the air mass and carried all the way to New Jersey from Canada. Those particles are extremely small: you can stack maybe a hundred of such particles across single human hair thickness. Q: Is breathing it the equivalent of smoking a pack of cigarettes? That would be a reasonable comparison. A cigarette is made of plant material. When it smolders and burns it releases particles that are very much like those particles from wildfires. Maybe the only difference is that the wildfires have no nicotine. But they have lots of other chemicals. Q: What factors contribute to the density of the smoke? Well, it's a major wildfire. It covers a huge territory in Canada. And the meteorology is such that this smoke is carried all the way from Canada to the U.S. without significant dilution. And due to that, the concentration of those particles is very high. Q: When did we last experienced something of this magnitude? We had some Canadian and Alaskan wildfires a few years ago. And air mass transport brought the smoke all the way to New Jersey, but it wasn't as bad as what we are observing today. Q: What about in terms of EPA standards? The Environmental Protection Agency has a list of criteria pollutants. One of those pollutants is particles smaller than 2.5 microns. And typically, if the concentration of those particles exceeds 35 micrograms per cubic meter, the air is considered unhealthy. When I looked at the map of pollution today (June 7, 2023), it showed that throughout the majority of New Jersey, the concentration is around 90 micrograms, which is two to three times higher than this unhealthy threshold. And actually, there is a location, I believe it's around Paterson, where the concentration is 140 micrograms, which is four to five times above the threshold. Q: Can the wildfires in South Jersey be contributing to this? It's possible, but probably it's not a major contribution. Also, if you look at the wind pattern, it's probably not a major factor at all. Q: Why is wind unable to disperse the smoke? For the wind to disperse the smoke, one needs to mix clean air with all this contaminated air and the amount of contaminated air is so high that there’s no clean air around to actually produce any dilution. Q: Why is there so much haze? It’s because of the continuous inflow of air, which is contaminated by emissions from the wildfires. The haze itself has a relatively short lifespan. Q: How does temperature change affect the smoke? If the temperature increases that may accelerate the rate of some chemical reactions that will also be accelerated by the sunlight. And that's one reason why the smoke that was released in Canada is not exactly the same smoke that we experience in New Jersey. As this haze is traveling over three to six hundred miles, it undergoes a number of chemical reactions and even the smell changes. You know how freshly released wood smoke smells — it's actually pretty pleasant. What we're smelling now, it's not pleasant at all. That's the result of those chemical reactions, which makes this even more unhealthy. Q: Will rain immediately clear the smoke? Yes, it will. If we could have rain, then the rain would remove the majority of these particles. And in fact, I believe we've been experiencing the smoke for several days, almost a week now. It would go up and decrease. And we’ve had several rains and those rains did really clear out some smoke. Q: What can we do individually and collectively to protect ourselves? We can help ourselves by staying indoors and wearing masks if you have to go outside. Certainly, exercising outside is not a good idea even while wearing a mask. Also, if you have a central air conditioning system, you can turn on the fan to run the air through the filter, which will remove some of these particles. It depends on what kind of filter you have — high efficiency or regular. Q: What kind of mask? Make sure that it's an N-95 mask, not a surgical mask. A surgical mask is not is not going to help you at all. Q: How does what we’re experiencing relate to your research? My collaborator and I received a major grant from the National Science Foundation to study the particles released by combustion. As they travel through the air, they change both in shape and in composition. And these changes affect their toxicity and they affect their impact on climate. These particles actually are one of the warming agents. So, we hope that within about three years of working on this project, we’ll be able to explain better what happens and then modelers will be able to predict the impacts of such events with better accuracy. Looking to know more - we can help. Alexei Khalizov is available to discuss this important topic with media - simply click on his icon now to arrange an interview.
Frequent tanning can signal excessive concern over image and vulnerability to taking health risks, researcher says Getty Images People who often sunbathe or use tanning beds are more likely to try risky weight-loss methods and have cosmetic surgery, as well as get tattoos and piercings. But while people who seldom tan also may try unsafe diets and cosmetic surgery, they rarely opt for tattoos or piercings, according to a Baylor University study. "When compared to infrequent tanners, frequent body-tanners — regardless of whether they are tanned by ultraviolet light from the sun, ultraviolet light from a tanning bed or methods such as tanning sprays that do not involve UV light — showed significantly higher behavioral intentions to engage in risky appearance-related behaviors overall," said Jay Yoo, Ph.D., associate professor of family and consumer sciences in Baylor's Robbins College of Health and Human Sciences. "Safer tanners, on the other hand, are more concerned about modifying their bodies in ways such as tattoos and piercing that may carry a stigma," Yoo said. Most skin cancer prevention campaigns have emphasized avoidance of getting sunburned, reducing UV exposure and applying sunscreen, but they have neglected the individual's experience with social and appearance concerns, he said. But "Excessive tanning can serve as a possible sign of overt concern over body image, with vulnerability to greater health risks," Yoo said. His research article — "A Study of the Relationships between Tanning Methods and the Intention to Engage in Risky Appearance-Related Behaviors" — is published in Family and Consumer Sciences Research Journal. Data for the study was collected from an online survey of 395 female college students in the southern United States. The major contributor to skin cancer is frequent exposure to ultraviolet rays, with skin cancer the most common — and one of the most preventable — types of cancer, according to the American Cancer Society. Ironically, previous research has found that many people choose to tan because they believe a tan makes them look thinner and more fit, Yoo said. Tanning has gone in and out of fashion, Yoo noted. Tans at one time were associated with lower classes who worked outdoors — in contrast with the Southern belles of more than a century ago, who used parasols to protect their skin and to look pale and refined. In the 1920s, fashion designer Coco Chanel started a fad after accidentally getting sunburned while visiting the French Riviera, Yoo said. Tanning remained popular, with high-fashion models often sporting tans, whether from UV exposure or sprays and bronzers. And these days, some people sport tattoos along with their tans, he said. The study found that: Frequent tanners who expose themselves to UV rays through sunbathing or tanning beds have the strongest intentions to engage in a wider range of risky appearance-related behaviors when compared to infrequent tanners or spray tanners. Such behaviors include extreme weight control methods, such as diet pills, self-induced vomiting, laxatives and diuretics; cosmetic surgery and Botox injections; spa treatments, such as hair removal by waxing (which has been associated with rashes and infections) and gel nail polish (done with UV curing and associated with DNA damage to the skin that can result in premature aging and possibly cancer; and tattoos or piercings. Infrequent tanners, as well as "safe" tanners who seek to achieve an ideal tan without ultraviolet methods (sprays, lotions or bronzers) are much less likely to engage in behaviors that may convey certain stereotypes, such as tattoos or piercings with visual symbols or messages. But they are willing to try other risky appearance-related behaviors. Yoo suggested that intervention strategies adapted for healthcare providers to reduce UV exposure and skin cancer could use stigmatization — perhaps through images of tattooed or pierced individuals who also are tanned. "A negative stigma attached to UV exposure can create ambivalence in our society about achieving a tanned appearance," Yoo said. "This could decrease the popularity of tanning in much the same way the negative stereotyping of smoking and education about its health risks have reduced the number of people who smoke." He noted that in the 1940s and 1950s, smoking was idealized, especially in Hollywood movies, but "there has been a cultural shift," he said. "One way to change the appeal of tanning would be to make it un-cool," Yoo said. "If I tan and people look at me funny, I'm not going to tan anymore." While another way to stigmatize tanning would be to stress the health consequences, "for young people it may be more effective to emphasize the appearance," Yoo said. "The tanning that makes me attractive now may be counteracted for the long haul because at 50 or 60, I may have leathery skin. "Given that tanning emerged as a fashion trend, gradual attitudes toward dangerous tanning can be made possible in a similar fashion," he said.
Deprivation in childhood linked to impulsive behaviour in adulthood – research
Researchers found a link between childhood deprivation, impulsive behaviour and addictions later in life Behaviours include overeating, taking drugs, smoking cigarettes and gambling A second study found adults living in deprived areas displayed similar impulsive traits Children who have experienced deprivation are more likely to make more impulsive choices than those who don’t and can lead to addictions in later life - research has shown. ‘Trait impulsivity’, the preference for immediate gratification, has been linked to spending more on food, especially unhealthy, highly calorific food. Studies have shown that children who experience poverty and food insecurity tend to have a higher body-mass index as adults than those who do not. Researchers from the School of Psychology at Aston University found a link between deprivation in childhood and impulsive behaviour – leading to addictions later in life. The findings, which are a culmination of six years of research, also found a further link between impulsivity, obesity and the cost of living crisis. Professor Richard Tunney, head of the School of Psychology at Aston University, published a study in Scientific Reports earlier this year where he showed that children who experience deprivation make more impulsive choices than children who don’t. The research team studied 146 children, with an average age of eight, living in some of the most deprived areas of England and compared them with children living in some of the most affluent neighbourhoods. Children were given a choice between taking home a small amount of money (for example, £1) or getting £10 a week, or even more a year later. How long a person is willing to wait for the larger amount of money can be used to calculate a ‘discount rate’ that shows how much the waiting time reduces the value of the money. An impulsive person might prefer £1 now because the value of £10 in six months is ‘discounted’ to less than £1 right now. This means that, for them, the £10, is discounted by £9 over the six-month wait. A less impulsive person might be willing to wait six months for £10, but not wait for a whole year for £15. This means that, for them, the value of the £15 is discounted by £5 over the additional six-month wait. This discount rate is a measure of how impulsive someone is. Commenting on the findings, Professor Tunney said: “The results showed that children living in the most deprived areas had significantly higher discount rates than children living in the least deprived areas, regardless of age or intelligence, indicating that deprivation was the causal factor in the children’s choice. “This preference for immediate outcomes is a stable personality trait that remains constant throughout a person’s life.” However, in the research team’s most recent study published by the Royal Society, they investigated impulsivity in over 1,000 older adults aged between 50 and 90. The study found that older adults living in the most deprived areas showed the same preference for smaller-sooner financial outcomes as the children in the first study. It also found that a person’s job predicted the choices they made. Adults working in technical or routine occupations, such as mechanics or cleaners, chose to receive smaller amounts of money than wait for larger amounts compared with people in professional occupations, such as engineers or scientists. Professor Tunney added: “These findings are concerning because impulsivity doesn’t just predict obesity. These findings tell us a lot about why people living in poorer areas tend to be unhealthier than people living in wealthy areas. “People who experience deprivation as children are more likely to choose to do things that, although they might be pleasurable in the short term, are unhealthy in the long run. This includes overeating, taking drugs, smoking cigarettes and gambling. “We know too, that impulsivity can help to explain why some people go on to become addicts, while other people can avoid some of the more harmful effects of drugs and alcohol. “Deprivation is one of many factors that can lead to impulsive behaviour throughout a person’s lifetime. Genetics also plays a role in impulsivity. Policymakers can’t do anything about a person’s genes but they can influence the nation’s long-term mental and physical health by minimising child poverty. Failing to do so will have long-term implications for the children living through today’s cost of living crisis.” For more information about the School of Psychology at Aston University, please visit our website.
Deprivation in childhood linked to impulsive behaviour in adulthood – new study
Inflation is running high around the globe, largely fuelled by Russia’s war in Ukraine and the COVID pandemic. As a result, many households are having to choose between eating and heating. Deprivation has a terrible immediate effect on children – as anyone who has experienced real hunger knows – but it can also affect things like impulsive behaviour in later life. “Trait impulsivity”, the preference for immediate gratification, has been linked to spending more on food, especially unhealthy, highly calorific food. Studies have shown that children who experience poverty and food insecurity tend to have a higher body-mass index as adults than those who do not. In a study published in Scientific Reports earlier this year, my colleagues and I showed that children who experience deprivation make more impulsive choices than children who don’t. We studied 146 children, with an average age of eight, living in some of the most deprived areas of England and compared them with children living in some of the most affluent neighbourhoods. Children were given a choice between taking home a small amount of money (for example, £1) or getting £10 a week, or even more a year later. How long a person is willing to wait for the larger amount of money can be used to calculate a “discount rate” that shows how much the waiting time reduces the value of the money. An impulsive person might prefer £1 now because the value of £10 in six months is “discounted” to less than £1 right now. This means that, for them, the £10, is discounted by £9 over the six-month wait. A less impulsive person might be willing to wait six months for £10, but not wait for a whole year for £15. This means that, for them, the value of the £15 is discounted by £5 over the additional six-month wait. This discount rate is a measure of how impulsive someone is. The results showed that children living in the most deprived areas had significantly higher discount rates than children living in the least deprived areas, regardless of age or intelligence, indicating that deprivation was the causal factor in the children’s choice. A stable trait This preference for immediate outcomes is a stable personality trait that remains constant throughout a person’s life. In our most recent study, published by the Royal Society, we investigated impulsivity in over 1,000 older adults aged between 50 and 90. We found that older adults, living in the most deprived areas, show the same preference for smaller-sooner financial outcomes as the children in our first study. We also found that a person’s job predicted the choices they made. Adults working in technical or routine occupations, such as mechanics or cleaners, chose to receive smaller amounts of money than wait for larger amounts compared with people in professional occupations, such as engineers or scientists. These findings are concerning because impulsivity doesn’t just predict obesity. These findings tell us a lot about why people living in poorer areas tend to be unhealthier than people living in wealthy areas. People who experience deprivation as children are more likely to choose to do things that, although they might be pleasurable in the short term, are unhealthy in the long run. This includes overeating, taking drugs, smoking cigarettes and gambling. We know too, that impulsivity can help to explain why some people go on to become addicts, while other people can avoid some of the more harmful effects of drugs and alcohol. Deprivation is one of many factors that can lead to impulsive behaviour throughout a person’s lifetime. Genetics also plays a role in impulsivity. Policymakers can’t do anything about a person’s genes but they can influence the nation’s long-term mental and physical health by minimising child poverty. Failing to do so will have long-term implications for the children living through today’s cost of living crisis.